P40063 (RT105_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of Ty1 transposition protein 105

Gene names

Name:	RTT105
Ordered Locus Names:	YER104W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in regulation of Ty1 transposition. Inhibits Ty1 transposition at a post-transcriptional and pre-integrational stage of the Ty1 retrotransposition cycle. Ref.4
Subcellular location	Cytoplasm. Nucleus Ref.5.
Miscellaneous	Present with 259 molecules/cell in log phase SD medium.

Ontologies

Keywords
Biological process	Transposition
Cellular component	Cytoplasm Nucleus
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of transposition, RNA-mediated Inferred from mutant phenotype Ref.4. Source: SGD transposition Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay Ref.5. Source: SGD nucleus Inferred from direct assay Ref.5. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Regulator of Ty1 transposition protein 105		PRO_0000202644
Amino acid modifications
	Modified residue	87	1	Phosphoserine Ref.7
	Modified residue	88	1	Phosphoserine Ref.7

Sequences

	Sequence		Length	Mass (Da)
	P40063 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: FE14F6F48E8232E7	FASTA	208	24,413
	10 20 30 40 50 60 MYSNHNLNSD DCCFDWNEEK AAELQRTGVS FDRSLTPQSL RTSTRRLSEE NKQQSGTMHI 70 80 90 100 110 120 DTSPSVVSDI ISSRRDRSQD FFGPHSSSPI APSERQRADQ RSRLESMRLT RRRDKMTKVR 130 140 150 160 170 180 GGLEKMEEMI MQGEHLREMQ RLKQEAQKNA LPSDMAEYME WQNNEDLEDD ELLAFIEKQE 190 200 TYKNELEHFL NNANKNVYEN NSYPNSHT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance." Scholes D.T., Banerjee M., Bowen B., Curcio M.J. Genetics 159:1449-1465(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87 AND SER-88, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U18839 Genomic DNA. Translation: AAB64659.1. AY692872 Genomic DNA. Translation: AAT92891.1. BK006939 Genomic DNA. Translation: DAA07765.1.
PIR	S50607.
RefSeq	NP_011030.3. NM_001178995.3.
3D structure databases
ProteinModelPortal	P40063.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2766N.
IntAct	P40063. 3 interactions.
MINT	MINT-486951.
STRING	4932.YER104W.
Proteomic databases
PaxDb	P40063.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YER104W; YER104W; YER104W.
GeneID	856841.
KEGG	sce:YER104W.
Organism-specific databases
CYGD	YER104w.
SGD	S000000906. RTT105.
Phylogenomic databases
eggNOG	NOG136304.
OrthoDB	EOG4T1MXG.
Enzyme and pathway databases
BioCyc	YEAST:G3O-30269-MONOMER.
Gene expression databases
Genevestigator	P40063.
GermOnline	YER104W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	983156.

Entry information

Entry name

RT105_YEAST

Accession

Primary (citable) accession number: P40063
Secondary accession number(s): D3DM11

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 29, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program