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Protein

Enhancer of mRNA-decapping protein 2

Gene

EDC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

mRNA-binding protein which stimulates mRNA decapping by DCP1 and DCP2.3 Publications

GO - Molecular functioni

  • mRNA binding Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, Nonsense-mediated mRNA decay

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30216-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of mRNA-decapping protein 2
Gene namesi
Name:EDC2
Ordered Locus Names:YER035W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome V

Organism-specific databases

CYGDiYER035w.
EuPathDBiFungiDB:YER035W.
SGDiS000000837. EDC2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleolus Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Enhancer of mRNA-decapping protein 2PRO_0000202626Add
BLAST

Proteomic databases

PaxDbiP40023.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DCP2P535501EBI-22493,EBI-270
DHH1P395171EBI-22493,EBI-158

Protein-protein interaction databases

BioGridi36770. 53 interactions.
DIPiDIP-5234N.
IntActiP40023. 4 interactions.
MINTiMINT-488950.
STRINGi4932.YER035W.

Structurei

3D structure databases

ProteinModelPortaliP40023.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EDC family.Curated

Phylogenomic databases

InParanoidiP40023.
KOiK18759.
OrthoDBiEOG72RN9X.

Sequencei

Sequence statusi: Complete.

P40023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSETKHSAK VKIVTRESPP SAKEHMRPTK TQILVPPTQS LPNGKKPNFG
60 70 80 90 100
KSTKQRREPR ERTSKTGHED DKATMVTVNI DAFLHDKAPK KKSCKYKKKK
110 120 130 140
TRQYQDRAAA SIDSKPHVAG HTAFAGASFT TDIPHEAALP KPSFV
Length:145
Mass (Da):16,071
Last modified:February 1, 1995 - v1
Checksum:i4D8A461EFD78BFA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18796 Genomic DNA. Translation: AAB64570.1.
AY558451 Genomic DNA. Translation: AAS56777.1.
BK006939 Genomic DNA. Translation: DAA07688.1.
PIRiS50538.
RefSeqiNP_010952.3. NM_001178926.3.

Genome annotation databases

EnsemblFungiiYER035W; YER035W; YER035W.
GeneIDi856757.
KEGGisce:YER035W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18796 Genomic DNA. Translation: AAB64570.1.
AY558451 Genomic DNA. Translation: AAS56777.1.
BK006939 Genomic DNA. Translation: DAA07688.1.
PIRiS50538.
RefSeqiNP_010952.3. NM_001178926.3.

3D structure databases

ProteinModelPortaliP40023.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36770. 53 interactions.
DIPiDIP-5234N.
IntActiP40023. 4 interactions.
MINTiMINT-488950.
STRINGi4932.YER035W.

Proteomic databases

PaxDbiP40023.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER035W; YER035W; YER035W.
GeneIDi856757.
KEGGisce:YER035W.

Organism-specific databases

CYGDiYER035w.
EuPathDBiFungiDB:YER035W.
SGDiS000000837. EDC2.

Phylogenomic databases

InParanoidiP40023.
KOiK18759.
OrthoDBiEOG72RN9X.

Enzyme and pathway databases

BioCyciYEAST:G3O-30216-MONOMER.

Miscellaneous databases

NextBioi982920.
PROiP40023.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae."
    Dunckley T., Tucker M., Parker R.
    Genetics 157:27-37(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. Cited for: FUNCTION.
  8. "The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme."
    Schwartz D., Decker C.J., Parker R.
    RNA 9:239-251(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiEDC2_YEAST
AccessioniPrimary (citable) accession number: P40023
Secondary accession number(s): D3DLT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 24, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.