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Protein

Plasma membrane iron permease

Gene

FTR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Permease for high affinity iron uptake.

GO - Molecular functioni

  • iron ion transmembrane transporter activity Source: SGD

GO - Biological processi

  • arsenate ion transmembrane transport Source: SGD
  • high-affinity iron ion transmembrane transport Source: SGD
  • iron assimilation by reduction and transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciYEAST:G3O-30306-MONOMER.

Protein family/group databases

TCDBi2.A.108.1.1. the iron/lead transporter (ilt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane iron permease
Gene namesi
Name:FTR1
Ordered Locus Names:YER145C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome V

Organism-specific databases

CYGDiYER145c.
EuPathDBiFungiDB:YER145C.
SGDiS000000947. FTR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence AnalysisAdd
BLAST
Transmembranei51 – 7121HelicalSequence AnalysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence AnalysisAdd
BLAST
Transmembranei207 – 22721HelicalSequence AnalysisAdd
BLAST
Transmembranei294 – 31421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • high-affinity iron permease complex Source: SGD
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Plasma membrane iron permeasePRO_0000159649Add
BLAST

Proteomic databases

MaxQBiP40088.
PaxDbiP40088.
PeptideAtlasiP40088.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FET3P389936EBI-7138,EBI-6876

Protein-protein interaction databases

BioGridi36894. 63 interactions.
DIPiDIP-5376N.
IntActiP40088. 27 interactions.
MINTiMINT-530729.

Structurei

3D structure databases

ProteinModelPortaliP40088.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0672.
GeneTreeiENSGT00530000067281.
HOGENOMiHOG000159782.
InParanoidiP40088.
KOiK07243.
OMAiIATIMIS.
OrthoDBiEOG7B5X58.

Family and domain databases

InterProiIPR005217. FTR1-like.
IPR004923. FTR1/Fip1/EfeU.
[Graphical view]
PANTHERiPTHR31632. PTHR31632. 1 hit.
PfamiPF03239. FTR1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00145. TIGR00145. 1 hit.

Sequencei

Sequence statusi: Complete.

P40088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNKVFNVAV FFVVFRECLE AVIVISVLLS FLKQAIGEHD RALYRKLRIQ
60 70 80 90 100
VWVGVLLGFI ICLAIGAGFI GAYYSLQKDI FGSAEDLWEG IFCMIATIMI
110 120 130 140 150
SMMGIPMLRM NKMQSKWRVK IARSLVEIPH RKRDYFKIGF LSRRYAMFLL
160 170 180 190 200
PFITVLREGL EAVVFVAGAG ITTQGSHASA YPLPVVVGLI CGGLVGYLLY
210 220 230 240 250
YGASKSSLQI FLILSTSILY LISAGLFSRG AWYFENYRFN LASGGDASEG
260 270 280 290 300
GDGNGSYNIR KAVYHVNCCN PELDNGWDIF NALLGWQNTG YLSSMLCYNI
310 320 330 340 350
YWLVLIIVLS LMIFEERRGH LPFTKNLQLK HLNPGYWIKN KKKQELTEEQ
360 370 380 390 400
KRQLFAKMEN INFNEDGEIN VQENYELPEQ TTSHSSSQNV ATDKEVLHVK

ADSL
Length:404
Mass (Da):45,722
Last modified:February 1, 1995 - v1
Checksum:i3E155BF6195AD867
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18917 Genomic DNA. Translation: AAB64672.1.
BK006939 Genomic DNA. Translation: DAA07806.1.
PIRiS50648.
RefSeqiNP_011072.1. NM_001179035.1.

Genome annotation databases

EnsemblFungiiYER145C; YER145C; YER145C.
GeneIDi856888.
KEGGisce:YER145C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18917 Genomic DNA. Translation: AAB64672.1.
BK006939 Genomic DNA. Translation: DAA07806.1.
PIRiS50648.
RefSeqiNP_011072.1. NM_001179035.1.

3D structure databases

ProteinModelPortaliP40088.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36894. 63 interactions.
DIPiDIP-5376N.
IntActiP40088. 27 interactions.
MINTiMINT-530729.

Protein family/group databases

TCDBi2.A.108.1.1. the iron/lead transporter (ilt) family.

Proteomic databases

MaxQBiP40088.
PaxDbiP40088.
PeptideAtlasiP40088.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER145C; YER145C; YER145C.
GeneIDi856888.
KEGGisce:YER145C.

Organism-specific databases

CYGDiYER145c.
EuPathDBiFungiDB:YER145C.
SGDiS000000947. FTR1.

Phylogenomic databases

eggNOGiCOG0672.
GeneTreeiENSGT00530000067281.
HOGENOMiHOG000159782.
InParanoidiP40088.
KOiK07243.
OMAiIATIMIS.
OrthoDBiEOG7B5X58.

Enzyme and pathway databases

BioCyciYEAST:G3O-30306-MONOMER.

Miscellaneous databases

NextBioi983287.
PROiP40088.

Family and domain databases

InterProiIPR005217. FTR1-like.
IPR004923. FTR1/Fip1/EfeU.
[Graphical view]
PANTHERiPTHR31632. PTHR31632. 1 hit.
PfamiPF03239. FTR1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00145. TIGR00145. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "A permease-oxidase complex involved in high-affinity iron uptake in yeast."
    Stearman R., Yuan D.S., Yamaguchi-Iwai Y., Klausner R.D., Dancis A.
    Science 271:1552-1557(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFTR1_YEAST
AccessioniPrimary (citable) accession number: P40088
Secondary accession number(s): D3DM52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 22, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8370 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.