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Protein

MAU2 chromatid cohesion factor homolog

Gene

SCC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in sister chromatid cohesion. Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes.1 Publication

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. double-strand break repair Source: SGD
  3. establishment of protein localization to chromatin Source: SGD
  4. mitotic chromosome condensation Source: SGD
  5. mitotic sister chromatid cohesion Source: SGD
  6. rDNA condensation Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-30308-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
MAU2 chromatid cohesion factor homolog
Alternative name(s):
Sister chromatid cohesion protein 4
Gene namesi
Name:SCC4
Ordered Locus Names:YER147C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER147c.
SGDiS000000949. SCC4.

Subcellular locationi

Nucleus
Note: Associates with chromatin.

GO - Cellular componenti

  1. nuclear chromatin Source: SGD
  2. SMC loading complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 624624MAU2 chromatid cohesion factor homologPRO_0000193217Add
BLAST

Proteomic databases

MaxQBiP40090.
PaxDbiP40090.
PeptideAtlasiP40090.

Expressioni

Gene expression databases

GenevestigatoriP40090.

Interactioni

Subunit structurei

Interacts with SCC2 to form the cohesin loading complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SCC2Q040025EBI-16679,EBI-16662

Protein-protein interaction databases

BioGridi36896. 16 interactions.
DIPiDIP-5627N.
IntActiP40090. 3 interactions.
MINTiMINT-555872.
STRINGi4932.YER147C.

Structurei

3D structure databases

ProteinModelPortaliP40090.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SCC4/mau-2 family.Curated

Phylogenomic databases

eggNOGiNOG39193.
HOGENOMiHOG000066106.
InParanoidiP40090.
KOiK06673.
OMAiGIWHLMN.
OrthoDBiEOG72892V.

Family and domain databases

InterProiIPR019440. Cohesin_loading_factor.
[Graphical view]
PfamiPF10345. Cohesin_load. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40090-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENLGDKLSI SQVYHLAQEY RDHAYSIANK IGSEEGLKQY YGLMNMSIQM
60 70 80 90 100
FQLLKTKCTL SVLEDSKVTF EMVELLIQET YNFDLAELYI SSLKERLQTH
110 120 130 140 150
QSDTDLVEEI MRCEFLLLHD LPLMRDSKFH YKIALRNCNE LVQYMVNLQD
160 170 180 190 200
ELYQNWASVF QYVGVMLCIK LKQHRRVKTS FHGLLSQCRE KSQWKWFLNL
210 220 230 240 250
CYVNYLLNER FPIPEDALQE LRSTELHTVG PELYAWKLAL EMVIQLCKDG
260 270 280 290 300
NITDHLNEFK NFFDTNKQSL VTNEGKGCVI KIMPRIALKV ELPMIFHYKE
310 320 330 340 350
LKNILLLLQS VSYIVNCYDE KGNFSRKFLP KVYSTTQKLI KNIAAGGVSM
360 370 380 390 400
NELDSRIQTY KSILEFCEFY KVWEQTLLKG AVVTTESPKL GPSPGYVRLL
410 420 430 440 450
QAMKVQFEGG GAVEEYTRLA QSGGTSSEVK MISLLNCYTV QAARVSRCSG
460 470 480 490 500
DKQGELVEQC NKVWLQVEKL LQETDLQFNP IWECTVTILW LFSHFEPFSW
510 520 530 540 550
NPLPCSDKQR AEYVSKLREF YSSNKFVAGE AVADNRFKLK KALLLQILVN
560 570 580 590 600
YLGGRMLEHD LGEIYAISAK CFDMCRQQGG MRKVQYVIGI WHLMNCTVAM
610 620
RGKDVALTNA KLEALVKQIT SVKQ
Length:624
Mass (Da):72,141
Last modified:February 1, 1995 - v1
Checksum:i1269D931C656E608
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18917 Genomic DNA. Translation: AAB64674.1.
BK006939 Genomic DNA. Translation: DAA07808.1.
PIRiS50650.
RefSeqiNP_011074.3. NM_001179037.3.

Genome annotation databases

EnsemblFungiiYER147C; YER147C; YER147C.
GeneIDi856890.
KEGGisce:YER147C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18917 Genomic DNA. Translation: AAB64674.1.
BK006939 Genomic DNA. Translation: DAA07808.1.
PIRiS50650.
RefSeqiNP_011074.3. NM_001179037.3.

3D structure databases

ProteinModelPortaliP40090.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36896. 16 interactions.
DIPiDIP-5627N.
IntActiP40090. 3 interactions.
MINTiMINT-555872.
STRINGi4932.YER147C.

Proteomic databases

MaxQBiP40090.
PaxDbiP40090.
PeptideAtlasiP40090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER147C; YER147C; YER147C.
GeneIDi856890.
KEGGisce:YER147C.

Organism-specific databases

CYGDiYER147c.
SGDiS000000949. SCC4.

Phylogenomic databases

eggNOGiNOG39193.
HOGENOMiHOG000066106.
InParanoidiP40090.
KOiK06673.
OMAiGIWHLMN.
OrthoDBiEOG72892V.

Enzyme and pathway databases

BioCyciYEAST:G3O-30308-MONOMER.

Miscellaneous databases

NextBioi983293.

Gene expression databases

GenevestigatoriP40090.

Family and domain databases

InterProiIPR019440. Cohesin_loading_factor.
[Graphical view]
PfamiPF10345. Cohesin_load. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins."
    Ciosk R., Shirayama M., Shevchenko A., Tanaka T., Toth A., Shevchenko A., Nasmyth K.
    Mol. Cell 5:243-254(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 390-398, FUNCTION, INTERACTION WITH SCC2.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSCC4_YEAST
AccessioniPrimary (citable) accession number: P40090
Secondary accession number(s): D3DM54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 4, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.