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P40074

- AVT6_YEAST

UniProt

P40074 - AVT6_YEAST

Protein

Vacuolar amino acid transporter 6

Gene

AVT6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting aspartate and glutamate. Requires ATP for function.1 Publication

    GO - Molecular functioni

    1. L-aspartate transmembrane transporter activity Source: SGD
    2. L-glutamate transmembrane transporter activity Source: SGD
    3. transporter activity Source: SGD

    GO - Biological processi

    1. amino acid transmembrane export from vacuole Source: SGD
    2. aspartate transport Source: GOC
    3. L-glutamate transport Source: GOC
    4. transmembrane transport Source: SGD

    Keywords - Biological processi

    Amino-acid transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30283-MONOMER.

    Protein family/group databases

    TCDBi2.A.18.6.6. the amino acid/auxin permease (aaap) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar amino acid transporter 6
    Gene namesi
    Name:AVT6
    Ordered Locus Names:YER119C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER119c.
    SGDiS000000921. AVT6.

    Subcellular locationi

    Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. fungal-type vacuole Source: SGD
    2. fungal-type vacuole membrane Source: SGD
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Vacuolar amino acid transporter 6PRO_0000093839Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei344 – 3441Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP40074.

    Expressioni

    Gene expression databases

    GenevestigatoriP40074.

    Interactioni

    Protein-protein interaction databases

    BioGridi36864. 30 interactions.
    DIPiDIP-4489N.
    IntActiP40074. 1 interaction.
    MINTiMINT-478670.
    STRINGi4932.YER119C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40074.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77CytoplasmicSequence Analysis
    Topological domaini29 – 324VacuolarSequence Analysis
    Topological domaini54 – 8027CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini102 – 12524VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini147 – 1504CytoplasmicSequence Analysis
    Topological domaini172 – 19524VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini217 – 22913CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini251 – 26717VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini289 – 35769CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini379 – 3813VacuolarSequence Analysis
    Topological domaini403 – 42422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini446 – 4483VacuolarSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei358 – 37821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei382 – 40221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei425 – 44521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0814.
    GeneTreeiENSGT00710000106751.
    HOGENOMiHOG000173527.
    OMAiARASIHQ.
    OrthoDBiEOG7C8GSX.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40074-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVASIRSGVL TLLHTACGAG ILAMPYAFKP FGLIPGVIMI VLCGACAMQS    50
    LFIQARVAKY VPQGRASFSA LTRLINPNLG IVFDLAIAIK CFGVGVSYMI 100
    VVGDLMPQIM SVWTRNAWLL NRNVQISLIM LFFVAPLSFL KKLNSLRYAS 150
    MVAISSVAYL CVLVLLHYVA PSDEILRLKG RISYLLPPQS HDLNVLNTLP 200
    IFVFAYTCHH NMFSIINEQR SSRFEHVMKI PLIAISLALI LYIAIGCAGY 250
    LTFGDNIIGN IIMLYPQAVS STIGRIAIVL LVMLAFPLQC HPARASIHQI 300
    LQHFAEENVS ISATSADEPT VATESSPLIR DSSLDLNEVI EEESIYQPKE 350
    TPLRGKSFIV ITCSILVASY LVAISVSSLA RVLAIVGATG STSISFILPG 400
    LFGYKLIGTE HKTAVPLTTK IFKYTGLLLF IWGLIIMITC LTAALKLN 448
    Length:448
    Mass (Da):48,840
    Last modified:February 1, 1995 - v1
    Checksum:i77F4642429E7D1CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18916 Genomic DNA. Translation: AAC03217.1.
    U15653 Genomic DNA. Translation: AAA61905.1.
    BK006939 Genomic DNA. Translation: DAA07779.1.
    PIRiS50622.
    RefSeqiNP_011044.1. NM_001179009.1.

    Genome annotation databases

    EnsemblFungiiYER119C; YER119C; YER119C.
    GeneIDi856855.
    KEGGisce:YER119C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18916 Genomic DNA. Translation: AAC03217.1 .
    U15653 Genomic DNA. Translation: AAA61905.1 .
    BK006939 Genomic DNA. Translation: DAA07779.1 .
    PIRi S50622.
    RefSeqi NP_011044.1. NM_001179009.1.

    3D structure databases

    ProteinModelPortali P40074.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36864. 30 interactions.
    DIPi DIP-4489N.
    IntActi P40074. 1 interaction.
    MINTi MINT-478670.
    STRINGi 4932.YER119C.

    Protein family/group databases

    TCDBi 2.A.18.6.6. the amino acid/auxin permease (aaap) family.

    Proteomic databases

    PaxDbi P40074.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER119C ; YER119C ; YER119C .
    GeneIDi 856855.
    KEGGi sce:YER119C.

    Organism-specific databases

    CYGDi YER119c.
    SGDi S000000921. AVT6.

    Phylogenomic databases

    eggNOGi COG0814.
    GeneTreei ENSGT00710000106751.
    HOGENOMi HOG000173527.
    OMAi ARASIHQ.
    OrthoDBi EOG7C8GSX.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30283-MONOMER.

    Miscellaneous databases

    NextBioi 983198.

    Gene expression databases

    Genevestigatori P40074.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Sequence, map position and genome organization of the RPL17B gene, encoding ribosomal protein L17b in Saccharomyces cerevisiae."
      Berroteran R.W., Hampsey M.
      Yeast 11:761-766(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 270-448.
    4. "A family of yeast proteins mediating bidirectional vacuolar amino acid transport."
      Russnak R., Konczal D., McIntire S.L.
      J. Biol. Chem. 276:23849-23857(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAVT6_YEAST
    AccessioniPrimary (citable) accession number: P40074
    Secondary accession number(s): D3DM25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3