P40077 (DSE1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein DSE1

Alternative name(s):
Daughter-specific expression protein 1

Gene names

Name:	DSE1
Ordered Locus Names:	YER124C
ORF Names:	SYGP-ORF48

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	573 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in cell wall metabolism and required for the separation of the mother and daughter cells. Ref.4
Subcellular location	Bud neck Ref.5.
Developmental stage	Expressed in daughter cells. Ref.3
Induction	Expressed periodically during cell division. Requires ACE2, CBK1, MOB2 and SWI5. Expression is also increased under microgravity conditions. Ref.3 Ref.4 Ref.7 Ref.8
Miscellaneous	Present with 3080 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the WD repeat DSE1 family. Contains 4 WD repeats.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell wall biogenesis/degradation
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis, completion of separation Inferred from mutant phenotype Ref.4. Source: SGD invasive growth in response to glucose limitation Inferred from mutant phenotype PubMed 19820940. Source: SGD regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion Inferred from mutant phenotype PubMed 19820940. Source: SGD
Cellular_component	cellular bud neck Inferred from direct assay Ref.5. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 573	573	Protein DSE1		PRO_0000202647
Regions
	Repeat	144 – 185	42	WD 1
	Repeat	315 – 351	37	WD 2
	Repeat	356 – 395	40	WD 3
	Repeat	397 – 448	52	WD 4

Sequences

	Sequence		Length	Mass (Da)
	P40077 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: D5FE871E7C76B260	FASTA	573	63,999
	10 20 30 40 50 60 MQDTKYYEPT NIFRQPAINI KKRSDKKRIL QSMMTLSTYK KTWQNNTSKM NSPILRKASD 70 80 90 100 110 120 NFNDYYTTKK LKSDYWKLYG VDESELSIPS DMSIVDNILL VSTMNEKDNL KLFEISAEKK 130 140 150 160 170 180 LKELQTITVP GKPITCICLL PMVDFPPQIF PSSQINPNHN QLILTGHQDG IVNLIATSTY 190 200 210 220 230 240 KGCAKIIKRF NHNKFLKSTV STSIPILEIT PKTAPILKVS PWNKTGFVSL LNDSLFIYDL 250 260 270 280 290 300 KSNLDCIKTP IFLQSYPGIN SFAVNEFHDP FLLALVGSKF GPNGISLLDL RTNLYIPDIL 310 320 330 340 350 360 DNSISAGCGK DHLQRKNTSL DCVWISNHHV AQSLNDKIQI WDIQSCDGKP VCELYAKKGY 370 380 390 400 410 420 IESLKFNENT GALYSSDDQG FVICWDLQNL QNMKYGELVH GFNSISLDSE SELLLTKQVF 430 440 450 460 470 480 QCGNIIVSGM SDKNICLKSN DTKANGKGCG FLFLDMANDG SLVTLDNFCE LGLHQICQVQ 490 500 510 520 530 540 FNVDTGKIID GNGTGKSGIS DSSMLSLSNE SDHSMTETSD DMFSNSGNWD CSSANTVSEG 550 560 570 RLNDDQEDIV FTKRMYSVND VHLSGSTIDT TVV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates." Colman-Lerner A., Chin T.E., Brent R. Cell 107:739-750(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION, DEVELOPMENTAL STAGE.
[4]	"Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p." Doolin M.-T., Johnson A.L., Johnston L.H., Butler G. Mol. Microbiol. 40:422-432(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION, FUNCTION.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"Swm1p subunit of the APC/cyclosome is required for activation of the daughter-specific gene expression program mediated by Ace2p during growth at high temperature in Saccharomyces cerevisiae." Ufano S., Pablo M.E., Calzada A., del Rey F., Vazquez de Aldana C.R. J. Cell Sci. 117:545-557(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[8]	"Effects of low-shear modeled microgravity on cell function, gene expression, and phenotype in Saccharomyces cerevisiae." Purevdorj-Gage B., Sheehan K.B., Hyman L.E. Appl. Environ. Microbiol. 72:4569-4575(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U18916 Genomic DNA. Translation: AAC03222.1. BK006939 Genomic DNA. Translation: DAA07784.1.
PIR	S50627.
RefSeq	NP_011050.3. NM_001179014.3.
3D structure databases
ProteinModelPortal	P40077.
SMR	P40077. Positions 450-476.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2585N.
IntAct	P40077. 4 interactions.
MINT	MINT-425764.
STRING	4932.YER124C.
Proteomic databases
PaxDb	P40077.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YER124C; YER124C; YER124C.
GeneID	856861.
KEGG	sce:YER124C. sce:YER128W.
Organism-specific databases
CYGD	YER124c.
SGD	S000000926. DSE1.
Phylogenomic databases
eggNOG	NOG45845.
HOGENOM	HOG000112282.
OMA	LQTITVP.
OrthoDB	EOG4PVS7F.
Gene expression databases
Genevestigator	P40077.
GermOnline	YER124C. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	2.130.10.10. 2 hits.
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. [Graphical view]
SMART	SM00320. WD40. 2 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	983213.

Entry information

Entry name

DSE1_YEAST

Accession

Primary (citable) accession number: P40077
Secondary accession number(s): D3DM30

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program