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P40077

- DSE1_YEAST

UniProt

P40077 - DSE1_YEAST

Protein

Protein DSE1

Gene

DSE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in cell wall metabolism and required for the separation of the mother and daughter cells.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cytokinesis, completion of separation Source: SGD
    2. invasive growth in response to glucose limitation Source: SGD
    3. regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: SGD

    Keywords - Biological processi

    Cell cycle, Cell division, Cell wall biogenesis/degradation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30287-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein DSE1
    Alternative name(s):
    Daughter-specific expression protein 1
    Gene namesi
    Name:DSE1
    Ordered Locus Names:YER124C
    ORF Names:SYGP-ORF48
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER124c.
    SGDiS000000926. DSE1.

    Subcellular locationi

    Bud neck 1 Publication

    GO - Cellular componenti

    1. cellular bud neck Source: UniProtKB-SubCell

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 573573Protein DSE1PRO_0000202647Add
    BLAST

    Proteomic databases

    MaxQBiP40077.
    PaxDbiP40077.

    Expressioni

    Developmental stagei

    Expressed in daughter cells.1 Publication

    Inductioni

    Expressed periodically during cell division. Requires ACE2, CBK1, MOB2 and SWI5. Expression is also increased under microgravity conditions.4 Publications

    Gene expression databases

    GenevestigatoriP40077.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BOI2P399693EBI-22676,EBI-3727

    Protein-protein interaction databases

    BioGridi36868. 36 interactions.
    DIPiDIP-2585N.
    IntActiP40077. 5 interactions.
    MINTiMINT-425764.
    STRINGi4932.YER124C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40077.
    SMRiP40077. Positions 212-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati144 – 18542WD 1Add
    BLAST
    Repeati315 – 35137WD 2Add
    BLAST
    Repeati356 – 39540WD 3Add
    BLAST
    Repeati397 – 44852WD 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat DSE1 family.Curated
    Contains 4 WD repeats.Curated

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG45845.
    HOGENOMiHOG000112282.
    OMAiYLNSFPG.
    OrthoDBiEOG7Q8CX1.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    SMARTiSM00320. WD40. 2 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P40077-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQDTKYYEPT NIFRQPAINI KKRSDKKRIL QSMMTLSTYK KTWQNNTSKM    50
    NSPILRKASD NFNDYYTTKK LKSDYWKLYG VDESELSIPS DMSIVDNILL 100
    VSTMNEKDNL KLFEISAEKK LKELQTITVP GKPITCICLL PMVDFPPQIF 150
    PSSQINPNHN QLILTGHQDG IVNLIATSTY KGCAKIIKRF NHNKFLKSTV 200
    STSIPILEIT PKTAPILKVS PWNKTGFVSL LNDSLFIYDL KSNLDCIKTP 250
    IFLQSYPGIN SFAVNEFHDP FLLALVGSKF GPNGISLLDL RTNLYIPDIL 300
    DNSISAGCGK DHLQRKNTSL DCVWISNHHV AQSLNDKIQI WDIQSCDGKP 350
    VCELYAKKGY IESLKFNENT GALYSSDDQG FVICWDLQNL QNMKYGELVH 400
    GFNSISLDSE SELLLTKQVF QCGNIIVSGM SDKNICLKSN DTKANGKGCG 450
    FLFLDMANDG SLVTLDNFCE LGLHQICQVQ FNVDTGKIID GNGTGKSGIS 500
    DSSMLSLSNE SDHSMTETSD DMFSNSGNWD CSSANTVSEG RLNDDQEDIV 550
    FTKRMYSVND VHLSGSTIDT TVV 573
    Length:573
    Mass (Da):63,999
    Last modified:February 1, 1995 - v1
    Checksum:iD5FE871E7C76B260
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18916 Genomic DNA. Translation: AAC03222.1.
    BK006939 Genomic DNA. Translation: DAA07784.1.
    PIRiS50627.
    RefSeqiNP_011050.3. NM_001179014.3.

    Genome annotation databases

    EnsemblFungiiYER124C; YER124C; YER124C.
    GeneIDi856861.
    KEGGisce:YER124C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18916 Genomic DNA. Translation: AAC03222.1 .
    BK006939 Genomic DNA. Translation: DAA07784.1 .
    PIRi S50627.
    RefSeqi NP_011050.3. NM_001179014.3.

    3D structure databases

    ProteinModelPortali P40077.
    SMRi P40077. Positions 212-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36868. 36 interactions.
    DIPi DIP-2585N.
    IntActi P40077. 5 interactions.
    MINTi MINT-425764.
    STRINGi 4932.YER124C.

    Proteomic databases

    MaxQBi P40077.
    PaxDbi P40077.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER124C ; YER124C ; YER124C .
    GeneIDi 856861.
    KEGGi sce:YER124C.

    Organism-specific databases

    CYGDi YER124c.
    SGDi S000000926. DSE1.

    Phylogenomic databases

    eggNOGi NOG45845.
    HOGENOMi HOG000112282.
    OMAi YLNSFPG.
    OrthoDBi EOG7Q8CX1.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30287-MONOMER.

    Miscellaneous databases

    NextBioi 983213.

    Gene expression databases

    Genevestigatori P40077.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    SMARTi SM00320. WD40. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates."
      Colman-Lerner A., Chin T.E., Brent R.
      Cell 107:739-750(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, DEVELOPMENTAL STAGE.
    4. "Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p."
      Doolin M.-T., Johnson A.L., Johnston L.H., Butler G.
      Mol. Microbiol. 40:422-432(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, FUNCTION.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Swm1p subunit of the APC/cyclosome is required for activation of the daughter-specific gene expression program mediated by Ace2p during growth at high temperature in Saccharomyces cerevisiae."
      Ufano S., Pablo M.E., Calzada A., del Rey F., Vazquez de Aldana C.R.
      J. Cell Sci. 117:545-557(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    8. "Effects of low-shear modeled microgravity on cell function, gene expression, and phenotype in Saccharomyces cerevisiae."
      Purevdorj-Gage B., Sheehan K.B., Hyman L.E.
      Appl. Environ. Microbiol. 72:4569-4575(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    9. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDSE1_YEAST
    AccessioniPrimary (citable) accession number: P40077
    Secondary accession number(s): D3DM30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3080 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3