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P40088

- FTR1_YEAST

UniProt

P40088 - FTR1_YEAST

Protein

Plasma membrane iron permease

Gene

FTR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Permease for high affinity iron uptake.

    GO - Molecular functioni

    1. iron ion transmembrane transporter activity Source: SGD
    2. protein binding Source: IntAct

    GO - Biological processi

    1. arsenate ion transmembrane transport Source: SGD
    2. high-affinity iron ion transmembrane transport Source: SGD
    3. iron assimilation by reduction and transport Source: SGD

    Keywords - Biological processi

    Ion transport, Iron transport, Transport

    Keywords - Ligandi

    Iron

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30306-MONOMER.

    Protein family/group databases

    TCDBi2.A.108.1.1. the iron/lead transporter (ilt) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plasma membrane iron permease
    Gene namesi
    Name:FTR1
    Ordered Locus Names:YER145C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER145c.
    SGDiS000000947. FTR1.

    Subcellular locationi

    GO - Cellular componenti

    1. high-affinity iron permease complex Source: SGD
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Plasma membrane iron permeasePRO_0000159649Add
    BLAST

    Proteomic databases

    MaxQBiP40088.
    PaxDbiP40088.
    PeptideAtlasiP40088.

    Expressioni

    Gene expression databases

    GenevestigatoriP40088.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FET3P389936EBI-7138,EBI-6876

    Protein-protein interaction databases

    BioGridi36894. 64 interactions.
    DIPiDIP-5376N.
    IntActiP40088. 27 interactions.
    MINTiMINT-530729.
    STRINGi4932.YER145C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40088.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei51 – 7121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei207 – 22721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei294 – 31421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0672.
    GeneTreeiENSGT00530000067281.
    HOGENOMiHOG000159782.
    KOiK07243.
    OMAiIATIMIS.
    OrthoDBiEOG7B5X58.

    Family and domain databases

    InterProiIPR005217. FTR1-like.
    IPR004923. FTR1/Fip1/EfeU.
    [Graphical view]
    PANTHERiPTHR31632. PTHR31632. 1 hit.
    PfamiPF03239. FTR1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00145. TIGR00145. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P40088-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPNKVFNVAV FFVVFRECLE AVIVISVLLS FLKQAIGEHD RALYRKLRIQ    50
    VWVGVLLGFI ICLAIGAGFI GAYYSLQKDI FGSAEDLWEG IFCMIATIMI 100
    SMMGIPMLRM NKMQSKWRVK IARSLVEIPH RKRDYFKIGF LSRRYAMFLL 150
    PFITVLREGL EAVVFVAGAG ITTQGSHASA YPLPVVVGLI CGGLVGYLLY 200
    YGASKSSLQI FLILSTSILY LISAGLFSRG AWYFENYRFN LASGGDASEG 250
    GDGNGSYNIR KAVYHVNCCN PELDNGWDIF NALLGWQNTG YLSSMLCYNI 300
    YWLVLIIVLS LMIFEERRGH LPFTKNLQLK HLNPGYWIKN KKKQELTEEQ 350
    KRQLFAKMEN INFNEDGEIN VQENYELPEQ TTSHSSSQNV ATDKEVLHVK 400
    ADSL 404
    Length:404
    Mass (Da):45,722
    Last modified:February 1, 1995 - v1
    Checksum:i3E155BF6195AD867
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18917 Genomic DNA. Translation: AAB64672.1.
    BK006939 Genomic DNA. Translation: DAA07806.1.
    PIRiS50648.
    RefSeqiNP_011072.1. NM_001179035.1.

    Genome annotation databases

    EnsemblFungiiYER145C; YER145C; YER145C.
    GeneIDi856888.
    KEGGisce:YER145C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18917 Genomic DNA. Translation: AAB64672.1 .
    BK006939 Genomic DNA. Translation: DAA07806.1 .
    PIRi S50648.
    RefSeqi NP_011072.1. NM_001179035.1.

    3D structure databases

    ProteinModelPortali P40088.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36894. 64 interactions.
    DIPi DIP-5376N.
    IntActi P40088. 27 interactions.
    MINTi MINT-530729.
    STRINGi 4932.YER145C.

    Protein family/group databases

    TCDBi 2.A.108.1.1. the iron/lead transporter (ilt) family.

    Proteomic databases

    MaxQBi P40088.
    PaxDbi P40088.
    PeptideAtlasi P40088.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER145C ; YER145C ; YER145C .
    GeneIDi 856888.
    KEGGi sce:YER145C.

    Organism-specific databases

    CYGDi YER145c.
    SGDi S000000947. FTR1.

    Phylogenomic databases

    eggNOGi COG0672.
    GeneTreei ENSGT00530000067281.
    HOGENOMi HOG000159782.
    KOi K07243.
    OMAi IATIMIS.
    OrthoDBi EOG7B5X58.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30306-MONOMER.

    Miscellaneous databases

    NextBioi 983287.

    Gene expression databases

    Genevestigatori P40088.

    Family and domain databases

    InterProi IPR005217. FTR1-like.
    IPR004923. FTR1/Fip1/EfeU.
    [Graphical view ]
    PANTHERi PTHR31632. PTHR31632. 1 hit.
    Pfami PF03239. FTR1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00145. TIGR00145. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "A permease-oxidase complex involved in high-affinity iron uptake in yeast."
      Stearman R., Yuan D.S., Yamaguchi-Iwai Y., Klausner R.D., Dancis A.
      Science 271:1552-1557(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFTR1_YEAST
    AccessioniPrimary (citable) accession number: P40088
    Secondary accession number(s): D3DM52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 8370 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3