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P40091

- PEA2_YEAST

UniProt

P40091 - PEA2_YEAST

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Protein

Protein PEA2

Gene

PEA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Localized to sites of polarized growth and is required for efficient mating and bipolar budding.

GO - Biological processi

  1. bipolar cellular bud site selection Source: SGD
  2. budding cell apical bud growth Source: SGD
  3. establishment of cell polarity Source: SGD
  4. filamentous growth Source: SGD
  5. positive regulation of actin cytoskeleton reorganization Source: SGD
  6. pseudohyphal growth Source: SGD
  7. regulation of initiation of mating projection growth Source: SGD
  8. regulation of protein localization Source: SGD
  9. regulation of termination of mating projection growth Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30310-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PEA2
Alternative name(s):
Protein PPF2
Gene namesi
Name:PEA2
Synonyms:PPF2
Ordered Locus Names:YER149C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER149c.
SGDiS000000951. PEA2.

Subcellular locationi

GO - Cellular componenti

  1. cellular bud Source: SGD
  2. cellular bud neck Source: SGD
  3. cellular bud tip Source: SGD
  4. incipient cellular bud site Source: SGD
  5. mating projection tip Source: SGD
  6. polarisome Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Protein PEA2PRO_0000058300Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei230 – 2301Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40091.

Expressioni

Gene expression databases

GenevestigatoriP40091.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FUS1P117105EBI-13106,EBI-7179
YMR124WP395233EBI-13106,EBI-27256

Protein-protein interaction databases

BioGridi36898. 70 interactions.
DIPiDIP-2463N.
IntActiP40091. 7 interactions.
MINTiMINT-436009.

Family & Domainsi

Phylogenomic databases

InParanoidiP40091.
OrthoDBiEOG72ZCQJ.

Sequencei

Sequence statusi: Complete.

P40091-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHKFDLELSR RANPLLFSAE RYEEYPLKYD ELKQYLLSQN PSHPHHNSRP
60 70 80 90 100
YTSIDYFDYL LYRSKNDESE IDLDKKLVSE FALYYVQKEH LNSDDLNPTL
110 120 130 140 150
NELLKLQPKS ADWYEMMLRI LESINTTGID QLTKENNNSF PNSKRARSST
160 170 180 190 200
NMGGTDKFNK GAYHTDKADD DKNEILQELT SFLMSNSIQK GIDIKPIPLD
210 220 230 240 250
DPVKFLKNGI NSILDTCVSL EKNTSSPPIS PNAAAIQEED SSKKLEELET
260 270 280 290 300
AFSDLQLAHN FLTKQFENDR AEYVQDIEKL TRTNRELQDK LLNNHSNLSK
310 320 330 340 350
TEKKLHELEQ ENKELEKANN KLNSSRHNFG MSSPASSPVT WDPSSPSSVG
360 370 380 390 400
SPTSGSGSRS LSIMTSEFKK VLTSTQRKYE KELSDEREHR FKLERELALL
410 420
KNAEANTSLA LNRDDPPDML
Length:420
Mass (Da):48,165
Last modified:February 1, 1995 - v1
Checksum:i594B9A14E71A943D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901H → R in strain: CLIB 219. 1 Publication
Natural varianti117 – 1171M → T in strain: CLIB 630. 1 Publication
Natural varianti157 – 1571K → T in strain: CLIB 219. 1 Publication
Natural varianti161 – 1611G → S in strain: CLIB 630. 1 Publication
Natural varianti165 – 1651T → I in strain: CLIB 630. 1 Publication
Natural varianti171 – 1711D → N in strain: CLIB 630. 1 Publication
Natural varianti189 – 1891Q → L in strain: CLIB 382. 1 Publication
Natural varianti210 – 2101I → M in strain: CLIB 413 haplotype Ha2. 1 Publication
Natural varianti249 – 2491E → K in strain: CLIB 556. 1 Publication
Natural varianti253 – 2531S → R in strain: Sigma 1278B. 1 Publication
Natural varianti325 – 3251S → N in strain: CLIB 219. 1 Publication
Natural varianti355 – 3551G → S in strain: R12. 1 Publication
Natural varianti384 – 3841S → L in strain: CLIB 219. 1 Publication
Natural varianti409 – 4091L → M in strain: CLIB 410, CLIB 413 and Sigma 1278B. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07594 Genomic DNA. Translation: CAA68869.1.
D38413 Genomic DNA. Translation: BAA07465.1.
AJ585620 Genomic DNA. Translation: CAE52140.1.
AJ585621 Genomic DNA. Translation: CAE52141.1.
AJ585622 Genomic DNA. Translation: CAE52142.1.
AJ585623 Genomic DNA. Translation: CAE52143.1.
AJ585624 Genomic DNA. Translation: CAE52144.1.
AJ585625 Genomic DNA. Translation: CAE52145.1.
AJ585626 Genomic DNA. Translation: CAE52146.1.
AJ585627 Genomic DNA. Translation: CAE52147.1.
AJ585628 Genomic DNA. Translation: CAE52148.1.
AJ585629 Genomic DNA. Translation: CAE52149.1.
AJ585630 Genomic DNA. Translation: CAE52150.1.
AJ585631 Genomic DNA. Translation: CAE52151.1.
AJ585632 Genomic DNA. Translation: CAE52152.1.
AJ585633 Genomic DNA. Translation: CAE52153.1.
AJ585634 Genomic DNA. Translation: CAE52154.1.
AJ585635 Genomic DNA. Translation: CAE52155.1.
AJ585636 Genomic DNA. Translation: CAE52156.1.
U18917 Genomic DNA. Translation: AAB64676.1.
BK006939 Genomic DNA. Translation: DAA07810.1.
PIRiS50652.
RefSeqiNP_011076.1. NM_001179039.1.

Genome annotation databases

EnsemblFungiiYER149C; YER149C; YER149C.
GeneIDi856892.
KEGGisce:YER149C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07594 Genomic DNA. Translation: CAA68869.1 .
D38413 Genomic DNA. Translation: BAA07465.1 .
AJ585620 Genomic DNA. Translation: CAE52140.1 .
AJ585621 Genomic DNA. Translation: CAE52141.1 .
AJ585622 Genomic DNA. Translation: CAE52142.1 .
AJ585623 Genomic DNA. Translation: CAE52143.1 .
AJ585624 Genomic DNA. Translation: CAE52144.1 .
AJ585625 Genomic DNA. Translation: CAE52145.1 .
AJ585626 Genomic DNA. Translation: CAE52146.1 .
AJ585627 Genomic DNA. Translation: CAE52147.1 .
AJ585628 Genomic DNA. Translation: CAE52148.1 .
AJ585629 Genomic DNA. Translation: CAE52149.1 .
AJ585630 Genomic DNA. Translation: CAE52150.1 .
AJ585631 Genomic DNA. Translation: CAE52151.1 .
AJ585632 Genomic DNA. Translation: CAE52152.1 .
AJ585633 Genomic DNA. Translation: CAE52153.1 .
AJ585634 Genomic DNA. Translation: CAE52154.1 .
AJ585635 Genomic DNA. Translation: CAE52155.1 .
AJ585636 Genomic DNA. Translation: CAE52156.1 .
U18917 Genomic DNA. Translation: AAB64676.1 .
BK006939 Genomic DNA. Translation: DAA07810.1 .
PIRi S50652.
RefSeqi NP_011076.1. NM_001179039.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36898. 70 interactions.
DIPi DIP-2463N.
IntActi P40091. 7 interactions.
MINTi MINT-436009.

Proteomic databases

MaxQBi P40091.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER149C ; YER149C ; YER149C .
GeneIDi 856892.
KEGGi sce:YER149C.

Organism-specific databases

CYGDi YER149c.
SGDi S000000951. PEA2.

Phylogenomic databases

InParanoidi P40091.
OrthoDBi EOG72ZCQJ.

Enzyme and pathway databases

BioCyci YEAST:G3O-30310-MONOMER.

Miscellaneous databases

NextBioi 983299.

Gene expression databases

Genevestigatori P40091.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Pea2 protein of yeast is localized to sites of polarized growth and is required for efficient mating and bipolar budding."
    Valtz N.L.M., Herskowitz I.
    J. Cell Biol. 135:725-739(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A novel yeast gene necessary for pheromone-induced pointed projection formation."
    Yorihuzi T., Ohsumi Y.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 26109 / X2180.
  3. "Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and implication of recombination in phylogeny."
    Leh-Louis V., Wirth B., Despons L., Wain-Hobson S., Potier S., Souciet J.-L.
    Nucleic Acids Res. 32:2069-2078(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-90; THR-117; THR-157; SER-161; ILE-165; ASN-171; LEU-189; MET-210; LYS-249; ARG-253; ASN-325; SER-355; LEU-384 AND MET-409.
    Strain: CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, CLIB 95, K1, R12, R13, Sigma 1278B, YIIc12 and YIIc17.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPEA2_YEAST
AccessioniPrimary (citable) accession number: P40091
Secondary accession number(s): D3DM56
, Q70DC9, Q70DD1, Q70DD2, Q70DD3, Q70DD4, Q70DD6, Q70DD7, Q70DD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7820 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3