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P40024

- ARB1_YEAST

UniProt

P40024 - ARB1_YEAST

Protein

ABC transporter ATP-binding protein ARB1

Gene

ARB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Stimulates 40S and 60S ribosome biogenesis.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi114 – 1218ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi428 – 4358ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, uncoupled Source: SGD
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. ribosomal small subunit export from nucleus Source: SGD
    3. ribosome biogenesis Source: SGD

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30217-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ABC transporter ATP-binding protein ARB1
    Alternative name(s):
    ATP-binding cassette protein involved in ribosome biogenesis 1
    Gene namesi
    Name:ARB1
    Ordered Locus Names:YER036C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER036c.
    SGDiS000000838. ARB1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Shuttles between the cytoplasm and the nucleus.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 610610ABC transporter ATP-binding protein ARB1PRO_0000093463Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei43 – 431Phosphoserine1 Publication
    Modified residuei65 – 651Phosphoserine1 Publication
    Modified residuei196 – 1961Phosphoserine1 Publication
    Modified residuei446 – 4461Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP40024.
    PaxDbiP40024.
    PeptideAtlasiP40024.

    Expressioni

    Gene expression databases

    GenevestigatoriP40024.

    Interactioni

    Subunit structurei

    Interacts with LSG1.1 Publication

    Protein-protein interaction databases

    BioGridi36771. 77 interactions.
    DIPiDIP-4341N.
    IntActiP40024. 26 interactions.
    MINTiMINT-508979.
    STRINGi4932.YER036C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40024.
    SMRiP40024. Positions 96-601.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini82 – 323242ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini393 – 610218ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0488.
    GeneTreeiENSGT00630000089910.
    HOGENOMiHOG000271637.
    KOiK06185.
    OMAiDEMSADC.
    OrthoDBiEOG718KNB.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40024-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPVSASKAK RDAKKAEREA KKAAAGKTIR KLGRKKEAAA EESEVDAAAR    50
    EIKMMKLQQD KDGLSDRVVT GVLSSLETSR DIKLSSVSLL FHGKVLIQDS 100
    GLELNYGRRY GLLGENGCGK STFLKALATR EYPIPEHIDI YLLDEPAEPS 150
    ELSALDYVVT EAQHELKRIE DLVEKTILED GPESELLEPL YERMDSLDPD 200
    TFESRAAIIL IGLGFNKKTI LKKTKDMSGG WKMRVALAKA LFVKPTLLLL 250
    DDPTAHLDLE ACVWLEEYLK RFDRTLVLVS HSQDFLNGVC TNMIDMRAQK 300
    LTAYGGNYDS YHKTRSELET NQMKQYNKQQ EEIQHIKKFI ASAGTYANLV 350
    KQAKSRQKIL DKMEADGLVQ PVVPDKVFSF RFPQVERLPP PVLAFDDISF 400
    HYESNPSENL YEHLNFGVDM DSRIALVGPN GVGKSTLLKI MTGELTPQSG 450
    RVSRHTHVKL GVYSQHSQDQ LDLTKSALEF VRDKYSNISQ DFQFWRGQLG 500
    RYGLTGEGQT VQMATLSEGQ RSRVVFALLA LEQPNVLLLD EPTNGLDIPT 550
    IDSLADAINE FNGGVVVVSH DFRLLDKIAQ DIFVVENKTA TRWDGSILQY 600
    KNKLAKNVVL 610
    Length:610
    Mass (Da):68,377
    Last modified:February 1, 1995 - v1
    Checksum:i0E5DB4A33059B4F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18796 Genomic DNA. Translation: AAB64571.1.
    BK006939 Genomic DNA. Translation: DAA07689.1.
    PIRiS50539.
    RefSeqiNP_010953.1. NM_001178927.1.

    Genome annotation databases

    EnsemblFungiiYER036C; YER036C; YER036C.
    GeneIDi856758.
    KEGGisce:YER036C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18796 Genomic DNA. Translation: AAB64571.1 .
    BK006939 Genomic DNA. Translation: DAA07689.1 .
    PIRi S50539.
    RefSeqi NP_010953.1. NM_001178927.1.

    3D structure databases

    ProteinModelPortali P40024.
    SMRi P40024. Positions 96-601.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36771. 77 interactions.
    DIPi DIP-4341N.
    IntActi P40024. 26 interactions.
    MINTi MINT-508979.
    STRINGi 4932.YER036C.

    Proteomic databases

    MaxQBi P40024.
    PaxDbi P40024.
    PeptideAtlasi P40024.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER036C ; YER036C ; YER036C .
    GeneIDi 856758.
    KEGGi sce:YER036C.

    Organism-specific databases

    CYGDi YER036c.
    SGDi S000000838. ARB1.

    Phylogenomic databases

    eggNOGi COG0488.
    GeneTreei ENSGT00630000089910.
    HOGENOMi HOG000271637.
    KOi K06185.
    OMAi DEMSADC.
    OrthoDBi EOG718KNB.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30217-MONOMER.

    Miscellaneous databases

    NextBioi 982923.
    PROi P40024.

    Gene expression databases

    Genevestigatori P40024.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    4. "The novel ATP-binding cassette protein ARB1 is a shuttling factor that stimulates 40S and 60S ribosome biogenesis."
      Dong J., Lai R., Jennings J.L., Link A.J., Hinnebusch A.G.
      Mol. Cell. Biol. 25:9859-9873(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH LSG1.
    5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43; SER-65; SER-196 AND THR-446, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiARB1_YEAST
    AccessioniPrimary (citable) accession number: P40024
    Secondary accession number(s): D3DLT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 17600 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3