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Protein

Aldehyde dehydrogenase

Gene

CLAH10

Organism
Davidiella tassiana (Mycosphaerella tassiana) (Cladosporium herbarum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei263 – 2631By similarity
Active sitei296 – 2961By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase (EC:1.2.1.3)
Short name:
ALDDH
Short name:
ALDH
Alternative name(s):
Allergen Cla h 3
Allergen Cla h III
Allergen: Cla h 10
Gene namesi
Name:CLAH10
Synonyms:CLAH3
OrganismiDavidiella tassiana (Mycosphaerella tassiana) (Cladosporium herbarum)
Taxonomic identifieri29918 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesDothideomycetidaeCapnodialesCladosporiaceaeCladosporium

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei218. Cla h 10.
3201. Cla h 10.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Aldehyde dehydrogenasePRO_0000056437Add
BLAST

Proteomic databases

PRIDEiP40108.

Structurei

3D structure databases

ProteinModelPortaliP40108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view]
PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSVQLETPH SGKYEQPTGL FINNEFVKGQ EGKTFDVINP SDESVITQVH
60 70 80 90 100
EATEKDVDIA VAAARKAFEG SWRQETPENR GKLLNNLANL FEKNIDLLAA
110 120 130 140 150
VESLDNGKAI SMAKGDISMC VGCLRYYGGW ADKITGKVID TTPDTFNYVK
160 170 180 190 200
KEPIGVCGQI IPWNFPLLMW AWKIGPAIAC GNTVVLKTAE QTPLGGLVAA
210 220 230 240 250
SLVKEAGFPP GVINVISGFG KVAGAALSSH MDVDKVAFTG STVVGRTILK
260 270 280 290 300
AAASSNLKKV TLELGGKSPN IVFEDADIDN AISWVNFGIF FNHGQCCCAG
310 320 330 340 350
SRVYVQESIY DKFVQKFKER AQKNVVGDPF AADTFQGPQV SKVQFDRIME
360 370 380 390 400
YIQAGKDAGA TVETGGKRKG DKGYFIEPTI FSNVTEDMKI VKEEIFGPVC
410 420 430 440 450
SIAKFKTKED AIKLGNASTY GLAAAVHTKN LNTAIEVSNA LKAGTVWVNT
460 470 480 490
YNTLHHQMPF GGYKESGIGR ELGEDALANY TQTKTVSIRL GDALFG
Length:496
Mass (Da):53,554
Last modified:June 13, 2006 - v2
Checksum:iD938B5D0D9B26999
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78228 mRNA. Translation: CAA55072.2.
PIRiS43114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78228 mRNA. Translation: CAA55072.2.
PIRiS43114.

3D structure databases

ProteinModelPortaliP40108.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei218. Cla h 10.
3201. Cla h 10.0101.

Proteomic databases

PRIDEiP40108.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view]
PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of major and minor allergens of Alternaria alternata and Cladosporium herbarum."
    Achatz G., Oberkofler H., Lechenauer E., Simon-Nobbe B., Unger A., Kandler D., Ebner C., Prillinger H., Kraft D., Breitenbach M.
    Mol. Immunol. 32:213-227(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
    Strain: 280202-Berlin.
  2. Simon-Nobbe B.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 66; 74; 95; 110; 114-121; 158-165 AND 367.

Entry informationi

Entry nameiALDH_DAVTA
AccessioniPrimary (citable) accession number: P40108
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 13, 2006
Last modified: January 7, 2015
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.