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P39984

- HAT2_YEAST

UniProt

P39984 - HAT2_YEAST

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Protein

Histone acetyltransferase type B subunit 2

Gene
HAT2, YEL056W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. HAT2 is required for high affinity binding of the acetyltransferase to histone H4, for the nuclear location of HAT1 and for the HAT1-HIF1 interaction. Alone, it is unable to bind to H4, requiring HAT1 for high affinity interaction with the histone tail. HAT2 has also a HAT1 independent function in life-span regulation.4 Publications

GO - Molecular functioni

  1. histone binding Source: SGD
  2. protein binding Source: IntAct

GO - Biological processi

  1. chromatin assembly or disassembly Source: SGD
  2. chromatin silencing at telomere Source: SGD
  3. histone acetylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Enzyme and pathway databases

BioCyciYEAST:G3O-30174-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B subunit 2
Gene namesi
Name:HAT2
Ordered Locus Names:YEL056W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYEL056w.
SGDiS000000782. HAT2.

Subcellular locationi

Cytoplasm. Nucleus
Note: The nuclear location requires the presence of HAT2.2 Publications

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. histone acetyltransferase complex Source: SGD
  3. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Histone acetyltransferase type B subunit 2PRO_0000051014Add
BLAST

Proteomic databases

MaxQBiP39984.
PaxDbiP39984.
PeptideAtlasiP39984.

Expressioni

Inductioni

Repressed in presence of farnesol, probably through a intracellular decrease of diacylglycerol.1 Publication

Gene expression databases

GenevestigatoriP39984.

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least HAT1 and HAT2. In the cytoplasm, this complex binds to the histone H4 tail. In the nucleus, the HAT-B complex has an additional component, the histone H3/H4 chaperone HIF1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HAT1Q123415EBI-8185,EBI-8176
HIF1Q123733EBI-8185,EBI-31911

Protein-protein interaction databases

BioGridi36673. 68 interactions.
DIPiDIP-2363N.
IntActiP39984. 7 interactions.
MINTiMINT-654148.
STRINGi4932.YEL056W.

Structurei

3D structure databases

ProteinModelPortaliP39984.
SMRiP39984. Positions 10-386.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati116 – 14732WD 1Add
BLAST
Repeati158 – 18932WD 2Add
BLAST
Repeati206 – 23732WD 3Add
BLAST
Repeati249 – 28032WD 4Add
BLAST
Repeati293 – 32432WD 5Add
BLAST
Repeati350 – 38132WD 6Add
BLAST

Sequence similaritiesi

Contains 6 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00570000079069.
HOGENOMiHOG000160330.
KOiK10752.
OMAiVLYDLVI.
OrthoDBiEOG7D865N.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR022052. Histone-bd_RBBP4_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12265. CAF1C_H4-bd. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39984-1 [UniParc]FASTAAdd to Basket

« Hide

MENQEKPLSV DEEYDLWKSN VPLMYDFVSE TRLTWPSLTV QWLPTPVQEL    50
DGGFIKQELI IGTHTSGEEE NYLKFAEINL PKEILSNEDP QEEAGEEYQS 100
SLPAPRSNIR ITAKYEHEEE ITRARYMPQD PNIVATINGQ GTVFLYSRSE 150
GLQSTLKFHK DNGYALSFST LVKGRLLSGS DDHTVALWEV GSGGDPTKPV 200
RTWNDLHSDI INDNKWHNFN KDLFGTVSED SLLKINDVRA NNTTIDTVKC 250
PQPFNTLAFS HHSSNLLAAA GMDSYVYLYD LRNMKEPLHH MSGHEDAVNN 300
LEFSTHVDGV VVSSGSDNRL MMWDLKQIGA EQTPDDAEDG VPELIMVHAG 350
HRSSVNDFDL NPQIPWLVAS AEEENILQVW KCSHSLPIVG GPPKVNKDII 400
S 401
Length:401
Mass (Da):45,060
Last modified:February 1, 1995 - v1
Checksum:iC27A91C99D9FCAB7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18795 Genomic DNA. Translation: AAB65031.1.
BK006939 Genomic DNA. Translation: DAA07598.1.
PIRiS50533.
RefSeqiNP_010858.3. NM_001178871.3.

Genome annotation databases

EnsemblFungiiYEL056W; YEL056W; YEL056W.
GeneIDi856654.
KEGGisce:YEL056W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18795 Genomic DNA. Translation: AAB65031.1 .
BK006939 Genomic DNA. Translation: DAA07598.1 .
PIRi S50533.
RefSeqi NP_010858.3. NM_001178871.3.

3D structure databases

ProteinModelPortali P39984.
SMRi P39984. Positions 10-386.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36673. 68 interactions.
DIPi DIP-2363N.
IntActi P39984. 7 interactions.
MINTi MINT-654148.
STRINGi 4932.YEL056W.

Proteomic databases

MaxQBi P39984.
PaxDbi P39984.
PeptideAtlasi P39984.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YEL056W ; YEL056W ; YEL056W .
GeneIDi 856654.
KEGGi sce:YEL056W.

Organism-specific databases

CYGDi YEL056w.
SGDi S000000782. HAT2.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00570000079069.
HOGENOMi HOG000160330.
KOi K10752.
OMAi VLYDLVI.
OrthoDBi EOG7D865N.

Enzyme and pathway databases

BioCyci YEAST:G3O-30174-MONOMER.

Miscellaneous databases

NextBioi 982637.
PROi P39984.

Gene expression databases

Genevestigatori P39984.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR022052. Histone-bd_RBBP4_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF12265. CAF1C_H4-bd. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view ]
SMARTi SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism."
    Parthun M.R., Widom J., Gottschling D.E.
    Cell 87:85-94(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 83-105, ACETYLATION OF HISTONE H4, INTERACTION WITH HAT1 AND HISTONE H4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "HAT1 and HAT2 proteins are components of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4."
    Ruiz-Garcia A.B., Sendra R., Galiana M., Pamblanco M., Perez-Ortin J.E., Tordera V.
    J. Biol. Chem. 273:12599-12605(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION OF HISTONE H4 BY THE HAT-B COMPLEX.
  5. "Farnesol-induced growth inhibition in Saccharomyces cerevisiae by a cell cycle mechanism."
    Machida K., Tanaka T., Yano Y., Otani S., Taniguchi M.
    Microbiology 145:293-299(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  6. "Type B histone acetyltransferase Hat1p participates in telomeric silencing."
    Kelly T.J., Qin S., Gottschling D.E., Parthun M.R.
    Mol. Cell. Biol. 20:7051-7058(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ACETYLATION OF HISTONE H4.
  7. "Hif1 is a component of yeast histone acetyltransferase B, a complex mainly localized in the nucleus."
    Poveda A., Pamblanco M., Tafrov S., Tordera V., Sternglanz R., Sendra R.
    J. Biol. Chem. 279:16033-16043(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE HAT-B COMPLEX, FUNCTION OF THE HAT-B COMPLEX, INTERACTION WITH HISTONE H4, SUBCELLULAR LOCATION.
  8. "The nuclear Hat1p/Hat2p complex: a molecular link between type B histone acetyltransferases and chromatin assembly."
    Ai X., Parthun M.R.
    Mol. Cell 14:195-205(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE HAT-B COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH HISTONES H3 AND H4, SUBCELLULAR LOCATION.
  9. "Yeast HAT1 and HAT2 deletions have different life-span and transcriptome phenotypes."
    Rosaleny L.E., Antunez O., Ruiz-Garcia A.B., Perez-Ortin J.E., Tordera V.
    FEBS Lett. 579:4063-4068(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiHAT2_YEAST
AccessioniPrimary (citable) accession number: P39984
Secondary accession number(s): D3DLJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

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