Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptide methionine sulfoxide reductase

Gene

MXR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Also able to reduce dimethyl sulfoxide (DMSO) as well, with DMS as the product.

Miscellaneous

Present with 3070 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.

GO - Molecular functioni

  • peptide-methionine (S)-S-oxide reductase activity Source: SGD

GO - Biological processi

  • cellular response to oxidative stress Source: SGD

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciYEAST:YER042W-MONOMER
ReactomeiR-SCE-5676934 Protein repair

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase (EC:1.8.4.11)
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name:
Peptide Met(O) reductase
Protein-methionine-S-oxide reductase
Gene namesi
Name:MXR1
Ordered Locus Names:YER042W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER042W
SGDiS000000844 MXR1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001386301 – 184Peptide methionine sulfoxide reductaseAdd BLAST184

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40029
PaxDbiP40029
PRIDEiP40029

PTM databases

iPTMnetiP40029

Interactioni

Protein-protein interaction databases

BioGridi36778125 interactors.
IntActiP40029 7 interactors.
MINTiP40029
STRINGi4932.YER042W

Structurei

Secondary structure

1184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4Combined sources3
Beta strandi7 – 9Combined sources3
Turni13 – 15Combined sources3
Beta strandi17 – 24Combined sources8
Helixi26 – 37Combined sources12
Helixi38 – 40Combined sources3
Beta strandi41 – 51Combined sources11
Helixi53 – 55Combined sources3
Helixi64 – 67Combined sources4
Beta strandi75 – 82Combined sources8
Turni84 – 86Combined sources3
Helixi89 – 96Combined sources8
Beta strandi104 – 108Combined sources5
Beta strandi111 – 113Combined sources3
Helixi114 – 116Combined sources3
Beta strandi119 – 124Combined sources6
Helixi125 – 138Combined sources14
Helixi139 – 142Combined sources4
Beta strandi149 – 158Combined sources10
Helixi159 – 166Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PILX-ray2.04A/B2-184[»]
3PIMX-ray1.90A/B/C2-184[»]
3PINX-ray2.70B2-184[»]
ProteinModelPortaliP40029
SMRiP40029
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000003823
HOGENOMiHOG000263863
InParanoidiP40029
KOiK07304
OMAiMRQGGDI
OrthoDBiEOG092C4O0I

Family and domain databases

Gene3Di3.30.1060.101 hit
HAMAPiMF_01401 MsrA, 1 hit
InterProiView protein in InterPro
IPR002569 Met_Sox_Rdtase_MsrA
IPR036509 Met_Sox_Rdtase_MsrA_sf
PfamiView protein in Pfam
PF01625 PMSR, 1 hit
SUPFAMiSSF55068 SSF55068, 1 hit
TIGRFAMsiTIGR00401 msrA, 1 hit

Sequencei

Sequence statusi: Complete.

P40029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLISKTIK YDPAKDKLIT LACGCFWGTE HMYRKYLNDR IVDCKVGYAN
60 70 80 90 100
GEESKKDSPS SVSYKRVCGG DTDFAEVLQV SYNPKVITLR ELTDFFFRIH
110 120 130 140 150
DPTTSNSQGP DKGTQYRSGL FAHSDADLKE LAKIKEEWQP KWGNKIATVI
160 170 180
EPIKNFYDAE EYHQLYLDKN PQGYACPTHY LREM
Length:184
Mass (Da):21,141
Last modified:February 1, 1995 - v1
Checksum:i329CE3E8F4B006AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18796 Genomic DNA Translation: AAB64577.1
AY692798 Genomic DNA Translation: AAT92817.1
BK006939 Genomic DNA Translation: DAA07696.1
PIRiS50545
RefSeqiNP_010960.1, NM_001178933.1

Genome annotation databases

EnsemblFungiiYER042W; YER042W; YER042W
GeneIDi856765
KEGGisce:YER042W

Similar proteinsi

Entry informationi

Entry nameiMSRA_YEAST
AccessioniPrimary (citable) accession number: P40029
Secondary accession number(s): D3DLU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome