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P40108 (ALDH_DAVTA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase

Short name=ALDDH
Short name=ALDH
EC=1.2.1.3
Alternative name(s):
Allergen Cla h 3
Allergen Cla h III
Allergen=Cla h 10
Gene names
Name:CLAH10
Synonyms:CLAH3
OrganismDavidiella tassiana (Mycosphaerella tassiana) (Cladosporium herbarum)
Taxonomic identifier29918 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesDothideomycetidaeCapnodialesCladosporiaceaeCladosporium

Protein attributes

Sequence length496 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Subcellular location

Cytoplasm Probable.

Allergenic properties

Causes an allergic reaction in human. Ref.1

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   DiseaseAllergen
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 496496Aldehyde dehydrogenase
PRO_0000056437

Sites

Active site2631 By similarity
Active site2961 By similarity

Sequences

Sequence LengthMass (Da)Tools
P40108 [UniParc].

Last modified June 13, 2006. Version 2.
Checksum: D938B5D0D9B26999

FASTA49653,554
        10         20         30         40         50         60 
MTSVQLETPH SGKYEQPTGL FINNEFVKGQ EGKTFDVINP SDESVITQVH EATEKDVDIA 

        70         80         90        100        110        120 
VAAARKAFEG SWRQETPENR GKLLNNLANL FEKNIDLLAA VESLDNGKAI SMAKGDISMC 

       130        140        150        160        170        180 
VGCLRYYGGW ADKITGKVID TTPDTFNYVK KEPIGVCGQI IPWNFPLLMW AWKIGPAIAC 

       190        200        210        220        230        240 
GNTVVLKTAE QTPLGGLVAA SLVKEAGFPP GVINVISGFG KVAGAALSSH MDVDKVAFTG 

       250        260        270        280        290        300 
STVVGRTILK AAASSNLKKV TLELGGKSPN IVFEDADIDN AISWVNFGIF FNHGQCCCAG 

       310        320        330        340        350        360 
SRVYVQESIY DKFVQKFKER AQKNVVGDPF AADTFQGPQV SKVQFDRIME YIQAGKDAGA 

       370        380        390        400        410        420 
TVETGGKRKG DKGYFIEPTI FSNVTEDMKI VKEEIFGPVC SIAKFKTKED AIKLGNASTY 

       430        440        450        460        470        480 
GLAAAVHTKN LNTAIEVSNA LKAGTVWVNT YNTLHHQMPF GGYKESGIGR ELGEDALANY 

       490 
TQTKTVSIRL GDALFG 

« Hide

References

[1]"Molecular cloning of major and minor allergens of Alternaria alternata and Cladosporium herbarum."
Achatz G., Oberkofler H., Lechenauer E., Simon-Nobbe B., Unger A., Kandler D., Ebner C., Prillinger H., Kraft D., Breitenbach M.
Mol. Immunol. 32:213-227(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
Strain: 280202-Berlin.
[2]Simon-Nobbe B.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 66; 74; 95; 110; 114-121; 158-165 AND 367.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78228 mRNA. Translation: CAA55072.2.
PIRS43114.

3D structure databases

ProteinModelPortalP40108.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome218. Cla h 10.
3201. Cla h 10.0101.

Proteomic databases

PRIDEP40108.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH_DAVTA
AccessionPrimary (citable) accession number: P40108
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 13, 2006
Last modified: March 19, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries