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P40041

- VHR2_YEAST

UniProt

P40041 - VHR2_YEAST

Protein

Transcription factor VHR2

Gene

VHR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Transcription factor that regulates ERG9, but seems to have a more global function in transcription.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: SGD
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30239-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor VHR2
    Alternative name(s):
    VHT1 regulator 2
    Gene namesi
    Name:VHR2
    Ordered Locus Names:YER064C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER064c.
    SGDiS000000866. VHR2.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 505505Transcription factor VHR2PRO_0000202632Add
    BLAST

    Proteomic databases

    MaxQBiP40041.
    PaxDbiP40041.

    Expressioni

    Gene expression databases

    GenevestigatoriP40041.

    Interactioni

    Protein-protein interaction databases

    BioGridi36806. 24 interactions.
    DIPiDIP-4619N.
    IntActiP40041. 4 interactions.
    MINTiMINT-513670.
    STRINGi4932.YER064C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40041.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the VHR1 family.Curated

    Phylogenomic databases

    eggNOGiNOG43836.
    GeneTreeiENSGT00530000068544.
    OrthoDBiEOG7JX3DC.

    Family and domain databases

    InterProiIPR007147. TF_Vhr.
    [Graphical view]
    PfamiPF04001. Vhr1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40041-1 [UniParc]FASTAAdd to Basket

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    MIDDTENSKI HLEGSHKTGK YTGYGTTHKI RAQLNFNDEK KWKKFSSRRL    50
    ELIDSFGLSQ HKASEQDDNI RQIATILRSE FEYPDTFSAE FEKLVTAAVQ 100
    SVRRNRKRSK KKLLDSKKKI ARGKVQKIPL SPPSSSNMGS CSASNASSSD 150
    EEASVKEEPA EHALPSLNTI TSQKLLPYPN GRTLPPVPTQ VRSLLKKNAS 200
    LLRDPSAPYA HGGDEKLQKF DIEDQPLESE QEYDFIAKSI IVEIVNNAIP 250
    LPEQIQRDKF IRPNLTKKKG CQSKVVISNN LRKLILSKIH NSRTCLEMSK 300
    DERNLDSFAN LETLGKNSLM ASISLVVENS FSHLPSSTKQ YLTERLSSIE 350
    FLTILSQRLF MPATRQLFAD LSQEKIQVRV LNLILGSLVK DYGFDASLAP 400
    INEIIYHMTL HQYPLVCSNK QSNPMRPHST SEVLSAHSST KDASTPGKEE 450
    PRVTRSSTSA DSTIITLPSI EVPNTYDDDR LKMLSAISLQ IENSTFSKPF 500
    STISK 505
    Length:505
    Mass (Da):56,638
    Last modified:February 1, 1995 - v1
    Checksum:iDF7C3CB5506AC763
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18813 Genomic DNA. Translation: AAB64600.1.
    BK006939 Genomic DNA. Translation: DAA07723.1.
    PIRiS50567.
    RefSeqiNP_010986.1. NM_001178955.1.

    Genome annotation databases

    EnsemblFungiiYER064C; YER064C; YER064C.
    GeneIDi856793.
    KEGGisce:YER064C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18813 Genomic DNA. Translation: AAB64600.1 .
    BK006939 Genomic DNA. Translation: DAA07723.1 .
    PIRi S50567.
    RefSeqi NP_010986.1. NM_001178955.1.

    3D structure databases

    ProteinModelPortali P40041.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36806. 24 interactions.
    DIPi DIP-4619N.
    IntActi P40041. 4 interactions.
    MINTi MINT-513670.
    STRINGi 4932.YER064C.

    Proteomic databases

    MaxQBi P40041.
    PaxDbi P40041.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER064C ; YER064C ; YER064C .
    GeneIDi 856793.
    KEGGi sce:YER064C.

    Organism-specific databases

    CYGDi YER064c.
    SGDi S000000866. VHR2.

    Phylogenomic databases

    eggNOGi NOG43836.
    GeneTreei ENSGT00530000068544.
    OrthoDBi EOG7JX3DC.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30239-MONOMER.

    Miscellaneous databases

    NextBioi 983027.

    Gene expression databases

    Genevestigatori P40041.

    Family and domain databases

    InterProi IPR007147. TF_Vhr.
    [Graphical view ]
    Pfami PF04001. Vhr1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Positive and negative regulation of squalene synthase (ERG9), an ergosterol biosynthetic gene, in Saccharomyces cerevisiae."
      Kennedy M.A., Bard M.
      Biochim. Biophys. Acta 1517:177-189(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights."
      Gordan R., Murphy K.F., McCord R.P., Zhu C., Vedenko A., Bulyk M.L.
      Genome Biol. 12:RESEARCH0125.1-RESEARCH0125.18(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING, POSSIBLE FUNCTION.

    Entry informationi

    Entry nameiVHR2_YEAST
    AccessioniPrimary (citable) accession number: P40041
    Secondary accession number(s): D3DLW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1730 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3