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P40074 (AVT6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vacuolar amino acid transporter 6
Gene names
Name:AVT6
Ordered Locus Names:YER119C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting aspartate and glutamate. Requires ATP for function. Ref.4

Subcellular location

Vacuole membrane; Multi-pass membrane protein Ref.4.

Sequence similarities

Belongs to the amino acid/polyamine transporter 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Vacuolar amino acid transporter 6
PRO_0000093839

Regions

Topological domain1 – 77Cytoplasmic Potential
Transmembrane8 – 2821Helical; Potential
Topological domain29 – 324Vacuolar Potential
Transmembrane33 – 5321Helical; Potential
Topological domain54 – 8027Cytoplasmic Potential
Transmembrane81 – 10121Helical; Potential
Topological domain102 – 12524Vacuolar Potential
Transmembrane126 – 14621Helical; Potential
Topological domain147 – 1504Cytoplasmic Potential
Transmembrane151 – 17121Helical; Potential
Topological domain172 – 19524Vacuolar Potential
Transmembrane196 – 21621Helical; Potential
Topological domain217 – 22913Cytoplasmic Potential
Transmembrane230 – 25021Helical; Potential
Topological domain251 – 26717Vacuolar Potential
Transmembrane268 – 28821Helical; Potential
Topological domain289 – 35769Cytoplasmic Potential
Transmembrane358 – 37821Helical; Potential
Topological domain379 – 3813Vacuolar Potential
Transmembrane382 – 40221Helical; Potential
Topological domain403 – 42422Cytoplasmic Potential
Transmembrane425 – 44521Helical; Potential
Topological domain446 – 4483Vacuolar Potential

Amino acid modifications

Modified residue3251Phosphoserine Ref.6
Modified residue3261Phosphoserine Ref.6
Modified residue3441Phosphoserine Ref.6

Sequences

Sequence LengthMass (Da)Tools
P40074 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 77F4642429E7D1CF

FASTA44848,840
        10         20         30         40         50         60 
MVASIRSGVL TLLHTACGAG ILAMPYAFKP FGLIPGVIMI VLCGACAMQS LFIQARVAKY 

        70         80         90        100        110        120 
VPQGRASFSA LTRLINPNLG IVFDLAIAIK CFGVGVSYMI VVGDLMPQIM SVWTRNAWLL 

       130        140        150        160        170        180 
NRNVQISLIM LFFVAPLSFL KKLNSLRYAS MVAISSVAYL CVLVLLHYVA PSDEILRLKG 

       190        200        210        220        230        240 
RISYLLPPQS HDLNVLNTLP IFVFAYTCHH NMFSIINEQR SSRFEHVMKI PLIAISLALI 

       250        260        270        280        290        300 
LYIAIGCAGY LTFGDNIIGN IIMLYPQAVS STIGRIAIVL LVMLAFPLQC HPARASIHQI 

       310        320        330        340        350        360 
LQHFAEENVS ISATSADEPT VATESSPLIR DSSLDLNEVI EEESIYQPKE TPLRGKSFIV 

       370        380        390        400        410        420 
ITCSILVASY LVAISVSSLA RVLAIVGATG STSISFILPG LFGYKLIGTE HKTAVPLTTK 

       430        440 
IFKYTGLLLF IWGLIIMITC LTAALKLN

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Sequence, map position and genome organization of the RPL17B gene, encoding ribosomal protein L17b in Saccharomyces cerevisiae."
Berroteran R.W., Hampsey M.
Yeast 11:761-766(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 270-448.
[4]"A family of yeast proteins mediating bidirectional vacuolar amino acid transport."
Russnak R., Konczal D., McIntire S.L.
J. Biol. Chem. 276:23849-23857(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[6]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325; SER-326 AND SER-344, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U18916 Genomic DNA. Translation: AAC03217.1.
U15653 Genomic DNA. Translation: AAA61905.1.
BK006939 Genomic DNA. Translation: DAA07779.1.
PIRS50622.
RefSeqNP_011044.1. NM_001179009.1.

3D structure databases

ProteinModelPortalP40074.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4489N.
IntActP40074. 1 interaction.
MINTMINT-478670.
STRING4932.YER119C.

Protein family/group databases

TCDB2.A.18.6.6. amino acid/auxin permease (AAAP) family.

Proteomic databases

PaxDbP40074.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER119C; YER119C; YER119C.
GeneID856855.
KEGGsce:YER119C.

Organism-specific databases

CYGDYER119c.
SGDS000000921. AVT6.

Phylogenomic databases

eggNOGCOG0814.
GeneTreeENSGT00700000105417.
HOGENOMHOG000173527.
OMAGVSYMIV.
OrthoDBEOG4GMZ5X.

Gene expression databases

GenevestigatorP40074.
GermOnlineYER119C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR013057. AA_transpt_TM.
[Graphical view]
PfamPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio983198.

Entry information

Entry nameAVT6_YEAST
AccessionPrimary (citable) accession number: P40074
Secondary accession number(s): D3DM25
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 3, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents