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P40041 (VHR2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor VHR2
Alternative name(s):
VHT1 regulator 2
Gene names
Name:VHR2
Ordered Locus Names:YER064C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor that regulates ERG9, but seems to have a more global function in transcription. Ref.3 Ref.6

Subcellular location

Nucleus Ref.4.

Miscellaneous

Present with 1730 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the VHR1 family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from mutant phenotype Ref.3. Source: SGD

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505Transcription factor VHR2
PRO_0000202632

Sequences

Sequence LengthMass (Da)Tools
P40041 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: DF7C3CB5506AC763

FASTA50556,638
        10         20         30         40         50         60 
MIDDTENSKI HLEGSHKTGK YTGYGTTHKI RAQLNFNDEK KWKKFSSRRL ELIDSFGLSQ 

        70         80         90        100        110        120 
HKASEQDDNI RQIATILRSE FEYPDTFSAE FEKLVTAAVQ SVRRNRKRSK KKLLDSKKKI 

       130        140        150        160        170        180 
ARGKVQKIPL SPPSSSNMGS CSASNASSSD EEASVKEEPA EHALPSLNTI TSQKLLPYPN 

       190        200        210        220        230        240 
GRTLPPVPTQ VRSLLKKNAS LLRDPSAPYA HGGDEKLQKF DIEDQPLESE QEYDFIAKSI 

       250        260        270        280        290        300 
IVEIVNNAIP LPEQIQRDKF IRPNLTKKKG CQSKVVISNN LRKLILSKIH NSRTCLEMSK 

       310        320        330        340        350        360 
DERNLDSFAN LETLGKNSLM ASISLVVENS FSHLPSSTKQ YLTERLSSIE FLTILSQRLF 

       370        380        390        400        410        420 
MPATRQLFAD LSQEKIQVRV LNLILGSLVK DYGFDASLAP INEIIYHMTL HQYPLVCSNK 

       430        440        450        460        470        480 
QSNPMRPHST SEVLSAHSST KDASTPGKEE PRVTRSSTSA DSTIITLPSI EVPNTYDDDR 

       490        500 
LKMLSAISLQ IENSTFSKPF STISK 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Positive and negative regulation of squalene synthase (ERG9), an ergosterol biosynthetic gene, in Saccharomyces cerevisiae."
Kennedy M.A., Bard M.
Biochim. Biophys. Acta 1517:177-189(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights."
Gordan R., Murphy K.F., McCord R.P., Zhu C., Vedenko A., Bulyk M.L.
Genome Biol. 12:RESEARCH0125.1-RESEARCH0125.18(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: DNA-BINDING, POSSIBLE FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18813 Genomic DNA. Translation: AAB64600.1.
BK006939 Genomic DNA. Translation: DAA07723.1.
PIRS50567.
RefSeqNP_010986.1. NM_001178955.1.

3D structure databases

ProteinModelPortalP40041.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36806. 23 interactions.
DIPDIP-4619N.
IntActP40041. 4 interactions.
MINTMINT-513670.
STRING4932.YER064C.

Proteomic databases

PaxDbP40041.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER064C; YER064C; YER064C.
GeneID856793.
KEGGsce:YER064C.

Organism-specific databases

CYGDYER064c.
SGDS000000866. VHR2.

Phylogenomic databases

eggNOGNOG43836.
GeneTreeENSGT00530000068544.
OrthoDBEOG7JX3DC.

Enzyme and pathway databases

BioCycYEAST:G3O-30239-MONOMER.

Gene expression databases

GenevestigatorP40041.

Family and domain databases

InterProIPR007147. TF_Vhr.
[Graphical view]
PfamPF04001. Vhr1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio983027.

Entry information

Entry nameVHR2_YEAST
AccessionPrimary (citable) accession number: P40041
Secondary accession number(s): D3DLW9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families