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Protein

Protein HMF1

Gene

HMF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-30234-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HMF1
Alternative name(s):
High dosage growth inhibitor
Homologous mitochondrial matrix factor 1
Gene namesi
Name:HMF1
Synonyms:HIG1
Ordered Locus Names:YER057C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER057C.
SGDiS000000859. HMF1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • cytosol Source: SGD
  • mitochondrial intermembrane space Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 129129Protein HMF1PRO_0000170312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki52 – 52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP40037.
TopDownProteomicsiP40037.

Interactioni

Protein-protein interaction databases

BioGridi36798. 7 interactions.
DIPiDIP-4314N.
IntActiP40037. 1 interaction.
MINTiMINT-555220.

Structurei

Secondary structure

1
129
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 84Combined sources
Beta strandi17 – 193Combined sources
Beta strandi22 – 265Combined sources
Beta strandi29 – 357Combined sources
Helixi49 – 6618Combined sources
Helixi71 – 733Combined sources
Beta strandi74 – 829Combined sources
Helixi84 – 863Combined sources
Helixi87 – 9711Combined sources
Beta strandi98 – 1014Combined sources
Beta strandi104 – 1096Combined sources
Helixi114 – 1163Combined sources
Beta strandi118 – 1269Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JD1X-ray1.70A/B/C/D/E/F1-129[»]
ProteinModelPortaliP40037.
SMRiP40037. Positions 3-128.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40037.

Family & Domainsi

Sequence similaritiesi

Belongs to the RutC family.Curated

Phylogenomic databases

GeneTreeiENSGT00420000029792.
HOGENOMiHOG000267215.
InParanoidiP40037.
OMAiKTTCYLT.
OrthoDBiEOG092C3IOJ.

Family and domain databases

Gene3Di3.30.1330.40. 1 hit.
InterProiIPR013813. Endoribo_LPSP/chorism_mut-like.
IPR006056. RidA.
IPR019897. RidA_CS.
IPR006175. YjgF/YER057c/UK114.
[Graphical view]
PANTHERiPTHR11803. PTHR11803. 1 hit.
PfamiPF01042. Ribonuc_L-PSP. 1 hit.
[Graphical view]
SUPFAMiSSF55298. SSF55298. 1 hit.
TIGRFAMsiTIGR00004. TIGR00004. 1 hit.
PROSITEiPS01094. UPF0076. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTTLTPVIC ESAPAAAASY SHAMKVNNLI FLSGQIPVTP DNKLVEGSIA
60 70 80 90 100
DKAEQVIQNI KNVLEASNSS LDRVVKVNIF LADINHFAEF NSVYAKYFNT
110 120
HKPARSCVAV AALPLGVDME MEAIAAERD
Length:129
Mass (Da):13,906
Last modified:February 1, 1995 - v1
Checksum:iD1D252BBA47F81E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050475 Genomic DNA. Translation: BAB20815.1.
U18813 Genomic DNA. Translation: AAB64593.1.
AY558456 Genomic DNA. Translation: AAS56782.1.
BK006939 Genomic DNA. Translation: DAA07715.1.
PIRiS50560.
RefSeqiNP_010978.3. NM_001178948.3.

Genome annotation databases

EnsemblFungiiYER057C; YER057C; YER057C.
GeneIDi856785.
KEGGisce:YER057C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050475 Genomic DNA. Translation: BAB20815.1.
U18813 Genomic DNA. Translation: AAB64593.1.
AY558456 Genomic DNA. Translation: AAS56782.1.
BK006939 Genomic DNA. Translation: DAA07715.1.
PIRiS50560.
RefSeqiNP_010978.3. NM_001178948.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JD1X-ray1.70A/B/C/D/E/F1-129[»]
ProteinModelPortaliP40037.
SMRiP40037. Positions 3-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36798. 7 interactions.
DIPiDIP-4314N.
IntActiP40037. 1 interaction.
MINTiMINT-555220.

Proteomic databases

MaxQBiP40037.
TopDownProteomicsiP40037.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER057C; YER057C; YER057C.
GeneIDi856785.
KEGGisce:YER057C.

Organism-specific databases

EuPathDBiFungiDB:YER057C.
SGDiS000000859. HMF1.

Phylogenomic databases

GeneTreeiENSGT00420000029792.
HOGENOMiHOG000267215.
InParanoidiP40037.
OMAiKTTCYLT.
OrthoDBiEOG092C3IOJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-30234-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP40037.
PROiP40037.

Family and domain databases

Gene3Di3.30.1330.40. 1 hit.
InterProiIPR013813. Endoribo_LPSP/chorism_mut-like.
IPR006056. RidA.
IPR019897. RidA_CS.
IPR006175. YjgF/YER057c/UK114.
[Graphical view]
PANTHERiPTHR11803. PTHR11803. 1 hit.
PfamiPF01042. Ribonuc_L-PSP. 1 hit.
[Graphical view]
SUPFAMiSSF55298. SSF55298. 1 hit.
TIGRFAMsiTIGR00004. TIGR00004. 1 hit.
PROSITEiPS01094. UPF0076. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMF1_YEAST
AccessioniPrimary (citable) accession number: P40037
Secondary accession number(s): D3DLW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 672 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.