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P40123

- CAP2_HUMAN

UniProt

P40123 - CAP2_HUMAN

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Protein

Adenylyl cyclase-associated protein 2

Gene

CAP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May have a regulatory bifunctional role.

GO - Biological processi

  1. activation of adenylate cyclase activity Source: ProtInc
  2. axon guidance Source: Reactome
  3. cytoskeleton organization Source: InterPro
  4. establishment or maintenance of cell polarity Source: ProtInc
  5. signal transduction Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_19230. Role of Abl in Robo-Slit signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl cyclase-associated protein 2
Short name:
CAP 2
Gene namesi
Name:CAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:20039. CAP2.

Subcellular locationi

Cell membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134989437.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 477476Adenylyl cyclase-associated protein 2PRO_0000205700Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP40123.
PaxDbiP40123.
PRIDEiP40123.

PTM databases

PhosphoSiteiP40123.

Expressioni

Gene expression databases

BgeeiP40123.
CleanExiHS_CAP2.
ExpressionAtlasiP40123. baseline and differential.
GenevestigatoriP40123.

Organism-specific databases

HPAiHPA050530.
HPA054147.

Interactioni

Protein-protein interaction databases

BioGridi115749. 10 interactions.
IntActiP40123. 2 interactions.
MINTiMINT-1182008.
STRINGi9606.ENSP00000229922.

Structurei

3D structure databases

ProteinModelPortaliP40123.
SMRiP40123. Positions 45-220, 324-475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini317 – 455139C-CAP/cofactor C-likePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi232 – 24514Poly-ProAdd
BLAST

Sequence similaritiesi

Belongs to the CAP family.Curated
Contains 1 C-CAP/cofactor C-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG254262.
GeneTreeiENSGT00390000017955.
HOGENOMiHOG000206192.
HOVERGENiHBG003080.
InParanoidiP40123.
KOiK17261.
OMAiAQGGQTR.
OrthoDBiEOG7DNNTH.
PhylomeDBiP40123.
TreeFamiTF313791.

Family and domain databases

Gene3Di2.160.20.70. 1 hit.
InterProiIPR001837. Adenylate_cyclase-assoc_CAP.
IPR013912. Adenylate_cyclase-assoc_CAP_C.
IPR013992. Adenylate_cyclase-assoc_CAP_N.
IPR017901. C-CAP_CF_C-like.
IPR016098. CAP/MinC_C.
IPR028418. CAP2.
IPR028417. CAP_CS_C.
IPR018106. CAP_CS_N.
IPR006599. CARP_motif.
[Graphical view]
PANTHERiPTHR10652. PTHR10652. 1 hit.
PTHR10652:SF2. PTHR10652:SF2. 1 hit.
PfamiPF08603. CAP_C. 1 hit.
PF01213. CAP_N. 1 hit.
[Graphical view]
SMARTiSM00673. CARP. 2 hits.
[Graphical view]
SUPFAMiSSF101278. SSF101278. 1 hit.
SSF69340. SSF69340. 1 hit.
PROSITEiPS51329. C_CAP_COFACTOR_C. 1 hit.
PS01088. CAP_1. 1 hit.
PS01089. CAP_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P40123-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANMQGLVER LERAVSRLES LSAESHRPPG NCGEVNGVIA GVAPSVEAFD
60 70 80 90 100
KLMDSMVAEF LKNSRILAGD VETHAEMVHS AFQAQRAFLL MASQYQQPHE
110 120 130 140 150
NDVAALLKPI SEKIQEIQTF RERNRGSNMF NHLSAVSESI PALGWIAVSP
160 170 180 190 200
KPGPYVKEMN DAATFYTNRV LKDYKHSDLR HVDWVKSYLN IWSELQAYIK
210 220 230 240 250
EHHTTGLTWS KTGPVASTVS AFSVLSSGPG LPPPPPPLPP PGPPPLFENE
260 270 280 290 300
GKKEESSPSR SALFAQLNQG EAITKGLRHV TDDQKTYKNP SLRAQGGQTQ
310 320 330 340 350
SPTKSHTPSP TSPKSYPSQK HAPVLELEGK KWRVEYQEDR NDLVISETEL
360 370 380 390 400
KQVAYIFKCE KSTIQIKGKV NSIIIDNCKK LGLVFDNVVG IVEVINSQDI
410 420 430 440 450
QIQVMGRVPT ISINKTEGCH IYLSEDALDC EIVSAKSSEM NILIPQDGDY
460 470
REFPIPEQFK TAWDGSKLIT EPAEIMA
Length:477
Mass (Da):52,824
Last modified:February 1, 1995 - v1
Checksum:i2FD3950C094F5AF7
GO
Isoform 2 (identifier: P40123-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-212: Missing.

Note: No experimental confirmation available.

Show »
Length:413
Mass (Da):45,245
Checksum:i9733239D20559B64
GO
Isoform 3 (identifier: P40123-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-334: Missing.

Note: No experimental confirmation available.

Show »
Length:217
Mass (Da):24,018
Checksum:iA112774A5C374E3C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti311 – 3111T → A.
Corresponds to variant rs34620829 [ dbSNP | Ensembl ].
VAR_033717
Natural varianti316 – 3161Y → C.
Corresponds to variant rs34206659 [ dbSNP | Ensembl ].
VAR_033718

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei75 – 334260Missing in isoform 3. 1 PublicationVSP_055519Add
BLAST
Alternative sequencei149 – 21264Missing in isoform 2. 1 PublicationVSP_055520Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02390 mRNA. Translation: AAA20587.1.
CR457022 mRNA. Translation: CAG33303.1.
AK294215 mRNA. Translation: BAH11700.1.
AL034372 Genomic DNA. No translation available.
AL138824 Genomic DNA. No translation available.
AK293134 mRNA. Translation: BAH11460.1.
AK312362 mRNA. Translation: BAG35280.1.
CH471087 Genomic DNA. Translation: EAW55380.1.
BC008481 mRNA. Translation: AAH08481.1.
CCDSiCCDS4539.1. [P40123-1]
PIRiI38409.
RefSeqiNP_006357.1. NM_006366.2. [P40123-1]
UniGeneiHs.132902.

Genome annotation databases

EnsembliENST00000229922; ENSP00000229922; ENSG00000112186. [P40123-1]
ENST00000465994; ENSP00000418604; ENSG00000112186. [P40123-2]
ENST00000493172; ENSP00000417208; ENSG00000112186. [P40123-3]
GeneIDi10486.
KEGGihsa:10486.
UCSCiuc003ncb.3. human. [P40123-1]

Polymorphism databases

DMDMi729015.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02390 mRNA. Translation: AAA20587.1 .
CR457022 mRNA. Translation: CAG33303.1 .
AK294215 mRNA. Translation: BAH11700.1 .
AL034372 Genomic DNA. No translation available.
AL138824 Genomic DNA. No translation available.
AK293134 mRNA. Translation: BAH11460.1 .
AK312362 mRNA. Translation: BAG35280.1 .
CH471087 Genomic DNA. Translation: EAW55380.1 .
BC008481 mRNA. Translation: AAH08481.1 .
CCDSi CCDS4539.1. [P40123-1 ]
PIRi I38409.
RefSeqi NP_006357.1. NM_006366.2. [P40123-1 ]
UniGenei Hs.132902.

3D structure databases

ProteinModelPortali P40123.
SMRi P40123. Positions 45-220, 324-475.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115749. 10 interactions.
IntActi P40123. 2 interactions.
MINTi MINT-1182008.
STRINGi 9606.ENSP00000229922.

PTM databases

PhosphoSitei P40123.

Polymorphism databases

DMDMi 729015.

Proteomic databases

MaxQBi P40123.
PaxDbi P40123.
PRIDEi P40123.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000229922 ; ENSP00000229922 ; ENSG00000112186 . [P40123-1 ]
ENST00000465994 ; ENSP00000418604 ; ENSG00000112186 . [P40123-2 ]
ENST00000493172 ; ENSP00000417208 ; ENSG00000112186 . [P40123-3 ]
GeneIDi 10486.
KEGGi hsa:10486.
UCSCi uc003ncb.3. human. [P40123-1 ]

Organism-specific databases

CTDi 10486.
GeneCardsi GC06P017393.
HGNCi HGNC:20039. CAP2.
HPAi HPA050530.
HPA054147.
neXtProti NX_P40123.
PharmGKBi PA134989437.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG254262.
GeneTreei ENSGT00390000017955.
HOGENOMi HOG000206192.
HOVERGENi HBG003080.
InParanoidi P40123.
KOi K17261.
OMAi AQGGQTR.
OrthoDBi EOG7DNNTH.
PhylomeDBi P40123.
TreeFami TF313791.

Enzyme and pathway databases

Reactomei REACT_19230. Role of Abl in Robo-Slit signaling.

Miscellaneous databases

ChiTaRSi CAP2. human.
GeneWikii CAP2.
GenomeRNAii 10486.
NextBioi 35478694.
PROi P40123.

Gene expression databases

Bgeei P40123.
CleanExi HS_CAP2.
ExpressionAtlasi P40123. baseline and differential.
Genevestigatori P40123.

Family and domain databases

Gene3Di 2.160.20.70. 1 hit.
InterProi IPR001837. Adenylate_cyclase-assoc_CAP.
IPR013912. Adenylate_cyclase-assoc_CAP_C.
IPR013992. Adenylate_cyclase-assoc_CAP_N.
IPR017901. C-CAP_CF_C-like.
IPR016098. CAP/MinC_C.
IPR028418. CAP2.
IPR028417. CAP_CS_C.
IPR018106. CAP_CS_N.
IPR006599. CARP_motif.
[Graphical view ]
PANTHERi PTHR10652. PTHR10652. 1 hit.
PTHR10652:SF2. PTHR10652:SF2. 1 hit.
Pfami PF08603. CAP_C. 1 hit.
PF01213. CAP_N. 1 hit.
[Graphical view ]
SMARTi SM00673. CARP. 2 hits.
[Graphical view ]
SUPFAMi SSF101278. SSF101278. 1 hit.
SSF69340. SSF69340. 1 hit.
PROSITEi PS51329. C_CAP_COFACTOR_C. 1 hit.
PS01088. CAP_1. 1 hit.
PS01089. CAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins."
    Yu G., Swiston J., Young D.
    J. Cell Sci. 107:1671-1678(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Amygdala.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Prostate.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCAP2_HUMAN
AccessioniPrimary (citable) accession number: P40123
Secondary accession number(s): B2R5Y3
, B7Z1C4, B7Z214, Q6IAY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3