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Reviewed, UniProtKB/Swiss-Prot P40088 (FTR1_YEAST)

Last modified November 24, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Plasma membrane iron permease
Gene names
Name: FTR1
Ordered Locus Names: YER145C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Permease for high affinity iron uptake.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Miscellaneous

Present with 8370 molecules/cell in log phase SD medium. Ref.3

Sequence similarities

Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family. [View classification]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404Plasma membrane iron permease
PRO_0000159649

Regions

Transmembrane8 – 2821 Potential
Transmembrane51 – 7121 Potential
Transmembrane87 – 10721 Potential
Transmembrane147 – 16721 Potential
Transmembrane183 – 20321 Potential
Transmembrane207 – 22721 Potential
Transmembrane294 – 31421 Potential

Amino acid modifications

Modified residue4031Phosphoserine Ref.4

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Sequences

Sequence LengthMass (Da)Tools
P40088-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 3E155BF6195AD867

FASTA40445,722
        10         20         30         40         50         60 
MPNKVFNVAV FFVVFRECLE AVIVISVLLS FLKQAIGEHD RALYRKLRIQ VWVGVLLGFI 

        70         80         90        100        110        120 
ICLAIGAGFI GAYYSLQKDI FGSAEDLWEG IFCMIATIMI SMMGIPMLRM NKMQSKWRVK 

       130        140        150        160        170        180 
IARSLVEIPH RKRDYFKIGF LSRRYAMFLL PFITVLREGL EAVVFVAGAG ITTQGSHASA 

       190        200        210        220        230        240 
YPLPVVVGLI CGGLVGYLLY YGASKSSLQI FLILSTSILY LISAGLFSRG AWYFENYRFN 

       250        260        270        280        290        300 
LASGGDASEG GDGNGSYNIR KAVYHVNCCN PELDNGWDIF NALLGWQNTG YLSSMLCYNI 

       310        320        330        340        350        360 
YWLVLIIVLS LMIFEERRGH LPFTKNLQLK HLNPGYWIKN KKKQELTEEQ KRQLFAKMEN 

       370        380        390        400 
INFNEDGEIN VQENYELPEQ TTSHSSSQNV ATDKEVLHVK ADSL

« Hide

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References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed: 9169868] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"A permease-oxidase complex involved in high-affinity iron uptake in yeast."
Stearman R., Yuan D.S., Yamaguchi-Iwai Y., Klausner R.D., Dancis A.
Science 271:1552-1557(1996) [PubMed: 8599111] [Abstract]
Cited for: CHARACTERIZATION.
[3]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
Mol. Cell. Proteomics 4:310-327(2005) [PubMed: 15665377] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-403, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U18917 Genomic DNA. Translation: AAB64672.1.
PIRS50648.
RefSeqNP_011072.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:5376N.
IntActP40088. 40 interactions.
STRINGP40088.

Protein family/group databases

TCDB9.A.10.1.1. iron/lead transporter (ILT) superfamily.

Proteomic databases

PeptideAtlasP40088.

Genome annotation databases

EnsemblYER145C; YER145C; YER145C; Saccharomyces cerevisiae. [Genome view]
GeneID856888.
KEGGsce:YER145C.
NMPDRfig|4932.3.peg.2151.

Organism-specific databases

CYGDYER145c.
SGDS000000947. FTR1.

Phylogenomic databases

HOGENOMP40088.
OMAWDIFNAL
OrthoDBEOG9DFR4P

Gene expression databases

ArrayExpressP40088.
GenevestigatorP40088.
GermOnlineYER145C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR005217. CHP00145.
IPR004923. FTR1.
[Graphical view]
PfamPF03239. FTR1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00145. CHP145. 1 hit.
ProtoNetSearch...

Other Resources

NextBio983287.

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Entry information

Entry nameFTR1_YEAST
AccessionPrimary (citable) accession number: P40088
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 24, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents