Reviewed, UniProtKB/Swiss-Prot P40123 (CAP2_HUMAN)

Names and origin

Protein names

Recommended name:
    Adenylyl cyclase-associated protein 2
      Short name=CAP 2

Gene names

Name:

CAP2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May have a regulatory bifunctional role.
Subcellular location	Cell membrane; Peripheral membrane proteinBy similarity.
Sequence similarities	Belongs to the CAP family. Contains 1 C-CAP/cofactor C-like domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	activation of adenylate cyclase activity Ref.1 Traceable author statement. Source: ProtInc cytoskeleton organization Inferred from electronic annotation. Source: InterPro establishment or maintenance of cell polarity Ref.1 Traceable author statement. Source: ProtInc signal transduction Ref.1 Traceable author statement. Source: ProtInc
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	actin binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 477	477	Adenylyl cyclase-associated protein 2		PRO_0000205700
Regions
	Domain	317 – 455	139	C-CAP/cofactor C-like
	Compositional bias	232 – 245	14	Poly-Pro
Amino acid modifications
	Modified residue	261	1	Phosphoserine By similarity
	Modified residue	301	1	Phosphoserine
Natural variations
	Natural variant	311	1	T → A: dbSNP rs34620829.		VAR_033717
	Natural variant	316	1	Y → C: dbSNP rs34206659.		VAR_033718

Sequences

	Sequence		Length	Mass (Da)
	P40123-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 2FD3950C094F5AF7	FASTA	477	52,824
	10 20 30 40 50 60 MANMQGLVER LERAVSRLES LSAESHRPPG NCGEVNGVIA GVAPSVEAFD KLMDSMVAEF 70 80 90 100 110 120 LKNSRILAGD VETHAEMVHS AFQAQRAFLL MASQYQQPHE NDVAALLKPI SEKIQEIQTF 130 140 150 160 170 180 RERNRGSNMF NHLSAVSESI PALGWIAVSP KPGPYVKEMN DAATFYTNRV LKDYKHSDLR 190 200 210 220 230 240 HVDWVKSYLN IWSELQAYIK EHHTTGLTWS KTGPVASTVS AFSVLSSGPG LPPPPPPLPP 250 260 270 280 290 300 PGPPPLFENE GKKEESSPSR SALFAQLNQG EAITKGLRHV TDDQKTYKNP SLRAQGGQTQ 310 320 330 340 350 360 SPTKSHTPSP TSPKSYPSQK HAPVLELEGK KWRVEYQEDR NDLVISETEL KQVAYIFKCE 370 380 390 400 410 420 KSTIQIKGKV NSIIIDNCKK LGLVFDNVVG IVEVINSQDI QIQVMGRVPT ISINKTEGCH 430 440 450 460 470 IYLSEDALDC EIVSAKSSEM NILIPQDGDY REFPIPEQFK TAWDGSKLIT EPAEIMA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins." Yu G., Swiston J., Young D. J. Cell Sci. 107:1671-1678(1994) [PubMed: 7962207] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[4]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U02390 mRNA. Translation: AAA20587.1. CR457022 mRNA. Translation: CAG33303.1. BC008481 mRNA. Translation: AAH08481.1.
PIR	I38409.
RefSeq	NP_006357.1.
UniGene	Hs.132902
3D structure databases
HSSP	HSSP built from PDB template 1K8F based on UniProtKB Q01518.
ModBase	Search...
Protein-protein interaction databases
IntAct	P40123.
PTM databases
PhosphoSite	P40123.
Genome annotation databases
Ensembl	ENSG00000112186. Homo sapiens. [Contig view]
GeneID	10486.
KEGG	hsa:10486.
Organism-specific databases
H-InvDB	HIX0005604.
HGNC	HGNC:20039. CAP2.
PharmGKB	PA134989437.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P40123.
HOVERGEN	P40123.
Gene expression databases
ArrayExpress	P40123.
CleanEx	HS_CAP2.
Family and domain databases
InterPro	IPR001837. Adenylate_cyclase-assoc_CAP. IPR013912. Adenylate_cyclase-assoc_CAP_C. IPR013992. Adenylate_cyclase-assoc_CAP_N. IPR016098. CAP/MinC_C. IPR006599. CARP_motif. [Graphical view]
Gene3D	G3DSA:2.160.20.70. CAP/MinC_C. 1 hit.
PANTHER	PTHR10652. CAP. 1 hit.
Pfam	PF08603. CAP_C. 1 hit. PF01213. CAP_N. 1 hit. [Graphical view]
SMART	SM00673. CARP. 2 hits. [Graphical view]
PROSITE	PS51329. C_CAP_COFACTOR_C. 1 hit. PS01088. CAP_1. 1 hit. PS01089. CAP_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	P40123.
NextBio	39788.

Entry information

Entry name

CAP2_HUMAN

Accession

Primary (citable) accession number: P40123
Secondary accession number(s): Q6IAY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 25, 2008
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)