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Protein

Glucans biosynthesis protein D

Gene

mdoD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs).

Pathwayi: osmoregulated periplasmic glucan (OPG) biosynthesis

This protein is involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis and in Glycan metabolism.

GO - Molecular functioni

GO - Biological processi

  • glucan biosynthetic process Source: UniProtKB-HAMAP
  • regulation of beta-glucan biosynthetic process Source: EcoliWiki
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG12859-MONOMER.
ECOL316407:JW1420-MONOMER.
UniPathwayiUPA00637.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucans biosynthesis protein D
Gene namesi
Name:mdoD
Synonyms:opgD, ydcG, yzzZ
Ordered Locus Names:b1424, JW1420
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12859. mdoD.

Subcellular locationi

GO - Cellular componenti

  • outer membrane-bounded periplasmic space Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Tat-type signal1 PublicationAdd BLAST32
ChainiPRO_000002020633 – 551Glucans biosynthesis protein DAdd BLAST519

Post-translational modificationi

Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. Can also be exported by the Sec system.

Proteomic databases

EPDiP40120.
PaxDbiP40120.
PRIDEiP40120.

Expressioni

Developmental stagei

Expressed essentially during the stationary growth phase when OPG synthesis has stopped.

Interactioni

Protein-protein interaction databases

BioGridi4261154. 12 interactors.
IntActiP40120. 6 interactors.
STRINGi511145.b1424.

Structurei

3D structure databases

ProteinModelPortaliP40120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OpgD/OpgG family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105DJ9. Bacteria.
COG3131. LUCA.
HOGENOMiHOG000288262.
InParanoidiP40120.
OMAiFAGFRAF.
PhylomeDBiP40120.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.70.98.10. 1 hit.
HAMAPiMF_01068. MdoD_OpgD. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR014718. GH-type_carb-bd.
IPR023724. Glucan_biosyn_MdoD.
IPR007444. Glucan_biosyn_MdoG_C.
IPR014438. Glucan_biosyn_MdoGD.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF04349. MdoG. 1 hit.
[Graphical view]
PIRSFiPIRSF006281. MdoG. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsiTIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40120-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRRRFIKGS MAMAAVCGTS GIASLFSQAA FAADSDIADG QTQRFDFSIL
60 70 80 90 100
QSMAHDLAQT AWRGAPRPLP DTLATMTPQA YNSIQYDAEK SLWHNVENRQ
110 120 130 140 150
LDAQFFHMGM GFRRRVRMFS VDPATHLARE IHFRPELFKY NDAGVDTKQL
160 170 180 190 200
EGQSDLGFAG FRVFKAPELA RRDVVSFLGA SYFRAVDDTY QYGLSARGLA
210 220 230 240 250
IDTYTDSKEE FPDFTAFWFD TVKPGATTFT VYALLDSASI TGAYKFTIHC
260 270 280 290 300
EKSQVIMDVE NHLYARKDIK QLGIAPMTSM FSCGTNERRM CDTIHPQIHD
310 320 330 340 350
SDRLSMWRGN GEWICRPLNN PQKLQFNAYT DNNPKGFGLL QLDRDFSHYQ
360 370 380 390 400
DIMGWYNKRP SLWVEPRNKW GKGTIGLMEI PTTGETLDNI VCFWQPEKAV
410 420 430 440 450
KAGDEFAFQY RLYWSAQPPV HCPLARVMAT RTGMGGFSEG WAPGEHYPEK
460 470 480 490 500
WARRFAVDFV GGDLKAAAPK GIEPVITLSS GEAKQIEILY IEPIDGYRIQ
510 520 530 540 550
FDWYPTSDST DPVDMRMYLR CQGDAISETW LYQYFPPAPD KRQYVDDRVM

S
Length:551
Mass (Da):62,758
Last modified:July 3, 2003 - v3
Checksum:i4FC3BE21F70D4C46
GO

Sequence cautioni

The sequence BAA15046 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74506.3.
AP009048 Genomic DNA. Translation: BAA15046.1. Different initiation.
X15860 Genomic DNA. No translation available.
PIRiC64894.
RefSeqiNP_415941.5. NC_000913.3.
WP_000375961.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74506; AAC74506; b1424.
BAA15046; BAA15046; BAA15046.
GeneIDi945994.
KEGGiecj:JW1420.
eco:b1424.
PATRICi32118134. VBIEscCol129921_1487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74506.3.
AP009048 Genomic DNA. Translation: BAA15046.1. Different initiation.
X15860 Genomic DNA. No translation available.
PIRiC64894.
RefSeqiNP_415941.5. NC_000913.3.
WP_000375961.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP40120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261154. 12 interactors.
IntActiP40120. 6 interactors.
STRINGi511145.b1424.

Proteomic databases

EPDiP40120.
PaxDbiP40120.
PRIDEiP40120.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74506; AAC74506; b1424.
BAA15046; BAA15046; BAA15046.
GeneIDi945994.
KEGGiecj:JW1420.
eco:b1424.
PATRICi32118134. VBIEscCol129921_1487.

Organism-specific databases

EchoBASEiEB2701.
EcoGeneiEG12859. mdoD.

Phylogenomic databases

eggNOGiENOG4105DJ9. Bacteria.
COG3131. LUCA.
HOGENOMiHOG000288262.
InParanoidiP40120.
OMAiFAGFRAF.
PhylomeDBiP40120.

Enzyme and pathway databases

UniPathwayiUPA00637.
BioCyciEcoCyc:EG12859-MONOMER.
ECOL316407:JW1420-MONOMER.

Miscellaneous databases

PROiP40120.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.70.98.10. 1 hit.
HAMAPiMF_01068. MdoD_OpgD. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR014718. GH-type_carb-bd.
IPR023724. Glucan_biosyn_MdoD.
IPR007444. Glucan_biosyn_MdoG_C.
IPR014438. Glucan_biosyn_MdoGD.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF04349. MdoG. 1 hit.
[Graphical view]
PIRSFiPIRSF006281. MdoG. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsiTIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPGD_ECOLI
AccessioniPrimary (citable) accession number: P40120
Secondary accession number(s): P46134, P76098, P77631
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 3, 2003
Last modified: November 2, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.