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P40117

- RPEC_CUPNH

UniProt

P40117 - RPEC_CUPNH

Protein

Ribulose-phosphate 3-epimerase, chromosomal

Gene

cbbEC

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.By similarity

    Catalytic activityi

    D-ribulose 5-phosphate = D-xylulose 5-phosphate.

    Cofactori

    Binds 1 divalent metal cation per subunit. Active with Co2+, Fe2+, Mn2+ and Zn2+ By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei21 – 211SubstrateBy similarity
    Metal bindingi46 – 461Divalent metal cationBy similarity
    Active sitei48 – 481Proton acceptorBy similarity
    Metal bindingi48 – 481Divalent metal cationBy similarity
    Metal bindingi79 – 791Divalent metal cationBy similarity
    Binding sitei79 – 791SubstrateBy similarity
    Active sitei192 – 1921Proton donorBy similarity
    Metal bindingi192 – 1921Divalent metal cationBy similarity
    Binding sitei194 – 1941Substrate; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribulose-phosphate 3-epimerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pentose-phosphate shunt Source: InterPro
    2. reductive pentose-phosphate cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Calvin cycle, Carbohydrate metabolism

    Keywords - Ligandi

    Cobalt, Iron, Manganese, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciCNEC381666:GJUJ-5096-MONOMER.
    UniPathwayiUPA00116.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribulose-phosphate 3-epimerase, chromosomal (EC:5.1.3.1)
    Alternative name(s):
    Pentose-5-phosphate 3-epimerase
    Short name:
    PPE
    R5P3E
    Gene namesi
    Name:cbbEC
    Synonyms:cbbE2, cfxE
    Ordered Locus Names:H16_B1391
    OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
    Taxonomic identifieri381666 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000008210: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 241241Ribulose-phosphate 3-epimerase, chromosomalPRO_0000171556Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi381666.H16_B1391.

    Structurei

    3D structure databases

    ProteinModelPortaliP40117.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni155 – 1584Substrate bindingBy similarity
    Regioni214 – 2152Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0036.
    HOGENOMiHOG000259347.
    KOiK01783.
    OMAiPLGWLDH.
    OrthoDBiEOG67HK17.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR026019. Ribul_P_3_epim.
    IPR000056. Ribul_P_3_epim-like.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PANTHERiPTHR11749. PTHR11749. 1 hit.
    PfamiPF00834. Ribul_P_3_epim. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001461. RPE. 1 hit.
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01163. rpe. 1 hit.
    PROSITEiPS01085. RIBUL_P_3_EPIMER_1. 1 hit.
    PS01086. RIBUL_P_3_EPIMER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40117-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHATELNTGH GSQRAIRLAP SILSADFARL GEEVCAIEAG GADLVHFDVM    50
    DNHYVPNLTI GPLVCEAIRP LVSIPIDVHL MVEPVDALIP LFAKAGANII 100
    SFHPEASRHV DRTIGLIRDH GCKAGLVLNP ATPLGWLDHT LDQLDLVLLM 150
    SVNPGFGGQA FIPGVLDKVR QARARIDRQV DAGGRPVWLE IDGGVKADNI 200
    AAIARAGADT FVAGSAVFGA PDADGGYSSI LYRLREAATV T 241
    Length:241
    Mass (Da):25,501
    Last modified:February 1, 1995 - v1
    Checksum:i9B6CC244FD1215CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64173 Genomic DNA. Translation: AAA21962.1.
    AM260480 Genomic DNA. Translation: CAJ96180.1.
    PIRiC47019.
    RefSeqiWP_011617203.1. NC_008314.1.
    YP_840910.1. NC_008314.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ96180; CAJ96180; H16_B1391.
    GeneIDi4456350.
    KEGGireh:H16_B1391.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64173 Genomic DNA. Translation: AAA21962.1 .
    AM260480 Genomic DNA. Translation: CAJ96180.1 .
    PIRi C47019.
    RefSeqi WP_011617203.1. NC_008314.1.
    YP_840910.1. NC_008314.1.

    3D structure databases

    ProteinModelPortali P40117.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381666.H16_B1391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ96180 ; CAJ96180 ; H16_B1391 .
    GeneIDi 4456350.
    KEGGi reh:H16_B1391.

    Phylogenomic databases

    eggNOGi COG0036.
    HOGENOMi HOG000259347.
    KOi K01783.
    OMAi PLGWLDH.
    OrthoDBi EOG67HK17.

    Enzyme and pathway databases

    UniPathwayi UPA00116 .
    BioCyci CNEC381666:GJUJ-5096-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR026019. Ribul_P_3_epim.
    IPR000056. Ribul_P_3_epim-like.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    PANTHERi PTHR11749. PTHR11749. 1 hit.
    Pfami PF00834. Ribul_P_3_epim. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001461. RPE. 1 hit.
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01163. rpe. 1 hit.
    PROSITEi PS01085. RIBUL_P_3_EPIMER_1. 1 hit.
    PS01086. RIBUL_P_3_EPIMER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Calvin cycle enzyme pentose-5-phosphate 3-epimerase is encoded within the cfx operons of the chemoautotroph Alcaligenes eutrophus."
      Kusian B., Yoo J.-G., Bednarski R., Bowien B.
      J. Bacteriol. 174:7337-7344(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

    Entry informationi

    Entry nameiRPEC_CUPNH
    AccessioniPrimary (citable) accession number: P40117
    Secondary accession number(s): Q0K1E4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3