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Protein

Plasma membrane iron permease

Gene

FTR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Permease for high affinity iron uptake.

Miscellaneous

Present with 8370 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • arsenate ion transmembrane transport Source: SGD
  • high-affinity iron ion transmembrane transport Source: SGD
  • iron assimilation by reduction and transport Source: SGD

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

BioCyciYEAST:G3O-30306-MONOMER.

Protein family/group databases

TCDBi2.A.108.1.1. the iron/lead transporter (ilt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane iron permease
Gene namesi
Name:FTR1
Ordered Locus Names:YER145C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER145C.
SGDiS000000947. FTR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • high-affinity iron permease complex Source: SGD
  • plasma membrane Source: SGD

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001596491 – 404Plasma membrane iron permeaseAdd BLAST404

Proteomic databases

MaxQBiP40088.
PRIDEiP40088.

PTM databases

iPTMnetiP40088.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FET3P389936EBI-7138,EBI-6876

Protein-protein interaction databases

BioGridi36894. 96 interactors.
DIPiDIP-5376N.
IntActiP40088. 27 interactors.
MINTiMINT-530729.
STRINGi4932.YER145C.

Structurei

3D structure databases

ProteinModelPortaliP40088.
SMRiP40088.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000067281.
HOGENOMiHOG000159782.
InParanoidiP40088.
KOiK07243.
OMAiNCCNPET.
OrthoDBiEOG092C31W9.

Family and domain databases

InterProiView protein in InterPro
IPR005217. FTR1-like.
IPR004923. FTR1/Fip1/EfeU.
PANTHERiPTHR31632. PTHR31632. 1 hit.
PfamiView protein in Pfam
PF03239. FTR1. 1 hit.
TIGRFAMsiTIGR00145. TIGR00145. 1 hit.

Sequencei

Sequence statusi: Complete.

P40088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNKVFNVAV FFVVFRECLE AVIVISVLLS FLKQAIGEHD RALYRKLRIQ
60 70 80 90 100
VWVGVLLGFI ICLAIGAGFI GAYYSLQKDI FGSAEDLWEG IFCMIATIMI
110 120 130 140 150
SMMGIPMLRM NKMQSKWRVK IARSLVEIPH RKRDYFKIGF LSRRYAMFLL
160 170 180 190 200
PFITVLREGL EAVVFVAGAG ITTQGSHASA YPLPVVVGLI CGGLVGYLLY
210 220 230 240 250
YGASKSSLQI FLILSTSILY LISAGLFSRG AWYFENYRFN LASGGDASEG
260 270 280 290 300
GDGNGSYNIR KAVYHVNCCN PELDNGWDIF NALLGWQNTG YLSSMLCYNI
310 320 330 340 350
YWLVLIIVLS LMIFEERRGH LPFTKNLQLK HLNPGYWIKN KKKQELTEEQ
360 370 380 390 400
KRQLFAKMEN INFNEDGEIN VQENYELPEQ TTSHSSSQNV ATDKEVLHVK

ADSL
Length:404
Mass (Da):45,722
Last modified:February 1, 1995 - v1
Checksum:i3E155BF6195AD867
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18917 Genomic DNA. Translation: AAB64672.1.
BK006939 Genomic DNA. Translation: DAA07806.1.
PIRiS50648.
RefSeqiNP_011072.1. NM_001179035.1.

Genome annotation databases

EnsemblFungiiYER145C; YER145C; YER145C.
GeneIDi856888.
KEGGisce:YER145C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFTR1_YEAST
AccessioniPrimary (citable) accession number: P40088
Secondary accession number(s): D3DM52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 5, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names