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P40090

- SCC4_YEAST

UniProt

P40090 - SCC4_YEAST

Protein

MAU2 chromatid cohesion factor homolog

Gene

SCC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in sister chromatid cohesion. Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. double-strand break repair Source: SGD
    2. establishment of protein localization to chromatin Source: SGD
    3. mitotic chromosome condensation Source: SGD
    4. mitotic sister chromatid cohesion Source: SGD
    5. rDNA condensation Source: SGD

    Keywords - Biological processi

    Cell cycle, Cell division, Chromosome partition, Mitosis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30308-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MAU2 chromatid cohesion factor homolog
    Alternative name(s):
    Sister chromatid cohesion protein 4
    Gene namesi
    Name:SCC4
    Ordered Locus Names:YER147C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER147c.
    SGDiS000000949. SCC4.

    Subcellular locationi

    Nucleus
    Note: Associates with chromatin.

    GO - Cellular componenti

    1. nuclear chromatin Source: SGD
    2. SMC loading complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 624624MAU2 chromatid cohesion factor homologPRO_0000193217Add
    BLAST

    Proteomic databases

    MaxQBiP40090.
    PaxDbiP40090.
    PeptideAtlasiP40090.

    Expressioni

    Gene expression databases

    GenevestigatoriP40090.

    Interactioni

    Subunit structurei

    Interacts with SCC2 to form the cohesin loading complex.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SCC2Q040025EBI-16679,EBI-16662

    Protein-protein interaction databases

    BioGridi36896. 16 interactions.
    DIPiDIP-5627N.
    IntActiP40090. 3 interactions.
    MINTiMINT-555872.
    STRINGi4932.YER147C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40090.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SCC4/mau-2 family.Curated

    Phylogenomic databases

    eggNOGiNOG39193.
    HOGENOMiHOG000066106.
    KOiK06673.
    OMAiGIWHLMN.
    OrthoDBiEOG72892V.

    Family and domain databases

    InterProiIPR019440. Cohesin_loading_factor.
    [Graphical view]
    PfamiPF10345. Cohesin_load. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40090-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENLGDKLSI SQVYHLAQEY RDHAYSIANK IGSEEGLKQY YGLMNMSIQM    50
    FQLLKTKCTL SVLEDSKVTF EMVELLIQET YNFDLAELYI SSLKERLQTH 100
    QSDTDLVEEI MRCEFLLLHD LPLMRDSKFH YKIALRNCNE LVQYMVNLQD 150
    ELYQNWASVF QYVGVMLCIK LKQHRRVKTS FHGLLSQCRE KSQWKWFLNL 200
    CYVNYLLNER FPIPEDALQE LRSTELHTVG PELYAWKLAL EMVIQLCKDG 250
    NITDHLNEFK NFFDTNKQSL VTNEGKGCVI KIMPRIALKV ELPMIFHYKE 300
    LKNILLLLQS VSYIVNCYDE KGNFSRKFLP KVYSTTQKLI KNIAAGGVSM 350
    NELDSRIQTY KSILEFCEFY KVWEQTLLKG AVVTTESPKL GPSPGYVRLL 400
    QAMKVQFEGG GAVEEYTRLA QSGGTSSEVK MISLLNCYTV QAARVSRCSG 450
    DKQGELVEQC NKVWLQVEKL LQETDLQFNP IWECTVTILW LFSHFEPFSW 500
    NPLPCSDKQR AEYVSKLREF YSSNKFVAGE AVADNRFKLK KALLLQILVN 550
    YLGGRMLEHD LGEIYAISAK CFDMCRQQGG MRKVQYVIGI WHLMNCTVAM 600
    RGKDVALTNA KLEALVKQIT SVKQ 624
    Length:624
    Mass (Da):72,141
    Last modified:February 1, 1995 - v1
    Checksum:i1269D931C656E608
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18917 Genomic DNA. Translation: AAB64674.1.
    BK006939 Genomic DNA. Translation: DAA07808.1.
    PIRiS50650.
    RefSeqiNP_011074.3. NM_001179037.3.

    Genome annotation databases

    EnsemblFungiiYER147C; YER147C; YER147C.
    GeneIDi856890.
    KEGGisce:YER147C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18917 Genomic DNA. Translation: AAB64674.1 .
    BK006939 Genomic DNA. Translation: DAA07808.1 .
    PIRi S50650.
    RefSeqi NP_011074.3. NM_001179037.3.

    3D structure databases

    ProteinModelPortali P40090.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36896. 16 interactions.
    DIPi DIP-5627N.
    IntActi P40090. 3 interactions.
    MINTi MINT-555872.
    STRINGi 4932.YER147C.

    Proteomic databases

    MaxQBi P40090.
    PaxDbi P40090.
    PeptideAtlasi P40090.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER147C ; YER147C ; YER147C .
    GeneIDi 856890.
    KEGGi sce:YER147C.

    Organism-specific databases

    CYGDi YER147c.
    SGDi S000000949. SCC4.

    Phylogenomic databases

    eggNOGi NOG39193.
    HOGENOMi HOG000066106.
    KOi K06673.
    OMAi GIWHLMN.
    OrthoDBi EOG72892V.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30308-MONOMER.

    Miscellaneous databases

    NextBioi 983293.

    Gene expression databases

    Genevestigatori P40090.

    Family and domain databases

    InterProi IPR019440. Cohesin_loading_factor.
    [Graphical view ]
    Pfami PF10345. Cohesin_load. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins."
      Ciosk R., Shirayama M., Shevchenko A., Tanaka T., Toth A., Shevchenko A., Nasmyth K.
      Mol. Cell 5:243-254(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 390-398, FUNCTION, INTERACTION WITH SCC2.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSCC4_YEAST
    AccessioniPrimary (citable) accession number: P40090
    Secondary accession number(s): D3DM54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 907 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3