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Protein

Putative 2-hydroxyacyl-CoA lyase

Gene

YEL020C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.By similarity

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity
  • thiamine diphosphateBy similarityNote: Binds 1 thiamine pyrophosphate per subunit.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandThiamine pyrophosphate

Enzyme and pathway databases

BioCyciYEAST:G3O-30145-MONOMER
ReactomeiR-SCE-389599 Alpha-oxidation of phytanate

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-hydroxyacyl-CoA lyase (EC:4.1.-.-)
Gene namesi
Ordered Locus Names:YEL020C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YEL020C
SGDiS000000746 YEL020C

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000908261 – 560Putative 2-hydroxyacyl-CoA lyaseAdd BLAST560

Proteomic databases

MaxQBiP39994
PaxDbiP39994
PRIDEiP39994

Interactioni

Protein-protein interaction databases

BioGridi36710, 136 interactors
DIPiDIP-5281N
IntActiP39994, 5 interactors
STRINGi4932.YEL020C

Structurei

3D structure databases

ProteinModelPortaliP39994
SMRiP39994
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TPP enzyme family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000063412
HOGENOMiHOG000053808
InParanoidiP39994
KOiK12261
OMAiPYLPMSM
OrthoDBiEOG092C1NSE

Family and domain databases

InterProiView protein in InterPro
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR029061 THDP-binding
IPR012000 Thiamin_PyroP_enz_cen_dom
IPR012001 Thiamin_PyroP_enz_TPP-bd_dom
IPR000399 TPP-bd_CS
IPR011766 TPP_enzyme-bd_C
PfamiView protein in Pfam
PF02775 TPP_enzyme_C, 1 hit
PF00205 TPP_enzyme_M, 1 hit
PF02776 TPP_enzyme_N, 1 hit
SUPFAMiSSF52467 SSF52467, 1 hit
SSF52518 SSF52518, 2 hits
PROSITEiView protein in PROSITE
PS00187 TPP_ENZYMES, 1 hit

Sequencei

Sequence statusi: Complete.

P39994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTATQHFA QLLQKYGIDT VFGIVGIPIV QLADTMVANG IKFIPCRNEQ
60 70 80 90 100
AASYAASAYG YISDKPGVLL IVGGPGLIHA LAGIYNSMSN RWPLLVIAGS
110 120 130 140 150
SSQSDIHKGG FQELDQVSLL SPFLKFTGKL TPDNIDMITQ KALNYCIQGT
160 170 180 190 200
AGVSYIDVPA DFIEYEKPLE GNDRTGNELP MILTPNICGP DPSKIKKVVQ
210 220 230 240 250
LILQHKNKNI LIVIGKGAVK NSHEIRRLVN TFNLPFLPTP MAKGIVPDSS
260 270 280 290 300
PLNVSSARSQ ALKIADIVLV LGARLNWILH FGTSPKWNSE SIFIQFDSNP
310 320 330 340 350
ETLGDNNVSP GADLSIWGDI GLSVTALVEE LTRQDSCWKY SGVKQEIREK
360 370 380 390 400
IQLNQTRLLR KEKTRGAQLN YNQVYGTLRP LIDDYRTILV TEGANTMDIA
410 420 430 440 450
RISFPTDAPR RRLDAGTNAT MGIGLGYALA CKASHPELDV VLIQGDSAFG
460 470 480 490 500
FSAMEIETAV RCQLALVIVV MNNSGIYHGE KDIEGDLPPT ALSKNCRYDL
510 520 530 540 550
VGKGLGANDF FVNTISELSR CFQQAVQLSR TKRETSVINV IIEPGEQKQI
560
AFAWQNKPRL
Length:560
Mass (Da):61,288
Last modified:February 1, 1995 - v1
Checksum:i48523C4E6BCB441F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18530 Genomic DNA Translation: AAB64497.1
BK006939 Genomic DNA Translation: DAA07633.1
PIRiS50439
RefSeqiNP_010895.1, NM_001178835.1

Genome annotation databases

EnsemblFungiiYEL020C; YEL020C; YEL020C
GeneIDi856694
KEGGisce:YEL020C

Similar proteinsi

Entry informationi

Entry nameiYEC0_YEAST
AccessioniPrimary (citable) accession number: P39994
Secondary accession number(s): D3DLM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health