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P40039

- FCY21_YEAST

UniProt

P40039 - FCY21_YEAST

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Protein

Purine-cytosine permease FCY21

Gene

FCY21

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probable purine-cytosine permease.By similarity

GO - Molecular functioni

  1. nucleobase transmembrane transporter activity Source: SGD

GO - Biological processi

  1. cytosine transport Source: SGD
  2. purine-containing compound transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30237-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine-cytosine permease FCY21
Short name:
PCP FCY21
Alternative name(s):
Cytosine/purine transport protein FCY21
Fluorocytosine resistance protein 21
Gene namesi
Name:FCY21
Synonyms:FCYY
Ordered Locus Names:YER060W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER060w.
SGDiS000000862. FCY21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9090CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence AnalysisAdd
BLAST
Topological domaini112 – 1187ExtracellularSequence Analysis
Transmembranei119 – 13921HelicalSequence AnalysisAdd
BLAST
Topological domaini140 – 16122CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Topological domaini183 – 19816ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence AnalysisAdd
BLAST
Topological domaini220 – 2212CytoplasmicSequence Analysis
Transmembranei222 – 24221HelicalSequence AnalysisAdd
BLAST
Topological domaini243 – 26018ExtracellularSequence AnalysisAdd
BLAST
Transmembranei261 – 28121HelicalSequence AnalysisAdd
BLAST
Topological domaini282 – 29514CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei296 – 31621HelicalSequence AnalysisAdd
BLAST
Topological domaini317 – 34024ExtracellularSequence AnalysisAdd
BLAST
Transmembranei341 – 36121HelicalSequence AnalysisAdd
BLAST
Topological domaini362 – 39332CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei394 – 41421HelicalSequence AnalysisAdd
BLAST
Topological domaini415 – 4162ExtracellularSequence Analysis
Transmembranei417 – 43721HelicalSequence AnalysisAdd
BLAST
Topological domaini438 – 46023CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei461 – 48121HelicalSequence AnalysisAdd
BLAST
Topological domaini482 – 49312ExtracellularSequence AnalysisAdd
BLAST
Transmembranei494 – 51421HelicalSequence AnalysisAdd
BLAST
Topological domaini515 – 52814CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Purine-cytosine permease FCY21PRO_0000197921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431Phosphoserine1 Publication
Modified residuei46 – 461Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP40039.

Expressioni

Gene expression databases

GenevestigatoriP40039.

Interactioni

Protein-protein interaction databases

BioGridi36801. 27 interactions.
MINTiMINT-2781903.
STRINGi4932.YER060W.

Structurei

3D structure databases

ProteinModelPortaliP40039.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine-cytosine permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1457.
GeneTreeiENSGT00390000004423.
HOGENOMiHOG000162981.
InParanoidiP40039.
OMAiACYYFST.
OrthoDBiEOG75QRD0.

Family and domain databases

InterProiIPR001248. Cyt_pur_permease.
IPR012681. NCS1.
IPR026030. Pur-cyt_permease.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
PIRSFiPIRSF002744. Pur-cyt_permease. 1 hit.
TIGRFAMsiTIGR00800. ncs1. 1 hit.

Sequencei

Sequence statusi: Complete.

P40039-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPQTHEMSLN GTQYLKYELK DLESRAHDAK TPSTNEFYDD VESHGTEELV
60 70 80 90 100
EAKLSFLNRI AAGLSAETKG IEPITEDEKT DDSILNAASM WFSANMVLPA
110 120 130 140 150
YAIGALGPMV FDLNFGQSVF VIIFFNLLGL VSVAFFSVFG AELGLRQMIL
160 170 180 190 200
SRYLVGNIAA RIFSFINFIA CIGWGIVNTV ASSQVLNMVN PGHQCPLWAG
210 220 230 240 250
CIVIIGATVI VTFFGYGVIH AYEKWAWVPN FAVFLVIIAR LARSKKFVLG
260 270 280 290 300
EWTSGPTTAG NVLSFGSTVY GFAAGWTTYA ADYTVYMPRK TNKYKIFFSL
310 320 330 340 350
VVGLATPLYF TMILGAAVAM AAIGDPAWKT YYDENSIGGL TFAVLVPNSV
360 370 380 390 400
HGFGQFCCVL LSLSTIANNV PNMYTIALSV QATWEPLAKV PRVIWTLLGN
410 420 430 440 450
AAALGIAIPA CYYFSTFMNY FMDSIGYYLA IYIAIACSEH FIYRRSFSAY
460 470 480 490 500
NVDDWDSWER LPIGIAGTAA LIVGAFGVAL GMCQTYWVGE ISRLIGDYGG
510 520
DIGFELGLSW AFIVYNIARP FELKYFGR
Length:528
Mass (Da):58,050
Last modified:October 1, 1996 - v2
Checksum:i1FD333C54E81D8CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97346 Genomic DNA. Translation: CAA66032.1.
U18813 Genomic DNA. Translation: AAB64596.1.
BK006939 Genomic DNA. Translation: DAA07718.1.
PIRiS50563.
RefSeqiNP_010981.3. NM_001178951.3.

Genome annotation databases

EnsemblFungiiYER060W; YER060W; YER060W.
GeneIDi856788.
KEGGisce:YER060W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97346 Genomic DNA. Translation: CAA66032.1 .
U18813 Genomic DNA. Translation: AAB64596.1 .
BK006939 Genomic DNA. Translation: DAA07718.1 .
PIRi S50563.
RefSeqi NP_010981.3. NM_001178951.3.

3D structure databases

ProteinModelPortali P40039.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36801. 27 interactions.
MINTi MINT-2781903.
STRINGi 4932.YER060W.

Proteomic databases

PaxDbi P40039.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER060W ; YER060W ; YER060W .
GeneIDi 856788.
KEGGi sce:YER060W.

Organism-specific databases

CYGDi YER060w.
SGDi S000000862. FCY21.

Phylogenomic databases

eggNOGi COG1457.
GeneTreei ENSGT00390000004423.
HOGENOMi HOG000162981.
InParanoidi P40039.
OMAi ACYYFST.
OrthoDBi EOG75QRD0.

Enzyme and pathway databases

BioCyci YEAST:G3O-30237-MONOMER.

Miscellaneous databases

NextBioi 983012.

Gene expression databases

Genevestigatori P40039.

Family and domain databases

InterProi IPR001248. Cyt_pur_permease.
IPR012681. NCS1.
IPR026030. Pur-cyt_permease.
[Graphical view ]
Pfami PF02133. Transp_cyt_pur. 1 hit.
[Graphical view ]
PIRSFi PIRSF002744. Pur-cyt_permease. 1 hit.
TIGRFAMsi TIGR00800. ncs1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Straub M.L., Souciet J.-L., Potier S., de Montigny J.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 28383 / FL100 / VTT C-80102.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  5. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43 AND THR-46, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFCY21_YEAST
AccessioniPrimary (citable) accession number: P40039
Secondary accession number(s): D3DLW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3