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Protein

GLC7-interacting protein 2

Gene

GIP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein phosphatase regulator activity Source: SGD

GO - Biological processi

  1. glycogen metabolic process Source: SGD
  2. protein dephosphorylation Source: SGD
  3. regulation of catalytic activity Source: GOC
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30232-MONOMER.

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

Names & Taxonomyi

Protein namesi
Recommended name:
GLC7-interacting protein 2
Gene namesi
Name:GIP2
Ordered Locus Names:YER054C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER054c.
SGDiS000000856. GIP2.

Subcellular locationi

GO - Cellular componenti

  1. protein phosphatase type 1 complex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548GLC7-interacting protein 2PRO_0000071521Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511Phosphoserine1 Publication
Modified residuei52 – 521Phosphothreonine1 Publication
Modified residuei155 – 1551Phosphoserine1 Publication
Modified residuei221 – 2211Phosphoserine2 Publications
Modified residuei238 – 2381Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40036.
PaxDbiP40036.

Expressioni

Gene expression databases

GenevestigatoriP40036.

Interactioni

Subunit structurei

Interacts with phosphatase 1 (GLC7).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SHO1P400732EBI-7612,EBI-18140

Protein-protein interaction databases

BioGridi36794. 36 interactions.
DIPiDIP-2376N.
IntActiP40036. 10 interactions.
MINTiMINT-600077.
STRINGi4932.YER054C.

Structurei

3D structure databases

ProteinModelPortaliP40036.
SMRiP40036. Positions 431-533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini419 – 534116CBM21PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CBM21 (carbohydrate binding type-21) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG288354.
GeneTreeiENSGT00530000067694.
HOGENOMiHOG000112724.
InParanoidiP40036.
OMAiRTTHEVE.
OrthoDBiEOG7XWPXD.

Family and domain databases

InterProiIPR005036. CBM_21.
IPR016717. Pase-1_int.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PIRSFiPIRSF018234. PPase_interacting. 1 hit.
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40036-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYIKAEQKPQ QFERKNEKLD RNKNQQLPDL ETDFKGYRVN SDLYNKERDG
60 70 80 90 100
STEETLNSLK FLHKPQRVTQ MRANRFPEEE VQRNTDLNKR IFSAGNDENV
110 120 130 140 150
DNESGWSKIA AAKNHTSVES LNGSTRPPFK IELPPLSPKS TVPKSFQAEY
160 170 180 190 200
PEAKSPGNDM NFEYDEEILI PFAPPVYKKS GELLKSSLKR RSKSLPTTPG
210 220 230 240 250
IRSGNGVQAR DGSPMLIRSK SVHFDQAAPV KYFAEDESPI NVNKTEQHDN
260 270 280 290 300
CLSFKHKPVN LMVDPEEETK MLSSGLETTS IDDDLTTVAP KGFAHPAKIS
310 320 330 340 350
NPNNGKGTNN TKLRKSKRFQ NLLKNRTDMP PSKSNKKFVN GGGAHEISDR
360 370 380 390 400
NSKNYHVVGL YSKNFPILSN KNPKSLKLNI FINLSQNKKV FLQELSLYIH
410 420 430 440 450
RDNNYFSNSS SFYNIPNSHN GNDCNGVAKG YNAGCTRLIA GRILVKNIFY
460 470 480 490 500
DKRVVVRYTW DSWRTTHEVE CVYISDGDGI LPGTNMDIFH FIIDDVSKVD
510 520 530 540
PRGKLEFCIH YSTRNDYERE EYWDNNNGNN YKVDVVMDGF NDPFAAAA
Length:548
Mass (Da):62,319
Last modified:February 1, 1995 - v1
Checksum:iB28EE5241989A9BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18813 Genomic DNA. Translation: AAB64590.1.
BK006939 Genomic DNA. Translation: DAA07711.1.
PIRiS50557.
RefSeqiNP_010974.1. NM_001178945.1.

Genome annotation databases

EnsemblFungiiYER054C; YER054C; YER054C.
GeneIDi856781.
KEGGisce:YER054C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18813 Genomic DNA. Translation: AAB64590.1.
BK006939 Genomic DNA. Translation: DAA07711.1.
PIRiS50557.
RefSeqiNP_010974.1. NM_001178945.1.

3D structure databases

ProteinModelPortaliP40036.
SMRiP40036. Positions 431-533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36794. 36 interactions.
DIPiDIP-2376N.
IntActiP40036. 10 interactions.
MINTiMINT-600077.
STRINGi4932.YER054C.

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

Proteomic databases

MaxQBiP40036.
PaxDbiP40036.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER054C; YER054C; YER054C.
GeneIDi856781.
KEGGisce:YER054C.

Organism-specific databases

CYGDiYER054c.
SGDiS000000856. GIP2.

Phylogenomic databases

eggNOGiNOG288354.
GeneTreeiENSGT00530000067694.
HOGENOMiHOG000112724.
InParanoidiP40036.
OMAiRTTHEVE.
OrthoDBiEOG7XWPXD.

Enzyme and pathway databases

BioCyciYEAST:G3O-30232-MONOMER.

Miscellaneous databases

NextBioi982991.

Gene expression databases

GenevestigatoriP40036.

Family and domain databases

InterProiIPR005036. CBM_21.
IPR016717. Pase-1_int.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PIRSFiPIRSF018234. PPase_interacting. 1 hit.
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Tu J., Song W., Carslon R.
    Unpublished observations (MAR-1996)
    Cited for: INTERACTION WITH GLC7.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51; THR-52; SER-155 AND SER-221, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGIP2_YEAST
AccessioniPrimary (citable) accession number: P40036
Secondary accession number(s): D3DLV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 7, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 125 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.