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P40085

- TAPT1_YEAST

UniProt

P40085 - TAPT1_YEAST

Protein

Protein TAPT1 homolog

Gene

YER140W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. protein folding in endoplasmic reticulum Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30301-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein TAPT1 homolog
    Gene namesi
    Ordered Locus Names:YER140W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER140w.
    SGDiS000000942. YER140W.

    Subcellular locationi

    Mitochondrion membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of endoplasmic reticulum membrane Source: SGD
    2. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Protein TAPT1 homologPRO_0000202654Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei22 – 221Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Gene expression databases

    GenevestigatoriP40085.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SLP1Q122321EBI-22717,EBI-35990

    Protein-protein interaction databases

    BioGridi36889. 62 interactions.
    DIPiDIP-5409N.
    IntActiP40085. 2 interactions.
    MINTiMINT-521141.
    STRINGi4932.YER140W.

    Structurei

    3D structure databases

    ProteinModelPortaliP40085.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8787CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini109 – 15143Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini173 – 22452CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini246 – 33085Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini352 – 39140CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini413 – 42816Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini450 – 556107CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei331 – 35121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei392 – 41221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei429 – 44921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TAPT1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG241124.
    GeneTreeiENSGT00390000010628.
    HOGENOMiHOG000066104.
    OMAiVDSENIF.
    OrthoDBiEOG71VT4B.

    Family and domain databases

    InterProiIPR008010. Membrane_Tatp1/CMV_rcpt.
    [Graphical view]
    PANTHERiPTHR13317. PTHR13317. 1 hit.
    PfamiPF05346. DUF747. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40085-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQHKDTAVAK DTAKKRLLRR NSAPSAIHII SRLDKKWSFL WNTIDRHNIV    50
    EEQDESSAAK SEEEHEDDYE LEQLLNMIRI PMFLEKFMLF ALLTSLDCFL 100
    YYFTVLPIRL IKGYVKQFKS YRQHYRLQQR SGHKNKIPFR YRITSREYKE 150
    RCMIFIIVIS SILLSKLDTS KLYHRIKRQS TMKLYMLFSV LEMADKMLAS 200
    LGQSLLTVML SRKNSERILL HKCLLVSMSL TYVTIHGYVL VYQAISLNIA 250
    VNSYSNALLT LLLSMQFAEI KSSVLKKFDK EGFFQITIAD VVERFKLTLL 300
    LSITGLRNLQ SWSSSLSNTS INFWSPRSTL SIVINILCGP MVSVVGSEVL 350
    VDWAKHAYIT KFNRIRPQIY DKFYYIIYKD YSTRTHKLED RLGLPLPAFV 400
    VLFIVMVRPT LFKSSEPSYL PSLFRILFMG ASVFLLALLA KFTLDLILIK 450
    WSKRIEQRFR DQAFNTVVTE EEYVPGLLSG GMGKVDVSTR IALHSDYNKE 500
    NRIETESVSP MRKRKTTLTA ECTPPSLNDI RRQKDSKNPR SLENVARYKM 550
    VSKRIW 556
    Length:556
    Mass (Da):64,794
    Last modified:February 1, 1995 - v1
    Checksum:i16B04343A0F33AAF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18917 Genomic DNA. Translation: AAB64667.1.
    BK006939 Genomic DNA. Translation: DAA07801.1.
    PIRiS50643.
    RefSeqiNP_011067.3. NM_001179030.3.

    Genome annotation databases

    EnsemblFungiiYER140W; YER140W; YER140W.
    GeneIDi856883.
    KEGGisce:YER140W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18917 Genomic DNA. Translation: AAB64667.1 .
    BK006939 Genomic DNA. Translation: DAA07801.1 .
    PIRi S50643.
    RefSeqi NP_011067.3. NM_001179030.3.

    3D structure databases

    ProteinModelPortali P40085.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36889. 62 interactions.
    DIPi DIP-5409N.
    IntActi P40085. 2 interactions.
    MINTi MINT-521141.
    STRINGi 4932.YER140W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER140W ; YER140W ; YER140W .
    GeneIDi 856883.
    KEGGi sce:YER140W.

    Organism-specific databases

    CYGDi YER140w.
    SGDi S000000942. YER140W.

    Phylogenomic databases

    eggNOGi NOG241124.
    GeneTreei ENSGT00390000010628.
    HOGENOMi HOG000066104.
    OMAi VDSENIF.
    OrthoDBi EOG71VT4B.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30301-MONOMER.

    Miscellaneous databases

    NextBioi 983272.
    PROi P40085.

    Gene expression databases

    Genevestigatori P40085.

    Family and domain databases

    InterProi IPR008010. Membrane_Tatp1/CMV_rcpt.
    [Graphical view ]
    PANTHERi PTHR13317. PTHR13317. 1 hit.
    Pfami PF05346. DUF747. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: ATCC 76625 / YPH499.
    4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTAPT1_YEAST
    AccessioniPrimary (citable) accession number: P40085
    Secondary accession number(s): D3DM47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3