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P40023

- EDC2_YEAST

UniProt

P40023 - EDC2_YEAST

Protein

Enhancer of mRNA-decapping protein 2

Gene

EDC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    mRNA-binding protein which stimulates mRNA decapping by DCP1 and DCP2.3 Publications

    GO - Molecular functioni

    1. mRNA binding Source: SGD

    GO - Biological processi

    1. deadenylation-dependent decapping of nuclear-transcribed mRNA Source: SGD
    2. mRNA processing Source: UniProtKB-KW
    3. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
    4. positive regulation of translation in response to stress Source: SGD

    Keywords - Biological processi

    mRNA processing, Nonsense-mediated mRNA decay

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30216-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enhancer of mRNA-decapping protein 2
    Gene namesi
    Name:EDC2
    Ordered Locus Names:YER035W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER035w.
    SGDiS000000837. EDC2.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleolus Source: SGD
    3. nucleus Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 145145Enhancer of mRNA-decapping protein 2PRO_0000202626Add
    BLAST

    Proteomic databases

    PaxDbiP40023.

    Expressioni

    Gene expression databases

    GenevestigatoriP40023.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DCP2P535501EBI-22493,EBI-270
    DHH1P395171EBI-22493,EBI-158

    Protein-protein interaction databases

    BioGridi36770. 53 interactions.
    DIPiDIP-5234N.
    IntActiP40023. 4 interactions.
    MINTiMINT-488950.
    STRINGi4932.YER035W.

    Structurei

    3D structure databases

    ProteinModelPortaliP40023.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EDC family.Curated

    Phylogenomic databases

    OrthoDBiEOG72RN9X.

    Sequencei

    Sequence statusi: Complete.

    P40023-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSETKHSAK VKIVTRESPP SAKEHMRPTK TQILVPPTQS LPNGKKPNFG    50
    KSTKQRREPR ERTSKTGHED DKATMVTVNI DAFLHDKAPK KKSCKYKKKK 100
    TRQYQDRAAA SIDSKPHVAG HTAFAGASFT TDIPHEAALP KPSFV 145
    Length:145
    Mass (Da):16,071
    Last modified:February 1, 1995 - v1
    Checksum:i4D8A461EFD78BFA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18796 Genomic DNA. Translation: AAB64570.1.
    AY558451 Genomic DNA. Translation: AAS56777.1.
    BK006939 Genomic DNA. Translation: DAA07688.1.
    PIRiS50538.
    RefSeqiNP_010952.3. NM_001178926.3.

    Genome annotation databases

    EnsemblFungiiYER035W; YER035W; YER035W.
    GeneIDi856757.
    KEGGisce:YER035W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18796 Genomic DNA. Translation: AAB64570.1 .
    AY558451 Genomic DNA. Translation: AAS56777.1 .
    BK006939 Genomic DNA. Translation: DAA07688.1 .
    PIRi S50538.
    RefSeqi NP_010952.3. NM_001178926.3.

    3D structure databases

    ProteinModelPortali P40023.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36770. 53 interactions.
    DIPi DIP-5234N.
    IntActi P40023. 4 interactions.
    MINTi MINT-488950.
    STRINGi 4932.YER035W.

    Proteomic databases

    PaxDbi P40023.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER035W ; YER035W ; YER035W .
    GeneIDi 856757.
    KEGGi sce:YER035W.

    Organism-specific databases

    CYGDi YER035w.
    SGDi S000000837. EDC2.

    Phylogenomic databases

    OrthoDBi EOG72RN9X.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30216-MONOMER.

    Miscellaneous databases

    NextBioi 982920.

    Gene expression databases

    Genevestigatori P40023.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae."
      Dunckley T., Tucker M., Parker R.
      Genetics 157:27-37(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. Cited for: FUNCTION.
    8. "The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme."
      Schwartz D., Decker C.J., Parker R.
      RNA 9:239-251(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiEDC2_YEAST
    AccessioniPrimary (citable) accession number: P40023
    Secondary accession number(s): D3DLT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 538 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3