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Protein

Protein HMF1

Gene

HMF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 672 molecules/cell in log phase SD medium.1 Publication

Enzyme and pathway databases

BioCyciYEAST:G3O-30234-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HMF1
Alternative name(s):
High dosage growth inhibitor
Homologous mitochondrial matrix factor 1
Gene namesi
Name:HMF1
Synonyms:HIG1
Ordered Locus Names:YER057C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER057C
SGDiS000000859 HMF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001703121 – 129Protein HMF1Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP40037
PaxDbiP40037
PRIDEiP40037
TopDownProteomicsiP40037

PTM databases

iPTMnetiP40037

Interactioni

Protein-protein interaction databases

BioGridi36798, 36 interactors
DIPiDIP-4314N
IntActiP40037, 6 interactors
MINTiP40037
STRINGi4932.YER057C

Structurei

Secondary structure

1129
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 8Combined sources4
Beta strandi17 – 19Combined sources3
Beta strandi22 – 26Combined sources5
Beta strandi29 – 35Combined sources7
Helixi49 – 66Combined sources18
Helixi71 – 73Combined sources3
Beta strandi74 – 82Combined sources9
Helixi84 – 86Combined sources3
Helixi87 – 97Combined sources11
Beta strandi98 – 101Combined sources4
Beta strandi104 – 109Combined sources6
Helixi114 – 116Combined sources3
Beta strandi118 – 126Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JD1X-ray1.70A/B/C/D/E/F1-129[»]
ProteinModelPortaliP40037
SMRiP40037
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40037

Family & Domainsi

Sequence similaritiesi

Belongs to the RutC family.Curated

Phylogenomic databases

GeneTreeiENSGT00420000029792
HOGENOMiHOG000267215
InParanoidiP40037
OMAiGSYFKEP
OrthoDBiEOG092C3IOJ

Family and domain databases

Gene3Di3.30.1330.40, 1 hit
InterProiView protein in InterPro
IPR006056 RidA
IPR019897 RidA_CS
IPR035959 RutC-like_sf
IPR006175 YjgF/YER057c/UK114
PANTHERiPTHR11803 PTHR11803, 1 hit
PfamiView protein in Pfam
PF01042 Ribonuc_L-PSP, 1 hit
SUPFAMiSSF55298 SSF55298, 1 hit
TIGRFAMsiTIGR00004 TIGR00004, 1 hit
PROSITEiView protein in PROSITE
PS01094 UPF0076, 1 hit

Sequencei

Sequence statusi: Complete.

P40037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTTLTPVIC ESAPAAAASY SHAMKVNNLI FLSGQIPVTP DNKLVEGSIA
60 70 80 90 100
DKAEQVIQNI KNVLEASNSS LDRVVKVNIF LADINHFAEF NSVYAKYFNT
110 120
HKPARSCVAV AALPLGVDME MEAIAAERD
Length:129
Mass (Da):13,906
Last modified:February 1, 1995 - v1
Checksum:iD1D252BBA47F81E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050475 Genomic DNA Translation: BAB20815.1
U18813 Genomic DNA Translation: AAB64593.1
AY558456 Genomic DNA Translation: AAS56782.1
BK006939 Genomic DNA Translation: DAA07715.1
PIRiS50560
RefSeqiNP_010978.3, NM_001178948.3

Genome annotation databases

EnsemblFungiiYER057C; YER057C; YER057C
GeneIDi856785
KEGGisce:YER057C

Similar proteinsi

Entry informationi

Entry nameiHMF1_YEAST
AccessioniPrimary (citable) accession number: P40037
Secondary accession number(s): D3DLW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health