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P40081

- MGDP1_YEAST

UniProt

P40081 - MGDP1_YEAST

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Protein

Putative magnesium-dependent phosphatase YER134C

Gene

YER134C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei11 – 111NucleophileBy similarity
Metal bindingi11 – 111MagnesiumBy similarity
Binding sitei12 – 121Phosphate; via amide nitrogenBy similarity
Active sitei13 – 131Proton donorBy similarity
Metal bindingi13 – 131MagnesiumBy similarity
Binding sitei13 – 131Phosphate; via amide nitrogenBy similarity
Binding sitei74 – 741PhosphateBy similarity
Binding sitei75 – 751PhosphateBy similarity
Binding sitei75 – 751SubstrateBy similarity
Metal bindingi141 – 1411MagnesiumBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: SGD
  2. metal ion binding Source: UniProtKB-KW
  3. protein tyrosine phosphatase activity, metal-dependent Source: SGD

GO - Biological processi

  1. dephosphorylation Source: GOC
  2. peptidyl-tyrosine dephosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30296-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative magnesium-dependent phosphatase YER134C (EC:3.1.3.48)
Gene namesi
Ordered Locus Names:YER134C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER134c.
SGDiS000000936. YER134C.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Putative magnesium-dependent phosphatase YER134CPRO_0000202650Add
BLAST

Proteomic databases

MaxQBiP40081.
PaxDbiP40081.
PeptideAtlasiP40081.

Expressioni

Gene expression databases

GenevestigatoriP40081.

Interactioni

Protein-protein interaction databases

BioGridi36880. 15 interactions.
IntActiP40081. 21 interactions.
MINTiMINT-4484417.
STRINGi4932.YER134C.

Structurei

3D structure databases

ProteinModelPortaliP40081.
SMRiP40081. Positions 1-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiNOG314346.
GeneTreeiENSGT00390000004110.
HOGENOMiHOG000216653.
InParanoidiP40081.
KOiK17619.
OMAiCWCDTHI.
OrthoDBiEOG718KQX.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR010033. HAD_SF_ppase_IIIC.
IPR024734. MDP_1_eu.
IPR010036. MDP_1_eu_arc.
[Graphical view]
PANTHERiPTHR17901. PTHR17901. 1 hit.
PfamiPF12689. Acid_PPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01681. HAD-SF-IIIC. 1 hit.
TIGR01685. MDP-1. 1 hit.

Sequencei

Sequence statusi: Complete.

P40081-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGYPDVAAF DLDYTIWPCY CDTHLHGPFK PVKSSNGEVL TIICRDGYEL
60 70 80 90 100
TIYKDIPRIL GDLKDNGVKL MTASRTWAPE IAQEILKIFK VKYAGVVTPL
110 120 130 140 150
ANLFDEFQWG ERSKIGHLRD GLKDLYNTSD LKSKKICLFD DESRNKEVEK
160 170
YGVKFVYVRD PENGPSWKLY QDYLSGKV
Length:178
Mass (Da):20,441
Last modified:February 1, 1995 - v1
Checksum:iF3F765AC0076CBFC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18916 Genomic DNA. Translation: AAC03232.1.
AY558562 Genomic DNA. Translation: AAS56888.1.
BK006939 Genomic DNA. Translation: DAA07794.1.
PIRiS50637.
RefSeqiNP_011060.1. NM_001179024.1.

Genome annotation databases

EnsemblFungiiYER134C; YER134C; YER134C.
GeneIDi856873.
KEGGisce:YER134C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18916 Genomic DNA. Translation: AAC03232.1 .
AY558562 Genomic DNA. Translation: AAS56888.1 .
BK006939 Genomic DNA. Translation: DAA07794.1 .
PIRi S50637.
RefSeqi NP_011060.1. NM_001179024.1.

3D structure databases

ProteinModelPortali P40081.
SMRi P40081. Positions 1-163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36880. 15 interactions.
IntActi P40081. 21 interactions.
MINTi MINT-4484417.
STRINGi 4932.YER134C.

Proteomic databases

MaxQBi P40081.
PaxDbi P40081.
PeptideAtlasi P40081.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER134C ; YER134C ; YER134C .
GeneIDi 856873.
KEGGi sce:YER134C.

Organism-specific databases

CYGDi YER134c.
SGDi S000000936. YER134C.

Phylogenomic databases

eggNOGi NOG314346.
GeneTreei ENSGT00390000004110.
HOGENOMi HOG000216653.
InParanoidi P40081.
KOi K17619.
OMAi CWCDTHI.
OrthoDBi EOG718KQX.

Enzyme and pathway databases

BioCyci YEAST:G3O-30296-MONOMER.

Miscellaneous databases

NextBioi 983247.
PROi P40081.

Gene expression databases

Genevestigatori P40081.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR023214. HAD-like_dom.
IPR010033. HAD_SF_ppase_IIIC.
IPR024734. MDP_1_eu.
IPR010036. MDP_1_eu_arc.
[Graphical view ]
PANTHERi PTHR17901. PTHR17901. 1 hit.
Pfami PF12689. Acid_PPase. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01681. HAD-SF-IIIC. 1 hit.
TIGR01685. MDP-1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMGDP1_YEAST
AccessioniPrimary (citable) accession number: P40081
Secondary accession number(s): D3DM40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6190 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3