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Protein

Putative pyridoxal kinase BUD16

Gene

BUD16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for synthesis of pyridoxal-5-phosphate from vitamin B6 (By similarity). Important for bud site selection.By similarity1 Publication

Catalytic activityi

ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9SubstrateBy similarity1
Binding sitei44SubstrateBy similarity1
Binding sitei122SubstrateBy similarity1
Binding sitei224SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi183 – 184ATPBy similarity2
Nucleotide bindingi211 – 223ATPBy similarityAdd BLAST13

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • pyridoxal 5'-phosphate salvage Source: GO_Central
  • pyridoxal phosphate biosynthetic process Source: SGD

Keywordsi

Molecular functionKinase, Transferase
Biological processCell cycle
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-37
YEAST:MONOMER3O-37
ReactomeiR-SCE-6798695 Neutrophil degranulation
R-SCE-964975 Vitamins B6 activation to pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pyridoxal kinase BUD16 (EC:2.7.1.35)
Alternative name(s):
Bud site selection protein 16
Gene namesi
Name:BUD16
Ordered Locus Names:YEL029C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YEL029C
SGDiS000000755 BUD16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002133481 – 312Putative pyridoxal kinase BUD16Add BLAST312

Proteomic databases

MaxQBiP39988
PaxDbiP39988
PRIDEiP39988

Interactioni

Protein-protein interaction databases

BioGridi36700, 80 interactors
IntActiP39988, 2 interactors
STRINGi4932.YEL029C

Structurei

3D structure databases

ProteinModelPortaliP39988
SMRiP39988
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyridoxine kinase family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000003874
HOGENOMiHOG000258174
InParanoidiP39988
KOiK00868
OMAiHVIKRTI
OrthoDBiEOG092C42OZ

Family and domain databases

CDDicd01173 pyridoxal_pyridoxamine_kinase, 1 hit
Gene3Di3.40.1190.20, 1 hit
InterProiView protein in InterPro
IPR013749 PM/HMP-P_kinase-1
IPR004625 PyrdxlKinase
IPR029056 Ribokinase-like
PANTHERiPTHR10534 PTHR10534, 1 hit
PfamiView protein in Pfam
PF08543 Phos_pyr_kin, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00687 pyridox_kin, 1 hit

Sequencei

Sequence statusi: Complete.

P39988-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLLATQSH VVHGYVGNKA ATFPLQCLGW DVDCCNSVQF SNHTGYGLDK
60 70 80 90 100
VFGTITRETD LKELLSGLFD NFSQDYQALL SGYLPNKNSV RCMGTYYAKF
110 120 130 140 150
KEANPEMIWL MDPVMGDEGQ LYVSEDVIPE YRKLALSPKQ LVDIITPNQF
160 170 180 190 200
ELEILYGGEI KTKEHLKKAL KKLHQTIPVI IVTSCDCKMF DDKDFIYCVA
210 220 230 240 250
SMEGKTPIVY RVPFIDSYFT GVGDLFSALL LDRVYKILSN PTTTLKFEDQ
260 270 280 290 300
VNNVLNVIQK VLKITRSYAS GKMKAKMGSA LEMKEMELRL IESRDIYETI
310
NIHQTDYIYA RL
Length:312
Mass (Da):35,559
Last modified:February 1, 1995 - v1
Checksum:i0A6C10767DE34073
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18530 Genomic DNA Translation: AAB64506.1
BK006939 Genomic DNA Translation: DAA07624.1
PIRiS50430
RefSeqiNP_010885.1, NM_001178844.1

Genome annotation databases

EnsemblFungiiYEL029C; YEL029C; YEL029C
GeneIDi856683
KEGGisce:YEL029C

Similar proteinsi

Entry informationi

Entry nameiBUD16_YEAST
AccessioniPrimary (citable) accession number: P39988
Secondary accession number(s): D3DLM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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