SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P40023

- EDC2_YEAST

UniProt

P40023 - EDC2_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Enhancer of mRNA-decapping protein 2
Gene
EDC2, YER035W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

mRNA-binding protein which stimulates mRNA decapping by DCP1 and DCP2.3 Publications

GO - Molecular functioni

  1. mRNA binding Source: SGD

GO - Biological processi

  1. deadenylation-dependent decapping of nuclear-transcribed mRNA Source: SGD
  2. mRNA processing Source: UniProtKB-KW
  3. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
  4. positive regulation of translation in response to stress Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA processing, Nonsense-mediated mRNA decay

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30216-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of mRNA-decapping protein 2
Gene namesi
Name:EDC2
Ordered Locus Names:YER035W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER035w.
SGDiS000000837. EDC2.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleolus Source: SGD
  3. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Enhancer of mRNA-decapping protein 2
PRO_0000202626Add
BLAST

Proteomic databases

PaxDbiP40023.

Expressioni

Gene expression databases

GenevestigatoriP40023.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DCP2P535501EBI-22493,EBI-270
DHH1P395171EBI-22493,EBI-158

Protein-protein interaction databases

BioGridi36770. 53 interactions.
DIPiDIP-5234N.
IntActiP40023. 4 interactions.
MINTiMINT-488950.
STRINGi4932.YER035W.

Structurei

3D structure databases

ProteinModelPortaliP40023.

Family & Domainsi

Sequence similaritiesi

Belongs to the EDC family.

Phylogenomic databases

OrthoDBiEOG72RN9X.

Sequencei

Sequence statusi: Complete.

P40023-1 [UniParc]FASTAAdd to Basket

« Hide

MGSETKHSAK VKIVTRESPP SAKEHMRPTK TQILVPPTQS LPNGKKPNFG    50
KSTKQRREPR ERTSKTGHED DKATMVTVNI DAFLHDKAPK KKSCKYKKKK 100
TRQYQDRAAA SIDSKPHVAG HTAFAGASFT TDIPHEAALP KPSFV 145
Length:145
Mass (Da):16,071
Last modified:February 1, 1995 - v1
Checksum:i4D8A461EFD78BFA9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18796 Genomic DNA. Translation: AAB64570.1.
AY558451 Genomic DNA. Translation: AAS56777.1.
BK006939 Genomic DNA. Translation: DAA07688.1.
PIRiS50538.
RefSeqiNP_010952.3. NM_001178926.3.

Genome annotation databases

EnsemblFungiiYER035W; YER035W; YER035W.
GeneIDi856757.
KEGGisce:YER035W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18796 Genomic DNA. Translation: AAB64570.1 .
AY558451 Genomic DNA. Translation: AAS56777.1 .
BK006939 Genomic DNA. Translation: DAA07688.1 .
PIRi S50538.
RefSeqi NP_010952.3. NM_001178926.3.

3D structure databases

ProteinModelPortali P40023.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36770. 53 interactions.
DIPi DIP-5234N.
IntActi P40023. 4 interactions.
MINTi MINT-488950.
STRINGi 4932.YER035W.

Proteomic databases

PaxDbi P40023.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER035W ; YER035W ; YER035W .
GeneIDi 856757.
KEGGi sce:YER035W.

Organism-specific databases

CYGDi YER035w.
SGDi S000000837. EDC2.

Phylogenomic databases

OrthoDBi EOG72RN9X.

Enzyme and pathway databases

BioCyci YEAST:G3O-30216-MONOMER.

Miscellaneous databases

NextBioi 982920.

Gene expression databases

Genevestigatori P40023.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae."
    Dunckley T., Tucker M., Parker R.
    Genetics 157:27-37(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. Cited for: FUNCTION.
  8. "The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme."
    Schwartz D., Decker C.J., Parker R.
    RNA 9:239-251(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiEDC2_YEAST
AccessioniPrimary (citable) accession number: P40023
Secondary accession number(s): D3DLT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi