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Protein

MAU2 chromatid cohesion factor homolog

Gene

SCC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in sister chromatid cohesion. Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes.1 Publication

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • double-strand break repair Source: SGD
  • establishment of protein localization to chromatin Source: SGD
  • mitotic chromosome condensation Source: SGD
  • mitotic sister chromatid cohesion Source: SGD
  • rDNA condensation Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-30308-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
MAU2 chromatid cohesion factor homolog
Alternative name(s):
Sister chromatid cohesion protein 4
Gene namesi
Name:SCC4
Ordered Locus Names:YER147C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER147C.
SGDiS000000949. SCC4.

Subcellular locationi

  • Nucleus

  • Note: Associates with chromatin.

GO - Cellular componenti

  • nuclear chromatin Source: SGD
  • SMC loading complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001932171 – 624MAU2 chromatid cohesion factor homologAdd BLAST624

Proteomic databases

MaxQBiP40090.
PRIDEiP40090.

Interactioni

Subunit structurei

Interacts with SCC2 to form the cohesin loading complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SCC2Q040025EBI-16679,EBI-16662

Protein-protein interaction databases

BioGridi36896. 16 interactors.
DIPiDIP-5627N.
IntActiP40090. 3 interactors.
MINTiMINT-555872.

Structurei

Secondary structure

1624
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 9Combined sources3
Helixi10 – 26Combined sources17
Turni27 – 29Combined sources3
Helixi34 – 57Combined sources24
Helixi62 – 79Combined sources18
Helixi83 – 100Combined sources18
Turni101 – 103Combined sources3
Helixi107 – 118Combined sources12
Helixi120 – 125Combined sources6
Helixi128 – 146Combined sources19
Helixi151 – 170Combined sources20
Helixi174 – 187Combined sources14
Helixi193 – 209Combined sources17
Helixi215 – 222Combined sources8
Helixi226 – 229Combined sources4
Helixi231 – 247Combined sources17
Helixi253 – 272Combined sources20
Turni273 – 275Combined sources3
Beta strandi278 – 283Combined sources6
Beta strandi286 – 291Combined sources6
Helixi293 – 296Combined sources4
Helixi298 – 312Combined sources15
Turni313 – 318Combined sources6
Helixi320 – 341Combined sources22
Helixi350 – 379Combined sources30
Helixi396 – 407Combined sources12
Helixi413 – 421Combined sources9
Helixi427 – 447Combined sources21
Turni450 – 452Combined sources3
Helixi453 – 471Combined sources19
Helixi475 – 478Combined sources4
Helixi480 – 494Combined sources15
Turni496 – 498Combined sources3
Helixi507 – 524Combined sources18
Helixi543 – 556Combined sources14
Helixi561 – 574Combined sources14
Helixi575 – 577Combined sources3
Helixi582 – 599Combined sources18
Helixi602 – 619Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XDNX-ray2.08A1-624[»]
ProteinModelPortaliP40090.
SMRiP40090.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SCC4/mau-2 family.Curated

Phylogenomic databases

HOGENOMiHOG000066106.
InParanoidiP40090.
KOiK06673.
OMAiVIGIWHL.
OrthoDBiEOG092C3T6T.

Family and domain databases

InterProiIPR019440. MAU2.
[Graphical view]
PfamiPF10345. Cohesin_load. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLGDKLSI SQVYHLAQEY RDHAYSIANK IGSEEGLKQY YGLMNMSIQM
60 70 80 90 100
FQLLKTKCTL SVLEDSKVTF EMVELLIQET YNFDLAELYI SSLKERLQTH
110 120 130 140 150
QSDTDLVEEI MRCEFLLLHD LPLMRDSKFH YKIALRNCNE LVQYMVNLQD
160 170 180 190 200
ELYQNWASVF QYVGVMLCIK LKQHRRVKTS FHGLLSQCRE KSQWKWFLNL
210 220 230 240 250
CYVNYLLNER FPIPEDALQE LRSTELHTVG PELYAWKLAL EMVIQLCKDG
260 270 280 290 300
NITDHLNEFK NFFDTNKQSL VTNEGKGCVI KIMPRIALKV ELPMIFHYKE
310 320 330 340 350
LKNILLLLQS VSYIVNCYDE KGNFSRKFLP KVYSTTQKLI KNIAAGGVSM
360 370 380 390 400
NELDSRIQTY KSILEFCEFY KVWEQTLLKG AVVTTESPKL GPSPGYVRLL
410 420 430 440 450
QAMKVQFEGG GAVEEYTRLA QSGGTSSEVK MISLLNCYTV QAARVSRCSG
460 470 480 490 500
DKQGELVEQC NKVWLQVEKL LQETDLQFNP IWECTVTILW LFSHFEPFSW
510 520 530 540 550
NPLPCSDKQR AEYVSKLREF YSSNKFVAGE AVADNRFKLK KALLLQILVN
560 570 580 590 600
YLGGRMLEHD LGEIYAISAK CFDMCRQQGG MRKVQYVIGI WHLMNCTVAM
610 620
RGKDVALTNA KLEALVKQIT SVKQ
Length:624
Mass (Da):72,141
Last modified:February 1, 1995 - v1
Checksum:i1269D931C656E608
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18917 Genomic DNA. Translation: AAB64674.1.
BK006939 Genomic DNA. Translation: DAA07808.1.
PIRiS50650.
RefSeqiNP_011074.3. NM_001179037.3.

Genome annotation databases

EnsemblFungiiYER147C; YER147C; YER147C.
GeneIDi856890.
KEGGisce:YER147C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18917 Genomic DNA. Translation: AAB64674.1.
BK006939 Genomic DNA. Translation: DAA07808.1.
PIRiS50650.
RefSeqiNP_011074.3. NM_001179037.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XDNX-ray2.08A1-624[»]
ProteinModelPortaliP40090.
SMRiP40090.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36896. 16 interactors.
DIPiDIP-5627N.
IntActiP40090. 3 interactors.
MINTiMINT-555872.

Proteomic databases

MaxQBiP40090.
PRIDEiP40090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER147C; YER147C; YER147C.
GeneIDi856890.
KEGGisce:YER147C.

Organism-specific databases

EuPathDBiFungiDB:YER147C.
SGDiS000000949. SCC4.

Phylogenomic databases

HOGENOMiHOG000066106.
InParanoidiP40090.
KOiK06673.
OMAiVIGIWHL.
OrthoDBiEOG092C3T6T.

Enzyme and pathway databases

BioCyciYEAST:G3O-30308-MONOMER.

Miscellaneous databases

PROiP40090.

Family and domain databases

InterProiIPR019440. MAU2.
[Graphical view]
PfamiPF10345. Cohesin_load. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCC4_YEAST
AccessioniPrimary (citable) accession number: P40090
Secondary accession number(s): D3DM54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.