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P40077 (DSE1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein DSE1
Alternative name(s):
Daughter-specific expression protein 1
Gene names
Name:DSE1
Ordered Locus Names:YER124C
ORF Names:SYGP-ORF48
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length573 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in cell wall metabolism and required for the separation of the mother and daughter cells. Ref.4

Subcellular location

Bud neck Ref.5.

Developmental stage

Expressed in daughter cells. Ref.3

Induction

Expressed periodically during cell division. Requires ACE2, CBK1, MOB2 and SWI5. Expression is also increased under microgravity conditions. Ref.3 Ref.4 Ref.7 Ref.8

Miscellaneous

Present with 3080 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the WD repeat DSE1 family.

Contains 4 WD repeats.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

BOI2P399693EBI-22676,EBI-3727

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 573573Protein DSE1
PRO_0000202647

Regions

Repeat144 – 18542WD 1
Repeat315 – 35137WD 2
Repeat356 – 39540WD 3
Repeat397 – 44852WD 4

Sequences

Sequence LengthMass (Da)Tools
P40077 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: D5FE871E7C76B260

FASTA57363,999
        10         20         30         40         50         60 
MQDTKYYEPT NIFRQPAINI KKRSDKKRIL QSMMTLSTYK KTWQNNTSKM NSPILRKASD 

        70         80         90        100        110        120 
NFNDYYTTKK LKSDYWKLYG VDESELSIPS DMSIVDNILL VSTMNEKDNL KLFEISAEKK 

       130        140        150        160        170        180 
LKELQTITVP GKPITCICLL PMVDFPPQIF PSSQINPNHN QLILTGHQDG IVNLIATSTY 

       190        200        210        220        230        240 
KGCAKIIKRF NHNKFLKSTV STSIPILEIT PKTAPILKVS PWNKTGFVSL LNDSLFIYDL 

       250        260        270        280        290        300 
KSNLDCIKTP IFLQSYPGIN SFAVNEFHDP FLLALVGSKF GPNGISLLDL RTNLYIPDIL 

       310        320        330        340        350        360 
DNSISAGCGK DHLQRKNTSL DCVWISNHHV AQSLNDKIQI WDIQSCDGKP VCELYAKKGY 

       370        380        390        400        410        420 
IESLKFNENT GALYSSDDQG FVICWDLQNL QNMKYGELVH GFNSISLDSE SELLLTKQVF 

       430        440        450        460        470        480 
QCGNIIVSGM SDKNICLKSN DTKANGKGCG FLFLDMANDG SLVTLDNFCE LGLHQICQVQ 

       490        500        510        520        530        540 
FNVDTGKIID GNGTGKSGIS DSSMLSLSNE SDHSMTETSD DMFSNSGNWD CSSANTVSEG 

       550        560        570 
RLNDDQEDIV FTKRMYSVND VHLSGSTIDT TVV 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates."
Colman-Lerner A., Chin T.E., Brent R.
Cell 107:739-750(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION, DEVELOPMENTAL STAGE.
[4]"Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p."
Doolin M.-T., Johnson A.L., Johnston L.H., Butler G.
Mol. Microbiol. 40:422-432(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION, FUNCTION.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Swm1p subunit of the APC/cyclosome is required for activation of the daughter-specific gene expression program mediated by Ace2p during growth at high temperature in Saccharomyces cerevisiae."
Ufano S., Pablo M.E., Calzada A., del Rey F., Vazquez de Aldana C.R.
J. Cell Sci. 117:545-557(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[8]"Effects of low-shear modeled microgravity on cell function, gene expression, and phenotype in Saccharomyces cerevisiae."
Purevdorj-Gage B., Sheehan K.B., Hyman L.E.
Appl. Environ. Microbiol. 72:4569-4575(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[9]"Sites of ubiquitin attachment in Saccharomyces cerevisiae."
Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18916 Genomic DNA. Translation: AAC03222.1.
BK006939 Genomic DNA. Translation: DAA07784.1.
PIRS50627.
RefSeqNP_011050.3. NM_001179014.3.

3D structure databases

ProteinModelPortalP40077.
SMRP40077. Positions 212-296.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36868. 36 interactions.
DIPDIP-2585N.
IntActP40077. 5 interactions.
MINTMINT-425764.
STRING4932.YER124C.

Proteomic databases

MaxQBP40077.
PaxDbP40077.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER124C; YER124C; YER124C.
GeneID856861.
KEGGsce:YER124C.

Organism-specific databases

CYGDYER124c.
SGDS000000926. DSE1.

Phylogenomic databases

eggNOGNOG45845.
HOGENOMHOG000112282.
OMAYLNSFPG.
OrthoDBEOG7Q8CX1.

Enzyme and pathway databases

BioCycYEAST:G3O-30287-MONOMER.

Gene expression databases

GenevestigatorP40077.

Family and domain databases

Gene3D2.130.10.10. 2 hits.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
ProtoNetSearch...

Other

NextBio983213.

Entry information

Entry nameDSE1_YEAST
AccessionPrimary (citable) accession number: P40077
Secondary accession number(s): D3DM30
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families