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P40036

- GIP2_YEAST

UniProt

P40036 - GIP2_YEAST

Protein

GLC7-interacting protein 2

Gene

GIP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein phosphatase regulator activity Source: SGD

    GO - Biological processi

    1. glycogen metabolic process Source: SGD
    2. protein dephosphorylation Source: SGD
    3. regulation of catalytic activity Source: GOC

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30232-MONOMER.

    Protein family/group databases

    CAZyiCBM21. Carbohydrate-Binding Module Family 21.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GLC7-interacting protein 2
    Gene namesi
    Name:GIP2
    Ordered Locus Names:YER054C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER054c.
    SGDiS000000856. GIP2.

    Subcellular locationi

    GO - Cellular componenti

    1. protein phosphatase type 1 complex Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 548548GLC7-interacting protein 2PRO_0000071521Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei51 – 511Phosphoserine1 Publication
    Modified residuei52 – 521Phosphothreonine1 Publication
    Modified residuei155 – 1551Phosphoserine1 Publication
    Modified residuei221 – 2211Phosphoserine2 Publications
    Modified residuei238 – 2381Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP40036.
    PaxDbiP40036.

    Expressioni

    Gene expression databases

    GenevestigatoriP40036.

    Interactioni

    Subunit structurei

    Interacts with phosphatase 1 (GLC7).1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SHO1P400732EBI-7612,EBI-18140

    Protein-protein interaction databases

    BioGridi36794. 36 interactions.
    DIPiDIP-2376N.
    IntActiP40036. 10 interactions.
    MINTiMINT-600077.
    STRINGi4932.YER054C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40036.
    SMRiP40036. Positions 437-533.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini419 – 534116CBM21PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CBM21 (carbohydrate binding type-21) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG288354.
    GeneTreeiENSGT00530000067694.
    HOGENOMiHOG000112724.
    OMAiRTTHEVE.
    OrthoDBiEOG7XWPXD.

    Family and domain databases

    InterProiIPR005036. CBM_21.
    IPR016717. Pase-1_int.
    [Graphical view]
    PfamiPF03370. CBM_21. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018234. PPase_interacting. 1 hit.
    PROSITEiPS51159. CBM21. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40036-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYIKAEQKPQ QFERKNEKLD RNKNQQLPDL ETDFKGYRVN SDLYNKERDG    50
    STEETLNSLK FLHKPQRVTQ MRANRFPEEE VQRNTDLNKR IFSAGNDENV 100
    DNESGWSKIA AAKNHTSVES LNGSTRPPFK IELPPLSPKS TVPKSFQAEY 150
    PEAKSPGNDM NFEYDEEILI PFAPPVYKKS GELLKSSLKR RSKSLPTTPG 200
    IRSGNGVQAR DGSPMLIRSK SVHFDQAAPV KYFAEDESPI NVNKTEQHDN 250
    CLSFKHKPVN LMVDPEEETK MLSSGLETTS IDDDLTTVAP KGFAHPAKIS 300
    NPNNGKGTNN TKLRKSKRFQ NLLKNRTDMP PSKSNKKFVN GGGAHEISDR 350
    NSKNYHVVGL YSKNFPILSN KNPKSLKLNI FINLSQNKKV FLQELSLYIH 400
    RDNNYFSNSS SFYNIPNSHN GNDCNGVAKG YNAGCTRLIA GRILVKNIFY 450
    DKRVVVRYTW DSWRTTHEVE CVYISDGDGI LPGTNMDIFH FIIDDVSKVD 500
    PRGKLEFCIH YSTRNDYERE EYWDNNNGNN YKVDVVMDGF NDPFAAAA 548
    Length:548
    Mass (Da):62,319
    Last modified:February 1, 1995 - v1
    Checksum:iB28EE5241989A9BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18813 Genomic DNA. Translation: AAB64590.1.
    BK006939 Genomic DNA. Translation: DAA07711.1.
    PIRiS50557.
    RefSeqiNP_010974.1. NM_001178945.1.

    Genome annotation databases

    EnsemblFungiiYER054C; YER054C; YER054C.
    GeneIDi856781.
    KEGGisce:YER054C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18813 Genomic DNA. Translation: AAB64590.1 .
    BK006939 Genomic DNA. Translation: DAA07711.1 .
    PIRi S50557.
    RefSeqi NP_010974.1. NM_001178945.1.

    3D structure databases

    ProteinModelPortali P40036.
    SMRi P40036. Positions 437-533.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36794. 36 interactions.
    DIPi DIP-2376N.
    IntActi P40036. 10 interactions.
    MINTi MINT-600077.
    STRINGi 4932.YER054C.

    Protein family/group databases

    CAZyi CBM21. Carbohydrate-Binding Module Family 21.

    Proteomic databases

    MaxQBi P40036.
    PaxDbi P40036.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER054C ; YER054C ; YER054C .
    GeneIDi 856781.
    KEGGi sce:YER054C.

    Organism-specific databases

    CYGDi YER054c.
    SGDi S000000856. GIP2.

    Phylogenomic databases

    eggNOGi NOG288354.
    GeneTreei ENSGT00530000067694.
    HOGENOMi HOG000112724.
    OMAi RTTHEVE.
    OrthoDBi EOG7XWPXD.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30232-MONOMER.

    Miscellaneous databases

    NextBioi 982991.

    Gene expression databases

    Genevestigatori P40036.

    Family and domain databases

    InterProi IPR005036. CBM_21.
    IPR016717. Pase-1_int.
    [Graphical view ]
    Pfami PF03370. CBM_21. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018234. PPase_interacting. 1 hit.
    PROSITEi PS51159. CBM21. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Tu J., Song W., Carslon R.
      Unpublished observations (MAR-1996)
      Cited for: INTERACTION WITH GLC7.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51; THR-52; SER-155 AND SER-221, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGIP2_YEAST
    AccessioniPrimary (citable) accession number: P40036
    Secondary accession number(s): D3DLV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 125 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3