Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

13 kDa ribonucleoprotein-associated protein

Gene

SNU13

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.3 Publications

GO - Molecular functioni

  • RNA binding Source: SGD
  • U3 snoRNA binding Source: GO_Central
  • U4 snRNA binding Source: GO_Central

GO - Biological processi

  • maturation of LSU-rRNA Source: GO_Central
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • mRNA splicing, via spliceosome Source: SGD
  • rRNA 2'-O-methylation Source: Reactome
  • rRNA methylation Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing, Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-30149-MONOMER
ReactomeiR-SCE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-SCE-72165 mRNA Splicing - Minor Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
13 kDa ribonucleoprotein-associated protein
Alternative name(s):
Small nuclear ribonucleoprotein-associated protein 1
Gene namesi
Name:SNU13
Ordered Locus Names:YEL026W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YEL026W
SGDiS000000752 SNU13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi59E → A: Impairs binding to U4 snRNA, but not U3 snoRNA. Causes pre-mRNA splicing and pre-rRNA processing defects. 1 Publication1
Mutagenesisi81V → L: Impairs binding to U4 snRNA, but not U3 snoRNA, and causes pre rRNA processing defects and an accumulation of unspliced U3 snoRNA; when associated with A-84. 1 Publication1
Mutagenesisi84R → A: Impairs binding to U4 snRNA, but not U3 snoRNA, and causes pre rRNA processing defects and an accumulation of unspliced U3 snoRNA; when associated with L-81. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367771 – 12613 kDa ribonucleoprotein-associated proteinAdd BLAST126

Proteomic databases

MaxQBiP39990
PaxDbiP39990
PRIDEiP39990

Interactioni

Subunit structurei

Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1. Binds to the 5'-stem-loop of U4 snRNA. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.6 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36703, 166 interactors
DIPiDIP-2870N
IntActiP39990, 28 interactors
MINTiP39990
STRINGi4932.YEL026W

Structurei

Secondary structure

1126
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 29Combined sources16
Beta strandi33 – 36Combined sources4
Helixi37 – 46Combined sources10
Beta strandi49 – 55Combined sources7
Helixi61 – 64Combined sources4
Helixi66 – 74Combined sources9
Beta strandi78 – 82Combined sources5
Helixi84 – 90Combined sources7
Beta strandi98 – 103Combined sources6
Helixi110 – 124Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZWZX-ray1.90A/B1-126[»]
2ALEX-ray1.80A1-126[»]
3JCMelectron microscopy3.80M1-126[»]
4NUTX-ray1.55A1-126[»]
5GANelectron microscopy3.60K1-126[»]
5GAPelectron microscopy3.60K1-126[»]
5NRLelectron microscopy7.20K1-126[»]
5TZSelectron microscopy5.10e/f1-126[»]
5WLCelectron microscopy3.80SE/SF1-126[»]
5WYJelectron microscopy8.703G/3H1-126[»]
5WYKelectron microscopy4.503G/3H1-126[»]
ProteinModelPortaliP39990
SMRiP39990
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39990

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000074840
HOGENOMiHOG000055226
InParanoidiP39990
KOiK12845
OMAiKPFYVRF
OrthoDBiEOG092C5PRN

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR002415 H/ACA_rnp_Nhp2_euk
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR018492 Ribosomal_L7Ae/L8/Nhp2
IPR004037 Ribosomal_L7Ae_CS
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
PRINTSiPR00881 L7ARS6FAMILY
PR00883 NUCLEARHMG
SUPFAMiSSF55315 SSF55315, 1 hit
PROSITEiView protein in PROSITE
PS01082 RIBOSOMAL_L7AE, 1 hit

Sequencei

Sequence statusi: Complete.

P39990-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPNPKAFP LADAALTQQI LDVVQQAANL RQLKKGANEA TKTLNRGISE
60 70 80 90 100
FIIMAADCEP IEILLHLPLL CEDKNVPYVF VPSRVALGRA CGVSRPVIAA
110 120
SITTNDASAI KTQIYAVKDK IETLLI
Length:126
Mass (Da):13,569
Last modified:February 1, 1995 - v1
Checksum:i4489780153E8F182
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18530 Genomic DNA Translation: AAB64503.1
AY558377 Genomic DNA Translation: AAS56703.1
BK006939 Genomic DNA Translation: DAA07626.1
PIRiS50433
RefSeqiNP_010888.1, NM_001178841.1

Genome annotation databases

EnsemblFungiiYEL026W; YEL026W; YEL026W
GeneIDi856687
KEGGisce:YEL026W

Similar proteinsi

Entry informationi

Entry nameiSNU13_YEAST
AccessioniPrimary (citable) accession number: P39990
Secondary accession number(s): D3DLM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health