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Protein

Protein DSE1

Gene

DSE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cell wall metabolism and required for the separation of the mother and daughter cells.1 Publication

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. invasive growth in response to glucose limitation Source: SGD
  5. regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:G3O-30287-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DSE1
Alternative name(s):
Daughter-specific expression protein 1
Gene namesi
Name:DSE1
Ordered Locus Names:YER124C
ORF Names:SYGP-ORF48
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome V

Organism-specific databases

CYGDiYER124c.
SGDiS000000926. DSE1.

Subcellular locationi

Bud neck 1 Publication

GO - Cellular componenti

  1. cellular bud neck Source: UniProtKB-SubCell
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Protein DSE1PRO_0000202647Add
BLAST

Proteomic databases

MaxQBiP40077.
PaxDbiP40077.

Expressioni

Developmental stagei

Expressed in daughter cells.1 Publication

Inductioni

Expressed periodically during cell division. Requires ACE2, CBK1, MOB2 and SWI5. Expression is also increased under microgravity conditions.4 Publications

Gene expression databases

GenevestigatoriP40077.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BOI2P399693EBI-22676,EBI-3727

Protein-protein interaction databases

BioGridi36868. 36 interactions.
DIPiDIP-2585N.
IntActiP40077. 5 interactions.
MINTiMINT-425764.
STRINGi4932.YER124C.

Structurei

3D structure databases

ProteinModelPortaliP40077.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati144 – 18542WD 1Add
BLAST
Repeati315 – 35137WD 2Add
BLAST
Repeati356 – 39540WD 3Add
BLAST
Repeati397 – 44852WD 4Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat DSE1 family.Curated
Contains 4 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG45845.
HOGENOMiHOG000112282.
InParanoidiP40077.
OMAiYLNSFPG.
OrthoDBiEOG7Q8CX1.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

P40077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDTKYYEPT NIFRQPAINI KKRSDKKRIL QSMMTLSTYK KTWQNNTSKM
60 70 80 90 100
NSPILRKASD NFNDYYTTKK LKSDYWKLYG VDESELSIPS DMSIVDNILL
110 120 130 140 150
VSTMNEKDNL KLFEISAEKK LKELQTITVP GKPITCICLL PMVDFPPQIF
160 170 180 190 200
PSSQINPNHN QLILTGHQDG IVNLIATSTY KGCAKIIKRF NHNKFLKSTV
210 220 230 240 250
STSIPILEIT PKTAPILKVS PWNKTGFVSL LNDSLFIYDL KSNLDCIKTP
260 270 280 290 300
IFLQSYPGIN SFAVNEFHDP FLLALVGSKF GPNGISLLDL RTNLYIPDIL
310 320 330 340 350
DNSISAGCGK DHLQRKNTSL DCVWISNHHV AQSLNDKIQI WDIQSCDGKP
360 370 380 390 400
VCELYAKKGY IESLKFNENT GALYSSDDQG FVICWDLQNL QNMKYGELVH
410 420 430 440 450
GFNSISLDSE SELLLTKQVF QCGNIIVSGM SDKNICLKSN DTKANGKGCG
460 470 480 490 500
FLFLDMANDG SLVTLDNFCE LGLHQICQVQ FNVDTGKIID GNGTGKSGIS
510 520 530 540 550
DSSMLSLSNE SDHSMTETSD DMFSNSGNWD CSSANTVSEG RLNDDQEDIV
560 570
FTKRMYSVND VHLSGSTIDT TVV
Length:573
Mass (Da):63,999
Last modified:January 31, 1995 - v1
Checksum:iD5FE871E7C76B260
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18916 Genomic DNA. Translation: AAC03222.1.
BK006939 Genomic DNA. Translation: DAA07784.1.
PIRiS50627.
RefSeqiNP_011050.3. NM_001179014.3.

Genome annotation databases

EnsemblFungiiYER124C; YER124C; YER124C.
GeneIDi856861.
KEGGisce:YER124C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18916 Genomic DNA. Translation: AAC03222.1.
BK006939 Genomic DNA. Translation: DAA07784.1.
PIRiS50627.
RefSeqiNP_011050.3. NM_001179014.3.

3D structure databases

ProteinModelPortaliP40077.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36868. 36 interactions.
DIPiDIP-2585N.
IntActiP40077. 5 interactions.
MINTiMINT-425764.
STRINGi4932.YER124C.

Proteomic databases

MaxQBiP40077.
PaxDbiP40077.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER124C; YER124C; YER124C.
GeneIDi856861.
KEGGisce:YER124C.

Organism-specific databases

CYGDiYER124c.
SGDiS000000926. DSE1.

Phylogenomic databases

eggNOGiNOG45845.
HOGENOMiHOG000112282.
InParanoidiP40077.
OMAiYLNSFPG.
OrthoDBiEOG7Q8CX1.

Enzyme and pathway databases

BioCyciYEAST:G3O-30287-MONOMER.

Miscellaneous databases

NextBioi983213.

Gene expression databases

GenevestigatoriP40077.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates."
    Colman-Lerner A., Chin T.E., Brent R.
    Cell 107:739-750(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, DEVELOPMENTAL STAGE.
  4. "Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p."
    Doolin M.-T., Johnson A.L., Johnston L.H., Butler G.
    Mol. Microbiol. 40:422-432(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, FUNCTION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Swm1p subunit of the APC/cyclosome is required for activation of the daughter-specific gene expression program mediated by Ace2p during growth at high temperature in Saccharomyces cerevisiae."
    Ufano S., Pablo M.E., Calzada A., del Rey F., Vazquez de Aldana C.R.
    J. Cell Sci. 117:545-557(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  8. "Effects of low-shear modeled microgravity on cell function, gene expression, and phenotype in Saccharomyces cerevisiae."
    Purevdorj-Gage B., Sheehan K.B., Hyman L.E.
    Appl. Environ. Microbiol. 72:4569-4575(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  9. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDSE1_YEAST
AccessioniPrimary (citable) accession number: P40077
Secondary accession number(s): D3DM30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1995
Last sequence update: January 31, 1995
Last modified: March 31, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3080 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.