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P40024

- ARB1_YEAST

UniProt

P40024 - ARB1_YEAST

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Protein

ABC transporter ATP-binding protein ARB1

Gene

ARB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Stimulates 40S and 60S ribosome biogenesis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi114 – 1218ATP 1PROSITE-ProRule annotation
Nucleotide bindingi428 – 4358ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity, uncoupled Source: SGD
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. ribosomal small subunit export from nucleus Source: SGD
  3. ribosome biogenesis Source: SGD
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30217-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter ATP-binding protein ARB1
Alternative name(s):
ATP-binding cassette protein involved in ribosome biogenesis 1
Gene namesi
Name:ARB1
Ordered Locus Names:YER036C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER036c.
SGDiS000000838. ARB1.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Shuttles between the cytoplasm and the nucleus.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610ABC transporter ATP-binding protein ARB1PRO_0000093463Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431Phosphoserine1 Publication
Modified residuei65 – 651Phosphoserine1 Publication
Modified residuei196 – 1961Phosphoserine1 Publication
Modified residuei446 – 4461Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40024.
PaxDbiP40024.
PeptideAtlasiP40024.

Expressioni

Gene expression databases

GenevestigatoriP40024.

Interactioni

Subunit structurei

Interacts with LSG1.1 Publication

Protein-protein interaction databases

BioGridi36771. 78 interactions.
DIPiDIP-4341N.
IntActiP40024. 26 interactions.
MINTiMINT-508979.
STRINGi4932.YER036C.

Structurei

3D structure databases

ProteinModelPortaliP40024.
SMRiP40024. Positions 96-601.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 323242ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini393 – 610218ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0488.
GeneTreeiENSGT00630000089910.
HOGENOMiHOG000271637.
InParanoidiP40024.
KOiK06185.
OMAiDEMSADC.
OrthoDBiEOG718KNB.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40024-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPVSASKAK RDAKKAEREA KKAAAGKTIR KLGRKKEAAA EESEVDAAAR
60 70 80 90 100
EIKMMKLQQD KDGLSDRVVT GVLSSLETSR DIKLSSVSLL FHGKVLIQDS
110 120 130 140 150
GLELNYGRRY GLLGENGCGK STFLKALATR EYPIPEHIDI YLLDEPAEPS
160 170 180 190 200
ELSALDYVVT EAQHELKRIE DLVEKTILED GPESELLEPL YERMDSLDPD
210 220 230 240 250
TFESRAAIIL IGLGFNKKTI LKKTKDMSGG WKMRVALAKA LFVKPTLLLL
260 270 280 290 300
DDPTAHLDLE ACVWLEEYLK RFDRTLVLVS HSQDFLNGVC TNMIDMRAQK
310 320 330 340 350
LTAYGGNYDS YHKTRSELET NQMKQYNKQQ EEIQHIKKFI ASAGTYANLV
360 370 380 390 400
KQAKSRQKIL DKMEADGLVQ PVVPDKVFSF RFPQVERLPP PVLAFDDISF
410 420 430 440 450
HYESNPSENL YEHLNFGVDM DSRIALVGPN GVGKSTLLKI MTGELTPQSG
460 470 480 490 500
RVSRHTHVKL GVYSQHSQDQ LDLTKSALEF VRDKYSNISQ DFQFWRGQLG
510 520 530 540 550
RYGLTGEGQT VQMATLSEGQ RSRVVFALLA LEQPNVLLLD EPTNGLDIPT
560 570 580 590 600
IDSLADAINE FNGGVVVVSH DFRLLDKIAQ DIFVVENKTA TRWDGSILQY
610
KNKLAKNVVL
Length:610
Mass (Da):68,377
Last modified:February 1, 1995 - v1
Checksum:i0E5DB4A33059B4F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18796 Genomic DNA. Translation: AAB64571.1.
BK006939 Genomic DNA. Translation: DAA07689.1.
PIRiS50539.
RefSeqiNP_010953.1. NM_001178927.1.

Genome annotation databases

EnsemblFungiiYER036C; YER036C; YER036C.
GeneIDi856758.
KEGGisce:YER036C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18796 Genomic DNA. Translation: AAB64571.1 .
BK006939 Genomic DNA. Translation: DAA07689.1 .
PIRi S50539.
RefSeqi NP_010953.1. NM_001178927.1.

3D structure databases

ProteinModelPortali P40024.
SMRi P40024. Positions 96-601.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36771. 78 interactions.
DIPi DIP-4341N.
IntActi P40024. 26 interactions.
MINTi MINT-508979.
STRINGi 4932.YER036C.

Proteomic databases

MaxQBi P40024.
PaxDbi P40024.
PeptideAtlasi P40024.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER036C ; YER036C ; YER036C .
GeneIDi 856758.
KEGGi sce:YER036C.

Organism-specific databases

CYGDi YER036c.
SGDi S000000838. ARB1.

Phylogenomic databases

eggNOGi COG0488.
GeneTreei ENSGT00630000089910.
HOGENOMi HOG000271637.
InParanoidi P40024.
KOi K06185.
OMAi DEMSADC.
OrthoDBi EOG718KNB.

Enzyme and pathway databases

BioCyci YEAST:G3O-30217-MONOMER.

Miscellaneous databases

NextBioi 982923.
PROi P40024.

Gene expression databases

Genevestigatori P40024.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  4. "The novel ATP-binding cassette protein ARB1 is a shuttling factor that stimulates 40S and 60S ribosome biogenesis."
    Dong J., Lai R., Jennings J.L., Link A.J., Hinnebusch A.G.
    Mol. Cell. Biol. 25:9859-9873(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH LSG1.
  5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43; SER-65; SER-196 AND THR-446, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARB1_YEAST
AccessioniPrimary (citable) accession number: P40024
Secondary accession number(s): D3DLT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 17600 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3