ID   RT105_YEAST             Reviewed;         208 AA.
AC   P40063; D3DM11;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   27-MAR-2024, entry version 144.
DE   RecName: Full=Regulator of Ty1 transposition protein 105;
GN   Name=RTT105; OrderedLocusNames=YER104W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169868;
RA   Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA   Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA   Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA   Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA   Botstein D., Davis R.W.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL   Nature 387:78-81(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   FUNCTION.
RX   PubMed=11779788; DOI=10.1093/genetics/159.4.1449;
RA   Scholes D.T., Banerjee M., Bowen B., Curcio M.J.;
RT   "Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have
RT   conserved roles in genome maintenance.";
RL   Genetics 159:1449-1465(2001).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [6]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA   Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT   "A multidimensional chromatography technology for in-depth phosphoproteome
RT   analysis.";
RL   Mol. Cell. Proteomics 7:1389-1396(2008).
RN   [8]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19779198; DOI=10.1126/science.1172867;
RA   Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT   "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT   into evolution.";
RL   Science 325:1682-1686(2009).
CC   -!- FUNCTION: Involved in regulation of Ty1 transposition. Inhibits Ty1
CC       transposition at a post-transcriptional and pre-integrational stage of
CC       the Ty1 retrotransposition cycle. {ECO:0000269|PubMed:11779788}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC       {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 259 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; U18839; AAB64659.1; -; Genomic_DNA.
DR   EMBL; AY692872; AAT92891.1; -; Genomic_DNA.
DR   EMBL; BK006939; DAA07765.1; -; Genomic_DNA.
DR   PIR; S50607; S50607.
DR   RefSeq; NP_011030.3; NM_001178995.3.
DR   AlphaFoldDB; P40063; -.
DR   SMR; P40063; -.
DR   BioGRID; 36850; 39.
DR   DIP; DIP-2766N; -.
DR   IntAct; P40063; 3.
DR   MINT; P40063; -.
DR   STRING; 4932.YER104W; -.
DR   iPTMnet; P40063; -.
DR   PaxDb; 4932-YER104W; -.
DR   PeptideAtlas; P40063; -.
DR   EnsemblFungi; YER104W_mRNA; YER104W; YER104W.
DR   GeneID; 856841; -.
DR   KEGG; sce:YER104W; -.
DR   AGR; SGD:S000000906; -.
DR   SGD; S000000906; RTT105.
DR   VEuPathDB; FungiDB:YER104W; -.
DR   eggNOG; ENOG502S9AV; Eukaryota.
DR   HOGENOM; CLU_1469340_0_0_1; -.
DR   InParanoid; P40063; -.
DR   OMA; MESERSH; -.
DR   OrthoDB; 2026189at2759; -.
DR   BioCyc; YEAST:G3O-30269-MONOMER; -.
DR   BioGRID-ORCS; 856841; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P40063; -.
DR   Proteomes; UP000002311; Chromosome V.
DR   RNAct; P40063; Protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0005634; C:nucleus; HDA:SGD.
DR   GO; GO:0010526; P:retrotransposon silencing; IMP:SGD.
DR   GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Transposition.
FT   CHAIN           1..208
FT                   /note="Regulator of Ty1 transposition protein 105"
FT                   /id="PRO_0000202644"
FT   REGION          28..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   208 AA;  24413 MW;  FE14F6F48E8232E7 CRC64;
     MYSNHNLNSD DCCFDWNEEK AAELQRTGVS FDRSLTPQSL RTSTRRLSEE NKQQSGTMHI
     DTSPSVVSDI ISSRRDRSQD FFGPHSSSPI APSERQRADQ RSRLESMRLT RRRDKMTKVR
     GGLEKMEEMI MQGEHLREMQ RLKQEAQKNA LPSDMAEYME WQNNEDLEDD ELLAFIEKQE
     TYKNELEHFL NNANKNVYEN NSYPNSHT
//