Protein THO1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P40040 (THO1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein THO1

Gene names

Name:	THO1
Ordered Locus Names:	YER063W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Unknown; suppressor of the transcriptional defect of HPR1 by overexpression.
Miscellaneous	Present with 6580 molecules/cell in log phase SD medium.
Sequence similarities	Contains 1 SAP domain.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	poly(A)+ mRNA export from nucleus Inferred from genetic interaction PubMed 16738307. Source: SGD ribonucleoprotein complex assembly Inferred from mutant phenotype PubMed 16738307. Source: SGD transcription, DNA-dependent Inferred from genetic interaction Ref.4. Source: SGD
Cellular_component	nucleus Inferred from direct assay PubMed 14562095. Source: SGD
Molecular_function	RNA binding Inferred from direct assay PubMed 16738307. Source: SGD chromatin binding Inferred from direct assay PubMed 16738307. Source: SGD double-stranded DNA binding Inferred from direct assay PubMed 16738307. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 218

218

Protein THO1

PRO_0000072519

Regions

Domain

4 – 38

SAP

Amino acid modifications

Modified residue

Phosphoserine Ref.6

Modified residue

102

Phosphoserine Ref.6

Secondary structure

218

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P40040 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 39CB897BA9FBA94A
Show »

FASTA

218

24,138

        10         20         30         40         50         60 
MADYSSLTVV QLKDLLTKRN LSVGGLKNEL VQRLIKDDEE SKGESEVSPQ EQNQEQGSEP 

        70         80         90        100        110        120 
AAIEEPASQN ITEKKEVSSE PKETNEPKEE NKDVQKPSDG PSATASENEQ AAASTAAPAL 

       130        140        150        160        170        180 
SPEEIKAKAL DLLNKKLHRA NKFGQDQADI DSLQRQINRV EKFGVDLNSK LAEELGLVSR 

       190        200        210 
KNEPESGNNG KFKNRNKNAN NRSRVSKNRR GNRSGYRR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. Davis R.W. Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination." Piruat J.I., Aguilera A. EMBO J. 17:4859-4872(1998) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-102, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U18813 Genomic DNA. Translation: AAB64599.1.
AY557779 Genomic DNA. Translation: AAS56105.1.
BK006939 Genomic DNA. Translation: DAA07722.1.

PIR

S50566.

RefSeq

NP_010985.1. NM_001178954.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1H1J	NMR	-	S	2-50	[»]
2WQG	NMR	-	A	2-50	[»]

ProteinModelPortal

P40040.

SMR

P40040. Positions 2-43.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-3983N.

IntAct

P40040. 2 interactions.

MINT

MINT-494243.

STRING

4932.YER063W.

Proteomic databases

PaxDb

P40040.

PeptideAtlas

P40040.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YER063W; YER063W; YER063W.

GeneID

856792.

KEGG

sce:YER063W.

Organism-specific databases

CYGD

YER063w.

SGD

S000000865. THO1.

Phylogenomic databases

eggNOG

NOG48052.

HOGENOM

HOG000000840.

OMA

NRVEKFG.

OrthoDB

EOG4RNFK1.

Enzyme and pathway databases

BioCyc

YEAST:G3O-30238-MONOMER.

Gene expression databases

Genevestigator

P40040.

GermOnline

YER063W. Saccharomyces cerevisiae.

Family and domain databases

Gene3D

1.10.720.30. 1 hit.

InterPro

IPR003034. SAP_dom.
[Graphical view]

Pfam

PF02037. SAP. 1 hit.
[Graphical view]

SMART

SM00513. SAP. 1 hit.
[Graphical view]

PROSITE

PS50800. SAP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P40040.

NextBio

983024.

Entry information

Entry name

THO1_YEAST

Accession

Primary (citable) accession number: P40040
Secondary accession number(s): D3DLW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 29, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents