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P40039

- FCY21_YEAST

UniProt

P40039 - FCY21_YEAST

Protein

Purine-cytosine permease FCY21

Gene

FCY21

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Probable purine-cytosine permease.By similarity

    GO - Molecular functioni

    1. nucleobase transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. cytosine transport Source: SGD
    2. purine-containing compound transmembrane transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30237-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Purine-cytosine permease FCY21
    Short name:
    PCP FCY21
    Alternative name(s):
    Cytosine/purine transport protein FCY21
    Fluorocytosine resistance protein 21
    Gene namesi
    Name:FCY21
    Synonyms:FCYY
    Ordered Locus Names:YER060W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER060w.
    SGDiS000000862. FCY21.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 528528Purine-cytosine permease FCY21PRO_0000197921Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei43 – 431Phosphoserine1 Publication
    Modified residuei46 – 461Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP40039.

    Expressioni

    Gene expression databases

    GenevestigatoriP40039.

    Interactioni

    Protein-protein interaction databases

    BioGridi36801. 27 interactions.
    MINTiMINT-2781903.
    STRINGi4932.YER060W.

    Structurei

    3D structure databases

    ProteinModelPortaliP40039.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9090CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini112 – 1187ExtracellularSequence Analysis
    Topological domaini140 – 16122CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini183 – 19816ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 2212CytoplasmicSequence Analysis
    Topological domaini243 – 26018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini282 – 29514CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini317 – 34024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini362 – 39332CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini415 – 4162ExtracellularSequence Analysis
    Topological domaini438 – 46023CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini482 – 49312ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini515 – 52814CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei91 – 11121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei119 – 13921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei261 – 28121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei296 – 31621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei341 – 36121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei394 – 41421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei417 – 43721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei461 – 48121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei494 – 51421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the purine-cytosine permease family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1457.
    GeneTreeiENSGT00390000004423.
    HOGENOMiHOG000162981.
    OMAiACYYFST.
    OrthoDBiEOG75QRD0.

    Family and domain databases

    InterProiIPR001248. Cyt_pur_permease.
    IPR012681. NCS1.
    IPR026030. Pur-cyt_permease.
    [Graphical view]
    PfamiPF02133. Transp_cyt_pur. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002744. Pur-cyt_permease. 1 hit.
    TIGRFAMsiTIGR00800. ncs1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P40039-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPQTHEMSLN GTQYLKYELK DLESRAHDAK TPSTNEFYDD VESHGTEELV    50
    EAKLSFLNRI AAGLSAETKG IEPITEDEKT DDSILNAASM WFSANMVLPA 100
    YAIGALGPMV FDLNFGQSVF VIIFFNLLGL VSVAFFSVFG AELGLRQMIL 150
    SRYLVGNIAA RIFSFINFIA CIGWGIVNTV ASSQVLNMVN PGHQCPLWAG 200
    CIVIIGATVI VTFFGYGVIH AYEKWAWVPN FAVFLVIIAR LARSKKFVLG 250
    EWTSGPTTAG NVLSFGSTVY GFAAGWTTYA ADYTVYMPRK TNKYKIFFSL 300
    VVGLATPLYF TMILGAAVAM AAIGDPAWKT YYDENSIGGL TFAVLVPNSV 350
    HGFGQFCCVL LSLSTIANNV PNMYTIALSV QATWEPLAKV PRVIWTLLGN 400
    AAALGIAIPA CYYFSTFMNY FMDSIGYYLA IYIAIACSEH FIYRRSFSAY 450
    NVDDWDSWER LPIGIAGTAA LIVGAFGVAL GMCQTYWVGE ISRLIGDYGG 500
    DIGFELGLSW AFIVYNIARP FELKYFGR 528
    Length:528
    Mass (Da):58,050
    Last modified:October 1, 1996 - v2
    Checksum:i1FD333C54E81D8CA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97346 Genomic DNA. Translation: CAA66032.1.
    U18813 Genomic DNA. Translation: AAB64596.1.
    BK006939 Genomic DNA. Translation: DAA07718.1.
    PIRiS50563.
    RefSeqiNP_010981.3. NM_001178951.3.

    Genome annotation databases

    EnsemblFungiiYER060W; YER060W; YER060W.
    GeneIDi856788.
    KEGGisce:YER060W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97346 Genomic DNA. Translation: CAA66032.1 .
    U18813 Genomic DNA. Translation: AAB64596.1 .
    BK006939 Genomic DNA. Translation: DAA07718.1 .
    PIRi S50563.
    RefSeqi NP_010981.3. NM_001178951.3.

    3D structure databases

    ProteinModelPortali P40039.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36801. 27 interactions.
    MINTi MINT-2781903.
    STRINGi 4932.YER060W.

    Proteomic databases

    PaxDbi P40039.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER060W ; YER060W ; YER060W .
    GeneIDi 856788.
    KEGGi sce:YER060W.

    Organism-specific databases

    CYGDi YER060w.
    SGDi S000000862. FCY21.

    Phylogenomic databases

    eggNOGi COG1457.
    GeneTreei ENSGT00390000004423.
    HOGENOMi HOG000162981.
    OMAi ACYYFST.
    OrthoDBi EOG75QRD0.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30237-MONOMER.

    Miscellaneous databases

    NextBioi 983012.

    Gene expression databases

    Genevestigatori P40039.

    Family and domain databases

    InterProi IPR001248. Cyt_pur_permease.
    IPR012681. NCS1.
    IPR026030. Pur-cyt_permease.
    [Graphical view ]
    Pfami PF02133. Transp_cyt_pur. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002744. Pur-cyt_permease. 1 hit.
    TIGRFAMsi TIGR00800. ncs1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Straub M.L., Souciet J.-L., Potier S., de Montigny J.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 28383 / FL100 / VTT C-80102.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    5. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43 AND THR-46, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFCY21_YEAST
    AccessioniPrimary (citable) accession number: P40039
    Secondary accession number(s): D3DLW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3