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Protein

DNA polymerase V

Gene

POL5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Presumed to play a role other than chromosomal DNA replication.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  • DNA binding Source: InterPro
  • DNA-directed DNA polymerase activity Source: SGD
  • nucleotide binding Source: InterPro

GO - Biological processi

  • rRNA transcription Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-30173-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase V (EC:2.7.7.7)
Short name:
POL V
Gene namesi
Name:POL5
Ordered Locus Names:YEL055C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YEL055C.
SGDiS000000781. POL5.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000464721 – 1022DNA polymerase VAdd BLAST1022

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei789PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39985.
PRIDEiP39985.

PTM databases

iPTMnetiP39985.

Interactioni

Subunit structurei

Interacts with FRK1.1 Publication

Protein-protein interaction databases

BioGridi36674. 80 interactors.
DIPiDIP-6314N.
IntActiP39985. 15 interactors.
MINTiMINT-650861.

Structurei

3D structure databases

ProteinModelPortaliP39985.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Phylogenomic databases

HOGENOMiHOG000247925.
InParanoidiP39985.
KOiK02331.
OMAiWTAQLHF.
OrthoDBiEOG092C0MFS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR007015. DNA_pol_V.
[Graphical view]
PANTHERiPTHR13213. PTHR13213. 4 hits.
PfamiPF04931. DNA_pol_phi. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39985-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGKVNRDLF FKLASDLREE RLHAAVALIK DLSALDLPDD AEEWSYVLNR
60 70 80 90 100
LIKGLSSDRN SARLGFSLCL TEVINLAVNM PPGQRPKGLE STNEFLSTLS
110 120 130 140 150
TILNVNVNEG TKKSMKGKDE RGILFGKLFG LKSLLNEPLF SEIFVKDLEK
160 170 180 190 200
GNTEFFIRFT EQLIDLALKK NWIKEPCFFT LFQTMKMLLP FMDESSAEKI
210 220 230 240 250
LLIYDKYDLT LTNEGLSTYL LLKYEGDESL IPSVLDLKNP GWKDNDPLAR
260 270 280 290 300
GNLPLLTKVL RNSSVIPDAN GGLKETKKQK NTNWNPRLHF VWSVLLPLFG
310 320 330 340 350
NGKLENTSHI SKKRKKTNNK KVQNSIQFPE FWKMAVDESF FNEKASSERK
360 370 380 390 400
YLGFLIIDAA FKAVPGSYIG FCFSQNVMRT LINQSIDSQR VLNKISQLTL
410 420 430 440 450
DSIVKACEED SANRLVPCLN AMLFGPHGSI NFDKLTKSGT VSKLIAIKEL
460 470 480 490 500
PSTVLAQLLD VFFLQLQDKK GVLSHTLFAL DSILHIVRAH KVEINDMDIM
510 520 530 540 550
KPVLRPIVYM AFFKHTSDDL KLEQLHELAK ERLYSILGEL TINKEIRCKD
560 570 580 590 600
PEINSWQYLT LKLILDIENS HVGDLINPLD ENLENIKNEA ISCLSKVCRS
610 620 630 640 650
RTAQSWGLST LLSMCLVQLY AGDTDSISVI EELCEFSKHE NNSMVGITEI
660 670 680 690 700
LLSLLAQKKA LLRKLSLIIW QQFIEEVGLE ELQILLDILK ARENKQGFAQ
710 720 730 740 750
LFEGEEEFEE IKEENDASED ESKTGSESES ESESDSDDAD EKDEEDEANE
760 770 780 790 800
DILNIDKEAT SALVKALNLP DNIVNDKGEV DLDQLEGLSD DGGDDEDEES
810 820 830 840 850
MDDEKMMELD DQLSEIFKRR KEALSSISTG NQRKFEVKQS RENVISFKHR
860 870 880 890 900
VVDMLAVYVK YCEKLTLANK SEHSNNLGGS LSKLVYFIIP MLKCVNETLD
910 920 930 940 950
RPLADKISKL LKGKIFKIKV TAFKDMNKDI ELMDLLKKTH KLMLTSKPGQ
960 970 980 990 1000
HAAVFYSMCS TSSLFLSKLY VEIGGNDKLD ELIDLYTATT KEWMQKGKCG
1010 1020
PNIFIDFINW LSSKKQTVMD KE
Length:1,022
Mass (Da):115,894
Last modified:February 1, 1995 - v1
Checksum:iA9F32B1D15039D18
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti625D → N Lethal. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027253 Genomic DNA. Translation: BAA77722.1.
U18795 Genomic DNA. Translation: AAB65032.1.
BK006939 Genomic DNA. Translation: DAA07599.1.
PIRiS50534.
RefSeqiNP_010859.1. NM_001178870.1.

Genome annotation databases

EnsemblFungiiYEL055C; YEL055C; YEL055C.
GeneIDi856655.
KEGGisce:YEL055C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027253 Genomic DNA. Translation: BAA77722.1.
U18795 Genomic DNA. Translation: AAB65032.1.
BK006939 Genomic DNA. Translation: DAA07599.1.
PIRiS50534.
RefSeqiNP_010859.1. NM_001178870.1.

3D structure databases

ProteinModelPortaliP39985.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36674. 80 interactors.
DIPiDIP-6314N.
IntActiP39985. 15 interactors.
MINTiMINT-650861.

PTM databases

iPTMnetiP39985.

Proteomic databases

MaxQBiP39985.
PRIDEiP39985.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYEL055C; YEL055C; YEL055C.
GeneIDi856655.
KEGGisce:YEL055C.

Organism-specific databases

EuPathDBiFungiDB:YEL055C.
SGDiS000000781. POL5.

Phylogenomic databases

HOGENOMiHOG000247925.
InParanoidiP39985.
KOiK02331.
OMAiWTAQLHF.
OrthoDBiEOG092C0MFS.

Enzyme and pathway databases

BioCyciYEAST:G3O-30173-MONOMER.

Miscellaneous databases

PROiP39985.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR007015. DNA_pol_V.
[Graphical view]
PANTHERiPTHR13213. PTHR13213. 4 hits.
PfamiPF04931. DNA_pol_phi. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPO5_YEAST
AccessioniPrimary (citable) accession number: P39985
Secondary accession number(s): D3DLJ5, Q9Y737
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4490 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.