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P40081

- MGDP1_YEAST

UniProt

P40081 - MGDP1_YEAST

Protein

Putative magnesium-dependent phosphatase YER134C

Gene

YER134C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei11 – 111NucleophileBy similarity
    Metal bindingi11 – 111MagnesiumBy similarity
    Binding sitei12 – 121Phosphate; via amide nitrogenBy similarity
    Active sitei13 – 131Proton donorBy similarity
    Metal bindingi13 – 131MagnesiumBy similarity
    Binding sitei13 – 131Phosphate; via amide nitrogenBy similarity
    Binding sitei74 – 741PhosphateBy similarity
    Binding sitei75 – 751PhosphateBy similarity
    Binding sitei75 – 751SubstrateBy similarity
    Metal bindingi141 – 1411MagnesiumBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: SGD
    2. metal ion binding Source: UniProtKB-KW
    3. protein tyrosine phosphatase activity, metal-dependent Source: SGD

    GO - Biological processi

    1. dephosphorylation Source: GOC
    2. peptidyl-tyrosine dephosphorylation Source: GOC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30296-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative magnesium-dependent phosphatase YER134C (EC:3.1.3.48)
    Gene namesi
    Ordered Locus Names:YER134C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER134c.
    SGDiS000000936. YER134C.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 178178Putative magnesium-dependent phosphatase YER134CPRO_0000202650Add
    BLAST

    Proteomic databases

    MaxQBiP40081.
    PaxDbiP40081.
    PeptideAtlasiP40081.

    Expressioni

    Gene expression databases

    GenevestigatoriP40081.

    Interactioni

    Protein-protein interaction databases

    BioGridi36880. 14 interactions.
    IntActiP40081. 21 interactions.
    MINTiMINT-4484417.
    STRINGi4932.YER134C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40081.
    SMRiP40081. Positions 1-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HAD-like hydrolase superfamily.Curated

    Phylogenomic databases

    eggNOGiNOG314346.
    GeneTreeiENSGT00390000004110.
    HOGENOMiHOG000216653.
    KOiK17619.
    OMAiCWCDTHI.
    OrthoDBiEOG718KQX.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR023214. HAD-like_dom.
    IPR010033. HAD_SF_ppase_IIIC.
    IPR024734. MDP_1_eu.
    IPR010036. MDP_1_eu_arc.
    [Graphical view]
    PANTHERiPTHR17901. PTHR17901. 1 hit.
    PfamiPF12689. Acid_PPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01681. HAD-SF-IIIC. 1 hit.
    TIGR01685. MDP-1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P40081-1 [UniParc]FASTAAdd to Basket

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    MTGYPDVAAF DLDYTIWPCY CDTHLHGPFK PVKSSNGEVL TIICRDGYEL    50
    TIYKDIPRIL GDLKDNGVKL MTASRTWAPE IAQEILKIFK VKYAGVVTPL 100
    ANLFDEFQWG ERSKIGHLRD GLKDLYNTSD LKSKKICLFD DESRNKEVEK 150
    YGVKFVYVRD PENGPSWKLY QDYLSGKV 178
    Length:178
    Mass (Da):20,441
    Last modified:February 1, 1995 - v1
    Checksum:iF3F765AC0076CBFC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18916 Genomic DNA. Translation: AAC03232.1.
    AY558562 Genomic DNA. Translation: AAS56888.1.
    BK006939 Genomic DNA. Translation: DAA07794.1.
    PIRiS50637.
    RefSeqiNP_011060.1. NM_001179024.1.

    Genome annotation databases

    EnsemblFungiiYER134C; YER134C; YER134C.
    GeneIDi856873.
    KEGGisce:YER134C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18916 Genomic DNA. Translation: AAC03232.1 .
    AY558562 Genomic DNA. Translation: AAS56888.1 .
    BK006939 Genomic DNA. Translation: DAA07794.1 .
    PIRi S50637.
    RefSeqi NP_011060.1. NM_001179024.1.

    3D structure databases

    ProteinModelPortali P40081.
    SMRi P40081. Positions 1-163.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36880. 14 interactions.
    IntActi P40081. 21 interactions.
    MINTi MINT-4484417.
    STRINGi 4932.YER134C.

    Proteomic databases

    MaxQBi P40081.
    PaxDbi P40081.
    PeptideAtlasi P40081.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER134C ; YER134C ; YER134C .
    GeneIDi 856873.
    KEGGi sce:YER134C.

    Organism-specific databases

    CYGDi YER134c.
    SGDi S000000936. YER134C.

    Phylogenomic databases

    eggNOGi NOG314346.
    GeneTreei ENSGT00390000004110.
    HOGENOMi HOG000216653.
    KOi K17619.
    OMAi CWCDTHI.
    OrthoDBi EOG718KQX.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30296-MONOMER.

    Miscellaneous databases

    NextBioi 983247.
    PROi P40081.

    Gene expression databases

    Genevestigatori P40081.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR023214. HAD-like_dom.
    IPR010033. HAD_SF_ppase_IIIC.
    IPR024734. MDP_1_eu.
    IPR010036. MDP_1_eu_arc.
    [Graphical view ]
    PANTHERi PTHR17901. PTHR17901. 1 hit.
    Pfami PF12689. Acid_PPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01681. HAD-SF-IIIC. 1 hit.
    TIGR01685. MDP-1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMGDP1_YEAST
    AccessioniPrimary (citable) accession number: P40081
    Secondary accession number(s): D3DM40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 6190 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3