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Protein

Respiratory growth induced protein 1

Gene

RGI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.1 Publication

Miscellaneous

Present with 8450 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • energy reserve metabolic process Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-30241-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Respiratory growth induced protein 1
Gene namesi
Name:RGI1
Ordered Locus Names:YER067W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER067W
SGDiS000000869 RGI1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002026331 – 161Respiratory growth induced protein 1Add BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki68Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP40043
PaxDbiP40043
PRIDEiP40043

PTM databases

iPTMnetiP40043

Expressioni

Inductioni

Up-regulated by a wide range of conditions, such as intracellular iron depletion, carbon source restriction, high temperature, high osmotic stress, cold stress, unfolded protein response, and high hydrostatic pressure. The promoter contains several binding sites for the stress response transcription factors MSN2, MSN4 and HSF1. Down-regulated when treated with different antifungal drugs from the azole class.3 Publications

Interactioni

Protein-protein interaction databases

BioGridi36810, 45 interactors
DIPiDIP-5346N
IntActiP40043, 3 interactors
MINTiP40043
STRINGi4932.YER067W

Structurei

Secondary structure

1161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi17 – 27Combined sources11
Helixi28 – 40Combined sources13
Beta strandi48 – 53Combined sources6
Helixi56 – 60Combined sources5
Turni61 – 64Combined sources4
Helixi66 – 68Combined sources3
Helixi78 – 90Combined sources13
Helixi92 – 99Combined sources8
Beta strandi108 – 114Combined sources7
Beta strandi116 – 129Combined sources14
Beta strandi132 – 145Combined sources14
Beta strandi149 – 159Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BCYX-ray1.70A11-161[»]
ProteinModelPortaliP40043
SMRiP40043
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40043

Family & Domainsi

Sequence similaritiesi

Belongs to the RGI1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000011508
HOGENOMiHOG000000841
InParanoidiP40043
OMAiWHYADES
OrthoDBiEOG092C5BT7

Family and domain databases

Gene3Di3.40.1000.40, 1 hit
InterProiView protein in InterPro
IPR022554 RGI1
IPR038235 RGI1_sf
PfamiView protein in Pfam
PF10843 RGI1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD034538 DUF2578, 1 hit

Sequencei

Sequence statusi: Complete.

P40043-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKDKKEVK VQTVTTEDGE TVKVFEDLQG FETFIANETE DDDFDHLHCK
60 70 80 90 100
LNYYPPFVLH ESHEDPEKIS DAANSHSKKF VRHLHQHIEK HLLKDIKQAV
110 120 130 140 150
RKPELKFHEK SKEETFDKIT WHYGEETEYH GRPFKIDVQV VCTHEDAMVF
160
VDYKTHPVGA N
Length:161
Mass (Da):18,989
Last modified:February 1, 1995 - v1
Checksum:i31C2929EBB19BF37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18813 Genomic DNA Translation: AAB64603.1
AY692724 Genomic DNA Translation: AAT92743.1
BK006939 Genomic DNA Translation: DAA07726.1
PIRiS50570
RefSeqiNP_010990.1, NM_001178958.1

Genome annotation databases

EnsemblFungiiYER067W; YER067W; YER067W
GeneIDi856797
KEGGisce:YER067W

Similar proteinsi

Entry informationi

Entry nameiRGI1_YEAST
AccessioniPrimary (citable) accession number: P40043
Secondary accession number(s): D3DLX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health