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Protein

Factor interacting with REF2

Gene

FIR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in 3' mRNA processing. Positively regulates poly(A) synthesis.2 Publications

GO - Biological processi

  • mRNA polyadenylation Source: SGD
  • RNA polyadenylation Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-30213-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Factor interacting with REF2
Alternative name(s):
PAP1-interacting protein
Polymerase-interacting protein 1
Gene namesi
Name:FIR1
Synonyms:PIP1
Ordered Locus Names:YER032W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER032W.
SGDiS000000834. FIR1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 876876Factor interacting with REF2PRO_0000058446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811PhosphoserineCombined sources
Modified residuei172 – 1721PhosphoserineCombined sources
Modified residuei225 – 2251PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated by CDC28.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40020.
PRIDEiP40020.

PTM databases

iPTMnetiP40020.

Interactioni

Subunit structurei

Interacts with PAP1, REF2 and PBP1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BOI1P380412EBI-13431,EBI-3719
BOI2P399692EBI-13431,EBI-3727

Protein-protein interaction databases

BioGridi36767. 66 interactions.
DIPiDIP-844N.
IntActiP40020. 12 interactions.
MINTiMINT-486334.

Structurei

3D structure databases

ProteinModelPortaliP40020.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi655 – 68329Ser-richAdd
BLAST

Phylogenomic databases

InParanoidiP40020.
OMAiVDMHSKI.
OrthoDBiEOG092C1KG7.

Sequencei

Sequence statusi: Complete.

P40020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPVTPVKS KVCSTLSIQH EMDHDQCRDV LCPRENLLAI NRTNNIESVA
60 70 80 90 100
IPRQRSSKNK KPHEHTQSQV RFSIPDPNEI SQDSPLKIVF PKSGNETERR
110 120 130 140 150
MSTSSLLMNS HGHLVDMHSK ILVDVPKEVW KFHHNRRKKC ESRHRKTRSD
160 170 180 190 200
VRSNTSSSGK EPNHSRSKSL QSIIVDTMNT YRATEVETSI NENTSNISQV
210 220 230 240 250
SPLNLSFDRP PPLTPEKNLY LTPESPLNRY HLPVPLEISL PPYLSPQNKD
260 270 280 290 300
KKRSSLVYDG DGYSQFQEGN TSSSTESSLE QPSSSYSDED DSIPYAHHDV
310 320 330 340 350
SFELNNADAD KLLGIDENAN VNLKIQRRNL KNPQHIKSKT DRECEEKNTE
360 370 380 390 400
KNVSLKILST PNKLIDIPDL EHMKSPPSTG LNGTLKFFQQ FEPSEEPTSP
410 420 430 440 450
TRQVNPESLD KLDMSFKFPS STTNNNVDKV HENRNSGDTN NEDFLKVDTS
460 470 480 490 500
PVNQSFESRR QMLIDLQKSP TNNNPRIHKH RRSRSVHNID DISLNFEATS
510 520 530 540 550
TPPAPTSAPS IPVEHSNPCT SIEIPKRSPL RFTSSPKTSD IPPEAQSPKN
560 570 580 590 600
GSFLQEISVP SIQIIPDESI SHTREPSPSL IECPEDENEA FSTEVADHSI
610 620 630 640 650
AIISETKSVP SIEPFKPLSS FNSFGQEIQN KEPTPLNQTP TDLIGKQRNC
660 670 680 690 700
VNPHSIPFSV LSSNSQSSQS GSSKSSYNSE FSSNTAITDT TSQPSVTINR
710 720 730 740 750
STLEHNFIEE KRSIKNLGHG PPSQKNNYSF PRNKNTPSNR HDLDFNTIYE
760 770 780 790 800
KRDGKMVEVI LLDEDEDVGL KNNDISRTRV CHAQKAKNEQ QKKRLSHCNE
810 820 830 840 850
ILGMCDKTAD DAKRIIYQLV NEKHKFSEKG QQTKPKKSRV LPPLPFPLYD
860 870
EKGNSLIPNK YQSSIHNDIP SHRKLK
Length:876
Mass (Da):98,812
Last modified:July 25, 2006 - v3
Checksum:iDFD2AB3684EBC1D2
GO

Sequence cautioni

The sequence AAB46625 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAB64565 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti614 – 6141P → R in strain: ATCC 200060 / W303. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17262 Genomic DNA. Translation: AAB46625.1. Different initiation.
U18778 Genomic DNA. Translation: AAB64565.1. Different initiation.
BK006939 Genomic DNA. Translation: DAA07685.1.
PIRiS50490.
RefSeqiNP_010949.4. NM_001178923.3.

Genome annotation databases

EnsemblFungiiYER032W; YER032W; YER032W.
GeneIDi856754.
KEGGisce:YER032W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17262 Genomic DNA. Translation: AAB46625.1. Different initiation.
U18778 Genomic DNA. Translation: AAB64565.1. Different initiation.
BK006939 Genomic DNA. Translation: DAA07685.1.
PIRiS50490.
RefSeqiNP_010949.4. NM_001178923.3.

3D structure databases

ProteinModelPortaliP40020.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36767. 66 interactions.
DIPiDIP-844N.
IntActiP40020. 12 interactions.
MINTiMINT-486334.

PTM databases

iPTMnetiP40020.

Proteomic databases

MaxQBiP40020.
PRIDEiP40020.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER032W; YER032W; YER032W.
GeneIDi856754.
KEGGisce:YER032W.

Organism-specific databases

EuPathDBiFungiDB:YER032W.
SGDiS000000834. FIR1.

Phylogenomic databases

InParanoidiP40020.
OMAiVDMHSKI.
OrthoDBiEOG092C1KG7.

Enzyme and pathway databases

BioCyciYEAST:G3O-30213-MONOMER.

Miscellaneous databases

PROiP40020.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiFIR1_YEAST
AccessioniPrimary (citable) accession number: P40020
Secondary accession number(s): D3DLT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 25, 2006
Last modified: September 7, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.