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P40088 (FTR1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Plasma membrane iron permease
Gene names
Name:FTR1
Ordered Locus Names:YER145C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Permease for high affinity iron uptake.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Miscellaneous

Present with 8370 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family. [View classification]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

FET3P389936EBI-7138,EBI-6876

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404Plasma membrane iron permease
PRO_0000159649

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane51 – 7121Helical; Potential
Transmembrane87 – 10721Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane207 – 22721Helical; Potential
Transmembrane294 – 31421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P40088 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 3E155BF6195AD867

FASTA40445,722
        10         20         30         40         50         60 
MPNKVFNVAV FFVVFRECLE AVIVISVLLS FLKQAIGEHD RALYRKLRIQ VWVGVLLGFI 

        70         80         90        100        110        120 
ICLAIGAGFI GAYYSLQKDI FGSAEDLWEG IFCMIATIMI SMMGIPMLRM NKMQSKWRVK 

       130        140        150        160        170        180 
IARSLVEIPH RKRDYFKIGF LSRRYAMFLL PFITVLREGL EAVVFVAGAG ITTQGSHASA 

       190        200        210        220        230        240 
YPLPVVVGLI CGGLVGYLLY YGASKSSLQI FLILSTSILY LISAGLFSRG AWYFENYRFN 

       250        260        270        280        290        300 
LASGGDASEG GDGNGSYNIR KAVYHVNCCN PELDNGWDIF NALLGWQNTG YLSSMLCYNI 

       310        320        330        340        350        360 
YWLVLIIVLS LMIFEERRGH LPFTKNLQLK HLNPGYWIKN KKKQELTEEQ KRQLFAKMEN 

       370        380        390        400 
INFNEDGEIN VQENYELPEQ TTSHSSSQNV ATDKEVLHVK ADSL 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"A permease-oxidase complex involved in high-affinity iron uptake in yeast."
Stearman R., Yuan D.S., Yamaguchi-Iwai Y., Klausner R.D., Dancis A.
Science 271:1552-1557(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18917 Genomic DNA. Translation: AAB64672.1.
BK006939 Genomic DNA. Translation: DAA07806.1.
PIRS50648.
RefSeqNP_011072.1. NM_001179035.1.

3D structure databases

ProteinModelPortalP40088.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36894. 64 interactions.
DIPDIP-5376N.
IntActP40088. 27 interactions.
MINTMINT-530729.
STRING4932.YER145C.

Protein family/group databases

TCDB2.A.108.1.1. the iron/lead transporter (ilt) family.

Proteomic databases

MaxQBP40088.
PaxDbP40088.
PeptideAtlasP40088.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER145C; YER145C; YER145C.
GeneID856888.
KEGGsce:YER145C.

Organism-specific databases

CYGDYER145c.
SGDS000000947. FTR1.

Phylogenomic databases

eggNOGCOG0672.
GeneTreeENSGT00530000067281.
HOGENOMHOG000159782.
KOK07243.
OMAIATIMIS.
OrthoDBEOG7B5X58.

Enzyme and pathway databases

BioCycYEAST:G3O-30306-MONOMER.

Gene expression databases

GenevestigatorP40088.

Family and domain databases

InterProIPR005217. CHP00145.
IPR004923. FTR1.
[Graphical view]
PfamPF03239. FTR1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00145. TIGR00145. 1 hit.
ProtoNetSearch...

Other

NextBio983287.

Entry information

Entry nameFTR1_YEAST
AccessionPrimary (citable) accession number: P40088
Secondary accession number(s): D3DM52
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families