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P40024 (ARB1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ABC transporter ATP-binding protein ARB1
Alternative name(s):
ATP-binding cassette protein involved in ribosome biogenesis 1
Gene names
Name:ARB1
Ordered Locus Names:YER036C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length610 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stimulates 40S and 60S ribosome biogenesis. Ref.4

Subunit structure

Interacts with LSG1. Ref.4

Subcellular location

Cytoplasm. Nucleus. Note: Shuttles between the cytoplasm and the nucleus. Ref.4

Miscellaneous

Present with 17600 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.

Contains 2 ABC transporter domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 610610ABC transporter ATP-binding protein ARB1
PRO_0000093463

Regions

Domain82 – 323242ABC transporter 1
Domain393 – 610218ABC transporter 2
Nucleotide binding114 – 1218ATP 1 Potential
Nucleotide binding428 – 4358ATP 2 Potential

Amino acid modifications

Modified residue431Phosphoserine Ref.5
Modified residue651Phosphoserine Ref.5
Modified residue1961Phosphoserine Ref.5
Modified residue4461Phosphothreonine Ref.5

Sequences

Sequence LengthMass (Da)Tools
P40024 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 0E5DB4A33059B4F0

FASTA61068,377
        10         20         30         40         50         60 
MPPVSASKAK RDAKKAEREA KKAAAGKTIR KLGRKKEAAA EESEVDAAAR EIKMMKLQQD 

        70         80         90        100        110        120 
KDGLSDRVVT GVLSSLETSR DIKLSSVSLL FHGKVLIQDS GLELNYGRRY GLLGENGCGK 

       130        140        150        160        170        180 
STFLKALATR EYPIPEHIDI YLLDEPAEPS ELSALDYVVT EAQHELKRIE DLVEKTILED 

       190        200        210        220        230        240 
GPESELLEPL YERMDSLDPD TFESRAAIIL IGLGFNKKTI LKKTKDMSGG WKMRVALAKA 

       250        260        270        280        290        300 
LFVKPTLLLL DDPTAHLDLE ACVWLEEYLK RFDRTLVLVS HSQDFLNGVC TNMIDMRAQK 

       310        320        330        340        350        360 
LTAYGGNYDS YHKTRSELET NQMKQYNKQQ EEIQHIKKFI ASAGTYANLV KQAKSRQKIL 

       370        380        390        400        410        420 
DKMEADGLVQ PVVPDKVFSF RFPQVERLPP PVLAFDDISF HYESNPSENL YEHLNFGVDM 

       430        440        450        460        470        480 
DSRIALVGPN GVGKSTLLKI MTGELTPQSG RVSRHTHVKL GVYSQHSQDQ LDLTKSALEF 

       490        500        510        520        530        540 
VRDKYSNISQ DFQFWRGQLG RYGLTGEGQT VQMATLSEGQ RSRVVFALLA LEQPNVLLLD 

       550        560        570        580        590        600 
EPTNGLDIPT IDSLADAINE FNGGVVVVSH DFRLLDKIAQ DIFVVENKTA TRWDGSILQY 

       610 
KNKLAKNVVL 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]"The novel ATP-binding cassette protein ARB1 is a shuttling factor that stimulates 40S and 60S ribosome biogenesis."
Dong J., Lai R., Jennings J.L., Link A.J., Hinnebusch A.G.
Mol. Cell. Biol. 25:9859-9873(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH LSG1.
[5]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43; SER-65; SER-196 AND THR-446, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18796 Genomic DNA. Translation: AAB64571.1.
BK006939 Genomic DNA. Translation: DAA07689.1.
PIRS50539.
RefSeqNP_010953.1. NM_001178927.1.

3D structure databases

ProteinModelPortalP40024.
SMRP40024. Positions 96-601.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36771. 77 interactions.
DIPDIP-4341N.
IntActP40024. 26 interactions.
MINTMINT-508979.
STRING4932.YER036C.

Proteomic databases

MaxQBP40024.
PaxDbP40024.
PeptideAtlasP40024.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER036C; YER036C; YER036C.
GeneID856758.
KEGGsce:YER036C.

Organism-specific databases

CYGDYER036c.
SGDS000000838. ARB1.

Phylogenomic databases

eggNOGCOG0488.
GeneTreeENSGT00630000089910.
HOGENOMHOG000271637.
KOK06185.
OMADEMSADC.
OrthoDBEOG718KNB.

Enzyme and pathway databases

BioCycYEAST:G3O-30217-MONOMER.

Gene expression databases

GenevestigatorP40024.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
PROSITEPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio982923.
PROP40024.

Entry information

Entry nameARB1_YEAST
AccessionPrimary (citable) accession number: P40024
Secondary accession number(s): D3DLT5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families