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P40043

- RGI1_YEAST

UniProt

P40043 - RGI1_YEAST

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Protein

Respiratory growth induced protein 1

Gene

RGI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.1 Publication

GO - Biological processi

  1. energy reserve metabolic process Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30241-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Respiratory growth induced protein 1
Gene namesi
Name:RGI1
Ordered Locus Names:YER067W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER067w.
SGDiS000000869. RGI1.

Subcellular locationi

Cell membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. cell periphery Source: SGD
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Respiratory growth induced protein 1PRO_0000202633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki68 – 68Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP40043.
PaxDbiP40043.
PeptideAtlasiP40043.

Expressioni

Inductioni

Up-regulated by a wide range of conditions, such as intracellular iron depletion, carbon source restriction, high temperature, high osmotic stress, cold stress, unfolded protein response, and high hydrostatic pressure. The promoter contains several binding sites for the stress response transcription factors MSN2, MSN4 and HSF1. Down-regulated when treated with different antifungal drugs from the azole class.3 Publications

Gene expression databases

GenevestigatoriP40043.

Interactioni

Protein-protein interaction databases

BioGridi36810. 17 interactions.
DIPiDIP-5346N.
MINTiMINT-551142.
STRINGi4932.YER067W.

Structurei

Secondary structure

1
161
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi17 – 2711
Helixi28 – 4013
Beta strandi48 – 536
Helixi56 – 605
Turni61 – 644
Helixi66 – 683
Helixi78 – 9013
Helixi92 – 998
Beta strandi108 – 1147
Beta strandi116 – 12914
Beta strandi132 – 14514
Beta strandi149 – 15911

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BCYX-ray1.70A11-161[»]
ProteinModelPortaliP40043.
SMRiP40043. Positions 16-161.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40043.

Family & Domainsi

Sequence similaritiesi

Belongs to the RGI1 family.Curated

Phylogenomic databases

eggNOGiNOG41208.
GeneTreeiENSGT00390000011508.
HOGENOMiHOG000000841.
InParanoidiP40043.
OMAiCTHEDAM.
OrthoDBiEOG7GTTFM.

Family and domain databases

InterProiIPR022554. DUF2578.
[Graphical view]
PfamiPF10843. DUF2578. 1 hit.
[Graphical view]
ProDomiPD034538. DUF2578. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P40043-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKKDKKEVK VQTVTTEDGE TVKVFEDLQG FETFIANETE DDDFDHLHCK
60 70 80 90 100
LNYYPPFVLH ESHEDPEKIS DAANSHSKKF VRHLHQHIEK HLLKDIKQAV
110 120 130 140 150
RKPELKFHEK SKEETFDKIT WHYGEETEYH GRPFKIDVQV VCTHEDAMVF
160
VDYKTHPVGA N
Length:161
Mass (Da):18,989
Last modified:February 1, 1995 - v1
Checksum:i31C2929EBB19BF37
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18813 Genomic DNA. Translation: AAB64603.1.
AY692724 Genomic DNA. Translation: AAT92743.1.
BK006939 Genomic DNA. Translation: DAA07726.1.
PIRiS50570.
RefSeqiNP_010990.1. NM_001178958.1.

Genome annotation databases

EnsemblFungiiYER067W; YER067W; YER067W.
GeneIDi856797.
KEGGisce:YER067W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18813 Genomic DNA. Translation: AAB64603.1 .
AY692724 Genomic DNA. Translation: AAT92743.1 .
BK006939 Genomic DNA. Translation: DAA07726.1 .
PIRi S50570.
RefSeqi NP_010990.1. NM_001178958.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3BCY X-ray 1.70 A 11-161 [» ]
ProteinModelPortali P40043.
SMRi P40043. Positions 16-161.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36810. 17 interactions.
DIPi DIP-5346N.
MINTi MINT-551142.
STRINGi 4932.YER067W.

Proteomic databases

MaxQBi P40043.
PaxDbi P40043.
PeptideAtlasi P40043.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER067W ; YER067W ; YER067W .
GeneIDi 856797.
KEGGi sce:YER067W.

Organism-specific databases

CYGDi YER067w.
SGDi S000000869. RGI1.

Phylogenomic databases

eggNOGi NOG41208.
GeneTreei ENSGT00390000011508.
HOGENOMi HOG000000841.
InParanoidi P40043.
OMAi CTHEDAM.
OrthoDBi EOG7GTTFM.

Enzyme and pathway databases

BioCyci YEAST:G3O-30241-MONOMER.

Miscellaneous databases

EvolutionaryTracei P40043.
NextBioi 983038.

Gene expression databases

Genevestigatori P40043.

Family and domain databases

InterProi IPR022554. DUF2578.
[Graphical view ]
Pfami PF10843. DUF2578. 1 hit.
[Graphical view ]
ProDomi PD034538. DUF2578. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Genome-wide expression patterns in Saccharomyces cerevisiae: comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol."
    Bammert G.F., Fostel J.M.
    Antimicrob. Agents Chemother. 44:1255-1265(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-68.
    Strain: SUB592.
  7. "Dynamical remodeling of the transcriptome during short-term anaerobiosis in Saccharomyces cerevisiae: differential response and role of Msn2 and/or Msn4 and other factors in galactose and glucose media."
    Lai L.C., Kosorukoff A.L., Burke P.V., Kwast K.E.
    Mol. Cell. Biol. 25:4075-4091(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  8. "Proteomic analysis of recombinant Saccharomyces cerevisiae upon iron deficiency induced via human H-ferritin production."
    Seo H.Y., Chang Y.J., Chung Y.J., Kim K.S.
    J. Microbiol. Biotechnol. 18:1368-1376(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  9. "Structural and functional study of YER067W, a new protein involved in yeast metabolism control and drug resistance."
    Domitrovic T., Kozlov G., Freire J.C., Masuda C.A., da Silva Almeida M., Montero-Lomeli M., Atella G.C., Matta-Camacho E., Gehring K., Kurtenbach E.
    PLoS ONE 5:E11163-E11163(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 11-161, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRGI1_YEAST
AccessioniPrimary (citable) accession number: P40043
Secondary accession number(s): D3DLX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8450 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3