P40060 (IES5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ino eighty subunit 5

Gene names

Name:	IES5
Ordered Locus Names:	YER092W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80. Ref.6
Subcellular location	Nucleus Ref.4.
Miscellaneous	Present with 2280 molecules/cell in log phase SD medium.

Ontologies

Keywords
Cellular component	Nucleus
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from direct assay Ref.4. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IES3	Q12345	3	EBI-22617,EBI-35758
NHP10	Q03435	4	EBI-22617,EBI-12010

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	Ino eighty subunit 5		PRO_0000084157
Amino acid modifications
	Modified residue	43	1	Phosphoserine Ref.7
	Modified residue	44	1	Phosphoserine Ref.8
	Modified residue	124	1	Phosphothreonine Ref.8

Sequences

	Sequence		Length	Mass (Da)
	P40060 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 777B96A00E9FF6E2	FASTA	125	14,312
	10 20 30 40 50 60 MPSKDPESVI DKEIRKISAR NDELIKQDGT LKREYTTLLR KVSSVITVLN SIDDADTGSA 70 80 90 100 110 120 ETELPRLISQ ATVEKVPELK WYNDQISLIT EKLEDDEDIE VPEELMDAYT LYKETPLLYN DTHTP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Korch C., Mountain H.A., Wenzlau J.M. Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Involvement of actin-related proteins in ATP-dependent chromatin remodeling." Shen X., Ranallo R., Choi E., Wu C. Mol. Cell 12:147-155(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE INO80 COMPLEX.
[7]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, MASS SPECTROMETRY.
[8]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44 AND THR-124, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U32508 Genomic DNA. Translation: AAB60299.1. U18839 Genomic DNA. Translation: AAB64647.1. BK006939 Genomic DNA. Translation: DAA07753.1.
PIR	S50595.
RefSeq	NP_011017.3. NM_001178983.3.
3D structure databases
ProteinModelPortal	P40060.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1468N.
IntAct	P40060. 17 interactions.
MINT	MINT-412117.
STRING	4932.YER092W.
Proteomic databases
PaxDb	P40060.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YER092W; YER092W; YER092W.
GeneID	856827.
KEGG	sce:YER092W. sce:YER095W.
Organism-specific databases
CYGD	YER092w.
SGD	S000000894. IES5.
Phylogenomic databases
eggNOG	NOG82552.
HOGENOM	HOG000000842.
KO	K04482. K11679.
OMA	TPLLYKD.
OrthoDB	EOG47Q1GS.
Gene expression databases
Genevestigator	P40060.
GermOnline	YER092W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR020366. INO80_Ies5. [Graphical view]
ProDom	PD079054. Ino_eighty_subunit_5. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
NextBio	983118.

Entry information

Entry name

IES5_YEAST

Accession

Primary (citable) accession number: P40060
Secondary accession number(s): D3DLZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program