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P40081 (MGDP1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative magnesium-dependent phosphatase YER134C

EC=3.1.3.48
Gene names
Ordered Locus Names:YER134C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Magnesium-dependent phosphatase which may act as a tyrosine phosphatase By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasm. Nucleus Ref.4.

Miscellaneous

Present with 6190 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the HAD-like hydrolase superfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 178178Putative magnesium-dependent phosphatase YER134C
PRO_0000202650

Sites

Active site111Nucleophile By similarity
Active site131Proton donor By similarity
Metal binding111Magnesium By similarity
Metal binding131Magnesium By similarity
Metal binding1411Magnesium By similarity
Binding site121Phosphate; via amide nitrogen By similarity
Binding site131Phosphate; via amide nitrogen By similarity
Binding site741Phosphate By similarity
Binding site751Phosphate By similarity
Binding site751Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P40081 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: F3F765AC0076CBFC

FASTA17820,441
        10         20         30         40         50         60 
MTGYPDVAAF DLDYTIWPCY CDTHLHGPFK PVKSSNGEVL TIICRDGYEL TIYKDIPRIL 

        70         80         90        100        110        120 
GDLKDNGVKL MTASRTWAPE IAQEILKIFK VKYAGVVTPL ANLFDEFQWG ERSKIGHLRD 

       130        140        150        160        170 
GLKDLYNTSD LKSKKICLFD DESRNKEVEK YGVKFVYVRD PENGPSWKLY QDYLSGKV 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18916 Genomic DNA. Translation: AAC03232.1.
AY558562 Genomic DNA. Translation: AAS56888.1.
BK006939 Genomic DNA. Translation: DAA07794.1.
PIRS50637.
RefSeqNP_011060.1. NM_001179024.1.

3D structure databases

ProteinModelPortalP40081.
SMRP40081. Positions 1-163.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36880. 14 interactions.
IntActP40081. 21 interactions.
MINTMINT-4484417.
STRING4932.YER134C.

Proteomic databases

PaxDbP40081.
PeptideAtlasP40081.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER134C; YER134C; YER134C.
GeneID856873.
KEGGsce:YER134C.

Organism-specific databases

CYGDYER134c.
SGDS000000936. YER134C.

Phylogenomic databases

eggNOGNOG314346.
GeneTreeENSGT00390000004110.
HOGENOMHOG000216653.
KOK17619.
OMACWCDTHI.
OrthoDBEOG718KQX.

Enzyme and pathway databases

BioCycYEAST:G3O-30296-MONOMER.

Gene expression databases

GenevestigatorP40081.

Family and domain databases

Gene3D3.40.50.1000. 1 hit.
InterProIPR023214. HAD-like_dom.
IPR010033. HAD_SF_ppase_IIIC.
IPR024734. MDP_1_eu.
IPR010036. MDP_1_eu_arc.
[Graphical view]
PANTHERPTHR17901. PTHR17901. 1 hit.
PfamPF12689. Acid_PPase. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR01681. HAD-SF-IIIC. 1 hit.
TIGR01685. MDP-1. 1 hit.
ProtoNetSearch...

Other

NextBio983247.
PROP40081.

Entry information

Entry nameMGDP1_YEAST
AccessionPrimary (citable) accession number: P40081
Secondary accession number(s): D3DM40
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families