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P40085 (TAPT1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein TAPT1 homolog
Gene names
Ordered Locus Names:YER140W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein Ref.3.

Sequence similarities

Belongs to the TAPT1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SLP1Q122321EBI-22717,EBI-35990

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Protein TAPT1 homolog
PRO_0000202654

Regions

Topological domain1 – 8787Cytoplasmic Potential
Transmembrane88 – 10821Helical; Potential
Topological domain109 – 15143Mitochondrial intermembrane Potential
Transmembrane152 – 17221Helical; Potential
Topological domain173 – 22452Cytoplasmic Potential
Transmembrane225 – 24521Helical; Potential
Topological domain246 – 33085Mitochondrial intermembrane Potential
Transmembrane331 – 35121Helical; Potential
Topological domain352 – 39140Cytoplasmic Potential
Transmembrane392 – 41221Helical; Potential
Topological domain413 – 42816Mitochondrial intermembrane Potential
Transmembrane429 – 44921Helical; Potential
Topological domain450 – 556107Cytoplasmic Potential

Amino acid modifications

Modified residue221Phosphoserine Ref.5 Ref.7

Sequences

Sequence LengthMass (Da)Tools
P40085 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 16B04343A0F33AAF

FASTA55664,794
        10         20         30         40         50         60 
MQHKDTAVAK DTAKKRLLRR NSAPSAIHII SRLDKKWSFL WNTIDRHNIV EEQDESSAAK 

        70         80         90        100        110        120 
SEEEHEDDYE LEQLLNMIRI PMFLEKFMLF ALLTSLDCFL YYFTVLPIRL IKGYVKQFKS 

       130        140        150        160        170        180 
YRQHYRLQQR SGHKNKIPFR YRITSREYKE RCMIFIIVIS SILLSKLDTS KLYHRIKRQS 

       190        200        210        220        230        240 
TMKLYMLFSV LEMADKMLAS LGQSLLTVML SRKNSERILL HKCLLVSMSL TYVTIHGYVL 

       250        260        270        280        290        300 
VYQAISLNIA VNSYSNALLT LLLSMQFAEI KSSVLKKFDK EGFFQITIAD VVERFKLTLL 

       310        320        330        340        350        360 
LSITGLRNLQ SWSSSLSNTS INFWSPRSTL SIVINILCGP MVSVVGSEVL VDWAKHAYIT 

       370        380        390        400        410        420 
KFNRIRPQIY DKFYYIIYKD YSTRTHKLED RLGLPLPAFV VLFIVMVRPT LFKSSEPSYL 

       430        440        450        460        470        480 
PSLFRILFMG ASVFLLALLA KFTLDLILIK WSKRIEQRFR DQAFNTVVTE EEYVPGLLSG 

       490        500        510        520        530        540 
GMGKVDVSTR IALHSDYNKE NRIETESVSP MRKRKTTLTA ECTPPSLNDI RRQKDSKNPR 

       550 
SLENVARYKM VSKRIW 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"The proteome of Saccharomyces cerevisiae mitochondria."
Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C.
Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Strain: ATCC 76625 / YPH499.
[4]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[5]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[6]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18917 Genomic DNA. Translation: AAB64667.1.
BK006939 Genomic DNA. Translation: DAA07801.1.
PIRS50643.
RefSeqNP_011067.3. NM_001179030.3.

3D structure databases

ProteinModelPortalP40085.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36889. 62 interactions.
DIPDIP-5409N.
IntActP40085. 2 interactions.
MINTMINT-521141.
STRING4932.YER140W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER140W; YER140W; YER140W.
GeneID856883.
KEGGsce:YER140W.

Organism-specific databases

CYGDYER140w.
SGDS000000942. YER140W.

Phylogenomic databases

eggNOGNOG241124.
GeneTreeENSGT00390000010628.
HOGENOMHOG000066104.
OMARYKMVSK.
OrthoDBEOG71VT4B.

Enzyme and pathway databases

BioCycYEAST:G3O-30301-MONOMER.

Gene expression databases

GenevestigatorP40085.

Family and domain databases

InterProIPR008010. Membrane_Tatp1/CMV_rcpt.
[Graphical view]
PANTHERPTHR13317. PTHR13317. 1 hit.
PfamPF05346. DUF747. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio983272.
PROP40085.

Entry information

Entry nameTAPT1_YEAST
AccessionPrimary (citable) accession number: P40085
Secondary accession number(s): D3DM47
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 19, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families