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P40037

- HMF1_YEAST

UniProt

P40037 - HMF1_YEAST

Protein

Protein HMF1

Gene

HMF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. deaminase activity Source: InterPro

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30234-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein HMF1
    Alternative name(s):
    High dosage growth inhibitor
    Homologous mitochondrial matrix factor 1
    Gene namesi
    Name:HMF1
    Synonyms:HIG1
    Ordered Locus Names:YER057C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER057c.
    SGDiS000000859. HMF1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: SGD
    2. cytosol Source: SGD
    3. mitochondrial intermembrane space Source: SGD
    4. nucleus Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 129129Protein HMF1PRO_0000170312Add
    BLAST

    Proteomic databases

    MaxQBiP40037.
    PaxDbiP40037.
    PeptideAtlasiP40037.

    Expressioni

    Gene expression databases

    GenevestigatoriP40037.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RPA34P470061EBI-8389,EBI-26109
    YPR097WQ068391EBI-8389,EBI-33913

    Protein-protein interaction databases

    BioGridi36798. 8 interactions.
    DIPiDIP-4314N.
    IntActiP40037. 1 interaction.
    MINTiMINT-555220.
    STRINGi4932.YER057C.

    Structurei

    Secondary structure

    1
    129
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 84
    Beta strandi17 – 193
    Beta strandi22 – 265
    Beta strandi29 – 357
    Helixi49 – 6618
    Helixi71 – 733
    Beta strandi74 – 829
    Helixi84 – 863
    Helixi87 – 9711
    Beta strandi98 – 1014
    Beta strandi104 – 1096
    Helixi114 – 1163
    Beta strandi118 – 1269

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JD1X-ray1.70A/B/C/D/E/F1-129[»]
    ProteinModelPortaliP40037.
    SMRiP40037. Positions 3-128.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP40037.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RutC family.Curated

    Phylogenomic databases

    eggNOGiCOG0251.
    GeneTreeiENSGT00420000029792.
    HOGENOMiHOG000267215.
    OMAiYPAIGPY.
    OrthoDBiEOG7N640Z.

    Family and domain databases

    Gene3Di3.30.1330.40. 1 hit.
    InterProiIPR013813. Endoribo_LPSP/chorism_mut-like.
    IPR006056. YjgF-like.
    IPR019897. YjgF-like_CS.
    IPR006175. YjgF/Yer057p/UK114.
    [Graphical view]
    PANTHERiPTHR11803. PTHR11803. 1 hit.
    PfamiPF01042. Ribonuc_L-PSP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55298. SSF55298. 1 hit.
    TIGRFAMsiTIGR00004. TIGR00004. 1 hit.
    PROSITEiPS01094. UPF0076. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40037-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTTLTPVIC ESAPAAAASY SHAMKVNNLI FLSGQIPVTP DNKLVEGSIA    50
    DKAEQVIQNI KNVLEASNSS LDRVVKVNIF LADINHFAEF NSVYAKYFNT 100
    HKPARSCVAV AALPLGVDME MEAIAAERD 129
    Length:129
    Mass (Da):13,906
    Last modified:February 1, 1995 - v1
    Checksum:iD1D252BBA47F81E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB050475 Genomic DNA. Translation: BAB20815.1.
    U18813 Genomic DNA. Translation: AAB64593.1.
    AY558456 Genomic DNA. Translation: AAS56782.1.
    BK006939 Genomic DNA. Translation: DAA07715.1.
    PIRiS50560.
    RefSeqiNP_010978.3. NM_001178948.3.

    Genome annotation databases

    EnsemblFungiiYER057C; YER057C; YER057C.
    GeneIDi856785.
    KEGGisce:YER057C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB050475 Genomic DNA. Translation: BAB20815.1 .
    U18813 Genomic DNA. Translation: AAB64593.1 .
    AY558456 Genomic DNA. Translation: AAS56782.1 .
    BK006939 Genomic DNA. Translation: DAA07715.1 .
    PIRi S50560.
    RefSeqi NP_010978.3. NM_001178948.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JD1 X-ray 1.70 A/B/C/D/E/F 1-129 [» ]
    ProteinModelPortali P40037.
    SMRi P40037. Positions 3-128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36798. 8 interactions.
    DIPi DIP-4314N.
    IntActi P40037. 1 interaction.
    MINTi MINT-555220.
    STRINGi 4932.YER057C.

    Proteomic databases

    MaxQBi P40037.
    PaxDbi P40037.
    PeptideAtlasi P40037.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER057C ; YER057C ; YER057C .
    GeneIDi 856785.
    KEGGi sce:YER057C.

    Organism-specific databases

    CYGDi YER057c.
    SGDi S000000859. HMF1.

    Phylogenomic databases

    eggNOGi COG0251.
    GeneTreei ENSGT00420000029792.
    HOGENOMi HOG000267215.
    OMAi YPAIGPY.
    OrthoDBi EOG7N640Z.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30234-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P40037.
    NextBioi 983003.

    Gene expression databases

    Genevestigatori P40037.

    Family and domain databases

    Gene3Di 3.30.1330.40. 1 hit.
    InterProi IPR013813. Endoribo_LPSP/chorism_mut-like.
    IPR006056. YjgF-like.
    IPR019897. YjgF-like_CS.
    IPR006175. YjgF/Yer057p/UK114.
    [Graphical view ]
    PANTHERi PTHR11803. PTHR11803. 1 hit.
    Pfami PF01042. Ribonuc_L-PSP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55298. SSF55298. 1 hit.
    TIGRFAMsi TIGR00004. TIGR00004. 1 hit.
    PROSITEi PS01094. UPF0076. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A member of the YER057c/yjgf/Uk114 family links isoleucine biosynthesis and intact mitochondria maintenance in Saccharomyces cerevisiae."
      Kim J.-M., Yoshikawa H., Shirahige K.
      Genes Cells 6:507-517(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Mmf1p, a novel yeast mitochondrial protein conserved throughout evolution and involved in maintenance of the mitochondrial genome."
      Oxelmark E., Marchini A., Malanchi I., Magherini F., Jaquet L., Hajibagheri M.A., Blight K.J., Jauniaux J.-C., Tommasino M.
      Mol. Cell. Biol. 20:7784-7797(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    8. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "X-ray structure of Saccharomyces cerevisiae homologous mitochondrial matrix factor 1 (Hmf1)."
      Deaconescu A.M., Roll-Mecak A., Bonanno J.B., Gerchman S.E., Kycia H., Studier F.W., Burley S.K.
      Proteins 48:431-436(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).

    Entry informationi

    Entry nameiHMF1_YEAST
    AccessioniPrimary (citable) accession number: P40037
    Secondary accession number(s): D3DLW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 139 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 672 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3