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Protein

Tyrosine-protein phosphatase 3

Gene

PTP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major phosphatase responsible for tyrosine dephosphorylation of MAP kinases FUS3 and HOG1 to inactivate their activity; it also has important roles, along with MSG5, in the inactivation of FUS3 following pheromone stimulation.2 Publications

Miscellaneous

Present with 768 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei804Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: SGD

GO - Biological processi

  • inactivation of MAPK activity Source: SGD
  • peptidyl-tyrosine dephosphorylation Source: SGD
  • regulation of protein localization Source: SGD
  • regulation of sporulation Source: SGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:G3O-30246-MONOMER
ReactomeiR-SCE-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 3 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 3
Short name:
PTPase 3
Gene namesi
Name:PTP3
Ordered Locus Names:YER075C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER075C
SGDiS000000877 PTP3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948571 – 928Tyrosine-protein phosphatase 3Add BLAST928

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75PhosphothreonineCombined sources1
Modified residuei248PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei368PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40048
PaxDbiP40048
PRIDEiP40048

PTM databases

iPTMnetiP40048

Interactioni

Subunit structurei

Interacts with HOG1.1 Publication

Protein-protein interaction databases

BioGridi36819, 102 interactors
DIPiDIP-2370N
IntActiP40048, 11 interactors
MINTiP40048
STRINGi4932.YER075C

Structurei

3D structure databases

ProteinModelPortaliP40048
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 232RhodanesePROSITE-ProRule annotationAdd BLAST122
Domaini502 – 878Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST377

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi308 – 311Poly-Ser4
Compositional biasi592 – 597Poly-Thr6
Compositional biasi702 – 715Poly-AsnAdd BLAST14
Compositional biasi724 – 732Poly-Asp9

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00910000144174
HOGENOMiHOG000115788
InParanoidiP40048
KOiK19806
OMAiRYKDIFP
OrthoDBiEOG092C0JT8

Family and domain databases

Gene3Di3.40.250.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00581 Rhodanese, 1 hit
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00450 RHOD, 1 hit
SUPFAMiSSF52799 SSF52799, 2 hits
SSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

P40048-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDSVDCPSI LPTDRTSVLS ETSTLVGSSS HVYSRHAPMN SYHNSMNSNI
60 70 80 90 100
YHSPKASSPL VSYKTSSPVL LKRATAPVLP SFKPKEQRYN KPQGCSLITA
110 120 130 140 150
VELGKIIETL PDEKVLLLDV RPFTEHAKSI ITNSIHVCLP STLLRRKNFT
160 170 180 190 200
FSKLLDNLTP SEQSVLKSKL AIDNLRIIIY DSTANQTESS VSLPCYGIAS
210 220 230 240 250
KLIEFDTNVK KTVSILMCGF PQFKILFPDH INTNTFNSDC ISSAEPKSPK
260 270 280 290 300
TNLMNSLHNT APHMTATTPL SSPQMNLKLK VPDDSRSDHS NFSSSPSPRN
310 320 330 340 350
VLSDSPMSSS SPISALFKFQ LPAPQTNINQ MFKFSQNEEI MGLETYLSAV
360 370 380 390 400
NIKEEHERWY NNDSAKKSLQ NFQFPKNQNS LEKDTNKDKL GFQIRYENLS
410 420 430 440 450
KNYEKEVIDS VIPEWFQHLM SIPKIELVSQ FQKLDFLEKR RLNHSVSFRK
460 470 480 490 500
KENSFILEKP SSYPEQLTST SSSTIMPPKF PDVNKVQKRS HSQPIFTQYS
510 520 530 540 550
KYKSMLSLES DSDSESDDVI ISSGVELGAK NRYKDIFPYE HSRVILKKGL
560 570 580 590 600
QSSKGIKHSH STSDGGILDN YINANYLSLP RFSVEQNSSF QTTTTTTRRV
610 620 630 640 650
RYIATQAPMP STVHDFYTCI LNNGVPLVLS LTNDFENGIE KCYRYWQEGN
660 670 680 690 700
YNGIHVKLLE KKILKMPSTT SMRKNTMGTQ NSSLYSAGVQ GNSSNYSTDN
710 720 730 740 750
DNDNDNNNNN NNNSNIAVTA AACDDDDDDD DDAILIRKIL LTYHDQEKPY
760 770 780 790 800
ELLQIQVKNW PDLGTLLNPI SILQAINVKN HIIDTLFARN YYQNDQLPTI
810 820 830 840 850
LVHCSAGCGR TGTLCTIDSI LSNFEMFEML QKEFVKLKYP AKLFDPISWT
860 870 880 890 900
INIFRKQRIS MVQNINQFIF IYDCLLFYFR LRLDDITERT DGDGSNKDNI
910 920
SLSALIEQIE KLEILQTFVD DKLKELPQ
Length:928
Mass (Da):105,224
Last modified:September 21, 2011 - v2
Checksum:i9BB710EDAF7E3940
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti717A → P in AAB70811 (PubMed:9224718).Curated1
Sequence conflicti717A → P in AAB64614 (PubMed:9169868).Curated1
Sequence conflicti738K → Q in AAB70811 (PubMed:9224718).Curated1
Sequence conflicti738K → Q in AAB64614 (PubMed:9169868).Curated1
Sequence conflicti857Q → E in AAB70811 (PubMed:9224718).Curated1
Sequence conflicti857Q → E in AAB64614 (PubMed:9169868).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006304 Genomic DNA Translation: AAB70811.1
U18814 Genomic DNA Translation: AAB64614.1
BK006939 Genomic DNA Translation: DAA07735.2
PIRiS50578
RefSeqiNP_010998.2, NM_001178966.2

Genome annotation databases

EnsemblFungiiYER075C; YER075C; YER075C
GeneIDi856807
KEGGisce:YER075C

Similar proteinsi

Entry informationi

Entry nameiPTP3_YEAST
AccessioniPrimary (citable) accession number: P40048
Secondary accession number(s): D3DLY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: September 21, 2011
Last modified: May 23, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

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