P40123 (CAP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylyl cyclase-associated protein 2
Short name=CAP 2

Gene names

Name:

CAP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have a regulatory bifunctional role.
Subcellular location	Cell membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the CAP family. Contains 1 C-CAP/cofactor C-like domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of adenylate cyclase activity Traceable author statement Ref.1. Source: ProtInc axon guidance Traceable author statement. Source: Reactome cytoskeleton organization Inferred from electronic annotation. Source: InterPro establishment or maintenance of cell polarity Traceable author statement Ref.1. Source: ProtInc signal transduction Traceable author statement Ref.1. Source: ProtInc
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 477	477	Adenylyl cyclase-associated protein 2		PRO_0000205700
Regions
	Domain	317 – 455	139	C-CAP/cofactor C-like
	Compositional bias	232 – 245	14	Poly-Pro
Amino acid modifications
	Modified residue	261	1	Phosphoserine By similarity
Natural variations
	Natural variant	311	1	T → A. Corresponds to variant rs34620829 [ dbSNP | Ensembl ].		VAR_033717
	Natural variant	316	1	Y → C. Corresponds to variant rs34206659 [ dbSNP | Ensembl ].		VAR_033718

Sequences

	Sequence		Length	Mass (Da)
	P40123 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 2FD3950C094F5AF7	FASTA	477	52,824
	10 20 30 40 50 60 MANMQGLVER LERAVSRLES LSAESHRPPG NCGEVNGVIA GVAPSVEAFD KLMDSMVAEF 70 80 90 100 110 120 LKNSRILAGD VETHAEMVHS AFQAQRAFLL MASQYQQPHE NDVAALLKPI SEKIQEIQTF 130 140 150 160 170 180 RERNRGSNMF NHLSAVSESI PALGWIAVSP KPGPYVKEMN DAATFYTNRV LKDYKHSDLR 190 200 210 220 230 240 HVDWVKSYLN IWSELQAYIK EHHTTGLTWS KTGPVASTVS AFSVLSSGPG LPPPPPPLPP 250 260 270 280 290 300 PGPPPLFENE GKKEESSPSR SALFAQLNQG EAITKGLRHV TDDQKTYKNP SLRAQGGQTQ 310 320 330 340 350 360 SPTKSHTPSP TSPKSYPSQK HAPVLELEGK KWRVEYQEDR NDLVISETEL KQVAYIFKCE 370 380 390 400 410 420 KSTIQIKGKV NSIIIDNCKK LGLVFDNVVG IVEVINSQDI QIQVMGRVPT ISINKTEGCH 430 440 450 460 470 IYLSEDALDC EIVSAKSSEM NILIPQDGDY REFPIPEQFK TAWDGSKLIT EPAEIMA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins." Yu G., Swiston J., Young D. J. Cell Sci. 107:1671-1678(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Amygdala.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[6]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U02390 mRNA. Translation: AAA20587.1. CR457022 mRNA. Translation: CAG33303.1. AK312362 mRNA. Translation: BAG35280.1. CH471087 Genomic DNA. Translation: EAW55380.1. BC008481 mRNA. Translation: AAH08481.1.
IPI	IPI00027342.
PIR	I38409.
RefSeq	NP_006357.1. NM_006366.2.
UniGene	Hs.132902.
3D structure databases
ProteinModelPortal	P40123.
ModBase	Search...
Protein-protein interaction databases
IntAct	P40123. 1 interaction.
MINT	MINT-1182008.
STRING	9606.ENSP00000229922.
PTM databases
PhosphoSite	P40123.
Polymorphism databases
DMDM	729015.
Proteomic databases
PaxDb	P40123.
PRIDE	P40123.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000229922; ENSP00000229922; ENSG00000112186.
GeneID	10486.
KEGG	hsa:10486.
UCSC	uc003ncb.3. human.
Organism-specific databases
CTD	10486.
GeneCards	GC06P017393.
HGNC	HGNC:20039. CAP2.
HPA	HPA050530. HPA054147.
neXtProt	NX_P40123.
PharmGKB	PA134989437.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG254262.
HOGENOM	HOG000206192.
HOVERGEN	HBG003080.
InParanoid	P40123.
OMA	LFENEGR.
OrthoDB	EOG4HT8SH.
PhylomeDB	P40123.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
ArrayExpress	P40123.
Bgee	P40123.
CleanEx	HS_CAP2.
Genevestigator	P40123.
Family and domain databases
Gene3D	2.160.20.70. 1 hit.
InterPro	IPR001837. Adenylate_cyclase-assoc_CAP. IPR013912. Adenylate_cyclase-assoc_CAP_C. IPR013992. Adenylate_cyclase-assoc_CAP_N. IPR017901. C-CAP_CF_C-like. IPR016098. CAP/MinC_C. IPR018106. CAP_CS. IPR006599. CARP_motif. [Graphical view]
PANTHER	PTHR10652. PTHR10652. 1 hit.
Pfam	PF08603. CAP_C. 1 hit. PF01213. CAP_N. 1 hit. [Graphical view]
SMART	SM00673. CARP. 2 hits. [Graphical view]
SUPFAM	SSF101278. Adenylate_cyclase-assoc_CAP_N. 1 hit. SSF69340. CARP. 1 hit.
PROSITE	PS51329. C_CAP_COFACTOR_C. 1 hit. PS01088. CAP_1. 1 hit. PS01089. CAP_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CAP2. human.
GenomeRNAi	10486.
NextBio	39788.

Entry information

Entry name

CAP2_HUMAN

Accession

Primary (citable) accession number: P40123
Secondary accession number(s): B2R5Y3, Q6IAY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.