Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P40010 (NUG1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear GTP-binding protein NUG1
Alternative name(s):
Nuclear GTPase 1
Gene names
Name:NUG1
Ordered Locus Names:YER006W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

GTPase required for 60S ribosomal subunit export to the cytoplasm. Ref.3

Subcellular location

Nucleus Ref.3.

Domain

In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.

Miscellaneous

Present with 7130 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the MMR1/HSR1 GTP-binding protein family.

Contains 1 G (guanine nucleotide-binding) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 520520Nuclear GTP-binding protein NUG1
PRO_0000122452

Regions

Domain292 – 37180G
Nucleotide binding213 – 2164GTP Potential
Nucleotide binding287 – 2948GTP Potential
Nucleotide binding336 – 3394GTP Potential

Amino acid modifications

Modified residue3371Phosphoserine Ref.6

Sequences

Sequence LengthMass (Da)Tools
P40010 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: F75E4860D114756A

FASTA52057,709
        10         20         30         40         50         60 
MRVRKRQSRR TSTKLKEGIK KKASAHRKKE KKMAKKDVTW RSRSKKDPGI PSNFPYKAKI 

        70         80         90        100        110        120 
LEEIEAKKMK DLEERELAKQ QRLEARKAAK EQGVDAMDED MIEDDENGLA ALVESAQQAA 

       130        140        150        160        170        180 
AEYEGTPSND ADVRDDELDV IDYNIDFYGE DVEGESELEK SRKAYDKIFK SVIDASDVIL 

       190        200        210        220        230        240 
YVLDARDPES TRSRKVEEAV LQSQGKRLIL ILNKVDLIPP HVLEQWLNYL KSSFPTIPLR 

       250        260        270        280        290        300 
ASSGAVNGTS FNRKLSQTTT ASALLESLKT YSNNSNLKRS IVVGVIGYPN VGKSSVINAL 

       310        320        330        340        350        360 
LARRGGQSKA CPVGNEAGVT TSLREIKIDN KLKILDSPGI CFPSENKKRS KVEHEAELAL 

       370        380        390        400        410        420 
LNALPAKHIV DPYPAVLMLV KRLAKSDEMT ESFKKLYEIP PIPANDADTF TKHFLIHVAR 

       430        440        450        460        470        480 
KRGRLGKGGI PNLASAGLSV LNDWRDGKIL GWVLPNTSAA ASQQDKQNLS TINTGTKQAP 

       490        500        510        520 
IAANESTIVS EWSKEFDLDG LFSSLDKAID ASKDQDTMME 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Identification of a 60S preribosomal particle that is closely linked to nuclear export."
Bassler J., Grandi P., Gadal O., Lessmann T., Petfalski E., Tollervey D., Lechner J., Hurt E.
Mol. Cell 8:517-529(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-337, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18778 Genomic DNA. Translation: AAB64539.1.
BK006939 Genomic DNA. Translation: DAA07656.1.
PIRS50464.
RefSeqNP_010921.1. NM_001178897.1.

3D structure databases

ProteinModelPortalP40010.
SMRP40010. Positions 169-448.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36736. 164 interactions.
DIPDIP-6291N.
IntActP40010. 66 interactions.
MINTMINT-597077.
STRING4932.YER006W.

Proteomic databases

PaxDbP40010.
PeptideAtlasP40010.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER006W; YER006W; YER006W.
GeneID856723.
KEGGsce:YER006W.

Organism-specific databases

CYGDYER006w.
SGDS000000808. NUG1.

Phylogenomic databases

eggNOGCOG1161.
GeneTreeENSGT00550000074731.
HOGENOMHOG000207716.
KOK14538.
OMALNDWRDG.
OrthoDBEOG7X9GHD.

Enzyme and pathway databases

BioCycYEAST:G3O-30193-MONOMER.

Gene expression databases

GenevestigatorP40010.

Family and domain databases

Gene3D1.10.1580.10. 1 hit.
3.40.50.300. 1 hit.
InterProIPR014813. Gnl3_N_dom.
IPR023179. GTP-bd_ortho_bundle.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF08701. GN3L_Grn1. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

NextBio982820.
PROP40010.

Entry information

Entry nameNUG1_YEAST
AccessionPrimary (citable) accession number: P40010
Secondary accession number(s): D3DLQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families