Reviewed, UniProtKB/Swiss-Prot P40025 (PHM8_YEAST)

Names and origin

Protein names

Recommended name:
    Phosphate metabolism protein 8

Gene names

Name:	PHM8
Ordered Locus Names:	YER037W

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in phosphate metabolism. Ref.2
Induction	By low phosphate level. Ref.2
Miscellaneous	Present with 195 molecules/cell in log phase SD medium. Ref.3
Sequence similarities	Belongs to the SSM1 family.

Ontologies

Keywords
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from direct assay. Source: SGD nucleus Inferred from direct assay. Source: SGD
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ADH1	P00330	1	EBI-22502,EBI-2218

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Phosphate metabolism protein 8		PRO_0000202627

Sequences

	Sequence		Length	Mass (Da)
	P40025-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: EAAA9BAFAF312982	FASTA	321	37,719
	10 20 30 40 50 60 MTIAKDYRTI YRNQIKKQIR LNQEHLQSLT HLGSQINFEV DPPKLPDPDP ARKVFFFDID 70 80 90 100 110 120 NTLYRKSTKV QLLMQQSLSN FFKYELGFDD DEAERLIESY YQEYGLSVKG LIKNKQIDDV 130 140 150 160 170 180 LQYNTFIDDS LPLQDYLKPD WKLRELLINL KKKKLGKFDK LWLFTNSYKN HAIRCVKILG 190 200 210 220 230 240 IADLFDGITY CHYDRPIEEE FICKPDPKFF ETAKLQSGLS SFANAWFIDD NESNVRSALS 250 260 270 280 290 300 MGMGHVIHLI EDYQYESENI VTKDHKNKQQ FSILKDILEI PLIMDVEVYR PSSIAIKEME 310 320 ELEEEGEAVN WSNQQINVQS S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed: 9169868] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis." Ogawa N., DeRisi J.L., Brown P.O. Mol. Biol. Cell 11:4309-4321(2000) [PubMed: 11102525] [Abstract] Cited for: PRELIMINARY FUNCTION, INDUCTION.
[3]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U18796 Genomic DNA. Translation: AAB64572.1.
PIR	S50540.
RefSeq	NP_010954.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:5338N.
IntAct	P40025. 4 interactions.
Genome annotation databases
Ensembl	YER037W. Saccharomyces cerevisiae. [Contig view]
GeneID	856759.
GenomeReviews	Gene locus YER037W in contig U00092_GR.
KEGG	sce:YER037W.
NMPDR	fig|4932.3.peg.2015.
Organism-specific databases
CYGD	YER037w.
SGD	S000000839. PHM8.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	P40025.
OMA	P40025. YQEYGLS.
Enzyme and pathway databases
BRENDA	3.1.3.5. 250.
Gene expression databases
ArrayExpress	P40025.
GermOnline	YER037W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR005834. Dehalogen-like_hydro. IPR006402. HAD-SF_hydro_IA_v3. IPR010237. Pyr-5-nucltdase. [Graphical view]
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01509. HAD-SF-IA-v3. 1 hit. TIGR01993. Pyr-5-nucltdase. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	982926.

Entry information

Entry name

PHM8_YEAST

Accession

Primary (citable) accession number: P40025

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)