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P40074

- AVT6_YEAST

UniProt

P40074 - AVT6_YEAST

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Protein
Vacuolar amino acid transporter 6
Gene
AVT6, YER119C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting aspartate and glutamate. Requires ATP for function.1 Publication

GO - Molecular functioni

  1. L-aspartate transmembrane transporter activity Source: SGD
  2. L-glutamate transmembrane transporter activity Source: SGD
  3. transporter activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. L-glutamate transport Source: GOC
  2. amino acid transmembrane export from vacuole Source: SGD
  3. aspartate transport Source: GOC
  4. transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30283-MONOMER.

Protein family/group databases

TCDBi2.A.18.6.6. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar amino acid transporter 6
Gene namesi
Name:AVT6
Ordered Locus Names:YER119C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER119c.
SGDiS000000921. AVT6.

Subcellular locationi

Vacuole membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Cytoplasmic Reviewed prediction
Transmembranei8 – 2821Helical; Reviewed prediction
Add
BLAST
Topological domaini29 – 324Vacuolar Reviewed prediction
Transmembranei33 – 5321Helical; Reviewed prediction
Add
BLAST
Topological domaini54 – 8027Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei81 – 10121Helical; Reviewed prediction
Add
BLAST
Topological domaini102 – 12524Vacuolar Reviewed prediction
Add
BLAST
Transmembranei126 – 14621Helical; Reviewed prediction
Add
BLAST
Topological domaini147 – 1504Cytoplasmic Reviewed prediction
Transmembranei151 – 17121Helical; Reviewed prediction
Add
BLAST
Topological domaini172 – 19524Vacuolar Reviewed prediction
Add
BLAST
Transmembranei196 – 21621Helical; Reviewed prediction
Add
BLAST
Topological domaini217 – 22913Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei230 – 25021Helical; Reviewed prediction
Add
BLAST
Topological domaini251 – 26717Vacuolar Reviewed prediction
Add
BLAST
Transmembranei268 – 28821Helical; Reviewed prediction
Add
BLAST
Topological domaini289 – 35769Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei358 – 37821Helical; Reviewed prediction
Add
BLAST
Topological domaini379 – 3813Vacuolar Reviewed prediction
Transmembranei382 – 40221Helical; Reviewed prediction
Add
BLAST
Topological domaini403 – 42422Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei425 – 44521Helical; Reviewed prediction
Add
BLAST
Topological domaini446 – 4483Vacuolar Reviewed prediction

GO - Cellular componenti

  1. fungal-type vacuole Source: SGD
  2. fungal-type vacuole membrane Source: SGD
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Vacuolar amino acid transporter 6
PRO_0000093839Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei344 – 3441Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP40074.

Expressioni

Gene expression databases

GenevestigatoriP40074.

Interactioni

Protein-protein interaction databases

BioGridi36864. 30 interactions.
DIPiDIP-4489N.
IntActiP40074. 1 interaction.
MINTiMINT-478670.
STRINGi4932.YER119C.

Structurei

3D structure databases

ProteinModelPortaliP40074.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00710000106751.
HOGENOMiHOG000173527.
OMAiARASIHQ.
OrthoDBiEOG7C8GSX.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40074-1 [UniParc]FASTAAdd to Basket

« Hide

MVASIRSGVL TLLHTACGAG ILAMPYAFKP FGLIPGVIMI VLCGACAMQS    50
LFIQARVAKY VPQGRASFSA LTRLINPNLG IVFDLAIAIK CFGVGVSYMI 100
VVGDLMPQIM SVWTRNAWLL NRNVQISLIM LFFVAPLSFL KKLNSLRYAS 150
MVAISSVAYL CVLVLLHYVA PSDEILRLKG RISYLLPPQS HDLNVLNTLP 200
IFVFAYTCHH NMFSIINEQR SSRFEHVMKI PLIAISLALI LYIAIGCAGY 250
LTFGDNIIGN IIMLYPQAVS STIGRIAIVL LVMLAFPLQC HPARASIHQI 300
LQHFAEENVS ISATSADEPT VATESSPLIR DSSLDLNEVI EEESIYQPKE 350
TPLRGKSFIV ITCSILVASY LVAISVSSLA RVLAIVGATG STSISFILPG 400
LFGYKLIGTE HKTAVPLTTK IFKYTGLLLF IWGLIIMITC LTAALKLN 448
Length:448
Mass (Da):48,840
Last modified:February 1, 1995 - v1
Checksum:i77F4642429E7D1CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18916 Genomic DNA. Translation: AAC03217.1.
U15653 Genomic DNA. Translation: AAA61905.1.
BK006939 Genomic DNA. Translation: DAA07779.1.
PIRiS50622.
RefSeqiNP_011044.1. NM_001179009.1.

Genome annotation databases

EnsemblFungiiYER119C; YER119C; YER119C.
GeneIDi856855.
KEGGisce:YER119C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18916 Genomic DNA. Translation: AAC03217.1 .
U15653 Genomic DNA. Translation: AAA61905.1 .
BK006939 Genomic DNA. Translation: DAA07779.1 .
PIRi S50622.
RefSeqi NP_011044.1. NM_001179009.1.

3D structure databases

ProteinModelPortali P40074.
ModBasei Search...

Protein-protein interaction databases

BioGridi 36864. 30 interactions.
DIPi DIP-4489N.
IntActi P40074. 1 interaction.
MINTi MINT-478670.
STRINGi 4932.YER119C.

Protein family/group databases

TCDBi 2.A.18.6.6. the amino acid/auxin permease (aaap) family.

Proteomic databases

PaxDbi P40074.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER119C ; YER119C ; YER119C .
GeneIDi 856855.
KEGGi sce:YER119C.

Organism-specific databases

CYGDi YER119c.
SGDi S000000921. AVT6.

Phylogenomic databases

eggNOGi COG0814.
GeneTreei ENSGT00710000106751.
HOGENOMi HOG000173527.
OMAi ARASIHQ.
OrthoDBi EOG7C8GSX.

Enzyme and pathway databases

BioCyci YEAST:G3O-30283-MONOMER.

Miscellaneous databases

NextBioi 983198.

Gene expression databases

Genevestigatori P40074.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Sequence, map position and genome organization of the RPL17B gene, encoding ribosomal protein L17b in Saccharomyces cerevisiae."
    Berroteran R.W., Hampsey M.
    Yeast 11:761-766(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 270-448.
  4. "A family of yeast proteins mediating bidirectional vacuolar amino acid transport."
    Russnak R., Konczal D., McIntire S.L.
    J. Biol. Chem. 276:23849-23857(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAVT6_YEAST
AccessioniPrimary (citable) accession number: P40074
Secondary accession number(s): D3DM25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

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