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Protein

ABC transporter ATP-binding protein ARB1

Gene

ARB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates 40S and 60S ribosome biogenesis.1 Publication

Miscellaneous

Present with 17600 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi114 – 121ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi428 – 435ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity, uncoupled Source: SGD
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • ribosomal small subunit export from nucleus Source: SGD
  • ribosome biogenesis Source: SGD

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30217-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter ATP-binding protein ARB1
Alternative name(s):
ATP-binding cassette protein involved in ribosome biogenesis 1
Gene namesi
Name:ARB1
Ordered Locus Names:YER036C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER036C
SGDiS000000838 ARB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000934631 – 610ABC transporter ATP-binding protein ARB1Add BLAST610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineCombined sources1
Modified residuei65PhosphoserineCombined sources1
Modified residuei196PhosphoserineCombined sources1
Modified residuei446PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40024
PaxDbiP40024
PRIDEiP40024

PTM databases

iPTMnetiP40024

Interactioni

Subunit structurei

Interacts with LSG1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TIF2P100812EBI-22498,EBI-9017

Protein-protein interaction databases

BioGridi36771, 86 interactors
DIPiDIP-4341N
IntActiP40024, 31 interactors
MINTiP40024
STRINGi4932.YER036C

Structurei

3D structure databases

ProteinModelPortaliP40024
SMRiP40024
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 323ABC transporter 1PROSITE-ProRule annotationAdd BLAST242
Domaini393 – 610ABC transporter 2PROSITE-ProRule annotationAdd BLAST218

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00630000089910
HOGENOMiHOG000271637
InParanoidiP40024
KOiK06185
OMAiCTHIADI
OrthoDBiEOG092C22OB

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR032781 ABC_tran_Xtn
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
PF12848 ABC_tran_Xtn, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

P40024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPVSASKAK RDAKKAEREA KKAAAGKTIR KLGRKKEAAA EESEVDAAAR
60 70 80 90 100
EIKMMKLQQD KDGLSDRVVT GVLSSLETSR DIKLSSVSLL FHGKVLIQDS
110 120 130 140 150
GLELNYGRRY GLLGENGCGK STFLKALATR EYPIPEHIDI YLLDEPAEPS
160 170 180 190 200
ELSALDYVVT EAQHELKRIE DLVEKTILED GPESELLEPL YERMDSLDPD
210 220 230 240 250
TFESRAAIIL IGLGFNKKTI LKKTKDMSGG WKMRVALAKA LFVKPTLLLL
260 270 280 290 300
DDPTAHLDLE ACVWLEEYLK RFDRTLVLVS HSQDFLNGVC TNMIDMRAQK
310 320 330 340 350
LTAYGGNYDS YHKTRSELET NQMKQYNKQQ EEIQHIKKFI ASAGTYANLV
360 370 380 390 400
KQAKSRQKIL DKMEADGLVQ PVVPDKVFSF RFPQVERLPP PVLAFDDISF
410 420 430 440 450
HYESNPSENL YEHLNFGVDM DSRIALVGPN GVGKSTLLKI MTGELTPQSG
460 470 480 490 500
RVSRHTHVKL GVYSQHSQDQ LDLTKSALEF VRDKYSNISQ DFQFWRGQLG
510 520 530 540 550
RYGLTGEGQT VQMATLSEGQ RSRVVFALLA LEQPNVLLLD EPTNGLDIPT
560 570 580 590 600
IDSLADAINE FNGGVVVVSH DFRLLDKIAQ DIFVVENKTA TRWDGSILQY
610
KNKLAKNVVL
Length:610
Mass (Da):68,377
Last modified:February 1, 1995 - v1
Checksum:i0E5DB4A33059B4F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18796 Genomic DNA Translation: AAB64571.1
BK006939 Genomic DNA Translation: DAA07689.1
PIRiS50539
RefSeqiNP_010953.1, NM_001178927.1

Genome annotation databases

EnsemblFungiiYER036C; YER036C; YER036C
GeneIDi856758
KEGGisce:YER036C

Similar proteinsi

Entry informationi

Entry nameiARB1_YEAST
AccessioniPrimary (citable) accession number: P40024
Secondary accession number(s): D3DLT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health