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Protein

Endoplasmic reticulum membrane protein 65

Gene

EMP65

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in membrane protein folding.1 Publication

GO - Biological processi

  • protein folding in endoplasmic reticulum Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-30301-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum membrane protein 651 Publication
Alternative name(s):
65 kDa endoplasmic reticulum membrane protein1 Publication
Gene namesi
Name:EMP651 Publication
Ordered Locus Names:YER140WImported
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER140W
SGDiS000000942 EMP65

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 87Cytoplasmic1 PublicationAdd BLAST87
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 151Lumenal1 PublicationAdd BLAST43
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 224Cytoplasmic1 PublicationAdd BLAST52
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 330Lumenal1 PublicationAdd BLAST85
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Topological domaini352 – 391Cytoplasmic1 PublicationAdd BLAST40
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Topological domaini413 – 428Lumenal1 PublicationAdd BLAST16
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 556Cytoplasmic1 PublicationAdd BLAST107

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002026541 – 556Endoplasmic reticulum membrane protein 65Add BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineCombined sources1
Glycosylationi318N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP40085
PRIDEiP40085

PTM databases

iPTMnetiP40085

Interactioni

Subunit structurei

Interacts with SLP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SLP1Q122323EBI-22717,EBI-35990

Protein-protein interaction databases

BioGridi36889, 109 interactors
DIPiDIP-5409N
IntActiP40085, 2 interactors
MINTiP40085
STRINGi4932.YER140W

Structurei

3D structure databases

ProteinModelPortaliP40085
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TAPT1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000010628
HOGENOMiHOG000066104
InParanoidiP40085
OMAiMSSKRIW
OrthoDBiEOG092C3JIJ

Family and domain databases

InterProiView protein in InterPro
IPR008010 Tatp1
PANTHERiPTHR13317 PTHR13317, 1 hit
PfamiView protein in Pfam
PF05346 DUF747, 1 hit

Sequencei

Sequence statusi: Complete.

P40085-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHKDTAVAK DTAKKRLLRR NSAPSAIHII SRLDKKWSFL WNTIDRHNIV
60 70 80 90 100
EEQDESSAAK SEEEHEDDYE LEQLLNMIRI PMFLEKFMLF ALLTSLDCFL
110 120 130 140 150
YYFTVLPIRL IKGYVKQFKS YRQHYRLQQR SGHKNKIPFR YRITSREYKE
160 170 180 190 200
RCMIFIIVIS SILLSKLDTS KLYHRIKRQS TMKLYMLFSV LEMADKMLAS
210 220 230 240 250
LGQSLLTVML SRKNSERILL HKCLLVSMSL TYVTIHGYVL VYQAISLNIA
260 270 280 290 300
VNSYSNALLT LLLSMQFAEI KSSVLKKFDK EGFFQITIAD VVERFKLTLL
310 320 330 340 350
LSITGLRNLQ SWSSSLSNTS INFWSPRSTL SIVINILCGP MVSVVGSEVL
360 370 380 390 400
VDWAKHAYIT KFNRIRPQIY DKFYYIIYKD YSTRTHKLED RLGLPLPAFV
410 420 430 440 450
VLFIVMVRPT LFKSSEPSYL PSLFRILFMG ASVFLLALLA KFTLDLILIK
460 470 480 490 500
WSKRIEQRFR DQAFNTVVTE EEYVPGLLSG GMGKVDVSTR IALHSDYNKE
510 520 530 540 550
NRIETESVSP MRKRKTTLTA ECTPPSLNDI RRQKDSKNPR SLENVARYKM

VSKRIW
Length:556
Mass (Da):64,794
Last modified:February 1, 1995 - v1
Checksum:i16B04343A0F33AAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18917 Genomic DNA Translation: AAB64667.1
BK006939 Genomic DNA Translation: DAA07801.1
PIRiS50643
RefSeqiNP_011067.3, NM_001179030.3

Genome annotation databases

EnsemblFungiiYER140W; YER140W; YER140W
GeneIDi856883
KEGGisce:YER140W

Similar proteinsi

Entry informationi

Entry nameiTAPT1_YEAST
AccessioniPrimary (citable) accession number: P40085
Secondary accession number(s): D3DM47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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