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Protein

Prefoldin subunit 2

Gene

GIM4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Miscellaneous

Present with 1660 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • protein folding Source: GO_Central
  • tubulin complex assembly Source: SGD

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-30132-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 2
Alternative name(s):
Genes involved in microtubule biogenesis protein 4
Gim complex subunit 4
Short name:
GimC subunit 4
Gene namesi
Name:GIM4
Synonyms:PFD2
Ordered Locus Names:YEL003W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YEL003W.
SGDiS000000729. GIM4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • prefoldin complex Source: SGD

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001248411 – 111Prefoldin subunit 2Add BLAST111

Proteomic databases

MaxQBiP40005.
PRIDEiP40005.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi36728. 586 interactors.
DIPiDIP-7472N.
IntActiP40005. 1 interactor.
MINTiMINT-2780320.

Structurei

3D structure databases

ProteinModelPortaliP40005.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 36Sequence analysisAdd BLAST36
Coiled coili72 – 92Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000009272.
HOGENOMiHOG000211843.
InParanoidiP40005.
KOiK09549.
OMAiERRCFRM.
OrthoDBiEOG092C5GR9.

Family and domain databases

InterProiView protein in InterPro
IPR027235. PFD2.
IPR002777. PFD_beta-like.
PANTHERiPTHR13303. PTHR13303. 1 hit.
PfamiView protein in Pfam
PF01920. Prefoldin_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P40005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQRNNVFQA KYNEYKQILE ELQTKIIELG HDKDEHTIVI KTLKDAEPTR
60 70 80 90 100
KCYRMIGGAL VESDVQTSLP ILETKKENIE GTISKMKETL IQTAKEFEKW
110
KKDNKIQVVK N
Length:111
Mass (Da):12,994
Last modified:June 26, 2007 - v2
Checksum:iE12DC1BE53C8C936
GO

Sequence cautioni

The sequence AAB64480 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAS56665 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59A → T in ABM97488 (PubMed:17244705).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18530 Genomic DNA. Translation: AAB64480.1. Sequence problems.
EF123144 mRNA. Translation: ABM97488.1.
AY558339 Genomic DNA. Translation: AAS56665.1. Sequence problems.
BK006939 Genomic DNA. Translation: DAA07648.1.
PIRiS50456.
RefSeqiNP_010913.2. NM_001178818.1.

Genome annotation databases

EnsemblFungiiYEL003W; YEL003W; YEL003W.
GeneIDi856715.
KEGGisce:YEL003W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18530 Genomic DNA. Translation: AAB64480.1. Sequence problems.
EF123144 mRNA. Translation: ABM97488.1.
AY558339 Genomic DNA. Translation: AAS56665.1. Sequence problems.
BK006939 Genomic DNA. Translation: DAA07648.1.
PIRiS50456.
RefSeqiNP_010913.2. NM_001178818.1.

3D structure databases

ProteinModelPortaliP40005.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36728. 586 interactors.
DIPiDIP-7472N.
IntActiP40005. 1 interactor.
MINTiMINT-2780320.

Proteomic databases

MaxQBiP40005.
PRIDEiP40005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYEL003W; YEL003W; YEL003W.
GeneIDi856715.
KEGGisce:YEL003W.

Organism-specific databases

EuPathDBiFungiDB:YEL003W.
SGDiS000000729. GIM4.

Phylogenomic databases

GeneTreeiENSGT00390000009272.
HOGENOMiHOG000211843.
InParanoidiP40005.
KOiK09549.
OMAiERRCFRM.
OrthoDBiEOG092C5GR9.

Enzyme and pathway databases

BioCyciYEAST:G3O-30132-MONOMER.

Miscellaneous databases

PROiPR:P40005.

Family and domain databases

InterProiView protein in InterPro
IPR027235. PFD2.
IPR002777. PFD_beta-like.
PANTHERiPTHR13303. PTHR13303. 1 hit.
PfamiView protein in Pfam
PF01920. Prefoldin_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPFD2_YEAST
AccessioniPrimary (citable) accession number: P40005
Secondary accession number(s): A2TBP1, D3DLP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 26, 2007
Last modified: June 7, 2017
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.