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P40064

- NU157_YEAST

UniProt

P40064 - NU157_YEAST

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Protein

Nucleoporin NUP157

Gene

NUP157

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.1 Publication

GO - Molecular functioni

  1. DNA binding Source: SGD
  2. RNA binding Source: SGD
  3. structural constituent of nuclear pore Source: SGD

GO - Biological processi

  1. mitotic spindle assembly checkpoint Source: SGD
  2. mRNA transport Source: UniProtKB-KW
  3. nuclear pore complex assembly Source: SGD
  4. nucleocytoplasmic transport Source: SGD
  5. posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery Source: SGD
  6. protein transport Source: UniProtKB-KW
  7. transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30270-MONOMER.

Protein family/group databases

TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin NUP157
Alternative name(s):
Nuclear pore protein NUP157
Gene namesi
Name:NUP157
Ordered Locus Names:YER105C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER105c.
SGDiS000000907. NUP157.

Subcellular locationi

GO - Cellular componenti

  1. nuclear pore Source: SGD
  2. nuclear pore inner ring Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13911391Nucleoporin NUP157PRO_0000204848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei1034 – 10341Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP40064.
PaxDbiP40064.
PeptideAtlasiP40064.

Expressioni

Gene expression databases

GenevestigatoriP40064.

Interactioni

Subunit structurei

The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 31 different subunits: ASM4, CDC31, GLE1, GLE2, NDC1, NIC96, NSP1, NUP1, NUP2, NUP100, NUP116, NUP120, NUP133, NUP145, NUP157, NUP159, NUP170, NUP188, NUP192, NUP42, NUP49, NUP53, NUP57, NUP60, NUP82, NUP84, NUP85, POM152, POM34, SEH1 and SEC1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP157 may be part of a NPC subcomplex containing NUP53, NUP170, and NUP59. In addition it may bind to MAD2.

Protein-protein interaction databases

BioGridi36851. 63 interactions.
DIPiDIP-846N.
IntActiP40064. 16 interactions.
MINTiMINT-385200.
STRINGi4932.YER105C.

Structurei

Secondary structure

1
1391
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi90 – 10617Combined sources
Helixi114 – 1163Combined sources
Beta strandi122 – 1287Combined sources
Turni129 – 1324Combined sources
Helixi133 – 1353Combined sources
Beta strandi138 – 1458Combined sources
Helixi148 – 1514Combined sources
Turni152 – 1543Combined sources
Beta strandi161 – 1666Combined sources
Turni167 – 1704Combined sources
Beta strandi171 – 1766Combined sources
Beta strandi179 – 1846Combined sources
Turni185 – 1873Combined sources
Beta strandi191 – 1944Combined sources
Beta strandi201 – 2077Combined sources
Turni214 – 2174Combined sources
Beta strandi218 – 23720Combined sources
Beta strandi239 – 2413Combined sources
Beta strandi244 – 25411Combined sources
Turni256 – 2583Combined sources
Beta strandi260 – 2667Combined sources
Turni267 – 2704Combined sources
Beta strandi271 – 2766Combined sources
Beta strandi284 – 2863Combined sources
Beta strandi303 – 3075Combined sources
Beta strandi341 – 3488Combined sources
Turni349 – 3524Combined sources
Beta strandi353 – 3586Combined sources
Beta strandi363 – 3697Combined sources
Beta strandi372 – 3798Combined sources
Helixi381 – 39111Combined sources
Helixi397 – 3993Combined sources
Turni401 – 4033Combined sources
Beta strandi406 – 4116Combined sources
Turni414 – 4163Combined sources
Beta strandi418 – 4269Combined sources
Beta strandi431 – 4355Combined sources
Beta strandi447 – 4526Combined sources
Helixi483 – 4864Combined sources
Beta strandi500 – 5023Combined sources
Turni503 – 5053Combined sources
Beta strandi506 – 5127Combined sources
Beta strandi536 – 5438Combined sources
Helixi545 – 5517Combined sources
Beta strandi555 – 5606Combined sources
Beta strandi567 – 5748Combined sources
Beta strandi581 – 5833Combined sources
Turni584 – 5874Combined sources
Helixi589 – 5924Combined sources
Turni593 – 5953Combined sources
Beta strandi600 – 61415Combined sources
Helixi617 – 6237Combined sources
Turni624 – 6263Combined sources
Helixi629 – 6357Combined sources
Helixi637 – 64913Combined sources
Helixi655 – 66713Combined sources
Turni670 – 6723Combined sources
Helixi707 – 71913Combined sources
Turni720 – 7256Combined sources
Beta strandi726 – 7294Combined sources
Beta strandi745 – 7473Combined sources
Helixi749 – 76820Combined sources
Helixi770 – 7723Combined sources
Helixi787 – 81529Combined sources
Helixi816 – 8183Combined sources
Helixi819 – 82911Combined sources
Helixi838 – 8458Combined sources
Helixi849 – 8535Combined sources
Helixi857 – 87216Combined sources
Helixi879 – 89012Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4MHCX-ray2.40A70-893[»]
ProteinModelPortaliP40064.
SMRiP40064. Positions 88-892.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5308.
GeneTreeiENSGT00390000016532.
HOGENOMiHOG000246581.
InParanoidiP40064.
OrthoDBiEOG7GXPKT.

Family and domain databases

InterProiIPR007187. Nucleoporin_Nup133/Nup155_C.
IPR014908. Nucleoporin_Nup133/Nup155_N.
IPR004870. Nucleoporin_Nup155.
[Graphical view]
PANTHERiPTHR10350. PTHR10350. 1 hit.
PfamiPF03177. Nucleoporin_C. 1 hit.
PF08801. Nucleoporin_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40064-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYSTPLKKRI DYDRETFTAS ASLGGNRLRN RPRDDQNNGK PNLSSRSFLS
60 70 80 90 100
ERKTRKDVLN KYGEAGNTIE SELRDVTTHV KISGLTSSEP LQLASEFVQD
110 120 130 140 150
LSFRDRNTPI LDNPDYYSKG LDYNFSDEVG GLGAFTPFQR QQVTNIPDEV
160 170 180 190 200
LSQVSNTEIK SDMGIFLELN YCWITSDNKL ILWNINNSSE YHCIDEIEHT
210 220 230 240 250
ILKVKLVKPS PNTFVSSVEN LLIVATLFDI YILTISFNDR THELNIFNTG
260 270 280 290 300
LKVNVTGFNV SNIISYERTG QIFFTGATDG VNVWELQYNC SENLFNSKSN
310 320 330 340 350
KICLTKSNLA NLLPTKLIPS IPGGKLIQKV LEGDAGTEEE TISQLEVDQS
360 370 380 390 400
RGVLHTLSTK SIVRSYLITS NGLVGPVLID AAHIRRGMNA LGVKNSPLLS
410 420 430 440 450
NRAFKIAKIV SISMCENNDL FLAVITTTGV RLYFKGSISR RSIGSLKLDS
460 470 480 490 500
VKFPPTSISS SLEQNKSFII GHHPLNTHDT GPLSTQKASS TYINTTCAST
510 520 530 540 550
IISPGIYFTC VRKRANSGEL SKGITNKALL ENKEEHKLYV SAPDYGILKN
560 570 580 590 600
YGKYVENTAL LDTTDEIKEI VPLTRSFNYT STPQGYANVF ASQYSAEPLK
610 620 630 640 650
VAVLTSNALE IYCYRTPDEV FESLIENPLP FIHSYGLSEA CSTALYLACK
660 670 680 690 700
FNKSEHIKSS ALAFFSAGIP GVVEIKPKSS RESGSVPPIS QNLFDKSGEC
710 720 730 740 750
DGIVLSPRFY GSALLITRLF SQIWEERVFV FKRASKTEKM DAFGISITRP
760 770 780 790 800
QVEYYLSSIS VLADFFNIHR PSFVSFVPPK GSNAITASDA ESIAMNALIL
810 820 830 840 850
LINSIKDALS LINVFYEDID AFKSLLNTLM GAGGVYDSKT REYFFDLKFH
860 870 880 890 900
DLFTPNAKTK QLIKEILIEV VNANIASGTS ADYIVNVLKE RFGSFCHSAD
910 920 930 940 950
ILCYRAGEHL EAAQKFEMID SKISRNHLDT AIDLYERCAE NIELCELRRV
960 970 980 990 1000
VDIMVKLNYQ PKTVGFLLRF ADKIDKGNQA QEYVSRGCNT ADPRKVFYDK
1010 1020 1030 1040 1050
RINVYTLIFE IVKSVDDYTS IEQSPSIANI SIFSPASSLK KRVYSVIMNS
1060 1070 1080 1090 1100
NNRFFHYCFY DWLVANKRQD YLLRLDSQFV LPYLKERAEK SLEISNLLWF
1110 1120 1130 1140 1150
YLFKEEHFLE AADVLYALAS SDFDLKLSER IECLARANGL CDSSTSFDQK
1160 1170 1180 1190 1200
PALVQLSENI HELFDIASIQ DDLLNLVRNE TRIDEDYRKQ LTLKLNGRVL
1210 1220 1230 1240 1250
PLSDLFNDCA DPLDYYEIKL RIFKVSQFKD EKVIQGEWNR LLDSMKNAPS
1260 1270 1280 1290 1300
PDVGSVGQES FLSSISNTLI RIGKTTRDTD VVFPVHFLMN KILESFIDKS
1310 1320 1330 1340 1350
SAADGSVCSM FLLAGVSHLK LYYILSRIIE NSEGNVELAK KEMVWLIKDW
1360 1370 1380 1390
YQSDSDLRGS IAPEQIKKLE KYDPNTDPVQ DYVKDRHHGL K
Length:1,391
Mass (Da):156,649
Last modified:February 1, 1995 - v1
Checksum:iCB47CEE27AB4FCE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18839 Genomic DNA. Translation: AAB64660.1.
BK006939 Genomic DNA. Translation: DAA07766.1.
PIRiS50608.
RefSeqiNP_011031.1. NM_001178996.1.

Genome annotation databases

EnsemblFungiiYER105C; YER105C; YER105C.
GeneIDi856842.
KEGGisce:YER105C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18839 Genomic DNA. Translation: AAB64660.1 .
BK006939 Genomic DNA. Translation: DAA07766.1 .
PIRi S50608.
RefSeqi NP_011031.1. NM_001178996.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4MHC X-ray 2.40 A 70-893 [» ]
ProteinModelPortali P40064.
SMRi P40064. Positions 88-892.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36851. 63 interactions.
DIPi DIP-846N.
IntActi P40064. 16 interactions.
MINTi MINT-385200.
STRINGi 4932.YER105C.

Protein family/group databases

TCDBi 1.I.1.1.1. the nuclear pore complex (npc) family.

Proteomic databases

MaxQBi P40064.
PaxDbi P40064.
PeptideAtlasi P40064.

Protocols and materials databases

DNASUi 856842.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER105C ; YER105C ; YER105C .
GeneIDi 856842.
KEGGi sce:YER105C.

Organism-specific databases

CYGDi YER105c.
SGDi S000000907. NUP157.

Phylogenomic databases

eggNOGi COG5308.
GeneTreei ENSGT00390000016532.
HOGENOMi HOG000246581.
InParanoidi P40064.
OrthoDBi EOG7GXPKT.

Enzyme and pathway databases

BioCyci YEAST:G3O-30270-MONOMER.

Miscellaneous databases

NextBioi 983159.

Gene expression databases

Genevestigatori P40064.

Family and domain databases

InterProi IPR007187. Nucleoporin_Nup133/Nup155_C.
IPR014908. Nucleoporin_Nup133/Nup155_N.
IPR004870. Nucleoporin_Nup155.
[Graphical view ]
PANTHERi PTHR10350. PTHR10350. 1 hit.
Pfami PF03177. Nucleoporin_C. 1 hit.
PF08801. Nucleoporin_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Two novel related yeast nucleoporins Nup170p and Nup157p: complementation with the vertebrate homologue Nup155p and functional interactions with the yeast nuclear pore-membrane protein Pom152p."
    Aitchison J.D., Rout M.P., Marelli M., Blobel G., Wozniak R.W.
    J. Cell Biol. 131:1133-1148(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, PROTEIN SEQUENCE OF 1016-1030 AND 1349-1367.
  4. "The yeast nuclear pore complex: composition, architecture, and transport mechanism."
    Rout M.P., Aitchison J.D., Suprapto A., Hjertaas K., Zhao Y., Chait B.T.
    J. Cell Biol. 148:635-651(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, NPC SUBUNIT LOCATION.
  5. "The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint."
    Iouk T., Kerscher O., Scott R.J., Basrai M.A., Wozniak R.W.
    J. Cell Biol. 159:807-819(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NUP170 AND NUP53.
  6. Cited for: INTERACTION WITH MAD2 AND NUP53.
  7. "Peering through the pore: nuclear pore complex structure, assembly, and function."
    Suntharalingam M., Wente S.R.
    Dev. Cell 4:775-789(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1034, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNU157_YEAST
AccessioniPrimary (citable) accession number: P40064
Secondary accession number(s): D3DM12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4420 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3