Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P40034 (JHD1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
JmjC domain-containing histone demethylation protein 1

EC=1.14.11.27
Alternative name(s):
Jumonji/ARID domain-containing protein 1
ScJHDM1
[Histone-H3]-lysine-36 demethylase 1
Gene names
Name:JHD1
Ordered Locus Names:YER051W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Does not demethylate H3 'Lys-4' nor 'Lys-79'. Ref.4

Catalytic activity

Protein N6,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2 = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2. Ref.4

Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2 = protein L-lysine + succinate + formaldehyde + CO2. Ref.4

Cofactor

Binds 1 Fe2+ ion per subunit By similarity.

Subcellular location

Nucleus By similarity.

Domain

The JmjC domain mediates the demethylation activity By similarity.

Miscellaneous

Present with 784 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the JHDM1 histone demethylase family.

Contains 1 JmjC domain.

Contains 1 PHD-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492JmjC domain-containing histone demethylation protein 1
PRO_0000202630

Regions

Domain254 – 409156JmjC
Zinc finger4 – 7269PHD-type; atypical

Sites

Metal binding3051Iron; catalytic Probable
Metal binding3071Iron; catalytic By similarity
Metal binding3771Iron; catalytic By similarity
Binding site3021Substrate By similarity
Binding site3221Substrate By similarity

Experimental info

Mutagenesis3051H → A: Abolishes histone demethylase activity. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P40034 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 5CBD09352131692B

FASTA49256,530
        10         20         30         40         50         60 
MQDPNICQHC QLKDNPGALI WVKCDSCPQW VHVKCVPLKR IHYSNLTSSE VLSYPNSAKQ 

        70         80         90        100        110        120 
IKSYRCPNHK EGEYLTAYAL ITQKGKRQRN KENPEDSHIN KRYNFRKKKL LDYIALNEGE 

       130        140        150        160        170        180 
SKRDKMNHPH KESFMKSFEK WKNGSNIINA ADFAEKFDNI DVPYKIIDPL NSGVYVPNVG 

       190        200        210        220        230        240 
TDNGCLTVNY ITEMIGEDYH VDVMDVQSQM NENWNLGSWN EYFTNTEPDR RDRIRNVISL 

       250        260        270        280        290        300 
EVSNIEGLEL ERPTAVRQND LVDKIWSFNG HLEKVNGEKA EENDPKPKVT KYILMSVKDA 

       310        320        330        340        350        360 
YTDFHLDFAG TSVYYNVISG QKKFLLFPPT QSNIDKYIEW SLKEDQNSVF LGDILEDGIA 

       370        380        390        400        410        420 
MELDAGDLFM IPAGYIHAVY TPVDSLVFGG NFLTIRDLET HLKIVEIEKL TKVPRRFTFP 

       430        440        450        460        470        480 
KFDQVMGKLC EYLALDKNKI TSDVSDGDLL SRTTNCAIQS LHAYVIKPEV KYKPLNFTSK 

       490 
KHLAKALADL IS 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]"Histone demethylation by a family of JmjC domain-containing proteins."
Tsukada Y., Fang J., Erdjument-Bromage H., Warren M.E., Borchers C.H., Tempst P., Zhang Y.
Nature 439:811-816(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, ENZYME ACTIVITY, MUTAGENESIS OF HIS-305.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18796 Genomic DNA. Translation: AAB64586.1.
BK006939 Genomic DNA. Translation: DAA07707.1.
PIRS50554.
RefSeqNP_010971.1. NM_001178942.1.

3D structure databases

ProteinModelPortalP40034.
SMRP40034. Positions 2-491.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36790. 9 interactions.
DIPDIP-5335N.
MINTMINT-540531.
STRING4932.YER051W.

Proteomic databases

PaxDbP40034.
PRIDEP40034.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER051W; YER051W; YER051W.
GeneID856777.
KEGGsce:YER051W.

Organism-specific databases

CYGDYER051w.
SGDS000000853. JHD1.

Phylogenomic databases

eggNOGNOG290496.
GeneTreeENSGT00550000074396.
HOGENOMHOG000246712.
KOK10276.
OMAGTSVYYN.
OrthoDBEOG73NGDR.

Enzyme and pathway databases

BioCycYEAST:G3O-30230-MONOMER.

Gene expression databases

GenevestigatorP40034.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR003347. JmjC_dom.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTSM00558. JmjC. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
PROSITEPS51184. JMJC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982979.

Entry information

Entry nameJHD1_YEAST
AccessionPrimary (citable) accession number: P40034
Secondary accession number(s): D3DLV3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families