P39996 (GTT3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione transferase 3

Gene names

Name:	GTT3
Ordered Locus Names:	YEL017W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus membrane; Multi-pass membrane protein Ref.3.
Miscellaneous	Present with 1300 molecules/cell in log phase SD medium. Ref.4

Ontologies

Keywords
Cellular component	Membrane Nucleus
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Glutathione transferase 3		PRO_0000202611
Regions
	Topological domain	1 – 239	239	Cytoplasmic Potential
	Transmembrane	240 – 260	21	Helical; Potential
	Topological domain	261 – 313	53	Perinuclear space Potential
	Transmembrane	314 – 336	23	Helical; Potential
	Topological domain	337	1	Cytoplasmic Potential
Amino acid modifications
	Modified residue	116	1	Phosphoserine Ref.6 Ref.7

Sequences

	Sequence		Length	Mass (Da)
	P39996 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: E9F07EFD2A522006	FASTA	337	38,235
	10 20 30 40 50 60 MPTKSTFSRW KKADLIDLAN KLEIDGFPNY AKKSDMIDYL ESHLNHLEKP VDFKDDYPEL 70 80 90 100 110 120 RSFYESMTVD QSKDERNEYG SGSGNGSGSG SCDTATNDSD LEKAYIKEDD DEKPQSGDET 130 140 150 160 170 180 SATKPLSSRN ANSNAKTNFN LLDFSTDNDS STSAFTKFKF NFQEYLSDIR YQTQKLNENV 190 200 210 220 230 240 QDYLSTISAV DTIFSLLEFS FLVRNILAAG QPTSSSSLAS SLEAAVAAHN KYQYTLDFCL 250 260 270 280 290 300 PILTWLLFFR GIPTLVSYYI NFIRYDLNIE LDPMTFNLTK FLISLAIFKT CNNKNIDFHS 310 320 330 FRCVNQLWTQ LCTVNRSLGM VPLVFSMVSC LLTLYVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed: 9169868] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
[6]	"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed: 17330950] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116, MASS SPECTROMETRY. Strain: ADR376.
[7]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U18530 Genomic DNA. Translation: AAB64494.1. BK006939 Genomic DNA. Translation: DAA07637.1.
PIR	S50442.
RefSeq	NP_010899.1. NM_001178832.1.
3D structure databases
ProteinModelPortal	P39996.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2062N.
IntAct	P39996. 8 interactions.
MINT	MINT-475059.
STRING	P39996.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YEL017W; YEL017W; YEL017W.
GeneID	856698.
KEGG	sce:YEL017W.
NMPDR	fig|4932.3.peg.1955.
Organism-specific databases
CYGD	YEL017w.
SGD	S000000743. GTT3.
Phylogenomic databases
eggNOG	fuNOG12018.
HOGENOM	HBG203732.
OMA	YINFIRY.
OrthoDB	EOG42RHJ2.
Gene expression databases
ArrayExpress	P39996.
Genevestigator	P39996.
GermOnline	YEL017W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	982757.

Entry information

Entry name

GTT3_YEAST

Accession

Primary (citable) accession number: P39996
Secondary accession number(s): D3DLN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	December 14, 2011
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program