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P40023

- EDC2_YEAST

UniProt

P40023 - EDC2_YEAST

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Protein

Enhancer of mRNA-decapping protein 2

Gene

EDC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

mRNA-binding protein which stimulates mRNA decapping by DCP1 and DCP2.3 Publications

GO - Molecular functioni

  1. mRNA binding Source: SGD

GO - Biological processi

  1. deadenylation-dependent decapping of nuclear-transcribed mRNA Source: SGD
  2. mRNA processing Source: UniProtKB-KW
  3. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
  4. positive regulation of translation in response to stress Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA processing, Nonsense-mediated mRNA decay

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30216-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of mRNA-decapping protein 2
Gene namesi
Name:EDC2
Ordered Locus Names:YER035W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER035w.
SGDiS000000837. EDC2.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleolus Source: SGD
  3. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Enhancer of mRNA-decapping protein 2PRO_0000202626Add
BLAST

Proteomic databases

PaxDbiP40023.

Expressioni

Gene expression databases

GenevestigatoriP40023.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DCP2P535501EBI-22493,EBI-270
DHH1P395171EBI-22493,EBI-158

Protein-protein interaction databases

BioGridi36770. 53 interactions.
DIPiDIP-5234N.
IntActiP40023. 4 interactions.
MINTiMINT-488950.
STRINGi4932.YER035W.

Structurei

3D structure databases

ProteinModelPortaliP40023.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EDC family.Curated

Phylogenomic databases

InParanoidiP40023.
OrthoDBiEOG72RN9X.

Sequencei

Sequence statusi: Complete.

P40023-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSETKHSAK VKIVTRESPP SAKEHMRPTK TQILVPPTQS LPNGKKPNFG
60 70 80 90 100
KSTKQRREPR ERTSKTGHED DKATMVTVNI DAFLHDKAPK KKSCKYKKKK
110 120 130 140
TRQYQDRAAA SIDSKPHVAG HTAFAGASFT TDIPHEAALP KPSFV
Length:145
Mass (Da):16,071
Last modified:February 1, 1995 - v1
Checksum:i4D8A461EFD78BFA9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18796 Genomic DNA. Translation: AAB64570.1.
AY558451 Genomic DNA. Translation: AAS56777.1.
BK006939 Genomic DNA. Translation: DAA07688.1.
PIRiS50538.
RefSeqiNP_010952.3. NM_001178926.3.

Genome annotation databases

EnsemblFungiiYER035W; YER035W; YER035W.
GeneIDi856757.
KEGGisce:YER035W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18796 Genomic DNA. Translation: AAB64570.1 .
AY558451 Genomic DNA. Translation: AAS56777.1 .
BK006939 Genomic DNA. Translation: DAA07688.1 .
PIRi S50538.
RefSeqi NP_010952.3. NM_001178926.3.

3D structure databases

ProteinModelPortali P40023.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36770. 53 interactions.
DIPi DIP-5234N.
IntActi P40023. 4 interactions.
MINTi MINT-488950.
STRINGi 4932.YER035W.

Proteomic databases

PaxDbi P40023.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER035W ; YER035W ; YER035W .
GeneIDi 856757.
KEGGi sce:YER035W.

Organism-specific databases

CYGDi YER035w.
SGDi S000000837. EDC2.

Phylogenomic databases

InParanoidi P40023.
OrthoDBi EOG72RN9X.

Enzyme and pathway databases

BioCyci YEAST:G3O-30216-MONOMER.

Miscellaneous databases

NextBioi 982920.

Gene expression databases

Genevestigatori P40023.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae."
    Dunckley T., Tucker M., Parker R.
    Genetics 157:27-37(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. Cited for: FUNCTION.
  8. "The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme."
    Schwartz D., Decker C.J., Parker R.
    RNA 9:239-251(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiEDC2_YEAST
AccessioniPrimary (citable) accession number: P40023
Secondary accession number(s): D3DLT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3