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Protein

Purine-cytosine permease FCY21

Gene

FCY21

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable purine-cytosine permease.By similarity

GO - Molecular functioni

  • nucleobase transmembrane transporter activity Source: SGD

GO - Biological processi

  • cytosine transport Source: SGD
  • purine-containing compound transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30237-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine-cytosine permease FCY21
Short name:
PCP FCY21
Alternative name(s):
Cytosine/purine transport protein FCY21
Fluorocytosine resistance protein 21
Gene namesi
Name:FCY21
Synonyms:FCYY
Ordered Locus Names:YER060W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER060W.
SGDiS000000862. FCY21.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 90CytoplasmicSequence analysisAdd BLAST90
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 118ExtracellularSequence analysis7
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 161CytoplasmicSequence analysisAdd BLAST22
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 198ExtracellularSequence analysisAdd BLAST16
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 221CytoplasmicSequence analysis2
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 260ExtracellularSequence analysisAdd BLAST18
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Topological domaini282 – 295CytoplasmicSequence analysisAdd BLAST14
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 340ExtracellularSequence analysisAdd BLAST24
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Topological domaini362 – 393CytoplasmicSequence analysisAdd BLAST32
Transmembranei394 – 414HelicalSequence analysisAdd BLAST21
Topological domaini415 – 416ExtracellularSequence analysis2
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Topological domaini438 – 460CytoplasmicSequence analysisAdd BLAST23
Transmembranei461 – 481HelicalSequence analysisAdd BLAST21
Topological domaini482 – 493ExtracellularSequence analysisAdd BLAST12
Transmembranei494 – 514HelicalSequence analysisAdd BLAST21
Topological domaini515 – 528CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001979211 – 528Purine-cytosine permease FCY21Add BLAST528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineCombined sources1
Modified residuei46PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP40039.

PTM databases

iPTMnetiP40039.

Interactioni

Protein-protein interaction databases

BioGridi36801. 26 interactors.
MINTiMINT-2781903.

Structurei

3D structure databases

ProteinModelPortaliP40039.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000004423.
HOGENOMiHOG000162981.
InParanoidiP40039.
OMAiACYYFST.
OrthoDBiEOG092C1MEG.

Family and domain databases

InterProiIPR012681. NCS1.
IPR001248. Pur-cyt_permease.
IPR026030. Pur-cyt_permease_Fcy2/21/22.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
PIRSFiPIRSF002744. Pur-cyt_permease. 1 hit.
TIGRFAMsiTIGR00800. ncs1. 1 hit.

Sequencei

Sequence statusi: Complete.

P40039-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQTHEMSLN GTQYLKYELK DLESRAHDAK TPSTNEFYDD VESHGTEELV
60 70 80 90 100
EAKLSFLNRI AAGLSAETKG IEPITEDEKT DDSILNAASM WFSANMVLPA
110 120 130 140 150
YAIGALGPMV FDLNFGQSVF VIIFFNLLGL VSVAFFSVFG AELGLRQMIL
160 170 180 190 200
SRYLVGNIAA RIFSFINFIA CIGWGIVNTV ASSQVLNMVN PGHQCPLWAG
210 220 230 240 250
CIVIIGATVI VTFFGYGVIH AYEKWAWVPN FAVFLVIIAR LARSKKFVLG
260 270 280 290 300
EWTSGPTTAG NVLSFGSTVY GFAAGWTTYA ADYTVYMPRK TNKYKIFFSL
310 320 330 340 350
VVGLATPLYF TMILGAAVAM AAIGDPAWKT YYDENSIGGL TFAVLVPNSV
360 370 380 390 400
HGFGQFCCVL LSLSTIANNV PNMYTIALSV QATWEPLAKV PRVIWTLLGN
410 420 430 440 450
AAALGIAIPA CYYFSTFMNY FMDSIGYYLA IYIAIACSEH FIYRRSFSAY
460 470 480 490 500
NVDDWDSWER LPIGIAGTAA LIVGAFGVAL GMCQTYWVGE ISRLIGDYGG
510 520
DIGFELGLSW AFIVYNIARP FELKYFGR
Length:528
Mass (Da):58,050
Last modified:October 1, 1996 - v2
Checksum:i1FD333C54E81D8CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97346 Genomic DNA. Translation: CAA66032.1.
U18813 Genomic DNA. Translation: AAB64596.1.
BK006939 Genomic DNA. Translation: DAA07718.1.
PIRiS50563.
RefSeqiNP_010981.3. NM_001178951.3.

Genome annotation databases

EnsemblFungiiYER060W; YER060W; YER060W.
GeneIDi856788.
KEGGisce:YER060W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97346 Genomic DNA. Translation: CAA66032.1.
U18813 Genomic DNA. Translation: AAB64596.1.
BK006939 Genomic DNA. Translation: DAA07718.1.
PIRiS50563.
RefSeqiNP_010981.3. NM_001178951.3.

3D structure databases

ProteinModelPortaliP40039.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36801. 26 interactors.
MINTiMINT-2781903.

PTM databases

iPTMnetiP40039.

Proteomic databases

PRIDEiP40039.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER060W; YER060W; YER060W.
GeneIDi856788.
KEGGisce:YER060W.

Organism-specific databases

EuPathDBiFungiDB:YER060W.
SGDiS000000862. FCY21.

Phylogenomic databases

GeneTreeiENSGT00390000004423.
HOGENOMiHOG000162981.
InParanoidiP40039.
OMAiACYYFST.
OrthoDBiEOG092C1MEG.

Enzyme and pathway databases

BioCyciYEAST:G3O-30237-MONOMER.

Miscellaneous databases

PROiP40039.

Family and domain databases

InterProiIPR012681. NCS1.
IPR001248. Pur-cyt_permease.
IPR026030. Pur-cyt_permease_Fcy2/21/22.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
PIRSFiPIRSF002744. Pur-cyt_permease. 1 hit.
TIGRFAMsiTIGR00800. ncs1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFCY21_YEAST
AccessioniPrimary (citable) accession number: P40039
Secondary accession number(s): D3DLW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.