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Protein

Vacuolar amino acid transporter 6

Gene

AVT6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting aspartate and glutamate. Requires ATP for function.1 Publication

GO - Molecular functioni

GO - Biological processi

  • amino acid transmembrane export from vacuole Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30283-MONOMER.

Protein family/group databases

TCDBi2.A.18.6.6. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar amino acid transporter 6
Gene namesi
Name:AVT6
Ordered Locus Names:YER119C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER119C.
SGDiS000000921. AVT6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 32VacuolarSequence analysis4
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 80CytoplasmicSequence analysisAdd BLAST27
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 125VacuolarSequence analysisAdd BLAST24
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Topological domaini147 – 150CytoplasmicSequence analysis4
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 195VacuolarSequence analysisAdd BLAST24
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 229CytoplasmicSequence analysisAdd BLAST13
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 267VacuolarSequence analysisAdd BLAST17
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Topological domaini289 – 357CytoplasmicSequence analysisAdd BLAST69
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
Topological domaini379 – 381VacuolarSequence analysis3
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Topological domaini403 – 424CytoplasmicSequence analysisAdd BLAST22
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21
Topological domaini446 – 448VacuolarSequence analysis3

GO - Cellular componenti

  • fungal-type vacuole Source: SGD
  • fungal-type vacuole membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938391 – 448Vacuolar amino acid transporter 6Add BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei344PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP40074.

PTM databases

iPTMnetiP40074.

Interactioni

Protein-protein interaction databases

BioGridi36864. 31 interactors.
DIPiDIP-4489N.
IntActiP40074. 1 interactor.
MINTiMINT-478670.

Structurei

3D structure databases

ProteinModelPortaliP40074.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00710000106751.
HOGENOMiHOG000173527.
InParanoidiP40074.
OMAiPARESIN.
OrthoDBiEOG092C2GRV.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40074-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVASIRSGVL TLLHTACGAG ILAMPYAFKP FGLIPGVIMI VLCGACAMQS
60 70 80 90 100
LFIQARVAKY VPQGRASFSA LTRLINPNLG IVFDLAIAIK CFGVGVSYMI
110 120 130 140 150
VVGDLMPQIM SVWTRNAWLL NRNVQISLIM LFFVAPLSFL KKLNSLRYAS
160 170 180 190 200
MVAISSVAYL CVLVLLHYVA PSDEILRLKG RISYLLPPQS HDLNVLNTLP
210 220 230 240 250
IFVFAYTCHH NMFSIINEQR SSRFEHVMKI PLIAISLALI LYIAIGCAGY
260 270 280 290 300
LTFGDNIIGN IIMLYPQAVS STIGRIAIVL LVMLAFPLQC HPARASIHQI
310 320 330 340 350
LQHFAEENVS ISATSADEPT VATESSPLIR DSSLDLNEVI EEESIYQPKE
360 370 380 390 400
TPLRGKSFIV ITCSILVASY LVAISVSSLA RVLAIVGATG STSISFILPG
410 420 430 440
LFGYKLIGTE HKTAVPLTTK IFKYTGLLLF IWGLIIMITC LTAALKLN
Length:448
Mass (Da):48,840
Last modified:February 1, 1995 - v1
Checksum:i77F4642429E7D1CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18916 Genomic DNA. Translation: AAC03217.1.
U15653 Genomic DNA. Translation: AAA61905.1.
BK006939 Genomic DNA. Translation: DAA07779.1.
PIRiS50622.
RefSeqiNP_011044.1. NM_001179009.1.

Genome annotation databases

EnsemblFungiiYER119C; YER119C; YER119C.
GeneIDi856855.
KEGGisce:YER119C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18916 Genomic DNA. Translation: AAC03217.1.
U15653 Genomic DNA. Translation: AAA61905.1.
BK006939 Genomic DNA. Translation: DAA07779.1.
PIRiS50622.
RefSeqiNP_011044.1. NM_001179009.1.

3D structure databases

ProteinModelPortaliP40074.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36864. 31 interactors.
DIPiDIP-4489N.
IntActiP40074. 1 interactor.
MINTiMINT-478670.

Protein family/group databases

TCDBi2.A.18.6.6. the amino acid/auxin permease (aaap) family.

PTM databases

iPTMnetiP40074.

Proteomic databases

PRIDEiP40074.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER119C; YER119C; YER119C.
GeneIDi856855.
KEGGisce:YER119C.

Organism-specific databases

EuPathDBiFungiDB:YER119C.
SGDiS000000921. AVT6.

Phylogenomic databases

GeneTreeiENSGT00710000106751.
HOGENOMiHOG000173527.
InParanoidiP40074.
OMAiPARESIN.
OrthoDBiEOG092C2GRV.

Enzyme and pathway databases

BioCyciYEAST:G3O-30283-MONOMER.

Miscellaneous databases

PROiP40074.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAVT6_YEAST
AccessioniPrimary (citable) accession number: P40074
Secondary accession number(s): D3DM25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.