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P40123

- CAP2_HUMAN

UniProt

P40123 - CAP2_HUMAN

Protein

Adenylyl cyclase-associated protein 2

Gene

CAP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    May have a regulatory bifunctional role.

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: ProtInc
    2. axon guidance Source: Reactome
    3. cell morphogenesis Source: InterPro
    4. cytoskeleton organization Source: InterPro
    5. establishment or maintenance of cell polarity Source: ProtInc
    6. signal transduction Source: ProtInc

    Enzyme and pathway databases

    ReactomeiREACT_19230. Role of Abl in Robo-Slit signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylyl cyclase-associated protein 2
    Short name:
    CAP 2
    Gene namesi
    Name:CAP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:20039. CAP2.

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134989437.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 477476Adenylyl cyclase-associated protein 2PRO_0000205700Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP40123.
    PaxDbiP40123.
    PRIDEiP40123.

    PTM databases

    PhosphoSiteiP40123.

    Expressioni

    Gene expression databases

    ArrayExpressiP40123.
    BgeeiP40123.
    CleanExiHS_CAP2.
    GenevestigatoriP40123.

    Organism-specific databases

    HPAiHPA050530.
    HPA054147.

    Interactioni

    Protein-protein interaction databases

    BioGridi115749. 9 interactions.
    IntActiP40123. 2 interactions.
    MINTiMINT-1182008.
    STRINGi9606.ENSP00000229922.

    Structurei

    3D structure databases

    ProteinModelPortaliP40123.
    SMRiP40123. Positions 45-220, 324-475.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini317 – 455139C-CAP/cofactor C-likePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi232 – 24514Poly-ProAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CAP family.Curated
    Contains 1 C-CAP/cofactor C-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG254262.
    HOGENOMiHOG000206192.
    HOVERGENiHBG003080.
    InParanoidiP40123.
    KOiK17261.
    OMAiAQGGQTR.
    OrthoDBiEOG7DNNTH.
    PhylomeDBiP40123.
    TreeFamiTF313791.

    Family and domain databases

    Gene3Di2.160.20.70. 1 hit.
    InterProiIPR001837. Adenylate_cyclase-assoc_CAP.
    IPR013912. Adenylate_cyclase-assoc_CAP_C.
    IPR013992. Adenylate_cyclase-assoc_CAP_N.
    IPR017901. C-CAP_CF_C-like.
    IPR016098. CAP/MinC_C.
    IPR028418. CAP2.
    IPR028417. CAP_CS_C.
    IPR018106. CAP_CS_N.
    IPR006599. CARP_motif.
    [Graphical view]
    PANTHERiPTHR10652. PTHR10652. 1 hit.
    PTHR10652:SF2. PTHR10652:SF2. 1 hit.
    PfamiPF08603. CAP_C. 1 hit.
    PF01213. CAP_N. 1 hit.
    [Graphical view]
    SMARTiSM00673. CARP. 2 hits.
    [Graphical view]
    SUPFAMiSSF101278. SSF101278. 1 hit.
    SSF69340. SSF69340. 1 hit.
    PROSITEiPS51329. C_CAP_COFACTOR_C. 1 hit.
    PS01088. CAP_1. 1 hit.
    PS01089. CAP_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P40123-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MANMQGLVER LERAVSRLES LSAESHRPPG NCGEVNGVIA GVAPSVEAFD    50
    KLMDSMVAEF LKNSRILAGD VETHAEMVHS AFQAQRAFLL MASQYQQPHE 100
    NDVAALLKPI SEKIQEIQTF RERNRGSNMF NHLSAVSESI PALGWIAVSP 150
    KPGPYVKEMN DAATFYTNRV LKDYKHSDLR HVDWVKSYLN IWSELQAYIK 200
    EHHTTGLTWS KTGPVASTVS AFSVLSSGPG LPPPPPPLPP PGPPPLFENE 250
    GKKEESSPSR SALFAQLNQG EAITKGLRHV TDDQKTYKNP SLRAQGGQTQ 300
    SPTKSHTPSP TSPKSYPSQK HAPVLELEGK KWRVEYQEDR NDLVISETEL 350
    KQVAYIFKCE KSTIQIKGKV NSIIIDNCKK LGLVFDNVVG IVEVINSQDI 400
    QIQVMGRVPT ISINKTEGCH IYLSEDALDC EIVSAKSSEM NILIPQDGDY 450
    REFPIPEQFK TAWDGSKLIT EPAEIMA 477
    Length:477
    Mass (Da):52,824
    Last modified:February 1, 1995 - v1
    Checksum:i2FD3950C094F5AF7
    GO
    Isoform 2 (identifier: P40123-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         149-212: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:413
    Mass (Da):45,245
    Checksum:i9733239D20559B64
    GO
    Isoform 3 (identifier: P40123-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         75-334: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:217
    Mass (Da):24,018
    Checksum:iA112774A5C374E3C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti311 – 3111T → A.
    Corresponds to variant rs34620829 [ dbSNP | Ensembl ].
    VAR_033717
    Natural varianti316 – 3161Y → C.
    Corresponds to variant rs34206659 [ dbSNP | Ensembl ].
    VAR_033718

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei75 – 334260Missing in isoform 3. 1 PublicationVSP_055519Add
    BLAST
    Alternative sequencei149 – 21264Missing in isoform 2. 1 PublicationVSP_055520Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U02390 mRNA. Translation: AAA20587.1.
    CR457022 mRNA. Translation: CAG33303.1.
    AK294215 mRNA. Translation: BAH11700.1.
    AL034372 Genomic DNA. No translation available.
    AL138824 Genomic DNA. No translation available.
    AK293134 mRNA. Translation: BAH11460.1.
    AK312362 mRNA. Translation: BAG35280.1.
    CH471087 Genomic DNA. Translation: EAW55380.1.
    BC008481 mRNA. Translation: AAH08481.1.
    CCDSiCCDS4539.1.
    PIRiI38409.
    RefSeqiNP_006357.1. NM_006366.2.
    UniGeneiHs.132902.

    Genome annotation databases

    EnsembliENST00000229922; ENSP00000229922; ENSG00000112186. [P40123-1]
    ENST00000465994; ENSP00000418604; ENSG00000112186. [P40123-2]
    ENST00000493172; ENSP00000417208; ENSG00000112186. [P40123-3]
    GeneIDi10486.
    KEGGihsa:10486.
    UCSCiuc003ncb.3. human.

    Polymorphism databases

    DMDMi729015.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U02390 mRNA. Translation: AAA20587.1 .
    CR457022 mRNA. Translation: CAG33303.1 .
    AK294215 mRNA. Translation: BAH11700.1 .
    AL034372 Genomic DNA. No translation available.
    AL138824 Genomic DNA. No translation available.
    AK293134 mRNA. Translation: BAH11460.1 .
    AK312362 mRNA. Translation: BAG35280.1 .
    CH471087 Genomic DNA. Translation: EAW55380.1 .
    BC008481 mRNA. Translation: AAH08481.1 .
    CCDSi CCDS4539.1.
    PIRi I38409.
    RefSeqi NP_006357.1. NM_006366.2.
    UniGenei Hs.132902.

    3D structure databases

    ProteinModelPortali P40123.
    SMRi P40123. Positions 45-220, 324-475.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115749. 9 interactions.
    IntActi P40123. 2 interactions.
    MINTi MINT-1182008.
    STRINGi 9606.ENSP00000229922.

    PTM databases

    PhosphoSitei P40123.

    Polymorphism databases

    DMDMi 729015.

    Proteomic databases

    MaxQBi P40123.
    PaxDbi P40123.
    PRIDEi P40123.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000229922 ; ENSP00000229922 ; ENSG00000112186 . [P40123-1 ]
    ENST00000465994 ; ENSP00000418604 ; ENSG00000112186 . [P40123-2 ]
    ENST00000493172 ; ENSP00000417208 ; ENSG00000112186 . [P40123-3 ]
    GeneIDi 10486.
    KEGGi hsa:10486.
    UCSCi uc003ncb.3. human.

    Organism-specific databases

    CTDi 10486.
    GeneCardsi GC06P017393.
    HGNCi HGNC:20039. CAP2.
    HPAi HPA050530.
    HPA054147.
    neXtProti NX_P40123.
    PharmGKBi PA134989437.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG254262.
    HOGENOMi HOG000206192.
    HOVERGENi HBG003080.
    InParanoidi P40123.
    KOi K17261.
    OMAi AQGGQTR.
    OrthoDBi EOG7DNNTH.
    PhylomeDBi P40123.
    TreeFami TF313791.

    Enzyme and pathway databases

    Reactomei REACT_19230. Role of Abl in Robo-Slit signaling.

    Miscellaneous databases

    ChiTaRSi CAP2. human.
    GeneWikii CAP2.
    GenomeRNAii 10486.
    NextBioi 39788.
    PROi P40123.

    Gene expression databases

    ArrayExpressi P40123.
    Bgeei P40123.
    CleanExi HS_CAP2.
    Genevestigatori P40123.

    Family and domain databases

    Gene3Di 2.160.20.70. 1 hit.
    InterProi IPR001837. Adenylate_cyclase-assoc_CAP.
    IPR013912. Adenylate_cyclase-assoc_CAP_C.
    IPR013992. Adenylate_cyclase-assoc_CAP_N.
    IPR017901. C-CAP_CF_C-like.
    IPR016098. CAP/MinC_C.
    IPR028418. CAP2.
    IPR028417. CAP_CS_C.
    IPR018106. CAP_CS_N.
    IPR006599. CARP_motif.
    [Graphical view ]
    PANTHERi PTHR10652. PTHR10652. 1 hit.
    PTHR10652:SF2. PTHR10652:SF2. 1 hit.
    Pfami PF08603. CAP_C. 1 hit.
    PF01213. CAP_N. 1 hit.
    [Graphical view ]
    SMARTi SM00673. CARP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF101278. SSF101278. 1 hit.
    SSF69340. SSF69340. 1 hit.
    PROSITEi PS51329. C_CAP_COFACTOR_C. 1 hit.
    PS01088. CAP_1. 1 hit.
    PS01089. CAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins."
      Yu G., Swiston J., Young D.
      J. Cell Sci. 107:1671-1678(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Amygdala.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Prostate.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCAP2_HUMAN
    AccessioniPrimary (citable) accession number: P40123
    Secondary accession number(s): B2R5Y3
    , B7Z1C4, B7Z214, Q6IAY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3