P40095 (YEY8_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein YER158C

Gene names

Ordered Locus Names:

YER158C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	573 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Post-translational modification	N-glycosylated.
Miscellaneous	Present with 784 molecules/cell in log phase SD medium.
Sequence similarities	To yeast AFR1.

Ontologies

Keywords
Domain	Repeat
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BOI1	P38041	2	EBI-22734,EBI-3719

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 573	573	Uncharacterized protein YER158C		PRO_0000202656
Regions
	Repeat	102 – 103	2	1
	Repeat	104 – 105	2	2
	Repeat	106 – 107	2	3
	Repeat	108 – 109	2	4
	Repeat	110 – 111	2	5
	Repeat	112 – 113	2	6
	Repeat	114 – 115	2	7
	Repeat	116 – 117	2	8
	Repeat	118 – 119	2	9
	Repeat	120 – 121	2	10
	Region	102 – 121	20	10 X 2 AA tandem repeats of N-M
Amino acid modifications
	Glycosylation	63	1	N-linked (GlcNAc...) Potential
	Glycosylation	123	1	N-linked (GlcNAc...) Potential
	Glycosylation	236	1	N-linked (GlcNAc...) Potential
	Glycosylation	437	1	N-linked (GlcNAc...) Potential
	Glycosylation	442	1	N-linked (GlcNAc...) Potential
	Glycosylation	498	1	N-linked (GlcNAc...) Potential
	Glycosylation	535	1	N-linked (GlcNAc...) Potential
	Glycosylation	541	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P40095 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 7D24F55CF5CFCA4D	FASTA	573	63,712
	10 20 30 40 50 60 MLQQGSSSRR SLHGNDFHTL TSPSRRDSLS IPRAVDARSA STIDLFYIPD ATVSRRHSTL 70 80 90 100 110 120 VANRSDNNGN GAPMRQYNKP NFASSSTSSL PSTRNRPSRY DNMNMNMNMN MNMNMNMNMN 130 140 150 160 170 180 MNNHTTSDHN AHPQYRCRPN PSRRHSLMTI PEKYSGSRYS LRSSPPTYSN PRVRKELTPF 190 200 210 220 230 240 QLQRKQMKSA FQFPNGENFT PRNQIARLPP SSTFPDSPSS SSLPLTQTGG PSSADNDSIA 250 260 270 280 290 300 TGTNNRSPQQ TKAADANQKS ESESPKAIRS NSKKISRFFR KIWSSKSSNS ADSVEENSKT 310 320 330 340 350 360 KQKRKNPERV VPEPITSLDQ PVEIIKQSFS TVNNHETAVP SIKDSGIVQE LTALGDNNRI 370 380 390 400 410 420 PVLPPPRSPN RPTLSDKRTT KLYYCSQDSS NEDIAPEEKS TVFLKRLQDE WSTVYLNKLP 430 440 450 460 470 480 LTASVPSSLS TTTDAANSSF INSSISSPAP SSSSSSSLVS RGPMQSISSS PTPAPSSGSS 490 500 510 520 530 540 KSKNAVKSLR FADEIYVNDT WSAADYCRCD NTFLNNFFKG KSQDITNPST FVGNNLSSTK 550 560 570 NISNIEIKME VNEFKRKEMR VHQDSAKYTH YYL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes." Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H. Mol. Syst. Biol. 5:308-308(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U18917 Genomic DNA. Translation: AAB64685.1. BK006939 Genomic DNA. Translation: DAA07819.1.
PIR	S50661.
RefSeq	NP_011085.1. NM_001179048.1.
3D structure databases
ProteinModelPortal	P40095.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2686N.
IntAct	P40095. 6 interactions.
MINT	MINT-557457.
STRING	4932.YER158C.
Proteomic databases
PaxDb	P40095.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YER158C; YER158C; YER158C.
GeneID	856903.
KEGG	sce:YER158C.
Organism-specific databases
CYGD	YER158c.
SGD	S000000960. YER158C.
Phylogenomic databases
eggNOG	NOG12793.
GeneTree	ENSGT00530000068793.
OrthoDB	EOG4C2MMD.
Gene expression databases
Genevestigator	P40095.
GermOnline	YER158C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	983330.

Entry information

Entry name

YEY8_YEAST

Accession

Primary (citable) accession number: P40095
Secondary accession number(s): D3DM65

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program