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P40077

- DSE1_YEAST

UniProt

P40077 - DSE1_YEAST

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Protein

Protein DSE1

Gene
DSE1, YER124C, SYGP-ORF48
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in cell wall metabolism and required for the separation of the mother and daughter cells.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. cytokinesis, completion of separation Source: SGD
  2. invasive growth in response to glucose limitation Source: SGD
  3. regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:G3O-30287-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DSE1
Alternative name(s):
Daughter-specific expression protein 1
Gene namesi
Name:DSE1
Ordered Locus Names:YER124C
ORF Names:SYGP-ORF48
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER124c.
SGDiS000000926. DSE1.

Subcellular locationi

Bud neck 1 Publication

GO - Cellular componenti

  1. cellular bud neck Source: UniProtKB-SubCell
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Protein DSE1PRO_0000202647Add
BLAST

Proteomic databases

MaxQBiP40077.
PaxDbiP40077.

Expressioni

Developmental stagei

Expressed in daughter cells.1 Publication

Inductioni

Expressed periodically during cell division. Requires ACE2, CBK1, MOB2 and SWI5. Expression is also increased under microgravity conditions.4 Publications

Gene expression databases

GenevestigatoriP40077.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BOI2P399693EBI-22676,EBI-3727

Protein-protein interaction databases

BioGridi36868. 36 interactions.
DIPiDIP-2585N.
IntActiP40077. 5 interactions.
MINTiMINT-425764.
STRINGi4932.YER124C.

Structurei

3D structure databases

ProteinModelPortaliP40077.
SMRiP40077. Positions 212-296.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati144 – 18542WD 1Add
BLAST
Repeati315 – 35137WD 2Add
BLAST
Repeati356 – 39540WD 3Add
BLAST
Repeati397 – 44852WD 4Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat DSE1 family.
Contains 4 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG45845.
HOGENOMiHOG000112282.
OMAiYLNSFPG.
OrthoDBiEOG7Q8CX1.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

P40077-1 [UniParc]FASTAAdd to Basket

« Hide

MQDTKYYEPT NIFRQPAINI KKRSDKKRIL QSMMTLSTYK KTWQNNTSKM    50
NSPILRKASD NFNDYYTTKK LKSDYWKLYG VDESELSIPS DMSIVDNILL 100
VSTMNEKDNL KLFEISAEKK LKELQTITVP GKPITCICLL PMVDFPPQIF 150
PSSQINPNHN QLILTGHQDG IVNLIATSTY KGCAKIIKRF NHNKFLKSTV 200
STSIPILEIT PKTAPILKVS PWNKTGFVSL LNDSLFIYDL KSNLDCIKTP 250
IFLQSYPGIN SFAVNEFHDP FLLALVGSKF GPNGISLLDL RTNLYIPDIL 300
DNSISAGCGK DHLQRKNTSL DCVWISNHHV AQSLNDKIQI WDIQSCDGKP 350
VCELYAKKGY IESLKFNENT GALYSSDDQG FVICWDLQNL QNMKYGELVH 400
GFNSISLDSE SELLLTKQVF QCGNIIVSGM SDKNICLKSN DTKANGKGCG 450
FLFLDMANDG SLVTLDNFCE LGLHQICQVQ FNVDTGKIID GNGTGKSGIS 500
DSSMLSLSNE SDHSMTETSD DMFSNSGNWD CSSANTVSEG RLNDDQEDIV 550
FTKRMYSVND VHLSGSTIDT TVV 573
Length:573
Mass (Da):63,999
Last modified:February 1, 1995 - v1
Checksum:iD5FE871E7C76B260
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18916 Genomic DNA. Translation: AAC03222.1.
BK006939 Genomic DNA. Translation: DAA07784.1.
PIRiS50627.
RefSeqiNP_011050.3. NM_001179014.3.

Genome annotation databases

EnsemblFungiiYER124C; YER124C; YER124C.
GeneIDi856861.
KEGGisce:YER124C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18916 Genomic DNA. Translation: AAC03222.1 .
BK006939 Genomic DNA. Translation: DAA07784.1 .
PIRi S50627.
RefSeqi NP_011050.3. NM_001179014.3.

3D structure databases

ProteinModelPortali P40077.
SMRi P40077. Positions 212-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36868. 36 interactions.
DIPi DIP-2585N.
IntActi P40077. 5 interactions.
MINTi MINT-425764.
STRINGi 4932.YER124C.

Proteomic databases

MaxQBi P40077.
PaxDbi P40077.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER124C ; YER124C ; YER124C .
GeneIDi 856861.
KEGGi sce:YER124C.

Organism-specific databases

CYGDi YER124c.
SGDi S000000926. DSE1.

Phylogenomic databases

eggNOGi NOG45845.
HOGENOMi HOG000112282.
OMAi YLNSFPG.
OrthoDBi EOG7Q8CX1.

Enzyme and pathway databases

BioCyci YEAST:G3O-30287-MONOMER.

Miscellaneous databases

NextBioi 983213.

Gene expression databases

Genevestigatori P40077.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
SMARTi SM00320. WD40. 2 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates."
    Colman-Lerner A., Chin T.E., Brent R.
    Cell 107:739-750(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, DEVELOPMENTAL STAGE.
  4. "Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p."
    Doolin M.-T., Johnson A.L., Johnston L.H., Butler G.
    Mol. Microbiol. 40:422-432(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, FUNCTION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Swm1p subunit of the APC/cyclosome is required for activation of the daughter-specific gene expression program mediated by Ace2p during growth at high temperature in Saccharomyces cerevisiae."
    Ufano S., Pablo M.E., Calzada A., del Rey F., Vazquez de Aldana C.R.
    J. Cell Sci. 117:545-557(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  8. "Effects of low-shear modeled microgravity on cell function, gene expression, and phenotype in Saccharomyces cerevisiae."
    Purevdorj-Gage B., Sheehan K.B., Hyman L.E.
    Appl. Environ. Microbiol. 72:4569-4575(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  9. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDSE1_YEAST
AccessioniPrimary (citable) accession number: P40077
Secondary accession number(s): D3DM30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3080 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

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