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Protein

Mitochondrial phosphate carrier protein 2

Gene

PIC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transport of phosphate groups from the cytosol to the mitochondrial matrix.2 Publications

Miscellaneous

Present with 2360 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular copper ion homeostasis Source: SGD
  • copper ion transmembrane transport Source: SGD
  • mitochondrial transport Source: GO_Central
  • phosphate ion transmembrane transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-30231-MONOMER

Protein family/group databases

TCDBi2.A.29.4.4 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial phosphate carrier protein 2
Alternative name(s):
Phosphate transport protein 2
Short name:
PTP 2
Pi carrier isoform 2
mPic 2
Gene namesi
Name:PIC2
Ordered Locus Names:YER053C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER053C
SGDiS000000855 PIC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei70 – 89Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei108 – 128Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei171 – 192Helical; Name=4Sequence analysisAdd BLAST22
Transmembranei211 – 231Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei260 – 280Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906401 – 300Mitochondrial phosphate carrier protein 2Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP40035
PaxDbiP40035
PRIDEiP40035

PTM databases

iPTMnetiP40035

Interactioni

Protein-protein interaction databases

BioGridi36792, 61 interactors
DIPiDIP-5340N
IntActiP40035, 41 interactors
MINTiP40035
STRINGi4932.YER053C

Structurei

3D structure databases

ProteinModelPortaliP40035
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati16 – 100Solcar 1Add BLAST85
Repeati107 – 193Solcar 2Add BLAST87
Repeati209 – 293Solcar 3Add BLAST85

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000008708
HOGENOMiHOG000164438
InParanoidiP40035
KOiK15102
OMAiAVWARAP
OrthoDBiEOG092C3W79

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P40035-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESNKQPRKI QLYTKEFYAT CTLGGIIACG PTHSSITPLD LVKCRLQVNP
60 70 80 90 100
KLYTSNLQGF RKIIANEGWK KVYTGFGATF VGYSLQGAGK YGGYEYFKHL
110 120 130 140 150
YSSWLSPGVT VYLMASATAE FLADIMLCPF EAIKVKQQTT MPPFCNNVVD
160 170 180 190 200
GWKKMYAESG GMKAFYKGIV PLWCRQIPYT MCKFTSFEKI VQKIYSVLPK
210 220 230 240 250
KKEEMNALQQ ISVSFVGGYL AGILCAAVSH PADVMVSKIN SERKANESMS
260 270 280 290 300
VASKRIYQKI GFTGLWNGLM VRIVMIGTLT SFQWLIYDSF KAYVGLPTTG
Length:300
Mass (Da):33,528
Last modified:February 1, 1995 - v1
Checksum:iD8A54864F06F8264
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18796 Genomic DNA Translation: AAB64588.1
BK006939 Genomic DNA Translation: DAA07709.1
PIRiS50556
RefSeqiNP_010973.3, NM_001178944.3

Genome annotation databases

EnsemblFungiiYER053C; YER053C; YER053C
GeneIDi856779
KEGGisce:YER053C

Similar proteinsi

Entry informationi

Entry nameiPIC2_YEAST
AccessioniPrimary (citable) accession number: P40035
Secondary accession number(s): D3DLV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health