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P40040

- THO1_YEAST

UniProt

P40040 - THO1_YEAST

Protein

Protein THO1

Gene

THO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Unknown; suppressor of the transcriptional defect of HPR1 by overexpression.

    GO - Molecular functioni

    1. chromatin binding Source: SGD
    2. double-stranded DNA binding Source: SGD
    3. RNA binding Source: SGD

    GO - Biological processi

    1. poly(A)+ mRNA export from nucleus Source: SGD
    2. ribonucleoprotein complex assembly Source: SGD
    3. transcription, DNA-templated Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30238-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein THO1
    Gene namesi
    Name:THO1
    Ordered Locus Names:YER063W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER063w.
    SGDiS000000865. THO1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 218218Protein THO1PRO_0000072519Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei22 – 221Phosphoserine1 Publication
    Modified residuei58 – 581Phosphoserine1 Publication
    Modified residuei68 – 681Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP40040.
    PaxDbiP40040.
    PeptideAtlasiP40040.

    Expressioni

    Gene expression databases

    GenevestigatoriP40040.

    Interactioni

    Protein-protein interaction databases

    BioGridi36805. 26 interactions.
    DIPiDIP-3983N.
    IntActiP40040. 2 interactions.
    MINTiMINT-494243.
    STRINGi4932.YER063W.

    Structurei

    Secondary structure

    1
    218
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 63
    Helixi9 – 1810
    Helixi27 – 4014

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1H1JNMR-S2-50[»]
    2WQGNMR-A2-50[»]
    ProteinModelPortaliP40040.
    SMRiP40040. Positions 2-43.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP40040.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 3835SAPPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SAP domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG48052.
    HOGENOMiHOG000000840.
    OMAiVRVEKFG.
    OrthoDBiEOG76HQD6.

    Family and domain databases

    Gene3Di1.10.720.30. 1 hit.
    InterProiIPR003034. SAP_dom.
    [Graphical view]
    PfamiPF02037. SAP. 1 hit.
    [Graphical view]
    SMARTiSM00513. SAP. 1 hit.
    [Graphical view]
    PROSITEiPS50800. SAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40040-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADYSSLTVV QLKDLLTKRN LSVGGLKNEL VQRLIKDDEE SKGESEVSPQ    50
    EQNQEQGSEP AAIEEPASQN ITEKKEVSSE PKETNEPKEE NKDVQKPSDG 100
    PSATASENEQ AAASTAAPAL SPEEIKAKAL DLLNKKLHRA NKFGQDQADI 150
    DSLQRQINRV EKFGVDLNSK LAEELGLVSR KNEPESGNNG KFKNRNKNAN 200
    NRSRVSKNRR GNRSGYRR 218
    Length:218
    Mass (Da):24,138
    Last modified:February 1, 1995 - v1
    Checksum:i39CB897BA9FBA94A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18813 Genomic DNA. Translation: AAB64599.1.
    AY557779 Genomic DNA. Translation: AAS56105.1.
    BK006939 Genomic DNA. Translation: DAA07722.1.
    PIRiS50566.
    RefSeqiNP_010985.1. NM_001178954.1.

    Genome annotation databases

    EnsemblFungiiYER063W; YER063W; YER063W.
    GeneIDi856792.
    KEGGisce:YER063W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18813 Genomic DNA. Translation: AAB64599.1 .
    AY557779 Genomic DNA. Translation: AAS56105.1 .
    BK006939 Genomic DNA. Translation: DAA07722.1 .
    PIRi S50566.
    RefSeqi NP_010985.1. NM_001178954.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1H1J NMR - S 2-50 [» ]
    2WQG NMR - A 2-50 [» ]
    ProteinModelPortali P40040.
    SMRi P40040. Positions 2-43.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36805. 26 interactions.
    DIPi DIP-3983N.
    IntActi P40040. 2 interactions.
    MINTi MINT-494243.
    STRINGi 4932.YER063W.

    Proteomic databases

    MaxQBi P40040.
    PaxDbi P40040.
    PeptideAtlasi P40040.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER063W ; YER063W ; YER063W .
    GeneIDi 856792.
    KEGGi sce:YER063W.

    Organism-specific databases

    CYGDi YER063w.
    SGDi S000000865. THO1.

    Phylogenomic databases

    eggNOGi NOG48052.
    HOGENOMi HOG000000840.
    OMAi VRVEKFG.
    OrthoDBi EOG76HQD6.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30238-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P40040.
    NextBioi 983024.
    PROi P40040.

    Gene expression databases

    Genevestigatori P40040.

    Family and domain databases

    Gene3Di 1.10.720.30. 1 hit.
    InterProi IPR003034. SAP_dom.
    [Graphical view ]
    Pfami PF02037. SAP. 1 hit.
    [Graphical view ]
    SMARTi SM00513. SAP. 1 hit.
    [Graphical view ]
    PROSITEi PS50800. SAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination."
      Piruat J.I., Aguilera A.
      EMBO J. 17:4859-4872(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58 AND SER-68, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTHO1_YEAST
    AccessioniPrimary (citable) accession number: P40040
    Secondary accession number(s): D3DLW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 6580 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3