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Protein

Nucleoporin NUP157

Gene

NUP157

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.1 Publication

GO - Molecular functioni

  • DNA binding Source: SGD
  • RNA binding Source: SGD
  • structural constituent of nuclear pore Source: SGD

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • nuclear pore complex assembly Source: SGD
  • nucleocytoplasmic transport Source: SGD
  • posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery Source: SGD
  • protein import into nucleus Source: GO_Central
  • protein targeting to nuclear inner membrane Source: GO_Central
  • RNA export from nucleus Source: GO_Central
  • transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30270-MONOMER.

Protein family/group databases

TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin NUP157
Alternative name(s):
Nuclear pore protein NUP157
Gene namesi
Name:NUP157
Ordered Locus Names:YER105C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER105C.
SGDiS000000907. NUP157.

Subcellular locationi

GO - Cellular componenti

  • nuclear membrane Source: UniProtKB-SubCell
  • nuclear pore Source: SGD
  • nuclear pore inner ring Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048481 – 1391Nucleoporin NUP157Add BLAST1391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei1034PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP40064.
PRIDEiP40064.
TopDownProteomicsiP40064.

PTM databases

iPTMnetiP40064.

Interactioni

Subunit structurei

The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 31 different subunits: ASM4, CDC31, GLE1, GLE2, NDC1, NIC96, NSP1, NUP1, NUP2, NUP100, NUP116, NUP120, NUP133, NUP145, NUP157, NUP159, NUP170, NUP188, NUP192, NUP42, NUP49, NUP53, NUP57, NUP60, NUP82, NUP84, NUP85, POM152, POM34, SEH1 and SEC1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP157 may be part of a NPC subcomplex containing NUP53, NUP170, and NUP59. In addition it may bind to MAD2.

Protein-protein interaction databases

BioGridi36851. 65 interactors.
DIPiDIP-846N.
IntActiP40064. 16 interactors.
MINTiMINT-385200.

Structurei

Secondary structure

11391
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi90 – 106Combined sources17
Helixi114 – 116Combined sources3
Beta strandi122 – 128Combined sources7
Turni129 – 132Combined sources4
Helixi133 – 135Combined sources3
Beta strandi138 – 145Combined sources8
Helixi148 – 151Combined sources4
Turni152 – 154Combined sources3
Beta strandi161 – 166Combined sources6
Turni167 – 170Combined sources4
Beta strandi171 – 176Combined sources6
Beta strandi179 – 184Combined sources6
Turni185 – 187Combined sources3
Beta strandi191 – 194Combined sources4
Beta strandi201 – 207Combined sources7
Turni214 – 217Combined sources4
Beta strandi218 – 237Combined sources20
Beta strandi239 – 241Combined sources3
Beta strandi244 – 254Combined sources11
Turni256 – 258Combined sources3
Beta strandi260 – 266Combined sources7
Turni267 – 270Combined sources4
Beta strandi271 – 276Combined sources6
Beta strandi284 – 286Combined sources3
Beta strandi303 – 307Combined sources5
Beta strandi341 – 348Combined sources8
Turni349 – 352Combined sources4
Beta strandi353 – 358Combined sources6
Beta strandi363 – 369Combined sources7
Beta strandi372 – 379Combined sources8
Helixi381 – 391Combined sources11
Helixi397 – 399Combined sources3
Turni401 – 403Combined sources3
Beta strandi406 – 411Combined sources6
Turni414 – 416Combined sources3
Beta strandi418 – 426Combined sources9
Beta strandi431 – 435Combined sources5
Beta strandi447 – 452Combined sources6
Helixi483 – 486Combined sources4
Beta strandi500 – 502Combined sources3
Turni503 – 505Combined sources3
Beta strandi506 – 512Combined sources7
Beta strandi536 – 543Combined sources8
Helixi545 – 551Combined sources7
Beta strandi555 – 560Combined sources6
Beta strandi567 – 574Combined sources8
Beta strandi581 – 583Combined sources3
Turni584 – 587Combined sources4
Helixi589 – 592Combined sources4
Turni593 – 595Combined sources3
Beta strandi600 – 614Combined sources15
Helixi617 – 623Combined sources7
Turni624 – 626Combined sources3
Helixi629 – 635Combined sources7
Helixi637 – 649Combined sources13
Helixi655 – 667Combined sources13
Turni670 – 672Combined sources3
Helixi707 – 719Combined sources13
Turni720 – 725Combined sources6
Beta strandi726 – 729Combined sources4
Beta strandi745 – 747Combined sources3
Helixi749 – 768Combined sources20
Helixi770 – 772Combined sources3
Helixi787 – 815Combined sources29
Helixi816 – 818Combined sources3
Helixi819 – 829Combined sources11
Helixi838 – 845Combined sources8
Helixi849 – 853Combined sources5
Helixi857 – 872Combined sources16
Helixi879 – 890Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MHCX-ray2.40A70-893[»]
ProteinModelPortaliP40064.
SMRiP40064.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000016532.
HOGENOMiHOG000246581.
InParanoidiP40064.
KOiK14312.
OrthoDBiEOG092C06XC.

Family and domain databases

InterProiIPR007187. Nucleoporin_Nup133/Nup155_C.
IPR014908. Nucleoporin_Nup133/Nup155_N.
IPR004870. Nucleoporin_Nup155.
[Graphical view]
PANTHERiPTHR10350. PTHR10350. 1 hit.
PfamiPF03177. Nucleoporin_C. 1 hit.
PF08801. Nucleoporin_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSTPLKKRI DYDRETFTAS ASLGGNRLRN RPRDDQNNGK PNLSSRSFLS
60 70 80 90 100
ERKTRKDVLN KYGEAGNTIE SELRDVTTHV KISGLTSSEP LQLASEFVQD
110 120 130 140 150
LSFRDRNTPI LDNPDYYSKG LDYNFSDEVG GLGAFTPFQR QQVTNIPDEV
160 170 180 190 200
LSQVSNTEIK SDMGIFLELN YCWITSDNKL ILWNINNSSE YHCIDEIEHT
210 220 230 240 250
ILKVKLVKPS PNTFVSSVEN LLIVATLFDI YILTISFNDR THELNIFNTG
260 270 280 290 300
LKVNVTGFNV SNIISYERTG QIFFTGATDG VNVWELQYNC SENLFNSKSN
310 320 330 340 350
KICLTKSNLA NLLPTKLIPS IPGGKLIQKV LEGDAGTEEE TISQLEVDQS
360 370 380 390 400
RGVLHTLSTK SIVRSYLITS NGLVGPVLID AAHIRRGMNA LGVKNSPLLS
410 420 430 440 450
NRAFKIAKIV SISMCENNDL FLAVITTTGV RLYFKGSISR RSIGSLKLDS
460 470 480 490 500
VKFPPTSISS SLEQNKSFII GHHPLNTHDT GPLSTQKASS TYINTTCAST
510 520 530 540 550
IISPGIYFTC VRKRANSGEL SKGITNKALL ENKEEHKLYV SAPDYGILKN
560 570 580 590 600
YGKYVENTAL LDTTDEIKEI VPLTRSFNYT STPQGYANVF ASQYSAEPLK
610 620 630 640 650
VAVLTSNALE IYCYRTPDEV FESLIENPLP FIHSYGLSEA CSTALYLACK
660 670 680 690 700
FNKSEHIKSS ALAFFSAGIP GVVEIKPKSS RESGSVPPIS QNLFDKSGEC
710 720 730 740 750
DGIVLSPRFY GSALLITRLF SQIWEERVFV FKRASKTEKM DAFGISITRP
760 770 780 790 800
QVEYYLSSIS VLADFFNIHR PSFVSFVPPK GSNAITASDA ESIAMNALIL
810 820 830 840 850
LINSIKDALS LINVFYEDID AFKSLLNTLM GAGGVYDSKT REYFFDLKFH
860 870 880 890 900
DLFTPNAKTK QLIKEILIEV VNANIASGTS ADYIVNVLKE RFGSFCHSAD
910 920 930 940 950
ILCYRAGEHL EAAQKFEMID SKISRNHLDT AIDLYERCAE NIELCELRRV
960 970 980 990 1000
VDIMVKLNYQ PKTVGFLLRF ADKIDKGNQA QEYVSRGCNT ADPRKVFYDK
1010 1020 1030 1040 1050
RINVYTLIFE IVKSVDDYTS IEQSPSIANI SIFSPASSLK KRVYSVIMNS
1060 1070 1080 1090 1100
NNRFFHYCFY DWLVANKRQD YLLRLDSQFV LPYLKERAEK SLEISNLLWF
1110 1120 1130 1140 1150
YLFKEEHFLE AADVLYALAS SDFDLKLSER IECLARANGL CDSSTSFDQK
1160 1170 1180 1190 1200
PALVQLSENI HELFDIASIQ DDLLNLVRNE TRIDEDYRKQ LTLKLNGRVL
1210 1220 1230 1240 1250
PLSDLFNDCA DPLDYYEIKL RIFKVSQFKD EKVIQGEWNR LLDSMKNAPS
1260 1270 1280 1290 1300
PDVGSVGQES FLSSISNTLI RIGKTTRDTD VVFPVHFLMN KILESFIDKS
1310 1320 1330 1340 1350
SAADGSVCSM FLLAGVSHLK LYYILSRIIE NSEGNVELAK KEMVWLIKDW
1360 1370 1380 1390
YQSDSDLRGS IAPEQIKKLE KYDPNTDPVQ DYVKDRHHGL K
Length:1,391
Mass (Da):156,649
Last modified:February 1, 1995 - v1
Checksum:iCB47CEE27AB4FCE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18839 Genomic DNA. Translation: AAB64660.1.
BK006939 Genomic DNA. Translation: DAA07766.1.
PIRiS50608.
RefSeqiNP_011031.1. NM_001178996.1.

Genome annotation databases

EnsemblFungiiYER105C; YER105C; YER105C.
GeneIDi856842.
KEGGisce:YER105C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18839 Genomic DNA. Translation: AAB64660.1.
BK006939 Genomic DNA. Translation: DAA07766.1.
PIRiS50608.
RefSeqiNP_011031.1. NM_001178996.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MHCX-ray2.40A70-893[»]
ProteinModelPortaliP40064.
SMRiP40064.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36851. 65 interactors.
DIPiDIP-846N.
IntActiP40064. 16 interactors.
MINTiMINT-385200.

Protein family/group databases

TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiP40064.

Proteomic databases

MaxQBiP40064.
PRIDEiP40064.
TopDownProteomicsiP40064.

Protocols and materials databases

DNASUi856842.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER105C; YER105C; YER105C.
GeneIDi856842.
KEGGisce:YER105C.

Organism-specific databases

EuPathDBiFungiDB:YER105C.
SGDiS000000907. NUP157.

Phylogenomic databases

GeneTreeiENSGT00390000016532.
HOGENOMiHOG000246581.
InParanoidiP40064.
KOiK14312.
OrthoDBiEOG092C06XC.

Enzyme and pathway databases

BioCyciYEAST:G3O-30270-MONOMER.

Miscellaneous databases

PROiP40064.

Family and domain databases

InterProiIPR007187. Nucleoporin_Nup133/Nup155_C.
IPR014908. Nucleoporin_Nup133/Nup155_N.
IPR004870. Nucleoporin_Nup155.
[Graphical view]
PANTHERiPTHR10350. PTHR10350. 1 hit.
PfamiPF03177. Nucleoporin_C. 1 hit.
PF08801. Nucleoporin_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNU157_YEAST
AccessioniPrimary (citable) accession number: P40064
Secondary accession number(s): D3DM12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4420 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.