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Protein

Transcriptional activator FLO8

Gene

FLO8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Required for diploid filamentous growth, haploid invasive growth and flocculation. Putative transcriptional activator of FLO1.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30273-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator FLO8
Alternative name(s):
Protein PDH5
Gene namesi
Name:FLO8
Synonyms:PDH5
Ordered Locus Names:YER109C
ORF Names:YER108C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

SGDiS000000911. FLO8.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873031 – 799Transcriptional activator FLO8Add BLAST799

Proteomic databases

PRIDEiP40068.

Interactioni

Protein-protein interaction databases

BioGridi36854. 49 interactors.
DIPiDIP-5470N.
IntActiP40068. 2 interactors.
MINTiMINT-527994.

Structurei

3D structure databases

ProteinModelPortaliP40068.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 105LisHPROSITE-ProRule annotationAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 55Poly-GlnAdd BLAST15

Sequence similaritiesi

Belongs to the FLO8 family.Curated
Contains 1 LisH domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiP40068.
OrthoDBiEOG092C2ONV.

Family and domain databases

InterProiIPR006594. LisH.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
[Graphical view]
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40068-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYKVNSSYP DSIPPTEQPY MASQYKQDLQ SNIAMATNSE QQRQQQQQQQ
60 70 80 90 100
QQQQQWINQP TAENSDLKEK MNCKNTLNEY IFDFLTKSSL KNTAAAFAQD
110 120 130 140 150
AHLDRDKGQN PVDGPKSKEN NGNQNTFSKV VDTPQGFLYE WWQIFWDIFN
160 170 180 190 200
TSSSRGGSEF AQQYYQLVLQ EQRQEQIYRS LAVHAARLQH DAERRGEYSN
210 220 230 240 250
EDIDPMHLAA MMLGNPMAPA VQMRNVNMNP IPIPMVGNPI VNNFSIPPYN
260 270 280 290 300
NANPTTGATA VAPTAPPSGD FTNVGPTQNR SQNVTGWPVY NYPMQPTTEN
310 320 330 340 350
PVGNPCNNNT TNNTTNNKSP VNQPKSLKTM HSTDKPNNVP TSKSTRSRSA
360 370 380 390 400
TSKAKGKVKA GLVAKRRRKN NTATVSAGST NACSPNITTP GSTTSEPAMV
410 420 430 440 450
GSRVNKTPRS DIATNFRNQA IIFGEEDIYS NSKSSPSLDG ASPSALASKQ
460 470 480 490 500
PTKVRKNTKK ASTSAFPVES TNKLGGNSVV TGKKRSPPNT RVSRRKSTPS
510 520 530 540 550
VILNADATKD ENNMLRTFSN TIAPNIHSAP PTKTANSLPF PGINLGSFNK
560 570 580 590 600
PAVSSPLSSV TESCFDPESG KIAGKNGPKR AVNSKVSASS PLSIATPRSG
610 620 630 640 650
DAQKQRSSKV PGNVVIKPPH GFSTTNLNIT LKNSKIITSQ NNTVSQELPN
660 670 680 690 700
GGNILEAQVG NDSRSSKGNR NTLSTPEEKK PSSNNQGYDF DALKNSSSLL
710 720 730 740 750
FPNQAYASNN RTPNENSNVA DETSASTNSG DNDNTLIQPS SNVGTTLGPQ
760 770 780 790
QTSTNENQNV HSQNLKFGNI GMVEDQGPDY DLNLLDTNEN DFNFINWEG
Length:799
Mass (Da):86,835
Last modified:November 1, 1997 - v2
Checksum:i91AAE10D8E586DAF
GO

Sequence cautioni

The sequence AAC03206 differs from that shown. Reason: Erroneous termination at position 142. Translated as Trp.Curated
The sequence AAC03207 differs from that shown. Reason: Erroneous termination at position 142. Translated as Trp.Curated
The sequence BAA12076 differs from that shown. Reason: Frameshift at position 62.Curated
The sequence BK006939 differs from that shown. Reason: Erroneous termination at position 142. Translated as Trp.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti54Q → QQQ in strain: Diastaticus / ATCC 60715 / YIY2-11A. 1
Natural varianti112V → I in strain: Diastaticus / ATCC 60715 / YIY2-11A. 1
Natural varianti115P → S in strain: Diastaticus / ATCC 60715 / YIY2-11A. 1
Natural varianti383C → G in strain: Diastaticus / ATCC 60715 / YIY2-11A. 1
Natural varianti441A → T in strain: Diastaticus / ATCC 60715 / YIY2-11A. 1
Natural varianti447A → V in strain: Diastaticus / ATCC 60715 / YIY2-11A. 1
Natural varianti598R → P in strain: Diastaticus / ATCC 60715 / YIY2-11A. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51431 Genomic DNA. Translation: AAC49522.1.
D83713 Genomic DNA. Translation: BAA12076.1. Frameshift.
U18916 Genomic DNA. Translation: AAC03207.1. Sequence problems.
U18916 Genomic DNA. Translation: AAC03206.1. Sequence problems.
BK006939 Genomic DNA. No translation available.
PIRiS50611.
S50612.

Genome annotation databases

EnsemblFungiiYER109C; YER109C; YER109C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51431 Genomic DNA. Translation: AAC49522.1.
D83713 Genomic DNA. Translation: BAA12076.1. Frameshift.
U18916 Genomic DNA. Translation: AAC03207.1. Sequence problems.
U18916 Genomic DNA. Translation: AAC03206.1. Sequence problems.
BK006939 Genomic DNA. No translation available.
PIRiS50611.
S50612.

3D structure databases

ProteinModelPortaliP40068.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36854. 49 interactors.
DIPiDIP-5470N.
IntActiP40068. 2 interactors.
MINTiMINT-527994.

Proteomic databases

PRIDEiP40068.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER109C; YER109C; YER109C.

Organism-specific databases

SGDiS000000911. FLO8.

Phylogenomic databases

InParanoidiP40068.
OrthoDBiEOG092C2ONV.

Enzyme and pathway databases

BioCyciYEAST:G3O-30273-MONOMER.

Miscellaneous databases

PROiP40068.

Family and domain databases

InterProiIPR006594. LisH.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
[Graphical view]
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLO8_YEAST
AccessioniPrimary (citable) accession number: P40068
Secondary accession number(s): D3DM15, P40067, Q05751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Strain S288c has a stop codon in position 142, which disrupts the gene coding for this protein and produces two ORFs.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.