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Protein

Cytochrome c oxidase assembly protein COX15

Gene

COX15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for the assembly of yeast cytochrome oxidase. Involved in the biosynthesis of heme A and the initial step in this pathway, the hydroxylation of heme O, is thought to be catalyzed by a three-component mono-oxygenase consisting of COX15, ferredoxin and ferredoxin reductase.2 Publications

GO - Molecular functioni

GO - Biological processi

  • heme a biosynthetic process Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30302-MONOMER.
ReactomeiR-SCE-189451. Heme biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX15
Gene namesi
Name:COX15
Ordered Locus Names:YER141W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER141W.
SGDiS000000943. COX15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence analysisAdd
BLAST
Transmembranei294 – 31421HelicalSequence analysisAdd
BLAST
Transmembranei403 – 42321HelicalSequence analysisAdd
BLAST
Transmembranei425 – 44521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Cytochrome c oxidase assembly protein COX15PRO_0000183933Add
BLAST

Proteomic databases

MaxQBiP40086.
PeptideAtlasiP40086.

Interactioni

Protein-protein interaction databases

BioGridi36890. 18 interactions.
IntActiP40086. 12 interactions.
MINTiMINT-4484446.

Structurei

3D structure databases

ProteinModelPortaliP40086.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COX15/CtaA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002223.
HOGENOMiHOG000214943.
InParanoidiP40086.
KOiK02259.
OMAiTALIYIV.
OrthoDBiEOG73V6VZ.

Family and domain databases

HAMAPiMF_01665. HemeA_synth_type2.
InterProiIPR003780. COX15/CtaA_fam.
IPR023754. HemeA_Synthase_type2.
[Graphical view]
PfamiPF02628. COX15-CtaA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFRNIEVGR QAAKLLTRTS SRLAWQSIGA SRNISTIRQQ IRKTQLYNFK
60 70 80 90 100
KTVSIRPFSL SSPVFKPHVA SESNPIESRL KTSKNVAYWL IGTSGLVFGI
110 120 130 140 150
VVLGGLTRLT ESGLSITEWK PVTGTLPPMN QKEWEEEFIK YKESPEFKLL
160 170 180 190 200
NSHIDLDEFK FIFFMEWIHR LWGRAIGAVF ILPAVYFAVS KKTSGHVNKR
210 220 230 240 250
LFGLAGLLGL QGFVGWWMVK SGLDQEQLDA RKSKPTVSQY RLTTHLGTAF
260 270 280 290 300
FLYMGMLWTG LEILRECKWI KNPVQAISLF KKLDNPAIGP MRKISLALLA
310 320 330 340 350
VSFLTAMSGG MVAGLDAGWV YNTWPKMGER WFPSSRELMD ENFCRREDKK
360 370 380 390 400
DLWWRNLLEN PVTVQLVHRT CAYVAFTSVL AAHMYAIKKK AVIPRNAMTS
410 420 430 440 450
LHVMMGVVTL QATLGILTIL YLVPISLASI HQAGALALLT SSLVFASQLR
460 470 480
KPRAPMRNVI ITLPHSSKVT SGKILSEASK LASKPL
Length:486
Mass (Da):54,658
Last modified:February 1, 1995 - v1
Checksum:i81E2B3C418D9527D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38643 Genomic DNA. Translation: AAA57471.1.
U18917 Genomic DNA. Translation: AAB64668.1.
BK006939 Genomic DNA. Translation: DAA07802.1.
PIRiS50644.
RefSeqiNP_011068.1. NM_001179031.1.

Genome annotation databases

EnsemblFungiiYER141W; YER141W; YER141W.
GeneIDi856884.
KEGGisce:YER141W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38643 Genomic DNA. Translation: AAA57471.1.
U18917 Genomic DNA. Translation: AAB64668.1.
BK006939 Genomic DNA. Translation: DAA07802.1.
PIRiS50644.
RefSeqiNP_011068.1. NM_001179031.1.

3D structure databases

ProteinModelPortaliP40086.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36890. 18 interactions.
IntActiP40086. 12 interactions.
MINTiMINT-4484446.

Proteomic databases

MaxQBiP40086.
PeptideAtlasiP40086.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER141W; YER141W; YER141W.
GeneIDi856884.
KEGGisce:YER141W.

Organism-specific databases

EuPathDBiFungiDB:YER141W.
SGDiS000000943. COX15.

Phylogenomic databases

GeneTreeiENSGT00390000002223.
HOGENOMiHOG000214943.
InParanoidiP40086.
KOiK02259.
OMAiTALIYIV.
OrthoDBiEOG73V6VZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-30302-MONOMER.
ReactomeiR-SCE-189451. Heme biosynthesis.

Miscellaneous databases

PROiP40086.

Family and domain databases

HAMAPiMF_01665. HemeA_synth_type2.
InterProiIPR003780. COX15/CtaA_fam.
IPR023754. HemeA_Synthase_type2.
[Graphical view]
PfamiPF02628. COX15-CtaA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "COX15 codes for a mitochondrial protein essential for the assembly of yeast cytochrome oxidase."
    Glerum D.M., Muroff I., Jin C., Tzagoloff A.
    J. Biol. Chem. 272:19088-19094(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
    Strain: ATCC 24657 / D273-10B.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Involvement of mitochondrial ferredoxin and Cox15p in hydroxylation of heme O."
    Barros M.H., Carlson C.G., Glerum D.M., Tzagoloff A.
    FEBS Lett. 492:133-138(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCOX15_YEAST
AccessioniPrimary (citable) accession number: P40086
Secondary accession number(s): D3DM48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 8, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.