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Protein

Putative magnesium-dependent phosphatase YER134C

Gene

YER134C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei11 – 111NucleophileBy similarity
Metal bindingi11 – 111MagnesiumBy similarity
Binding sitei12 – 121Phosphate; via amide nitrogenBy similarity
Active sitei13 – 131Proton donorBy similarity
Metal bindingi13 – 131MagnesiumBy similarity
Binding sitei13 – 131Phosphate; via amide nitrogenBy similarity
Binding sitei74 – 741PhosphateBy similarity
Binding sitei75 – 751PhosphateBy similarity
Binding sitei75 – 751SubstrateBy similarity
Metal bindingi141 – 1411MagnesiumBy similarity

GO - Molecular functioni

  • acid phosphatase activity Source: SGD
  • metal ion binding Source: UniProtKB-KW
  • protein tyrosine phosphatase activity, metal-dependent Source: SGD

GO - Biological processi

  • dephosphorylation Source: GOC
  • peptidyl-tyrosine dephosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30296-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative magnesium-dependent phosphatase YER134C (EC:3.1.3.48)
Gene namesi
Ordered Locus Names:YER134C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome V

Organism-specific databases

CYGDiYER134c.
EuPathDBiFungiDB:YER134C.
SGDiS000000936. YER134C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Putative magnesium-dependent phosphatase YER134CPRO_0000202650Add
BLAST

Proteomic databases

MaxQBiP40081.
PaxDbiP40081.
PeptideAtlasiP40081.

Interactioni

Protein-protein interaction databases

BioGridi36880. 14 interactions.
IntActiP40081. 21 interactions.
MINTiMINT-4484417.

Structurei

3D structure databases

ProteinModelPortaliP40081.
SMRiP40081. Positions 1-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiNOG314346.
GeneTreeiENSGT00390000004110.
HOGENOMiHOG000216653.
InParanoidiP40081.
KOiK17619.
OMAiPCWCDTH.
OrthoDBiEOG718KQX.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR010033. HAD_SF_ppase_IIIC.
IPR024734. MDP_1_eu.
IPR010036. MDP_1_eu_arc.
[Graphical view]
PANTHERiPTHR17901. PTHR17901. 1 hit.
PfamiPF12689. Acid_PPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01681. HAD-SF-IIIC. 1 hit.
TIGR01685. MDP-1. 1 hit.

Sequencei

Sequence statusi: Complete.

P40081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGYPDVAAF DLDYTIWPCY CDTHLHGPFK PVKSSNGEVL TIICRDGYEL
60 70 80 90 100
TIYKDIPRIL GDLKDNGVKL MTASRTWAPE IAQEILKIFK VKYAGVVTPL
110 120 130 140 150
ANLFDEFQWG ERSKIGHLRD GLKDLYNTSD LKSKKICLFD DESRNKEVEK
160 170
YGVKFVYVRD PENGPSWKLY QDYLSGKV
Length:178
Mass (Da):20,441
Last modified:February 1, 1995 - v1
Checksum:iF3F765AC0076CBFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18916 Genomic DNA. Translation: AAC03232.1.
AY558562 Genomic DNA. Translation: AAS56888.1.
BK006939 Genomic DNA. Translation: DAA07794.1.
PIRiS50637.
RefSeqiNP_011060.1. NM_001179024.1.

Genome annotation databases

EnsemblFungiiYER134C; YER134C; YER134C.
GeneIDi856873.
KEGGisce:YER134C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18916 Genomic DNA. Translation: AAC03232.1.
AY558562 Genomic DNA. Translation: AAS56888.1.
BK006939 Genomic DNA. Translation: DAA07794.1.
PIRiS50637.
RefSeqiNP_011060.1. NM_001179024.1.

3D structure databases

ProteinModelPortaliP40081.
SMRiP40081. Positions 1-163.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36880. 14 interactions.
IntActiP40081. 21 interactions.
MINTiMINT-4484417.

Proteomic databases

MaxQBiP40081.
PaxDbiP40081.
PeptideAtlasiP40081.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER134C; YER134C; YER134C.
GeneIDi856873.
KEGGisce:YER134C.

Organism-specific databases

CYGDiYER134c.
EuPathDBiFungiDB:YER134C.
SGDiS000000936. YER134C.

Phylogenomic databases

eggNOGiNOG314346.
GeneTreeiENSGT00390000004110.
HOGENOMiHOG000216653.
InParanoidiP40081.
KOiK17619.
OMAiPCWCDTH.
OrthoDBiEOG718KQX.

Enzyme and pathway databases

BioCyciYEAST:G3O-30296-MONOMER.

Miscellaneous databases

NextBioi983247.
PROiP40081.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR010033. HAD_SF_ppase_IIIC.
IPR024734. MDP_1_eu.
IPR010036. MDP_1_eu_arc.
[Graphical view]
PANTHERiPTHR17901. PTHR17901. 1 hit.
PfamiPF12689. Acid_PPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01681. HAD-SF-IIIC. 1 hit.
TIGR01685. MDP-1. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMGDP1_YEAST
AccessioniPrimary (citable) accession number: P40081
Secondary accession number(s): D3DM40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 22, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6190 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.