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Protein

Protein THO1

Gene

THO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Unknown; suppressor of the transcriptional defect of HPR1 by overexpression.

Miscellaneous

Present with 6580 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • chromatin binding Source: SGD
  • double-stranded DNA binding Source: SGD
  • RNA binding Source: SGD

GO - Biological processi

  • poly(A)+ mRNA export from nucleus Source: SGD
  • ribonucleoprotein complex assembly Source: SGD
  • transcription, DNA-templated Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-30238-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein THO1
Gene namesi
Name:THO1
Ordered Locus Names:YER063W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER063W
SGDiS000000865 THO1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725191 – 218Protein THO1Add BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei68PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40040
PaxDbiP40040
PRIDEiP40040

PTM databases

iPTMnetiP40040

Interactioni

Protein-protein interaction databases

BioGridi36805, 53 interactors
DIPiDIP-3983N
IntActiP40040, 10 interactors
MINTiP40040
STRINGi4932.YER063W

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Helixi9 – 18Combined sources10
Helixi27 – 40Combined sources14
Helixi122 – 143Combined sources22
Helixi147 – 162Combined sources16
Helixi170 – 175Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H1JNMR-S2-50[»]
2WQGNMR-A2-50[»]
4UZWNMR-A2-50[»]
4UZXNMR-A119-183[»]
ProteinModelPortaliP40040
SMRiP40040
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40040

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 38SAPPROSITE-ProRule annotationAdd BLAST35

Phylogenomic databases

HOGENOMiHOG000000840
InParanoidiP40040
KOiK18732
OMAiDDVIDWE
OrthoDBiEOG092C4VLE

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
PfamiView protein in Pfam
PF02037 SAP, 1 hit
SMARTiView protein in SMART
SM00513 SAP, 1 hit
SUPFAMiSSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50800 SAP, 1 hit

Sequencei

Sequence statusi: Complete.

P40040-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADYSSLTVV QLKDLLTKRN LSVGGLKNEL VQRLIKDDEE SKGESEVSPQ
60 70 80 90 100
EQNQEQGSEP AAIEEPASQN ITEKKEVSSE PKETNEPKEE NKDVQKPSDG
110 120 130 140 150
PSATASENEQ AAASTAAPAL SPEEIKAKAL DLLNKKLHRA NKFGQDQADI
160 170 180 190 200
DSLQRQINRV EKFGVDLNSK LAEELGLVSR KNEPESGNNG KFKNRNKNAN
210
NRSRVSKNRR GNRSGYRR
Length:218
Mass (Da):24,138
Last modified:February 1, 1995 - v1
Checksum:i39CB897BA9FBA94A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18813 Genomic DNA Translation: AAB64599.1
AY557779 Genomic DNA Translation: AAS56105.1
BK006939 Genomic DNA Translation: DAA07722.1
PIRiS50566
RefSeqiNP_010985.1, NM_001178954.1

Genome annotation databases

EnsemblFungiiYER063W; YER063W; YER063W
GeneIDi856792
KEGGisce:YER063W

Similar proteinsi

Entry informationi

Entry nameiTHO1_YEAST
AccessioniPrimary (citable) accession number: P40040
Secondary accession number(s): D3DLW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health