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Protein

Putative 2-hydroxyacyl-CoA lyase

Gene

YEL020C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.By similarity

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity
  • thiamine diphosphateBy similarityNote: Binds 1 thiamine pyrophosphate per subunit.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciYEAST:G3O-30145-MONOMER.
ReactomeiR-SCE-389599. Alpha-oxidation of phytanate.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-hydroxyacyl-CoA lyase (EC:4.1.-.-)
Gene namesi
Ordered Locus Names:YEL020C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YEL020C.
SGDiS000000746. YEL020C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Putative 2-hydroxyacyl-CoA lyasePRO_0000090826Add
BLAST

Proteomic databases

MaxQBiP39994.

Interactioni

Protein-protein interaction databases

BioGridi36710. 69 interactions.
DIPiDIP-5281N.
MINTiMINT-482237.

Structurei

3D structure databases

ProteinModelPortaliP39994.
SMRiP39994. Positions 2-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TPP enzyme family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000063412.
HOGENOMiHOG000053808.
InParanoidiP39994.
KOiK12261.
OMAiDIDASEM.
OrthoDBiEOG092C1NSE.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR029061. THDP-binding.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamiPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
PROSITEiPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTATQHFA QLLQKYGIDT VFGIVGIPIV QLADTMVANG IKFIPCRNEQ
60 70 80 90 100
AASYAASAYG YISDKPGVLL IVGGPGLIHA LAGIYNSMSN RWPLLVIAGS
110 120 130 140 150
SSQSDIHKGG FQELDQVSLL SPFLKFTGKL TPDNIDMITQ KALNYCIQGT
160 170 180 190 200
AGVSYIDVPA DFIEYEKPLE GNDRTGNELP MILTPNICGP DPSKIKKVVQ
210 220 230 240 250
LILQHKNKNI LIVIGKGAVK NSHEIRRLVN TFNLPFLPTP MAKGIVPDSS
260 270 280 290 300
PLNVSSARSQ ALKIADIVLV LGARLNWILH FGTSPKWNSE SIFIQFDSNP
310 320 330 340 350
ETLGDNNVSP GADLSIWGDI GLSVTALVEE LTRQDSCWKY SGVKQEIREK
360 370 380 390 400
IQLNQTRLLR KEKTRGAQLN YNQVYGTLRP LIDDYRTILV TEGANTMDIA
410 420 430 440 450
RISFPTDAPR RRLDAGTNAT MGIGLGYALA CKASHPELDV VLIQGDSAFG
460 470 480 490 500
FSAMEIETAV RCQLALVIVV MNNSGIYHGE KDIEGDLPPT ALSKNCRYDL
510 520 530 540 550
VGKGLGANDF FVNTISELSR CFQQAVQLSR TKRETSVINV IIEPGEQKQI
560
AFAWQNKPRL
Length:560
Mass (Da):61,288
Last modified:February 1, 1995 - v1
Checksum:i48523C4E6BCB441F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18530 Genomic DNA. Translation: AAB64497.1.
BK006939 Genomic DNA. Translation: DAA07633.1.
PIRiS50439.
RefSeqiNP_010895.1. NM_001178835.1.

Genome annotation databases

EnsemblFungiiYEL020C; YEL020C; YEL020C.
GeneIDi856694.
KEGGisce:YEL020C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18530 Genomic DNA. Translation: AAB64497.1.
BK006939 Genomic DNA. Translation: DAA07633.1.
PIRiS50439.
RefSeqiNP_010895.1. NM_001178835.1.

3D structure databases

ProteinModelPortaliP39994.
SMRiP39994. Positions 2-554.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36710. 69 interactions.
DIPiDIP-5281N.
MINTiMINT-482237.

Proteomic databases

MaxQBiP39994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYEL020C; YEL020C; YEL020C.
GeneIDi856694.
KEGGisce:YEL020C.

Organism-specific databases

EuPathDBiFungiDB:YEL020C.
SGDiS000000746. YEL020C.

Phylogenomic databases

GeneTreeiENSGT00530000063412.
HOGENOMiHOG000053808.
InParanoidiP39994.
KOiK12261.
OMAiDIDASEM.
OrthoDBiEOG092C1NSE.

Enzyme and pathway databases

BioCyciYEAST:G3O-30145-MONOMER.
ReactomeiR-SCE-389599. Alpha-oxidation of phytanate.

Miscellaneous databases

PROiP39994.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR029061. THDP-binding.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamiPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
PROSITEiPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYEC0_YEAST
AccessioniPrimary (citable) accession number: P39994
Secondary accession number(s): D3DLM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.