Enhancer of mRNA-decapping protein 2 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P40023 (EDC2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 88. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Enhancer of mRNA-decapping protein 2

Gene names

Name:	EDC2
Ordered Locus Names:	YER035W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	mRNA-binding protein which stimulates mRNA decapping by DCP1 and DCP2. Ref.4 Ref.7 Ref.8
Subcellular location	Cytoplasm. Nucleus Ref.5.
Miscellaneous	Present with 538 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the EDC family.

Ontologies

Keywords
Biological process	Nonsense-mediated mRNA decay mRNA processing
Cellular component	Cytoplasm Nucleus
Ligand	RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA Inferred from direct assay Ref.8. Source: SGD mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of translation in response to stress Inferred from mutant phenotype PubMed 19682251. Source: SGD
Cellular_component	cytoplasm Inferred from direct assay Ref.5 PubMed 22842922. Source: SGD nucleolus Inferred from direct assay PubMed 19682251. Source: SGD
Molecular_function	mRNA binding Inferred from direct assay Ref.8. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DCP2	P53550	1	EBI-22493,EBI-270
DHH1	P39517	1	EBI-22493,EBI-158

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 145

145

Enhancer of mRNA-decapping protein 2

PRO_0000202626

Sequences

Sequence

Length

Mass (Da)

Tools

P40023 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 4D8A461EFD78BFA9
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FASTA

145

16,071

        10         20         30         40         50         60 
MGSETKHSAK VKIVTRESPP SAKEHMRPTK TQILVPPTQS LPNGKKPNFG KSTKQRREPR 

        70         80         90        100        110        120 
ERTSKTGHED DKATMVTVNI DAFLHDKAPK KKSCKYKKKK TRQYQDRAAA SIDSKPHVAG 

       130        140 
HTAFAGASFT TDIPHEAALP KPSFV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. Davis R.W. Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae." Dunckley T., Tucker M., Parker R. Genetics 157:27-37(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"Analysis of recombinant yeast decapping enzyme." Steiger M., Carr-Schmid A., Schwartz D.C., Kiledjian M., Parker R. RNA 9:231-238(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[8]	"The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme." Schwartz D., Decker C.J., Parker R. RNA 9:239-251(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U18796 Genomic DNA. Translation: AAB64570.1. AY558451 Genomic DNA. Translation: AAS56777.1. BK006939 Genomic DNA. Translation: DAA07688.1.
PIR	S50538.
RefSeq	NP_010952.3. NM_001178926.3.
3D structure databases
ProteinModelPortal	P40023.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5234N.
IntAct	P40023. 4 interactions.
MINT	MINT-488950.
STRING	4932.YER035W.
Proteomic databases
PaxDb	P40023.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YER035W; YER035W; YER035W.
GeneID	856757.
KEGG	sce:YER035W. sce:YER038C.
Organism-specific databases
CYGD	YER035w.
SGD	S000000837. EDC2.
Gene expression databases
Genevestigator	P40023.
GermOnline	YER035W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	982920.

Entry information

Entry name

EDC2_YEAST

Accession

Primary (citable) accession number: P40023
Secondary accession number(s): D3DLT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents