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Protein

Protein THO1

Gene

THO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Unknown; suppressor of the transcriptional defect of HPR1 by overexpression.

GO - Molecular functioni

  • chromatin binding Source: SGD
  • double-stranded DNA binding Source: SGD
  • RNA binding Source: SGD

GO - Biological processi

  • poly(A)+ mRNA export from nucleus Source: SGD
  • ribonucleoprotein complex assembly Source: SGD
  • transcription, DNA-templated Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30238-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein THO1
Gene namesi
Name:THO1
Ordered Locus Names:YER063W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER063W.
SGDiS000000865. THO1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725191 – 218Protein THO1Add BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei68PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40040.
PRIDEiP40040.

PTM databases

iPTMnetiP40040.

Interactioni

Protein-protein interaction databases

BioGridi36805. 27 interactors.
DIPiDIP-3983N.
IntActiP40040. 2 interactors.
MINTiMINT-494243.

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Helixi9 – 18Combined sources10
Helixi27 – 40Combined sources14
Helixi122 – 143Combined sources22
Helixi147 – 162Combined sources16
Helixi170 – 175Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H1JNMR-S2-50[»]
2WQGNMR-A2-50[»]
4UZWNMR-A2-50[»]
4UZXNMR-A119-183[»]
ProteinModelPortaliP40040.
SMRiP40040.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40040.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 38SAPPROSITE-ProRule annotationAdd BLAST35

Sequence similaritiesi

Contains 1 SAP domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000000840.
InParanoidiP40040.
KOiK18732.
OMAiVRVEKFG.
OrthoDBiEOG092C4VLE.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
InterProiIPR003034. SAP_dom.
[Graphical view]
PfamiPF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]
PROSITEiPS50800. SAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40040-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADYSSLTVV QLKDLLTKRN LSVGGLKNEL VQRLIKDDEE SKGESEVSPQ
60 70 80 90 100
EQNQEQGSEP AAIEEPASQN ITEKKEVSSE PKETNEPKEE NKDVQKPSDG
110 120 130 140 150
PSATASENEQ AAASTAAPAL SPEEIKAKAL DLLNKKLHRA NKFGQDQADI
160 170 180 190 200
DSLQRQINRV EKFGVDLNSK LAEELGLVSR KNEPESGNNG KFKNRNKNAN
210
NRSRVSKNRR GNRSGYRR
Length:218
Mass (Da):24,138
Last modified:February 1, 1995 - v1
Checksum:i39CB897BA9FBA94A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18813 Genomic DNA. Translation: AAB64599.1.
AY557779 Genomic DNA. Translation: AAS56105.1.
BK006939 Genomic DNA. Translation: DAA07722.1.
PIRiS50566.
RefSeqiNP_010985.1. NM_001178954.1.

Genome annotation databases

EnsemblFungiiYER063W; YER063W; YER063W.
GeneIDi856792.
KEGGisce:YER063W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18813 Genomic DNA. Translation: AAB64599.1.
AY557779 Genomic DNA. Translation: AAS56105.1.
BK006939 Genomic DNA. Translation: DAA07722.1.
PIRiS50566.
RefSeqiNP_010985.1. NM_001178954.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H1JNMR-S2-50[»]
2WQGNMR-A2-50[»]
4UZWNMR-A2-50[»]
4UZXNMR-A119-183[»]
ProteinModelPortaliP40040.
SMRiP40040.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36805. 27 interactors.
DIPiDIP-3983N.
IntActiP40040. 2 interactors.
MINTiMINT-494243.

PTM databases

iPTMnetiP40040.

Proteomic databases

MaxQBiP40040.
PRIDEiP40040.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER063W; YER063W; YER063W.
GeneIDi856792.
KEGGisce:YER063W.

Organism-specific databases

EuPathDBiFungiDB:YER063W.
SGDiS000000865. THO1.

Phylogenomic databases

HOGENOMiHOG000000840.
InParanoidiP40040.
KOiK18732.
OMAiVRVEKFG.
OrthoDBiEOG092C4VLE.

Enzyme and pathway databases

BioCyciYEAST:G3O-30238-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP40040.
PROiP40040.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
InterProiIPR003034. SAP_dom.
[Graphical view]
PfamiPF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]
PROSITEiPS50800. SAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHO1_YEAST
AccessioniPrimary (citable) accession number: P40040
Secondary accession number(s): D3DLW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6580 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.