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P40043

- RGI1_YEAST

UniProt

P40043 - RGI1_YEAST

Protein

Respiratory growth induced protein 1

Gene

RGI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.1 Publication

    GO - Biological processi

    1. energy reserve metabolic process Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30241-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Respiratory growth induced protein 1
    Gene namesi
    Name:RGI1
    Ordered Locus Names:YER067W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER067w.
    SGDiS000000869. RGI1.

    Subcellular locationi

    Cell membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. cell periphery Source: SGD
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 161161Respiratory growth induced protein 1PRO_0000202633Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki68 – 68Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiP40043.
    PaxDbiP40043.
    PeptideAtlasiP40043.

    Expressioni

    Inductioni

    Up-regulated by a wide range of conditions, such as intracellular iron depletion, carbon source restriction, high temperature, high osmotic stress, cold stress, unfolded protein response, and high hydrostatic pressure. The promoter contains several binding sites for the stress response transcription factors MSN2, MSN4 and HSF1. Down-regulated when treated with different antifungal drugs from the azole class.3 Publications

    Gene expression databases

    GenevestigatoriP40043.

    Interactioni

    Protein-protein interaction databases

    BioGridi36810. 17 interactions.
    DIPiDIP-5346N.
    MINTiMINT-551142.
    STRINGi4932.YER067W.

    Structurei

    Secondary structure

    1
    161
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi17 – 2711
    Helixi28 – 4013
    Beta strandi48 – 536
    Helixi56 – 605
    Turni61 – 644
    Helixi66 – 683
    Helixi78 – 9013
    Helixi92 – 998
    Beta strandi108 – 1147
    Beta strandi116 – 12914
    Beta strandi132 – 14514
    Beta strandi149 – 15911

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3BCYX-ray1.70A11-161[»]
    ProteinModelPortaliP40043.
    SMRiP40043. Positions 16-161.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP40043.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RGI1 family.Curated

    Phylogenomic databases

    eggNOGiNOG41208.
    GeneTreeiENSGT00390000011508.
    HOGENOMiHOG000000841.
    OMAiCTHEDAM.
    OrthoDBiEOG7GTTFM.

    Family and domain databases

    InterProiIPR022554. DUF2578.
    [Graphical view]
    PfamiPF10843. DUF2578. 1 hit.
    [Graphical view]
    ProDomiPD034538. DUF2578. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P40043-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKKDKKEVK VQTVTTEDGE TVKVFEDLQG FETFIANETE DDDFDHLHCK    50
    LNYYPPFVLH ESHEDPEKIS DAANSHSKKF VRHLHQHIEK HLLKDIKQAV 100
    RKPELKFHEK SKEETFDKIT WHYGEETEYH GRPFKIDVQV VCTHEDAMVF 150
    VDYKTHPVGA N 161
    Length:161
    Mass (Da):18,989
    Last modified:February 1, 1995 - v1
    Checksum:i31C2929EBB19BF37
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18813 Genomic DNA. Translation: AAB64603.1.
    AY692724 Genomic DNA. Translation: AAT92743.1.
    BK006939 Genomic DNA. Translation: DAA07726.1.
    PIRiS50570.
    RefSeqiNP_010990.1. NM_001178958.1.

    Genome annotation databases

    EnsemblFungiiYER067W; YER067W; YER067W.
    GeneIDi856797.
    KEGGisce:YER067W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18813 Genomic DNA. Translation: AAB64603.1 .
    AY692724 Genomic DNA. Translation: AAT92743.1 .
    BK006939 Genomic DNA. Translation: DAA07726.1 .
    PIRi S50570.
    RefSeqi NP_010990.1. NM_001178958.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3BCY X-ray 1.70 A 11-161 [» ]
    ProteinModelPortali P40043.
    SMRi P40043. Positions 16-161.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36810. 17 interactions.
    DIPi DIP-5346N.
    MINTi MINT-551142.
    STRINGi 4932.YER067W.

    Proteomic databases

    MaxQBi P40043.
    PaxDbi P40043.
    PeptideAtlasi P40043.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER067W ; YER067W ; YER067W .
    GeneIDi 856797.
    KEGGi sce:YER067W.

    Organism-specific databases

    CYGDi YER067w.
    SGDi S000000869. RGI1.

    Phylogenomic databases

    eggNOGi NOG41208.
    GeneTreei ENSGT00390000011508.
    HOGENOMi HOG000000841.
    OMAi CTHEDAM.
    OrthoDBi EOG7GTTFM.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30241-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P40043.
    NextBioi 983038.

    Gene expression databases

    Genevestigatori P40043.

    Family and domain databases

    InterProi IPR022554. DUF2578.
    [Graphical view ]
    Pfami PF10843. DUF2578. 1 hit.
    [Graphical view ]
    ProDomi PD034538. DUF2578. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Genome-wide expression patterns in Saccharomyces cerevisiae: comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol."
      Bammert G.F., Fostel J.M.
      Antimicrob. Agents Chemother. 44:1255-1265(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-68.
      Strain: SUB592.
    7. "Dynamical remodeling of the transcriptome during short-term anaerobiosis in Saccharomyces cerevisiae: differential response and role of Msn2 and/or Msn4 and other factors in galactose and glucose media."
      Lai L.C., Kosorukoff A.L., Burke P.V., Kwast K.E.
      Mol. Cell. Biol. 25:4075-4091(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    8. "Proteomic analysis of recombinant Saccharomyces cerevisiae upon iron deficiency induced via human H-ferritin production."
      Seo H.Y., Chang Y.J., Chung Y.J., Kim K.S.
      J. Microbiol. Biotechnol. 18:1368-1376(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    9. "Structural and functional study of YER067W, a new protein involved in yeast metabolism control and drug resistance."
      Domitrovic T., Kozlov G., Freire J.C., Masuda C.A., da Silva Almeida M., Montero-Lomeli M., Atella G.C., Matta-Camacho E., Gehring K., Kurtenbach E.
      PLoS ONE 5:E11163-E11163(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 11-161, FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiRGI1_YEAST
    AccessioniPrimary (citable) accession number: P40043
    Secondary accession number(s): D3DLX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 8450 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3