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P40085

- TAPT1_YEAST

UniProt

P40085 - TAPT1_YEAST

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Protein

Protein TAPT1 homolog

Gene

YER140W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. protein folding in endoplasmic reticulum Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30301-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TAPT1 homolog
Gene namesi
Ordered Locus Names:YER140W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER140w.
SGDiS000000942. YER140W.

Subcellular locationi

Mitochondrion membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8787CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence AnalysisAdd
BLAST
Topological domaini109 – 15143Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence AnalysisAdd
BLAST
Topological domaini173 – 22452CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST
Topological domaini246 – 33085Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei331 – 35121HelicalSequence AnalysisAdd
BLAST
Topological domaini352 – 39140CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei392 – 41221HelicalSequence AnalysisAdd
BLAST
Topological domaini413 – 42816Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei429 – 44921HelicalSequence AnalysisAdd
BLAST
Topological domaini450 – 556107CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of endoplasmic reticulum membrane Source: SGD
  2. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Protein TAPT1 homologPRO_0000202654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

GenevestigatoriP40085.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SLP1Q122321EBI-22717,EBI-35990

Protein-protein interaction databases

BioGridi36889. 62 interactions.
DIPiDIP-5409N.
IntActiP40085. 2 interactions.
MINTiMINT-521141.
STRINGi4932.YER140W.

Structurei

3D structure databases

ProteinModelPortaliP40085.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TAPT1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG241124.
GeneTreeiENSGT00390000010628.
HOGENOMiHOG000066104.
InParanoidiP40085.
OMAiVDSENIF.
OrthoDBiEOG71VT4B.

Family and domain databases

InterProiIPR008010. Membrane_Tatp1/CMV_rcpt.
[Graphical view]
PANTHERiPTHR13317. PTHR13317. 1 hit.
PfamiPF05346. DUF747. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40085-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQHKDTAVAK DTAKKRLLRR NSAPSAIHII SRLDKKWSFL WNTIDRHNIV
60 70 80 90 100
EEQDESSAAK SEEEHEDDYE LEQLLNMIRI PMFLEKFMLF ALLTSLDCFL
110 120 130 140 150
YYFTVLPIRL IKGYVKQFKS YRQHYRLQQR SGHKNKIPFR YRITSREYKE
160 170 180 190 200
RCMIFIIVIS SILLSKLDTS KLYHRIKRQS TMKLYMLFSV LEMADKMLAS
210 220 230 240 250
LGQSLLTVML SRKNSERILL HKCLLVSMSL TYVTIHGYVL VYQAISLNIA
260 270 280 290 300
VNSYSNALLT LLLSMQFAEI KSSVLKKFDK EGFFQITIAD VVERFKLTLL
310 320 330 340 350
LSITGLRNLQ SWSSSLSNTS INFWSPRSTL SIVINILCGP MVSVVGSEVL
360 370 380 390 400
VDWAKHAYIT KFNRIRPQIY DKFYYIIYKD YSTRTHKLED RLGLPLPAFV
410 420 430 440 450
VLFIVMVRPT LFKSSEPSYL PSLFRILFMG ASVFLLALLA KFTLDLILIK
460 470 480 490 500
WSKRIEQRFR DQAFNTVVTE EEYVPGLLSG GMGKVDVSTR IALHSDYNKE
510 520 530 540 550
NRIETESVSP MRKRKTTLTA ECTPPSLNDI RRQKDSKNPR SLENVARYKM

VSKRIW
Length:556
Mass (Da):64,794
Last modified:February 1, 1995 - v1
Checksum:i16B04343A0F33AAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18917 Genomic DNA. Translation: AAB64667.1.
BK006939 Genomic DNA. Translation: DAA07801.1.
PIRiS50643.
RefSeqiNP_011067.3. NM_001179030.3.

Genome annotation databases

EnsemblFungiiYER140W; YER140W; YER140W.
GeneIDi856883.
KEGGisce:YER140W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18917 Genomic DNA. Translation: AAB64667.1 .
BK006939 Genomic DNA. Translation: DAA07801.1 .
PIRi S50643.
RefSeqi NP_011067.3. NM_001179030.3.

3D structure databases

ProteinModelPortali P40085.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36889. 62 interactions.
DIPi DIP-5409N.
IntActi P40085. 2 interactions.
MINTi MINT-521141.
STRINGi 4932.YER140W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER140W ; YER140W ; YER140W .
GeneIDi 856883.
KEGGi sce:YER140W.

Organism-specific databases

CYGDi YER140w.
SGDi S000000942. YER140W.

Phylogenomic databases

eggNOGi NOG241124.
GeneTreei ENSGT00390000010628.
HOGENOMi HOG000066104.
InParanoidi P40085.
OMAi VDSENIF.
OrthoDBi EOG71VT4B.

Enzyme and pathway databases

BioCyci YEAST:G3O-30301-MONOMER.

Miscellaneous databases

NextBioi 983272.
PROi P40085.

Gene expression databases

Genevestigatori P40085.

Family and domain databases

InterProi IPR008010. Membrane_Tatp1/CMV_rcpt.
[Graphical view ]
PANTHERi PTHR13317. PTHR13317. 1 hit.
Pfami PF05346. DUF747. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTAPT1_YEAST
AccessioniPrimary (citable) accession number: P40085
Secondary accession number(s): D3DM47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3