Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P40037 (HMF1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein HMF1
Alternative name(s):
High dosage growth inhibitor
Homologous mitochondrial matrix factor 1
Gene names
Name:HMF1
Synonyms:HIG1
Ordered Locus Names:YER057C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length129 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasm. Nucleus. Mitochondrion intermembrane space Ref.1 Ref.5 Ref.7.

Miscellaneous

Present with 672 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the RutC family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RPA34P470061EBI-8389,EBI-26109
YPR097WQ068391EBI-8389,EBI-33913

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 129129Protein HMF1
PRO_0000170312

Secondary structure

........................ 129
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P40037 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: D1D252BBA47F81E8

FASTA12913,906
        10         20         30         40         50         60 
MVTTLTPVIC ESAPAAAASY SHAMKVNNLI FLSGQIPVTP DNKLVEGSIA DKAEQVIQNI 

        70         80         90        100        110        120 
KNVLEASNSS LDRVVKVNIF LADINHFAEF NSVYAKYFNT HKPARSCVAV AALPLGVDME 


MEAIAAERD 

« Hide

References

« Hide 'large scale' references
[1]"A member of the YER057c/yjgf/Uk114 family links isoleucine biosynthesis and intact mitochondria maintenance in Saccharomyces cerevisiae."
Kim J.-M., Yoshikawa H., Shirahige K.
Genes Cells 6:507-517(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Mmf1p, a novel yeast mitochondrial protein conserved throughout evolution and involved in maintenance of the mitochondrial genome."
Oxelmark E., Marchini A., Malanchi I., Magherini F., Jaquet L., Hajibagheri M.A., Blight K.J., Jauniaux J.-C., Tommasino M.
Mol. Cell. Biol. 20:7784-7797(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Intermembrane space proteome of yeast mitochondria."
Voegtle F.N., Burkhart J.M., Rao S., Gerbeth C., Hinrichs J., Martinou J.C., Chacinska A., Sickmann A., Zahedi R.P., Meisinger C.
Mol. Cell. Proteomics 11:1840-1852(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
[8]"Sites of ubiquitin attachment in Saccharomyces cerevisiae."
Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"X-ray structure of Saccharomyces cerevisiae homologous mitochondrial matrix factor 1 (Hmf1)."
Deaconescu A.M., Roll-Mecak A., Bonanno J.B., Gerchman S.E., Kycia H., Studier F.W., Burley S.K.
Proteins 48:431-436(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB050475 Genomic DNA. Translation: BAB20815.1.
U18813 Genomic DNA. Translation: AAB64593.1.
AY558456 Genomic DNA. Translation: AAS56782.1.
BK006939 Genomic DNA. Translation: DAA07715.1.
PIRS50560.
RefSeqNP_010978.3. NM_001178948.3.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1JD1X-ray1.70A/B/C/D/E/F1-129[»]
ProteinModelPortalP40037.
SMRP40037. Positions 3-128.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36798. 8 interactions.
DIPDIP-4314N.
IntActP40037. 1 interaction.
MINTMINT-555220.
STRING4932.YER057C.

Proteomic databases

MaxQBP40037.
PaxDbP40037.
PeptideAtlasP40037.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER057C; YER057C; YER057C.
GeneID856785.
KEGGsce:YER057C.

Organism-specific databases

CYGDYER057c.
SGDS000000859. HMF1.

Phylogenomic databases

eggNOGCOG0251.
GeneTreeENSGT00420000029792.
HOGENOMHOG000267215.
OMAYPAIGPY.
OrthoDBEOG7N640Z.

Enzyme and pathway databases

BioCycYEAST:G3O-30234-MONOMER.

Gene expression databases

GenevestigatorP40037.

Family and domain databases

Gene3D3.30.1330.40. 1 hit.
InterProIPR013813. Endoribo_LPSP/chorism_mut-like.
IPR006056. YjgF-like.
IPR019897. YjgF-like_CS.
IPR006175. YjgF/Yer057p/UK114.
[Graphical view]
PANTHERPTHR11803. PTHR11803. 1 hit.
PfamPF01042. Ribonuc_L-PSP. 1 hit.
[Graphical view]
SUPFAMSSF55298. SSF55298. 1 hit.
TIGRFAMsTIGR00004. TIGR00004. 1 hit.
PROSITEPS01094. UPF0076. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP40037.
NextBio983003.

Entry information

Entry nameHMF1_YEAST
AccessionPrimary (citable) accession number: P40037
Secondary accession number(s): D3DLW1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references