P40108 (ALDH_DAVTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aldehyde dehydrogenase
Short name=ALDDH
Short name=ALDH
EC=1.2.1.3

Alternative name(s):
Allergen Cla h 3
Allergen Cla h III
Allergen=Cla h 10

Gene names

Name:	CLAH10
Synonyms:	CLAH3

Organism

Davidiella tassiana (Mycosphaerella tassiana) (Cladosporium herbarum)

Taxonomic identifier

29918 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Dothideomycetidae › Capnodiales › Davidiellaceae › Davidiella

Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = a carboxylate + NADH.
Subcellular location	Cytoplasm Probable.
Allergenic properties	Causes an allergic reaction in human. Ref.1
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Disease	Allergen
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 496	496	Aldehyde dehydrogenase		PRO_0000056437
Sites
	Active site	263	1	By similarity
	Active site	296	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P40108 [UniParc]. Last modified June 13, 2006. Version 2. Checksum: D938B5D0D9B26999	FASTA	496	53,554
	10 20 30 40 50 60 MTSVQLETPH SGKYEQPTGL FINNEFVKGQ EGKTFDVINP SDESVITQVH EATEKDVDIA 70 80 90 100 110 120 VAAARKAFEG SWRQETPENR GKLLNNLANL FEKNIDLLAA VESLDNGKAI SMAKGDISMC 130 140 150 160 170 180 VGCLRYYGGW ADKITGKVID TTPDTFNYVK KEPIGVCGQI IPWNFPLLMW AWKIGPAIAC 190 200 210 220 230 240 GNTVVLKTAE QTPLGGLVAA SLVKEAGFPP GVINVISGFG KVAGAALSSH MDVDKVAFTG 250 260 270 280 290 300 STVVGRTILK AAASSNLKKV TLELGGKSPN IVFEDADIDN AISWVNFGIF FNHGQCCCAG 310 320 330 340 350 360 SRVYVQESIY DKFVQKFKER AQKNVVGDPF AADTFQGPQV SKVQFDRIME YIQAGKDAGA 370 380 390 400 410 420 TVETGGKRKG DKGYFIEPTI FSNVTEDMKI VKEEIFGPVC SIAKFKTKED AIKLGNASTY 430 440 450 460 470 480 GLAAAVHTKN LNTAIEVSNA LKAGTVWVNT YNTLHHQMPF GGYKESGIGR ELGEDALANY 490 TQTKTVSIRL GDALFG

References

[1]	"Molecular cloning of major and minor allergens of Alternaria alternata and Cladosporium herbarum." Achatz G., Oberkofler H., Lechenauer E., Simon-Nobbe B., Unger A., Kandler D., Ebner C., Prillinger H., Kraft D., Breitenbach M. Mol. Immunol. 32:213-227(1995) [PubMed: 7898496] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN. Strain: 280202-Berlin.
[2]	Simon-Nobbe B. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 66; 74; 95; 110; 114-121; 158-165 AND 367.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X78228 mRNA. Translation: CAA55072.2.
PIR	S43114.
3D structure databases
ProteinModelPortal	P40108.
ModBase	Search...
Protein family/group databases
Allergome	218. Cla h 10. 3201. Cla h 10.0101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH_DAVTA

Accession

Primary (citable) accession number: P40108

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program