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P40090

- SCC4_YEAST

UniProt

P40090 - SCC4_YEAST

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Protein
MAU2 chromatid cohesion factor homolog
Gene
SCC4, YER147C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in sister chromatid cohesion. Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. double-strand break repair Source: SGD
  2. establishment of protein localization to chromatin Source: SGD
  3. mitotic chromosome condensation Source: SGD
  4. mitotic sister chromatid cohesion Source: SGD
  5. rDNA condensation Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-30308-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
MAU2 chromatid cohesion factor homolog
Alternative name(s):
Sister chromatid cohesion protein 4
Gene namesi
Name:SCC4
Ordered Locus Names:YER147C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER147c.
SGDiS000000949. SCC4.

Subcellular locationi

Nucleus
Note: Associates with chromatin.

GO - Cellular componenti

  1. SMC loading complex Source: SGD
  2. nuclear chromatin Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 624624MAU2 chromatid cohesion factor homolog
PRO_0000193217Add
BLAST

Proteomic databases

MaxQBiP40090.
PaxDbiP40090.
PeptideAtlasiP40090.

Expressioni

Gene expression databases

GenevestigatoriP40090.

Interactioni

Subunit structurei

Interacts with SCC2 to form the cohesin loading complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SCC2Q040025EBI-16679,EBI-16662

Protein-protein interaction databases

BioGridi36896. 16 interactions.
DIPiDIP-5627N.
IntActiP40090. 3 interactions.
MINTiMINT-555872.
STRINGi4932.YER147C.

Structurei

3D structure databases

ProteinModelPortaliP40090.

Family & Domainsi

Sequence similaritiesi

Belongs to the SCC4/mau-2 family.

Phylogenomic databases

eggNOGiNOG39193.
HOGENOMiHOG000066106.
KOiK06673.
OMAiGIWHLMN.
OrthoDBiEOG72892V.

Family and domain databases

InterProiIPR019440. Cohesin_loading_factor.
[Graphical view]
PfamiPF10345. Cohesin_load. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40090-1 [UniParc]FASTAAdd to Basket

« Hide

MENLGDKLSI SQVYHLAQEY RDHAYSIANK IGSEEGLKQY YGLMNMSIQM    50
FQLLKTKCTL SVLEDSKVTF EMVELLIQET YNFDLAELYI SSLKERLQTH 100
QSDTDLVEEI MRCEFLLLHD LPLMRDSKFH YKIALRNCNE LVQYMVNLQD 150
ELYQNWASVF QYVGVMLCIK LKQHRRVKTS FHGLLSQCRE KSQWKWFLNL 200
CYVNYLLNER FPIPEDALQE LRSTELHTVG PELYAWKLAL EMVIQLCKDG 250
NITDHLNEFK NFFDTNKQSL VTNEGKGCVI KIMPRIALKV ELPMIFHYKE 300
LKNILLLLQS VSYIVNCYDE KGNFSRKFLP KVYSTTQKLI KNIAAGGVSM 350
NELDSRIQTY KSILEFCEFY KVWEQTLLKG AVVTTESPKL GPSPGYVRLL 400
QAMKVQFEGG GAVEEYTRLA QSGGTSSEVK MISLLNCYTV QAARVSRCSG 450
DKQGELVEQC NKVWLQVEKL LQETDLQFNP IWECTVTILW LFSHFEPFSW 500
NPLPCSDKQR AEYVSKLREF YSSNKFVAGE AVADNRFKLK KALLLQILVN 550
YLGGRMLEHD LGEIYAISAK CFDMCRQQGG MRKVQYVIGI WHLMNCTVAM 600
RGKDVALTNA KLEALVKQIT SVKQ 624
Length:624
Mass (Da):72,141
Last modified:February 1, 1995 - v1
Checksum:i1269D931C656E608
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18917 Genomic DNA. Translation: AAB64674.1.
BK006939 Genomic DNA. Translation: DAA07808.1.
PIRiS50650.
RefSeqiNP_011074.3. NM_001179037.3.

Genome annotation databases

EnsemblFungiiYER147C; YER147C; YER147C.
GeneIDi856890.
KEGGisce:YER147C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18917 Genomic DNA. Translation: AAB64674.1 .
BK006939 Genomic DNA. Translation: DAA07808.1 .
PIRi S50650.
RefSeqi NP_011074.3. NM_001179037.3.

3D structure databases

ProteinModelPortali P40090.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36896. 16 interactions.
DIPi DIP-5627N.
IntActi P40090. 3 interactions.
MINTi MINT-555872.
STRINGi 4932.YER147C.

Proteomic databases

MaxQBi P40090.
PaxDbi P40090.
PeptideAtlasi P40090.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER147C ; YER147C ; YER147C .
GeneIDi 856890.
KEGGi sce:YER147C.

Organism-specific databases

CYGDi YER147c.
SGDi S000000949. SCC4.

Phylogenomic databases

eggNOGi NOG39193.
HOGENOMi HOG000066106.
KOi K06673.
OMAi GIWHLMN.
OrthoDBi EOG72892V.

Enzyme and pathway databases

BioCyci YEAST:G3O-30308-MONOMER.

Miscellaneous databases

NextBioi 983293.

Gene expression databases

Genevestigatori P40090.

Family and domain databases

InterProi IPR019440. Cohesin_loading_factor.
[Graphical view ]
Pfami PF10345. Cohesin_load. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins."
    Ciosk R., Shirayama M., Shevchenko A., Tanaka T., Toth A., Shevchenko A., Nasmyth K.
    Mol. Cell 5:243-254(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 390-398, FUNCTION, INTERACTION WITH SCC2.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSCC4_YEAST
AccessioniPrimary (citable) accession number: P40090
Secondary accession number(s): D3DM54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi