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P40065

- MAM1_YEAST

UniProt

P40065 - MAM1_YEAST

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Protein
Monopolin complex subunit MAM1
Gene
MAM1, YER106W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis.8 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. meiotic chromosome segregation Source: SGD
  2. meiotic sister chromatid cohesion involved in meiosis I Source: SGD
Complete GO annotation...

Keywords - Biological processi

Meiosis

Enzyme and pathway databases

BioCyciYEAST:G3O-30271-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Monopolin complex subunit MAM1
Alternative name(s):
Monopolar microtubule attachment during meiosis 1 protein 1
Gene namesi
Name:MAM1
Ordered Locus Names:YER106W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER106w.
SGDiS000000908. MAM1.

Subcellular locationi

Nucleus
Note: Localizes to kinechores during late pachytene.5 Publications

GO - Cellular componenti

  1. condensed nuclear chromosome kinetochore Source: SGD
  2. monopolin complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Monopolin complex subunit MAM1
PRO_0000202645Add
BLAST

Post-translational modificationi

Phosphorylated by CDC5. This phosphorylation is required for the location to the kinetochores during late pachytene.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PeptideAtlasiP40065.

Expressioni

Gene expression databases

GenevestigatoriP40065.

Interactioni

Subunit structurei

Component of the monopolin complex composed of at least CSM1, LRS4 and MAM1. The complex associates with the kinetochore during late pachytene.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CSM1P256518EBI-22643,EBI-22001
HRR25P292953EBI-22643,EBI-8536

Protein-protein interaction databases

BioGridi36852. 19 interactions.
DIPiDIP-5402N.
IntActiP40065. 3 interactions.
MINTiMINT-498700.
STRINGi4932.YER106W.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi233 – 2364
Helixi247 – 2559

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EMCX-ray3.05C221-290[»]
ProteinModelPortaliP40065.
SMRiP40065. Positions 223-263.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG70991.
KOiK12774.
OrthoDBiEOG7P2Z5N.

Family and domain databases

InterProiIPR018847. Monopolin_cplx_su_Mam1.
[Graphical view]
PfamiPF10434. MAM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40065-1 [UniParc]FASTAAdd to Basket

« Hide

MREKRTISNK DTNYLKFPNK LQRYSRFLSR KISNTSPEKQ PKKNIKEHCL    50
SSYHKEHSVK PKQNSGNVAA KEDKDTQHLQ NNVANEEATE CLTRSNLKKL 100
QEKIFDRELN DIACDHCLCS TENRRDIKYS RLWFLFELEM SENWNENLRL 150
SCYNKYVYSA IDESWKMENI LLKEQEKHYE YFPIGQLLIP NNIDYTNKQK 200
RKENIEDLTI EIDSIIETNH QKKRFLPQSV LIKREDEIAF DDFHLDARKV 250
LNDLSATSEN PFSSSPNTKK IKSKGKTLEV VPKKKNKKII GALERKLHID 300
EN 302
Length:302
Mass (Da):35,753
Last modified:February 1, 1995 - v1
Checksum:i64E467A38EB831FF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti202 – 2021K → E in AAT92900. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18839 Genomic DNA. Translation: AAB64661.1.
AY692881 Genomic DNA. Translation: AAT92900.1.
BK006939 Genomic DNA. Translation: DAA07767.1.
PIRiS50609.
RefSeqiNP_011032.1. NM_001178997.1.

Genome annotation databases

EnsemblFungiiYER106W; YER106W; YER106W.
GeneIDi856843.
KEGGisce:YER106W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18839 Genomic DNA. Translation: AAB64661.1 .
AY692881 Genomic DNA. Translation: AAT92900.1 .
BK006939 Genomic DNA. Translation: DAA07767.1 .
PIRi S50609.
RefSeqi NP_011032.1. NM_001178997.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4EMC X-ray 3.05 C 221-290 [» ]
ProteinModelPortali P40065.
SMRi P40065. Positions 223-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36852. 19 interactions.
DIPi DIP-5402N.
IntActi P40065. 3 interactions.
MINTi MINT-498700.
STRINGi 4932.YER106W.

Proteomic databases

PeptideAtlasi P40065.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER106W ; YER106W ; YER106W .
GeneIDi 856843.
KEGGi sce:YER106W.

Organism-specific databases

CYGDi YER106w.
SGDi S000000908. MAM1.

Phylogenomic databases

eggNOGi NOG70991.
KOi K12774.
OrthoDBi EOG7P2Z5N.

Enzyme and pathway databases

BioCyci YEAST:G3O-30271-MONOMER.

Miscellaneous databases

NextBioi 983162.

Gene expression databases

Genevestigatori P40065.

Family and domain databases

InterProi IPR018847. Monopolin_cplx_su_Mam1.
[Graphical view ]
Pfami PF10434. MAM1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Functional genomics identifies monopolin: a kinetochore protein required for segregation of homologs during meiosis I."
    Toth A., Rabitsch K.P., Galova M., Schleiffer A., Buonomo S.B.C., Nasmyth K.
    Cell 103:1155-1168(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. Cited for: FUNCTION.
  6. "Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I."
    Rabitsch K.P., Petronczki M., Javerzat J.-P., Genier S., Chwalla B., Schleiffer A., Tanaka T.U., Nasmyth K.
    Dev. Cell 4:535-548(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE MONOPOLIN COMPLEX.
  7. "Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae."
    Enyenihi A.H., Saunders W.S.
    Genetics 163:47-54(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Polo-like kinase Cdc5 promotes chiasmata formation and cosegregation of sister centromeres at meiosis I."
    Clyne R.K., Katis V.L., Jessop L., Benjamin K.R., Herskowitz I., Lichten M., Nasmyth K.
    Nat. Cell Biol. 5:480-485(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION.
  9. "Role of Polo-like kinase CDC5 in programming meiosis I chromosome segregation."
    Lee B.H., Amon A.
    Science 300:482-486(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION.
  10. "Spo13 facilitates monopolin recruitment to kinetochores and regulates maintenance of centromeric cohesion during yeast meiosis."
    Katis V.L., Matos J., Mori S., Shirahige K., Zachariae W., Nasmyth K.
    Curr. Biol. 14:2183-2196(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  11. "Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8, the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is essential for chromatid disjunction during meiosis II."
    Petronczki M., Chwalla B., Siomos M.F., Yokobayashi S., Helmhart W., Deutschbauer A.M., Davis R.W., Watanabe Y., Nasmyth K.
    J. Cell Sci. 117:3547-3559(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiMAM1_YEAST
AccessioniPrimary (citable) accession number: P40065
Secondary accession number(s): D3DM13, E9P8Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

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