Reviewed,
UniProtKB/Swiss-Prot P40123 (CAP2_HUMAN)
Last modified
November 25, 2008.
Version 69.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Adenylyl cyclase-associated protein 2 Short name=CAP 2 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 477 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May have a regulatory bifunctional role. |
| Subcellular location | Cell membrane; Peripheral membrane proteinBy similarity. |
| Sequence similarities | Belongs to the CAP family. Contains 1 C-CAP/cofactor C-like domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Polymorphism |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | activation of adenylate cyclase activity Ref.1 Traceable author statement. Source: ProtInc cytoskeleton organizationInferred from electronic annotation. Source: InterPro establishment or maintenance of cell polarity Ref.1Traceable author statement. Source: ProtInc signal transduction Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | actin binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 477 | 477 | Adenylyl cyclase-associated protein 2 | PRO_0000205700 | |||||
Regions | |||||||||
| Domain | 317 – 455 | 139 | C-CAP/cofactor C-like | ||||||
| Compositional bias | 232 – 245 | 14 | Poly-Pro | ||||||
Amino acid modifications | |||||||||
| Modified residue | 261 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 301 | 1 | Phosphoserine | ||||||
Natural variations | |||||||||
| Natural variant | 311 | 1 | T → A: dbSNP rs34620829. | VAR_033717 | |||||
| Natural variant | 316 | 1 | Y → C: dbSNP rs34206659. | VAR_033718 | |||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins." Yu G., Swiston J., Young D. J. Cell Sci. 107:1671-1678(1994) [PubMed: 7962207] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate. |
| [4] | "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U02390 mRNA. Translation: AAA20587.1. CR457022 mRNA. Translation: CAG33303.1. BC008481 mRNA. Translation: AAH08481.1. | |
| PIR | I38409. |
| RefSeq | NP_006357.1. |
| UniGene | Hs.132902 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1K8F based on UniProtKB Q01518. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P40123. |
PTM databases | |
| PhosphoSite | P40123. |
Genome annotation databases | |
| Ensembl | ENSG00000112186. Homo sapiens. [Contig view] |
| GeneID | 10486. |
| KEGG | hsa:10486. |
Organism-specific databases | |
| H-InvDB | HIX0005604. |
| HGNC | HGNC:20039. CAP2. |
| PharmGKB | PA134989437. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P40123. |
| HOVERGEN | P40123. |
Gene expression databases | |
| ArrayExpress | P40123. |
| CleanEx | HS_CAP2. |
Family and domain databases | |
| InterPro | IPR001837. Adenylate_cyclase-assoc_CAP. IPR013912. Adenylate_cyclase-assoc_CAP_C. IPR013992. Adenylate_cyclase-assoc_CAP_N. IPR016098. CAP/MinC_C. IPR006599. CARP_motif. [Graphical view] |
| Gene3D | G3DSA:2.160.20.70. CAP/MinC_C. 1 hit. |
| PANTHER | PTHR10652. CAP. 1 hit. |
| Pfam | PF08603. CAP_C. 1 hit. PF01213. CAP_N. 1 hit. [Graphical view] |
| SMART | SM00673. CARP. 2 hits. [Graphical view] |
| PROSITE | PS51329. C_CAP_COFACTOR_C. 1 hit. PS01088. CAP_1. 1 hit. PS01089. CAP_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | P40123. |
| NextBio | 39788. |
Entry information
| Entry name | CAP2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P40123 Secondary accession number(s): Q6IAY2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with


