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P40043 (RGI1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Respiratory growth induced protein 1
Gene names
Name:RGI1
Ordered Locus Names:YER067W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length161 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions. Ref.9

Subcellular location

Cell membrane; Peripheral membrane protein Ref.9.

Induction

Up-regulated by a wide range of conditions, such as intracellular iron depletion, carbon source restriction, high temperature, high osmotic stress, cold stress, unfolded protein response, and high hydrostatic pressure. The promoter contains several binding sites for the stress response transcription factors MSN2, MSN4 and HSF1. Down-regulated when treated with different antifungal drugs from the azole class. Ref.4 Ref.7 Ref.8

Miscellaneous

Present with 8450 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the RGI1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 161161Respiratory growth induced protein 1
PRO_0000202633

Amino acid modifications

Cross-link68Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6

Secondary structure

....................... 161
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P40043 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 31C2929EBB19BF37

FASTA16118,989
        10         20         30         40         50         60 
MTKKDKKEVK VQTVTTEDGE TVKVFEDLQG FETFIANETE DDDFDHLHCK LNYYPPFVLH 

        70         80         90        100        110        120 
ESHEDPEKIS DAANSHSKKF VRHLHQHIEK HLLKDIKQAV RKPELKFHEK SKEETFDKIT 

       130        140        150        160 
WHYGEETEYH GRPFKIDVQV VCTHEDAMVF VDYKTHPVGA N 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Genome-wide expression patterns in Saccharomyces cerevisiae: comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol."
Bammert G.F., Fostel J.M.
Antimicrob. Agents Chemother. 44:1255-1265(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"A proteomics approach to understanding protein ubiquitination."
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D., Marsischky G., Roelofs J., Finley D., Gygi S.P.
Nat. Biotechnol. 21:921-926(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-68.
Strain: SUB592.
[7]"Dynamical remodeling of the transcriptome during short-term anaerobiosis in Saccharomyces cerevisiae: differential response and role of Msn2 and/or Msn4 and other factors in galactose and glucose media."
Lai L.C., Kosorukoff A.L., Burke P.V., Kwast K.E.
Mol. Cell. Biol. 25:4075-4091(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[8]"Proteomic analysis of recombinant Saccharomyces cerevisiae upon iron deficiency induced via human H-ferritin production."
Seo H.Y., Chang Y.J., Chung Y.J., Kim K.S.
J. Microbiol. Biotechnol. 18:1368-1376(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[9]"Structural and functional study of YER067W, a new protein involved in yeast metabolism control and drug resistance."
Domitrovic T., Kozlov G., Freire J.C., Masuda C.A., da Silva Almeida M., Montero-Lomeli M., Atella G.C., Matta-Camacho E., Gehring K., Kurtenbach E.
PLoS ONE 5:E11163-E11163(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 11-161, FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18813 Genomic DNA. Translation: AAB64603.1.
AY692724 Genomic DNA. Translation: AAT92743.1.
BK006939 Genomic DNA. Translation: DAA07726.1.
PIRS50570.
RefSeqNP_010990.1. NM_001178958.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3BCYX-ray1.70A11-161[»]
ProteinModelPortalP40043.
SMRP40043. Positions 16-161.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36810. 17 interactions.
DIPDIP-5346N.
MINTMINT-551142.
STRING4932.YER067W.

Proteomic databases

PaxDbP40043.
PeptideAtlasP40043.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER067W; YER067W; YER067W.
GeneID856797.
KEGGsce:YER067W.

Organism-specific databases

CYGDYER067w.
SGDS000000869. RGI1.

Phylogenomic databases

eggNOGNOG41208.
GeneTreeENSGT00390000011508.
HOGENOMHOG000000841.
OMACTHEDAM.
OrthoDBEOG7GTTFM.

Enzyme and pathway databases

BioCycYEAST:G3O-30241-MONOMER.

Gene expression databases

GenevestigatorP40043.

Family and domain databases

InterProIPR022554. DUF2578.
[Graphical view]
PfamPF10843. DUF2578. 1 hit.
[Graphical view]
ProDomPD034538. DUF2578. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

EvolutionaryTraceP40043.
NextBio983038.

Entry information

Entry nameRGI1_YEAST
AccessionPrimary (citable) accession number: P40043
Secondary accession number(s): D3DLX2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 19, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references