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P40039 (FCY21_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Purine-cytosine permease FCY21

Short name=PCP FCY21
Alternative name(s):
Cytosine/purine transport protein FCY21
Fluorocytosine resistance protein 21
Gene names
Name:FCY21
Synonyms:FCYY
Ordered Locus Names:YER060W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable purine-cytosine permease By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the purine-cytosine permease family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 528528Purine-cytosine permease FCY21
PRO_0000197921

Regions

Topological domain1 – 9090Cytoplasmic Potential
Transmembrane91 – 11121Helical; Potential
Topological domain112 – 1187Extracellular Potential
Transmembrane119 – 13921Helical; Potential
Topological domain140 – 16122Cytoplasmic Potential
Transmembrane162 – 18221Helical; Potential
Topological domain183 – 19816Extracellular Potential
Transmembrane199 – 21921Helical; Potential
Topological domain220 – 2212Cytoplasmic Potential
Transmembrane222 – 24221Helical; Potential
Topological domain243 – 26018Extracellular Potential
Transmembrane261 – 28121Helical; Potential
Topological domain282 – 29514Cytoplasmic Potential
Transmembrane296 – 31621Helical; Potential
Topological domain317 – 34024Extracellular Potential
Transmembrane341 – 36121Helical; Potential
Topological domain362 – 39332Cytoplasmic Potential
Transmembrane394 – 41421Helical; Potential
Topological domain415 – 4162Extracellular Potential
Transmembrane417 – 43721Helical; Potential
Topological domain438 – 46023Cytoplasmic Potential
Transmembrane461 – 48121Helical; Potential
Topological domain482 – 49312Extracellular Potential
Transmembrane494 – 51421Helical; Potential
Topological domain515 – 52814Cytoplasmic Potential

Amino acid modifications

Modified residue431Phosphoserine Ref.5
Modified residue461Phosphothreonine Ref.5

Sequences

Sequence LengthMass (Da)Tools
P40039 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 1FD333C54E81D8CA

FASTA52858,050
        10         20         30         40         50         60 
MPQTHEMSLN GTQYLKYELK DLESRAHDAK TPSTNEFYDD VESHGTEELV EAKLSFLNRI 

        70         80         90        100        110        120 
AAGLSAETKG IEPITEDEKT DDSILNAASM WFSANMVLPA YAIGALGPMV FDLNFGQSVF 

       130        140        150        160        170        180 
VIIFFNLLGL VSVAFFSVFG AELGLRQMIL SRYLVGNIAA RIFSFINFIA CIGWGIVNTV 

       190        200        210        220        230        240 
ASSQVLNMVN PGHQCPLWAG CIVIIGATVI VTFFGYGVIH AYEKWAWVPN FAVFLVIIAR 

       250        260        270        280        290        300 
LARSKKFVLG EWTSGPTTAG NVLSFGSTVY GFAAGWTTYA ADYTVYMPRK TNKYKIFFSL 

       310        320        330        340        350        360 
VVGLATPLYF TMILGAAVAM AAIGDPAWKT YYDENSIGGL TFAVLVPNSV HGFGQFCCVL 

       370        380        390        400        410        420 
LSLSTIANNV PNMYTIALSV QATWEPLAKV PRVIWTLLGN AAALGIAIPA CYYFSTFMNY 

       430        440        450        460        470        480 
FMDSIGYYLA IYIAIACSEH FIYRRSFSAY NVDDWDSWER LPIGIAGTAA LIVGAFGVAL 

       490        500        510        520 
GMCQTYWVGE ISRLIGDYGG DIGFELGLSW AFIVYNIARP FELKYFGR 

« Hide

References

« Hide 'large scale' references
[1]Straub M.L., Souciet J.-L., Potier S., de Montigny J.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 28383 / FL100 / VTT C-80102.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[5]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43 AND THR-46, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X97346 Genomic DNA. Translation: CAA66032.1.
U18813 Genomic DNA. Translation: AAB64596.1.
BK006939 Genomic DNA. Translation: DAA07718.1.
PIRS50563.
RefSeqNP_010981.3. NM_001178951.3.

3D structure databases

ProteinModelPortalP40039.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36801. 27 interactions.
MINTMINT-2781903.
STRING4932.YER060W.

Proteomic databases

PaxDbP40039.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER060W; YER060W; YER060W.
GeneID856788.
KEGGsce:YER060W.

Organism-specific databases

CYGDYER060w.
SGDS000000862. FCY21.

Phylogenomic databases

eggNOGCOG1457.
GeneTreeENSGT00390000004423.
HOGENOMHOG000162981.
OMAACYYFST.
OrthoDBEOG75QRD0.

Enzyme and pathway databases

BioCycYEAST:G3O-30237-MONOMER.

Gene expression databases

GenevestigatorP40039.

Family and domain databases

InterProIPR001248. Cyt_pur_permease.
IPR012681. NCS1.
IPR026030. Pur-cyt_permease.
[Graphical view]
PfamPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
PIRSFPIRSF002744. Pur-cyt_permease. 1 hit.
TIGRFAMsTIGR00800. ncs1. 1 hit.
ProtoNetSearch...

Other

NextBio983012.

Entry information

Entry nameFCY21_YEAST
AccessionPrimary (citable) accession number: P40039
Secondary accession number(s): D3DLW4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families