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Protein

Respiratory growth induced protein 1

Gene

RGI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.1 Publication

GO - Biological processi

  • energy reserve metabolic process Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30241-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Respiratory growth induced protein 1
Gene namesi
Name:RGI1
Ordered Locus Names:YER067W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER067W.
SGDiS000000869. RGI1.

Subcellular locationi

GO - Cellular componenti

  • cell periphery Source: SGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002026331 – 161Respiratory growth induced protein 1Add BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki68Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP40043.
PRIDEiP40043.

Expressioni

Inductioni

Up-regulated by a wide range of conditions, such as intracellular iron depletion, carbon source restriction, high temperature, high osmotic stress, cold stress, unfolded protein response, and high hydrostatic pressure. The promoter contains several binding sites for the stress response transcription factors MSN2, MSN4 and HSF1. Down-regulated when treated with different antifungal drugs from the azole class.3 Publications

Interactioni

Protein-protein interaction databases

BioGridi36810. 16 interactors.
DIPiDIP-5346N.
MINTiMINT-551142.

Structurei

Secondary structure

1161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi17 – 27Combined sources11
Helixi28 – 40Combined sources13
Beta strandi48 – 53Combined sources6
Helixi56 – 60Combined sources5
Turni61 – 64Combined sources4
Helixi66 – 68Combined sources3
Helixi78 – 90Combined sources13
Helixi92 – 99Combined sources8
Beta strandi108 – 114Combined sources7
Beta strandi116 – 129Combined sources14
Beta strandi132 – 145Combined sources14
Beta strandi149 – 159Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BCYX-ray1.70A11-161[»]
ProteinModelPortaliP40043.
SMRiP40043.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40043.

Family & Domainsi

Sequence similaritiesi

Belongs to the RGI1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000011508.
HOGENOMiHOG000000841.
InParanoidiP40043.
OMAiTHEDAMV.
OrthoDBiEOG092C5BT7.

Family and domain databases

InterProiIPR022554. RGI1.
[Graphical view]
PfamiPF10843. RGI1. 1 hit.
[Graphical view]
ProDomiPD034538. DUF2578. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P40043-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKDKKEVK VQTVTTEDGE TVKVFEDLQG FETFIANETE DDDFDHLHCK
60 70 80 90 100
LNYYPPFVLH ESHEDPEKIS DAANSHSKKF VRHLHQHIEK HLLKDIKQAV
110 120 130 140 150
RKPELKFHEK SKEETFDKIT WHYGEETEYH GRPFKIDVQV VCTHEDAMVF
160
VDYKTHPVGA N
Length:161
Mass (Da):18,989
Last modified:February 1, 1995 - v1
Checksum:i31C2929EBB19BF37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18813 Genomic DNA. Translation: AAB64603.1.
AY692724 Genomic DNA. Translation: AAT92743.1.
BK006939 Genomic DNA. Translation: DAA07726.1.
PIRiS50570.
RefSeqiNP_010990.1. NM_001178958.1.

Genome annotation databases

EnsemblFungiiYER067W; YER067W; YER067W.
GeneIDi856797.
KEGGisce:YER067W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18813 Genomic DNA. Translation: AAB64603.1.
AY692724 Genomic DNA. Translation: AAT92743.1.
BK006939 Genomic DNA. Translation: DAA07726.1.
PIRiS50570.
RefSeqiNP_010990.1. NM_001178958.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BCYX-ray1.70A11-161[»]
ProteinModelPortaliP40043.
SMRiP40043.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36810. 16 interactors.
DIPiDIP-5346N.
MINTiMINT-551142.

Proteomic databases

MaxQBiP40043.
PRIDEiP40043.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER067W; YER067W; YER067W.
GeneIDi856797.
KEGGisce:YER067W.

Organism-specific databases

EuPathDBiFungiDB:YER067W.
SGDiS000000869. RGI1.

Phylogenomic databases

GeneTreeiENSGT00390000011508.
HOGENOMiHOG000000841.
InParanoidiP40043.
OMAiTHEDAMV.
OrthoDBiEOG092C5BT7.

Enzyme and pathway databases

BioCyciYEAST:G3O-30241-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP40043.
PROiP40043.

Family and domain databases

InterProiIPR022554. RGI1.
[Graphical view]
PfamiPF10843. RGI1. 1 hit.
[Graphical view]
ProDomiPD034538. DUF2578. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiRGI1_YEAST
AccessioniPrimary (citable) accession number: P40043
Secondary accession number(s): D3DLX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8450 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.