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Protein

Cytochrome c oxidase assembly protein COX15

Gene

COX15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for the assembly of yeast cytochrome oxidase. Involved in the biosynthesis of heme A and the initial step in this pathway, the hydroxylation of heme O, is thought to be catalyzed by a three-component mono-oxygenase consisting of COX15, ferredoxin and ferredoxin reductase.2 Publications

GO - Molecular functioni

GO - Biological processi

  • heme a biosynthetic process Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-30302-MONOMER
ReactomeiR-SCE-189451 Heme biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX15
Gene namesi
Name:COX15
Ordered Locus Names:YER141W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER141W
SGDiS000000943 COX15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839331 – 486Cytochrome c oxidase assembly protein COX15Add BLAST486

Proteomic databases

MaxQBiP40086
PaxDbiP40086
PRIDEiP40086

Interactioni

Protein-protein interaction databases

BioGridi36890, 62 interactors
IntActiP40086, 12 interactors
MINTiP40086
STRINGi4932.YER141W

Structurei

3D structure databases

ProteinModelPortaliP40086
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COX15/CtaA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002223
HOGENOMiHOG000214943
InParanoidiP40086
KOiK02259
OMAiAGLIYNT
OrthoDBiEOG092C5GZH

Family and domain databases

HAMAPiMF_01665 HemeA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR003780 COX15/CtaA_fam
IPR023754 HemeA_Synthase_type2
PANTHERiPTHR23289 PTHR23289, 1 hit
PfamiView protein in Pfam
PF02628 COX15-CtaA, 1 hit

Sequencei

Sequence statusi: Complete.

P40086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFRNIEVGR QAAKLLTRTS SRLAWQSIGA SRNISTIRQQ IRKTQLYNFK
60 70 80 90 100
KTVSIRPFSL SSPVFKPHVA SESNPIESRL KTSKNVAYWL IGTSGLVFGI
110 120 130 140 150
VVLGGLTRLT ESGLSITEWK PVTGTLPPMN QKEWEEEFIK YKESPEFKLL
160 170 180 190 200
NSHIDLDEFK FIFFMEWIHR LWGRAIGAVF ILPAVYFAVS KKTSGHVNKR
210 220 230 240 250
LFGLAGLLGL QGFVGWWMVK SGLDQEQLDA RKSKPTVSQY RLTTHLGTAF
260 270 280 290 300
FLYMGMLWTG LEILRECKWI KNPVQAISLF KKLDNPAIGP MRKISLALLA
310 320 330 340 350
VSFLTAMSGG MVAGLDAGWV YNTWPKMGER WFPSSRELMD ENFCRREDKK
360 370 380 390 400
DLWWRNLLEN PVTVQLVHRT CAYVAFTSVL AAHMYAIKKK AVIPRNAMTS
410 420 430 440 450
LHVMMGVVTL QATLGILTIL YLVPISLASI HQAGALALLT SSLVFASQLR
460 470 480
KPRAPMRNVI ITLPHSSKVT SGKILSEASK LASKPL
Length:486
Mass (Da):54,658
Last modified:February 1, 1995 - v1
Checksum:i81E2B3C418D9527D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38643 Genomic DNA Translation: AAA57471.1
U18917 Genomic DNA Translation: AAB64668.1
BK006939 Genomic DNA Translation: DAA07802.1
PIRiS50644
RefSeqiNP_011068.1, NM_001179031.1

Genome annotation databases

EnsemblFungiiYER141W; YER141W; YER141W
GeneIDi856884
KEGGisce:YER141W

Similar proteinsi

Entry informationi

Entry nameiCOX15_YEAST
AccessioniPrimary (citable) accession number: P40086
Secondary accession number(s): D3DM48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health