Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenylyl cyclase-associated protein 1

Gene

Cap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.By similarity

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • actin polymerization or depolymerization Source: GO_Central
  • ameboidal-type cell migration Source: MGI
  • cell morphogenesis Source: MGI
  • establishment or maintenance of cell polarity Source: GO_Central
  • receptor-mediated endocytosis Source: MGI
  • regulation of adenylate cyclase activity Source: GO_Central
  • signal transduction Source: GO_Central

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl cyclase-associated protein 1
Short name:
CAP 1
Gene namesi
Name:Cap1
Synonyms:Cap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88262 Cap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002056972 – 474Adenylyl cyclase-associated protein 1Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei31PhosphotyrosineCombined sources1
Modified residuei34PhosphoserineBy similarity1
Modified residuei80N6-acetyllysineBy similarity1
Modified residuei286N6-methyllysineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei294PhosphoserineBy similarity1
Modified residuei300PhosphoserineBy similarity1
Modified residuei306PhosphothreonineBy similarity1
Modified residuei307PhosphoserineBy similarity1
Modified residuei309PhosphoserineBy similarity1
Cross-linki347Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP40124
MaxQBiP40124
PaxDbiP40124
PeptideAtlasiP40124
PRIDEiP40124

2D gel databases

REPRODUCTION-2DPAGEiP40124

PTM databases

iPTMnetiP40124
PhosphoSitePlusiP40124
SwissPalmiP40124

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000028656
ExpressionAtlasiP40124 baseline and differential
GenevisibleiP40124 MM

Interactioni

Subunit structurei

Homodimer. Binds actin monomers (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Mcf2Q99N723EBI-641927,EBI-641874

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198468, 2 interactors
DIPiDIP-49641N
IntActiP40124, 8 interactors
MINTiP40124
STRINGi10090.ENSMUSP00000068260

Structurei

3D structure databases

ProteinModelPortaliP40124
SMRiP40124
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini312 – 452C-CAP/cofactor C-likePROSITE-ProRule annotationAdd BLAST141

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi217 – 255Ala/Pro/Ser-richAdd BLAST39
Compositional biasi229 – 240Poly-ProAdd BLAST12

Sequence similaritiesi

Belongs to the CAP family.Curated

Phylogenomic databases

eggNOGiKOG2675 Eukaryota
ENOG410XPXJ LUCA
GeneTreeiENSGT00390000017955
HOGENOMiHOG000206192
HOVERGENiHBG003080
InParanoidiP40124
KOiK17261
OMAiHCGYGDS
OrthoDBiEOG091G0DLX
TreeFamiTF313791

Family and domain databases

Gene3Di1.25.40.330, 1 hit
2.160.20.70, 1 hit
InterProiView protein in InterPro
IPR001837 Adenylate_cyclase-assoc_CAP
IPR013912 Adenylate_cyclase-assoc_CAP_C
IPR013992 Adenylate_cyclase-assoc_CAP_N
IPR017901 C-CAP_CF_C-like
IPR016098 CAP/MinC_C
IPR028415 CAP1
IPR036223 CAP_C_sf
IPR028417 CAP_CS_C
IPR018106 CAP_CS_N
IPR036222 CAP_N_sf
IPR006599 CARP_motif
PANTHERiPTHR10652 PTHR10652, 1 hit
PTHR10652:SF1 PTHR10652:SF1, 1 hit
PfamiView protein in Pfam
PF08603 CAP_C, 1 hit
PF01213 CAP_N, 1 hit
SMARTiView protein in SMART
SM00673 CARP, 2 hits
SUPFAMiSSF101278 SSF101278, 1 hit
SSF69340 SSF69340, 1 hit
PROSITEiView protein in PROSITE
PS51329 C_CAP_COFACTOR_C, 1 hit
PS01088 CAP_1, 1 hit
PS01089 CAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADMQNLVER LERAVGRLEA VSHTSDMHCG YGDSPSKGAV PYVQAFDSLL
60 70 80 90 100
ANPVAEYLKM SKEIGGDVQK HAEMVHTGLK LERALLATAS QCQQPAGNKL
110 120 130 140 150
SDLLAPISEQ IQEVITFREK NRGSKFFNHL SAVSESIQAL GWVALAAKPG
160 170 180 190 200
PFVKEMNDAA MFYTNRVLKE YRDVDKKHVD WVRAYLSIWT ELQAYIKEFH
210 220 230 240 250
TTGLAWSKTG PVAKELSGLP SGPSVGSGPP PPPPGPPPPP ISTSSGSDDS
260 270 280 290 300
ASRSALFAQI NQGESITHAL KHVSDDMKTH KNPALKAQSG PVRSGPKPFS
310 320 330 340 350
APKPQTSPSP KPATKKEPAL LELEGKKWRV ENQENVSNLV IDDTELKQVA
360 370 380 390 400
YIYKCVNTTL QIKGKINSIT VDNCKKLGLV FDDVVGIVEI INSRDVKVQV
410 420 430 440 450
MGKVPTISIN KTDGCHAYLS KNSLDCEIVS AKSSEMNVLI PTEGGDFNEF
460 470
PVPEQFKTLW NGQKLVTTVT EIAG
Length:474
Mass (Da):51,565
Last modified:July 27, 2011 - v4
Checksum:i076863277E7AF2F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242S → P in AAC37610 (PubMed:7691848).Curated1
Sequence conflicti242S → P in AAH05446 (PubMed:15489334).Curated1
Sequence conflicti242S → P in AAH05472 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12367 mRNA Translation: AAC37610.1
AK053351 mRNA Translation: BAC35357.1
AL606906, BX545849 Genomic DNA Translation: CAM13994.1
BX545849, AL606906 Genomic DNA Translation: CAM18197.1
BC005446 mRNA Translation: AAH05446.1
BC005472 mRNA Translation: AAH05472.1
CCDSiCCDS18604.1
PIRiI49572
RefSeqiNP_001287996.1, NM_001301067.1
NP_031624.2, NM_007598.4
XP_006502758.1, XM_006502695.1
XP_006502760.1, XM_006502697.3
UniGeneiMm.8687

Genome annotation databases

EnsembliENSMUST00000069533; ENSMUSP00000068260; ENSMUSG00000028656
ENSMUST00000106255; ENSMUSP00000101862; ENSMUSG00000028656
ENSMUST00000106257; ENSMUSP00000101864; ENSMUSG00000028656
GeneIDi12331
KEGGimmu:12331
UCSCiuc008uok.3 mouse

Similar proteinsi

Entry informationi

Entry nameiCAP1_MOUSE
AccessioniPrimary (citable) accession number: P40124
Secondary accession number(s): Q8BPT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 152 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health