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P40023 (EDC2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Enhancer of mRNA-decapping protein 2
Gene names
Name:EDC2
Ordered Locus Names:YER035W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length145 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

mRNA-binding protein which stimulates mRNA decapping by DCP1 and DCP2. Ref.4 Ref.7 Ref.8

Subcellular location

Cytoplasm. Nucleus Ref.5.

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the EDC family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

DCP2P535501EBI-22493,EBI-270
DHH1P395171EBI-22493,EBI-158

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 145145Enhancer of mRNA-decapping protein 2
PRO_0000202626

Sequences

Sequence LengthMass (Da)Tools
P40023 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 4D8A461EFD78BFA9

FASTA14516,071
        10         20         30         40         50         60 
MGSETKHSAK VKIVTRESPP SAKEHMRPTK TQILVPPTQS LPNGKKPNFG KSTKQRREPR 

        70         80         90        100        110        120 
ERTSKTGHED DKATMVTVNI DAFLHDKAPK KKSCKYKKKK TRQYQDRAAA SIDSKPHVAG 

       130        140 
HTAFAGASFT TDIPHEAALP KPSFV 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae."
Dunckley T., Tucker M., Parker R.
Genetics 157:27-37(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Analysis of recombinant yeast decapping enzyme."
Steiger M., Carr-Schmid A., Schwartz D.C., Kiledjian M., Parker R.
RNA 9:231-238(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme."
Schwartz D., Decker C.J., Parker R.
RNA 9:239-251(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18796 Genomic DNA. Translation: AAB64570.1.
AY558451 Genomic DNA. Translation: AAS56777.1.
BK006939 Genomic DNA. Translation: DAA07688.1.
PIRS50538.
RefSeqNP_010952.3. NM_001178926.3.

3D structure databases

ProteinModelPortalP40023.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36770. 52 interactions.
DIPDIP-5234N.
IntActP40023. 4 interactions.
MINTMINT-488950.
STRING4932.YER035W.

Proteomic databases

PaxDbP40023.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER035W; YER035W; YER035W.
GeneID856757.
KEGGsce:YER035W.

Organism-specific databases

CYGDYER035w.
SGDS000000837. EDC2.

Phylogenomic databases

OrthoDBEOG72RN9X.

Enzyme and pathway databases

BioCycYEAST:G3O-30216-MONOMER.

Gene expression databases

GenevestigatorP40023.

Family and domain databases

ProtoNetSearch...

Other

NextBio982920.

Entry information

Entry nameEDC2_YEAST
AccessionPrimary (citable) accession number: P40023
Secondary accession number(s): D3DLT4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families