P40041 (VHR2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor VHR2

Alternative name(s):
VHT1 regulator 2

Gene names

Name:	VHR2
Ordered Locus Names:	YER064C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tanscription factor that regulates ERG9, but seems to have a more global function in transcription. Ref.3 Ref.6
Subcellular location	Nucleus Ref.4.
Miscellaneous	Present with 1730 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the VHR1 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from mutant phenotype Ref.3. Source: SGD transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay PubMed 22842922. Source: SGD nucleus Inferred from direct assay Ref.4PubMed 22842922. Source: SGD
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	Transcription factor VHR2		PRO_0000202632

Sequences

	Sequence		Length	Mass (Da)
	P40041 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: DF7C3CB5506AC763	FASTA	505	56,638
	10 20 30 40 50 60 MIDDTENSKI HLEGSHKTGK YTGYGTTHKI RAQLNFNDEK KWKKFSSRRL ELIDSFGLSQ 70 80 90 100 110 120 HKASEQDDNI RQIATILRSE FEYPDTFSAE FEKLVTAAVQ SVRRNRKRSK KKLLDSKKKI 130 140 150 160 170 180 ARGKVQKIPL SPPSSSNMGS CSASNASSSD EEASVKEEPA EHALPSLNTI TSQKLLPYPN 190 200 210 220 230 240 GRTLPPVPTQ VRSLLKKNAS LLRDPSAPYA HGGDEKLQKF DIEDQPLESE QEYDFIAKSI 250 260 270 280 290 300 IVEIVNNAIP LPEQIQRDKF IRPNLTKKKG CQSKVVISNN LRKLILSKIH NSRTCLEMSK 310 320 330 340 350 360 DERNLDSFAN LETLGKNSLM ASISLVVENS FSHLPSSTKQ YLTERLSSIE FLTILSQRLF 370 380 390 400 410 420 MPATRQLFAD LSQEKIQVRV LNLILGSLVK DYGFDASLAP INEIIYHMTL HQYPLVCSNK 430 440 450 460 470 480 QSNPMRPHST SEVLSAHSST KDASTPGKEE PRVTRSSTSA DSTIITLPSI EVPNTYDDDR 490 500 LKMLSAISLQ IENSTFSKPF STISK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Positive and negative regulation of squalene synthase (ERG9), an ergosterol biosynthetic gene, in Saccharomyces cerevisiae." Kennedy M.A., Bard M. Biochim. Biophys. Acta 1517:177-189(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights." Gordan R., Murphy K.F., McCord R.P., Zhu C., Vedenko A., Bulyk M.L. Genome Biol. 12:RESEARCH0125.1-RESEARCH0125.18(2011) [PubMed] [Europe PMC] [Abstract] Cited for: DNA-BINDING, POSSIBLE FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U18813 Genomic DNA. Translation: AAB64600.1. BK006939 Genomic DNA. Translation: DAA07723.1.
PIR	S50567.
RefSeq	NP_010986.1. NM_001178955.1.
3D structure databases
ProteinModelPortal	P40041.
SMR	P40041. Positions 304-409.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4619N.
IntAct	P40041. 4 interactions.
MINT	MINT-513670.
STRING	4932.YER064C.
Proteomic databases
PaxDb	P40041.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YER064C; YER064C; YER064C.
GeneID	856793.
KEGG	sce:YER064C.
Organism-specific databases
CYGD	YER064c.
SGD	S000000866. VHR2.
Phylogenomic databases
eggNOG	NOG43836.
GeneTree	ENSGT00530000068544.
OrthoDB	EOG4HMNK0.
Gene expression databases
Genevestigator	P40041.
GermOnline	YER064C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR007147. DUF352. [Graphical view]
Pfam	PF04001. Vhr1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	983027.

Entry information

Entry name

VHR2_YEAST

Accession

Primary (citable) accession number: P40041
Secondary accession number(s): D3DLW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program