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P40090 (SCC4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MAU2 chromatid cohesion factor homolog
Alternative name(s):
Sister chromatid cohesion protein 4
Gene names
Name:SCC4
Ordered Locus Names:YER147C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length624 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in sister chromatid cohesion. Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes. Ref.3

Subunit structure

Interacts with SCC2 to form the cohesin loading complex. Ref.3

Subcellular location

Nucleus. Note: Associates with chromatin.

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the SCC4/mau-2 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SCC2Q040025EBI-16679,EBI-16662

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 624624MAU2 chromatid cohesion factor homolog
PRO_0000193217

Sequences

Sequence LengthMass (Da)Tools
P40090 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 1269D931C656E608

FASTA62472,141
        10         20         30         40         50         60 
MENLGDKLSI SQVYHLAQEY RDHAYSIANK IGSEEGLKQY YGLMNMSIQM FQLLKTKCTL 

        70         80         90        100        110        120 
SVLEDSKVTF EMVELLIQET YNFDLAELYI SSLKERLQTH QSDTDLVEEI MRCEFLLLHD 

       130        140        150        160        170        180 
LPLMRDSKFH YKIALRNCNE LVQYMVNLQD ELYQNWASVF QYVGVMLCIK LKQHRRVKTS 

       190        200        210        220        230        240 
FHGLLSQCRE KSQWKWFLNL CYVNYLLNER FPIPEDALQE LRSTELHTVG PELYAWKLAL 

       250        260        270        280        290        300 
EMVIQLCKDG NITDHLNEFK NFFDTNKQSL VTNEGKGCVI KIMPRIALKV ELPMIFHYKE 

       310        320        330        340        350        360 
LKNILLLLQS VSYIVNCYDE KGNFSRKFLP KVYSTTQKLI KNIAAGGVSM NELDSRIQTY 

       370        380        390        400        410        420 
KSILEFCEFY KVWEQTLLKG AVVTTESPKL GPSPGYVRLL QAMKVQFEGG GAVEEYTRLA 

       430        440        450        460        470        480 
QSGGTSSEVK MISLLNCYTV QAARVSRCSG DKQGELVEQC NKVWLQVEKL LQETDLQFNP 

       490        500        510        520        530        540 
IWECTVTILW LFSHFEPFSW NPLPCSDKQR AEYVSKLREF YSSNKFVAGE AVADNRFKLK 

       550        560        570        580        590        600 
KALLLQILVN YLGGRMLEHD LGEIYAISAK CFDMCRQQGG MRKVQYVIGI WHLMNCTVAM 

       610        620 
RGKDVALTNA KLEALVKQIT SVKQ 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins."
Ciosk R., Shirayama M., Shevchenko A., Tanaka T., Toth A., Shevchenko A., Nasmyth K.
Mol. Cell 5:243-254(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 390-398, FUNCTION, INTERACTION WITH SCC2.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18917 Genomic DNA. Translation: AAB64674.1.
BK006939 Genomic DNA. Translation: DAA07808.1.
PIRS50650.
RefSeqNP_011074.3. NM_001179037.3.

3D structure databases

ProteinModelPortalP40090.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36896. 16 interactions.
DIPDIP-5627N.
IntActP40090. 3 interactions.
MINTMINT-555872.
STRING4932.YER147C.

Proteomic databases

MaxQBP40090.
PaxDbP40090.
PeptideAtlasP40090.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER147C; YER147C; YER147C.
GeneID856890.
KEGGsce:YER147C.

Organism-specific databases

CYGDYER147c.
SGDS000000949. SCC4.

Phylogenomic databases

eggNOGNOG39193.
HOGENOMHOG000066106.
KOK06673.
OMAGIWHLMN.
OrthoDBEOG72892V.

Enzyme and pathway databases

BioCycYEAST:G3O-30308-MONOMER.

Gene expression databases

GenevestigatorP40090.

Family and domain databases

InterProIPR019440. Cohesin_loading_factor.
[Graphical view]
PfamPF10345. Cohesin_load. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio983293.

Entry information

Entry nameSCC4_YEAST
AccessionPrimary (citable) accession number: P40090
Secondary accession number(s): D3DM54
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families