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Protein

Peptide methionine sulfoxide reductase

Gene

MXR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Also able to reduce dimethyl sulfoxide (DMSO) as well, with DMS as the product.

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.

GO - Molecular functioni

  • peptide-methionine (S)-S-oxide reductase activity Source: SGD

GO - Biological processi

  • cellular response to oxidative stress Source: SGD
  • protein repair Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciYEAST:YER042W-MONOMER.
ReactomeiR-SCE-5676934. Protein repair.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase (EC:1.8.4.11)
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name:
Peptide Met(O) reductase
Protein-methionine-S-oxide reductase
Gene namesi
Name:MXR1
Ordered Locus Names:YER042W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER042W.
SGDiS000000844. MXR1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184Peptide methionine sulfoxide reductasePRO_0000138630Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40029.

PTM databases

iPTMnetiP40029.

Interactioni

Protein-protein interaction databases

BioGridi36778. 18 interactions.
IntActiP40029. 2 interactions.
MINTiMINT-4483927.

Structurei

Secondary structure

1
184
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 43Combined sources
Beta strandi7 – 93Combined sources
Turni13 – 153Combined sources
Beta strandi17 – 248Combined sources
Helixi26 – 3712Combined sources
Helixi38 – 403Combined sources
Beta strandi41 – 5111Combined sources
Helixi53 – 553Combined sources
Helixi64 – 674Combined sources
Beta strandi75 – 828Combined sources
Turni84 – 863Combined sources
Helixi89 – 968Combined sources
Beta strandi104 – 1085Combined sources
Beta strandi111 – 1133Combined sources
Helixi114 – 1163Combined sources
Beta strandi119 – 1246Combined sources
Helixi125 – 13814Combined sources
Helixi139 – 1424Combined sources
Beta strandi149 – 15810Combined sources
Helixi159 – 1668Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PILX-ray2.04A/B2-184[»]
3PIMX-ray1.90A/B/C2-184[»]
3PINX-ray2.70B2-184[»]
ProteinModelPortaliP40029.
SMRiP40029. Positions 2-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000003823.
HOGENOMiHOG000263863.
InParanoidiP40029.
KOiK07304.
OMAiTYEDICT.
OrthoDBiEOG092C4O0I.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequencei

Sequence statusi: Complete.

P40029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLISKTIK YDPAKDKLIT LACGCFWGTE HMYRKYLNDR IVDCKVGYAN
60 70 80 90 100
GEESKKDSPS SVSYKRVCGG DTDFAEVLQV SYNPKVITLR ELTDFFFRIH
110 120 130 140 150
DPTTSNSQGP DKGTQYRSGL FAHSDADLKE LAKIKEEWQP KWGNKIATVI
160 170 180
EPIKNFYDAE EYHQLYLDKN PQGYACPTHY LREM
Length:184
Mass (Da):21,141
Last modified:February 1, 1995 - v1
Checksum:i329CE3E8F4B006AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18796 Genomic DNA. Translation: AAB64577.1.
AY692798 Genomic DNA. Translation: AAT92817.1.
BK006939 Genomic DNA. Translation: DAA07696.1.
PIRiS50545.
RefSeqiNP_010960.1. NM_001178933.1.

Genome annotation databases

EnsemblFungiiYER042W; YER042W; YER042W.
GeneIDi856765.
KEGGisce:YER042W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18796 Genomic DNA. Translation: AAB64577.1.
AY692798 Genomic DNA. Translation: AAT92817.1.
BK006939 Genomic DNA. Translation: DAA07696.1.
PIRiS50545.
RefSeqiNP_010960.1. NM_001178933.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PILX-ray2.04A/B2-184[»]
3PIMX-ray1.90A/B/C2-184[»]
3PINX-ray2.70B2-184[»]
ProteinModelPortaliP40029.
SMRiP40029. Positions 2-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36778. 18 interactions.
IntActiP40029. 2 interactions.
MINTiMINT-4483927.

PTM databases

iPTMnetiP40029.

Proteomic databases

MaxQBiP40029.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER042W; YER042W; YER042W.
GeneIDi856765.
KEGGisce:YER042W.

Organism-specific databases

EuPathDBiFungiDB:YER042W.
SGDiS000000844. MXR1.

Phylogenomic databases

GeneTreeiENSGT00390000003823.
HOGENOMiHOG000263863.
InParanoidiP40029.
KOiK07304.
OMAiTYEDICT.
OrthoDBiEOG092C4O0I.

Enzyme and pathway databases

BioCyciYEAST:YER042W-MONOMER.
ReactomeiR-SCE-5676934. Protein repair.

Miscellaneous databases

PROiP40029.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSRA_YEAST
AccessioniPrimary (citable) accession number: P40029
Secondary accession number(s): D3DLU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3070 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.