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P40036

- GIP2_YEAST

UniProt

P40036 - GIP2_YEAST

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Protein
GLC7-interacting protein 2
Gene
GIP2, YER054C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein phosphatase regulator activity Source: SGD

GO - Biological processi

  1. glycogen metabolic process Source: SGD
  2. protein dephosphorylation Source: SGD
  3. regulation of catalytic activity Source: GOC
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30232-MONOMER.

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

Names & Taxonomyi

Protein namesi
Recommended name:
GLC7-interacting protein 2
Gene namesi
Name:GIP2
Ordered Locus Names:YER054C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER054c.
SGDiS000000856. GIP2.

Subcellular locationi

GO - Cellular componenti

  1. protein phosphatase type 1 complex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548GLC7-interacting protein 2
PRO_0000071521Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511Phosphoserine1 Publication
Modified residuei52 – 521Phosphothreonine1 Publication
Modified residuei155 – 1551Phosphoserine1 Publication
Modified residuei221 – 2211Phosphoserine2 Publications
Modified residuei238 – 2381Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40036.
PaxDbiP40036.

Expressioni

Gene expression databases

GenevestigatoriP40036.

Interactioni

Subunit structurei

Interacts with phosphatase 1 (GLC7).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SHO1P400732EBI-7612,EBI-18140

Protein-protein interaction databases

BioGridi36794. 36 interactions.
DIPiDIP-2376N.
IntActiP40036. 10 interactions.
MINTiMINT-600077.
STRINGi4932.YER054C.

Structurei

3D structure databases

ProteinModelPortaliP40036.
SMRiP40036. Positions 437-533.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini419 – 534116CBM21
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG288354.
GeneTreeiENSGT00530000067694.
HOGENOMiHOG000112724.
OMAiRTTHEVE.
OrthoDBiEOG7XWPXD.

Family and domain databases

InterProiIPR005036. CBM_21.
IPR016717. Pase-1_int.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PIRSFiPIRSF018234. PPase_interacting. 1 hit.
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40036-1 [UniParc]FASTAAdd to Basket

« Hide

MYIKAEQKPQ QFERKNEKLD RNKNQQLPDL ETDFKGYRVN SDLYNKERDG    50
STEETLNSLK FLHKPQRVTQ MRANRFPEEE VQRNTDLNKR IFSAGNDENV 100
DNESGWSKIA AAKNHTSVES LNGSTRPPFK IELPPLSPKS TVPKSFQAEY 150
PEAKSPGNDM NFEYDEEILI PFAPPVYKKS GELLKSSLKR RSKSLPTTPG 200
IRSGNGVQAR DGSPMLIRSK SVHFDQAAPV KYFAEDESPI NVNKTEQHDN 250
CLSFKHKPVN LMVDPEEETK MLSSGLETTS IDDDLTTVAP KGFAHPAKIS 300
NPNNGKGTNN TKLRKSKRFQ NLLKNRTDMP PSKSNKKFVN GGGAHEISDR 350
NSKNYHVVGL YSKNFPILSN KNPKSLKLNI FINLSQNKKV FLQELSLYIH 400
RDNNYFSNSS SFYNIPNSHN GNDCNGVAKG YNAGCTRLIA GRILVKNIFY 450
DKRVVVRYTW DSWRTTHEVE CVYISDGDGI LPGTNMDIFH FIIDDVSKVD 500
PRGKLEFCIH YSTRNDYERE EYWDNNNGNN YKVDVVMDGF NDPFAAAA 548
Length:548
Mass (Da):62,319
Last modified:February 1, 1995 - v1
Checksum:iB28EE5241989A9BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18813 Genomic DNA. Translation: AAB64590.1.
BK006939 Genomic DNA. Translation: DAA07711.1.
PIRiS50557.
RefSeqiNP_010974.1. NM_001178945.1.

Genome annotation databases

EnsemblFungiiYER054C; YER054C; YER054C.
GeneIDi856781.
KEGGisce:YER054C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18813 Genomic DNA. Translation: AAB64590.1 .
BK006939 Genomic DNA. Translation: DAA07711.1 .
PIRi S50557.
RefSeqi NP_010974.1. NM_001178945.1.

3D structure databases

ProteinModelPortali P40036.
SMRi P40036. Positions 437-533.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36794. 36 interactions.
DIPi DIP-2376N.
IntActi P40036. 10 interactions.
MINTi MINT-600077.
STRINGi 4932.YER054C.

Protein family/group databases

CAZyi CBM21. Carbohydrate-Binding Module Family 21.

Proteomic databases

MaxQBi P40036.
PaxDbi P40036.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER054C ; YER054C ; YER054C .
GeneIDi 856781.
KEGGi sce:YER054C.

Organism-specific databases

CYGDi YER054c.
SGDi S000000856. GIP2.

Phylogenomic databases

eggNOGi NOG288354.
GeneTreei ENSGT00530000067694.
HOGENOMi HOG000112724.
OMAi RTTHEVE.
OrthoDBi EOG7XWPXD.

Enzyme and pathway databases

BioCyci YEAST:G3O-30232-MONOMER.

Miscellaneous databases

NextBioi 982991.

Gene expression databases

Genevestigatori P40036.

Family and domain databases

InterProi IPR005036. CBM_21.
IPR016717. Pase-1_int.
[Graphical view ]
Pfami PF03370. CBM_21. 1 hit.
[Graphical view ]
PIRSFi PIRSF018234. PPase_interacting. 1 hit.
PROSITEi PS51159. CBM21. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Tu J., Song W., Carslon R.
    Unpublished observations (MAR-1996)
    Cited for: INTERACTION WITH GLC7.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51; THR-52; SER-155 AND SER-221, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGIP2_YEAST
AccessioniPrimary (citable) accession number: P40036
Secondary accession number(s): D3DLV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 125 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

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