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Protein

Protein HMF1

Gene

HMF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. deaminase activity Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30234-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HMF1
Alternative name(s):
High dosage growth inhibitor
Homologous mitochondrial matrix factor 1
Gene namesi
Name:HMF1
Synonyms:HIG1
Ordered Locus Names:YER057C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER057c.
SGDiS000000859. HMF1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. cytosol Source: SGD
  3. mitochondrial intermembrane space Source: SGD
  4. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 129129Protein HMF1PRO_0000170312Add
BLAST

Proteomic databases

MaxQBiP40037.
PaxDbiP40037.
PeptideAtlasiP40037.

Expressioni

Gene expression databases

GenevestigatoriP40037.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RPA34P470061EBI-8389,EBI-26109
YPR097WQ068391EBI-8389,EBI-33913

Protein-protein interaction databases

BioGridi36798. 8 interactions.
DIPiDIP-4314N.
IntActiP40037. 1 interaction.
MINTiMINT-555220.
STRINGi4932.YER057C.

Structurei

Secondary structure

1
129
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 84Combined sources
Beta strandi17 – 193Combined sources
Beta strandi22 – 265Combined sources
Beta strandi29 – 357Combined sources
Helixi49 – 6618Combined sources
Helixi71 – 733Combined sources
Beta strandi74 – 829Combined sources
Helixi84 – 863Combined sources
Helixi87 – 9711Combined sources
Beta strandi98 – 1014Combined sources
Beta strandi104 – 1096Combined sources
Helixi114 – 1163Combined sources
Beta strandi118 – 1269Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JD1X-ray1.70A/B/C/D/E/F1-129[»]
ProteinModelPortaliP40037.
SMRiP40037. Positions 3-128.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40037.

Family & Domainsi

Sequence similaritiesi

Belongs to the RutC family.Curated

Phylogenomic databases

eggNOGiCOG0251.
GeneTreeiENSGT00420000029792.
HOGENOMiHOG000267215.
InParanoidiP40037.
OMAiEIMVEIE.
OrthoDBiEOG7N640Z.

Family and domain databases

Gene3Di3.30.1330.40. 1 hit.
InterProiIPR013813. Endoribo_LPSP/chorism_mut-like.
IPR006056. YjgF-like.
IPR019897. YjgF-like_CS.
IPR006175. YjgF/Yer057p/UK114.
[Graphical view]
PANTHERiPTHR11803. PTHR11803. 1 hit.
PfamiPF01042. Ribonuc_L-PSP. 1 hit.
[Graphical view]
SUPFAMiSSF55298. SSF55298. 1 hit.
TIGRFAMsiTIGR00004. TIGR00004. 1 hit.
PROSITEiPS01094. UPF0076. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTTLTPVIC ESAPAAAASY SHAMKVNNLI FLSGQIPVTP DNKLVEGSIA
60 70 80 90 100
DKAEQVIQNI KNVLEASNSS LDRVVKVNIF LADINHFAEF NSVYAKYFNT
110 120
HKPARSCVAV AALPLGVDME MEAIAAERD
Length:129
Mass (Da):13,906
Last modified:February 1, 1995 - v1
Checksum:iD1D252BBA47F81E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050475 Genomic DNA. Translation: BAB20815.1.
U18813 Genomic DNA. Translation: AAB64593.1.
AY558456 Genomic DNA. Translation: AAS56782.1.
BK006939 Genomic DNA. Translation: DAA07715.1.
PIRiS50560.
RefSeqiNP_010978.3. NM_001178948.3.

Genome annotation databases

EnsemblFungiiYER057C; YER057C; YER057C.
GeneIDi856785.
KEGGisce:YER057C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050475 Genomic DNA. Translation: BAB20815.1.
U18813 Genomic DNA. Translation: AAB64593.1.
AY558456 Genomic DNA. Translation: AAS56782.1.
BK006939 Genomic DNA. Translation: DAA07715.1.
PIRiS50560.
RefSeqiNP_010978.3. NM_001178948.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JD1X-ray1.70A/B/C/D/E/F1-129[»]
ProteinModelPortaliP40037.
SMRiP40037. Positions 3-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36798. 8 interactions.
DIPiDIP-4314N.
IntActiP40037. 1 interaction.
MINTiMINT-555220.
STRINGi4932.YER057C.

Proteomic databases

MaxQBiP40037.
PaxDbiP40037.
PeptideAtlasiP40037.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER057C; YER057C; YER057C.
GeneIDi856785.
KEGGisce:YER057C.

Organism-specific databases

CYGDiYER057c.
SGDiS000000859. HMF1.

Phylogenomic databases

eggNOGiCOG0251.
GeneTreeiENSGT00420000029792.
HOGENOMiHOG000267215.
InParanoidiP40037.
OMAiEIMVEIE.
OrthoDBiEOG7N640Z.

Enzyme and pathway databases

BioCyciYEAST:G3O-30234-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP40037.
NextBioi983003.

Gene expression databases

GenevestigatoriP40037.

Family and domain databases

Gene3Di3.30.1330.40. 1 hit.
InterProiIPR013813. Endoribo_LPSP/chorism_mut-like.
IPR006056. YjgF-like.
IPR019897. YjgF-like_CS.
IPR006175. YjgF/Yer057p/UK114.
[Graphical view]
PANTHERiPTHR11803. PTHR11803. 1 hit.
PfamiPF01042. Ribonuc_L-PSP. 1 hit.
[Graphical view]
SUPFAMiSSF55298. SSF55298. 1 hit.
TIGRFAMsiTIGR00004. TIGR00004. 1 hit.
PROSITEiPS01094. UPF0076. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A member of the YER057c/yjgf/Uk114 family links isoleucine biosynthesis and intact mitochondria maintenance in Saccharomyces cerevisiae."
    Kim J.-M., Yoshikawa H., Shirahige K.
    Genes Cells 6:507-517(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Mmf1p, a novel yeast mitochondrial protein conserved throughout evolution and involved in maintenance of the mitochondrial genome."
    Oxelmark E., Marchini A., Malanchi I., Magherini F., Jaquet L., Hajibagheri M.A., Blight K.J., Jauniaux J.-C., Tommasino M.
    Mol. Cell. Biol. 20:7784-7797(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  8. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "X-ray structure of Saccharomyces cerevisiae homologous mitochondrial matrix factor 1 (Hmf1)."
    Deaconescu A.M., Roll-Mecak A., Bonanno J.B., Gerchman S.E., Kycia H., Studier F.W., Burley S.K.
    Proteins 48:431-436(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).

Entry informationi

Entry nameiHMF1_YEAST
AccessioniPrimary (citable) accession number: P40037
Secondary accession number(s): D3DLW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 7, 2015
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 672 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.