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Protein

Carnitine O-acetyltransferase YAT2

Gene

YAT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the shutteling of acetyl-CoA in the cell.1 Publication

Miscellaneous

Present with 319 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Acetyl-CoA + carnitine = CoA + O-acetylcarnitine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei576CarnitineBy similarity1

GO - Molecular functioni

  • carnitine O-acetyltransferase activity Source: SGD

GO - Biological processi

  • alcohol metabolic process Source: SGD
  • carnitine metabolic process Source: SGD
  • fatty acid metabolic process Source: UniProtKB-KW

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid metabolism, Transport

Enzyme and pathway databases

BioCyciYEAST:YER024W-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Carnitine O-acetyltransferase YAT2 (EC:2.3.1.7)
Gene namesi
Name:YAT2
Ordered Locus Names:YER024W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER024W
SGDiS000000826 YAT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002101762 – 923Carnitine O-acetyltransferase YAT2Add BLAST922

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei783PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP40017
PaxDbiP40017
PRIDEiP40017

PTM databases

iPTMnetiP40017

Interactioni

Protein-protein interaction databases

BioGridi36758, 52 interactors
IntActiP40017, 2 interactors
STRINGi4932.YER024W

Structurei

3D structure databases

ProteinModelPortaliP40017
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni530 – 541Coenzyme A bindingBy similarityAdd BLAST12

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000141908
InParanoidiP40017
KOiK00624
OMAiSRWYDKL
OrthoDBiEOG092C0G2X

Family and domain databases

InterProiView protein in InterPro
IPR000542 Carn_acyl_trans
PANTHERiPTHR22589 PTHR22589, 1 hit
PfamiView protein in Pfam
PF00755 Carn_acyltransf, 1 hit
PROSITEiView protein in PROSITE
PS00439 ACYLTRANSF_C_1, 1 hit
PS00440 ACYLTRANSF_C_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGSTIVSS DKSGRTFKHE EELPKLPLPK LCDTLQRLKE SLEPLYYADG
60 70 80 90 100
YYQHPLDPEQ IEKLSSIIRD FEENPVSEKL QSKLQSYHDT RDCYLDELHL
110 120 130 140 150
DINNQTSTRE IQDDVLPRNP FLVLADDALP NITQADRSAV LVHSAARFIS
160 170 180 190 200
ALKQDLLPPD INATNGKPLS MAPFLNLFGT TRSPVFQRGE VENFDLNKPY
210 220 230 240 250
TASDLEDPDY SSDEDDNDEP TQKDFDDRKR KHEEDIFTGN GITIKRHPDS
260 270 280 290 300
KHILIISRGQ YYTLEVLDST NKIIYTAAEL TTIFNHIIKD SSGIEKSTAL
310 320 330 340 350
GSLTSHSFRN WKYARKRLQK RYPNELHRID SALFVLVLDE SQEETTNDGD
360 370 380 390 400
DTADISQMFN RTITERDKKC TSANCKRVFY GTSIINSKGH QVGSCVSRWY
410 420 430 440 450
DKLQLVVTAD AKATVIWDSF TCDGSVVLRF TSEIYTESVL RLARDVNAGD
460 470 480 490 500
PQFSLWPNVT QMDPETKKLM TATISADGGG PSEIDPKLVV NKIDWSFSNI
510 520 530 540 550
LNTHVHLSET KLADLISKYD IVRASIPLGR RSAQRLGVKP DSMVQVALQI
560 570 580 590 600
AHYALYGRMV FGLEPVSTRG FKNSRSSFIN IQSQALLELC QLFISSSIDG
610 620 630 640 650
TDKLDKFIQT CETHNNMVKH AKSGVGYEKH FNALKYLFKF HDHFGIHLSG
660 670 680 690 700
DESSAAKDLF ENPLVLPFSQ PELIVANCGN AATTTFGITP AVPHGFGIGY
710 720 730 740 750
IIKDDQVDLT VTSQFRQGDR LMFMLSWVLG EIRSYWRMSR GTSHNKTGVK
760 770 780 790 800
ISPVVDKLYE MDNAVNNPPK RNGHTVNGSR KTSSSSQVNL NRYGGFFDLE
810 820 830 840 850
GHIDSRNISK TPSMKNLQKT FNGLTMSADN DHSSSAVSVP TEKEKLNTGH
860 870 880 890 900
EILQIQPREV ASNGLEADDE TDIEIVAGNA DGTSSSASSA TSLNSKKRNV
910 920
INSRFDIDFD RSRVGRKVAT LDQ
Length:923
Mass (Da):103,334
Last modified:February 1, 1995 - v1
Checksum:iB59AB881491D68A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18778 Genomic DNA Translation: AAB64557.1
BK006939 Genomic DNA Translation: DAA07677.1
PIRiS50482
RefSeqiNP_010941.1, NM_001178915.1

Genome annotation databases

EnsemblFungiiYER024W; YER024W; YER024W
GeneIDi856745
KEGGisce:YER024W

Similar proteinsi

Entry informationi

Entry nameiYAT2_YEAST
AccessioniPrimary (citable) accession number: P40017
Secondary accession number(s): D3DLS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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