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Protein

Prefoldin subunit 2

Gene

GIM4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

GO - Molecular functioni

  • tubulin binding Source: SGD

GO - Biological processi

  • protein folding Source: InterPro
  • tubulin complex assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-30132-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 2
Alternative name(s):
Genes involved in microtubule biogenesis protein 4
Gim complex subunit 4
Short name:
GimC subunit 4
Gene namesi
Name:GIM4
Synonyms:PFD2
Ordered Locus Names:YEL003W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YEL003W.
SGDiS000000729. GIM4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • prefoldin complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001248411 – 111Prefoldin subunit 2Add BLAST111

Proteomic databases

MaxQBiP40005.
PRIDEiP40005.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.1 Publication

GO - Molecular functioni

  • tubulin binding Source: SGD

Protein-protein interaction databases

BioGridi36728. 482 interactors.
DIPiDIP-7472N.
IntActiP40005. 1 interactor.
MINTiMINT-2780320.

Structurei

3D structure databases

ProteinModelPortaliP40005.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 36Sequence analysisAdd BLAST36
Coiled coili72 – 92Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000009272.
HOGENOMiHOG000211843.
InParanoidiP40005.
KOiK09549.
OMAiKCFRMVN.
OrthoDBiEOG092C5GR9.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR027235. PFD2.
IPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR13303. PTHR13303. 1 hit.
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

P40005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQRNNVFQA KYNEYKQILE ELQTKIIELG HDKDEHTIVI KTLKDAEPTR
60 70 80 90 100
KCYRMIGGAL VESDVQTSLP ILETKKENIE GTISKMKETL IQTAKEFEKW
110
KKDNKIQVVK N
Length:111
Mass (Da):12,994
Last modified:June 26, 2007 - v2
Checksum:iE12DC1BE53C8C936
GO

Sequence cautioni

The sequence AAB64480 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAS56665 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59A → T in ABM97488 (PubMed:17244705).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18530 Genomic DNA. Translation: AAB64480.1. Sequence problems.
EF123144 mRNA. Translation: ABM97488.1.
AY558339 Genomic DNA. Translation: AAS56665.1. Sequence problems.
BK006939 Genomic DNA. Translation: DAA07648.1.
PIRiS50456.
RefSeqiNP_010913.2. NM_001178818.1.

Genome annotation databases

EnsemblFungiiYEL003W; YEL003W; YEL003W.
GeneIDi856715.
KEGGisce:YEL003W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18530 Genomic DNA. Translation: AAB64480.1. Sequence problems.
EF123144 mRNA. Translation: ABM97488.1.
AY558339 Genomic DNA. Translation: AAS56665.1. Sequence problems.
BK006939 Genomic DNA. Translation: DAA07648.1.
PIRiS50456.
RefSeqiNP_010913.2. NM_001178818.1.

3D structure databases

ProteinModelPortaliP40005.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36728. 482 interactors.
DIPiDIP-7472N.
IntActiP40005. 1 interactor.
MINTiMINT-2780320.

Proteomic databases

MaxQBiP40005.
PRIDEiP40005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYEL003W; YEL003W; YEL003W.
GeneIDi856715.
KEGGisce:YEL003W.

Organism-specific databases

EuPathDBiFungiDB:YEL003W.
SGDiS000000729. GIM4.

Phylogenomic databases

GeneTreeiENSGT00390000009272.
HOGENOMiHOG000211843.
InParanoidiP40005.
KOiK09549.
OMAiKCFRMVN.
OrthoDBiEOG092C5GR9.

Enzyme and pathway databases

BioCyciYEAST:G3O-30132-MONOMER.

Miscellaneous databases

PROiP40005.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR027235. PFD2.
IPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR13303. PTHR13303. 1 hit.
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPFD2_YEAST
AccessioniPrimary (citable) accession number: P40005
Secondary accession number(s): A2TBP1, D3DLP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 26, 2007
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1660 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.