Skip Header

Contribute Send feedback
Read comments (?) or add your own

P39982 (HHY1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hypersensitivity to hygromycin-B protein 1
Gene names
Name:HHY1
Ordered Locus Names:YEL059W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length102 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in vacuolar trafficking. Ref.3

Subcellular location

Membrane; Multi-pass membrane protein.

Disruption phenotype

Leads to hygromycin B hypersentsitivity, increased vacuolar fragmentation, defective CPY processing, and extreme sensitivities to pH extremes, divalent cations, and multiple drugs. Ref.3

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 102102Hypersensitivity to hygromycin-B protein 1
PRO_0000202603

Regions

Topological domain1 – 1717Extracellular Potential
Transmembrane18 – 3821Helical; Potential
Topological domain39 – 6931Cytoplasmic Potential
Transmembrane70 – 9021Helical; Potential
Topological domain91 – 10212Extracellular Potential

Sequences

Sequence LengthMass (Da)Tools
P39982 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: C5EF6ECA78E2DB9A

FASTA10211,341
        10         20         30         40         50         60 
MSLSFLLFSP FLPPCFSSIS ICLSVLSTVS FFFAFTIPHY VLRCGSVDEW HIHSSAEDFR 

        70         80         90        100 
TQRCVCAVKL SASLLGCLLA CASWSLLLEV SRIKWHVGTA YS 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed: 9169868] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[3]"Genomic analysis of severe hypersensitivity to hygromycin B reveals linkage to vacuolar defects and new vacuolar gene functions in Saccharomyces cerevisiae."
Banuelos M.G., Moreno D.E., Olson D.K., Nguyen Q., Ricarte F., Aguilera-Sandoval C.R., Gharakhanian E.
Curr. Genet. 56:121-137(2010) [PubMed: 20043226] [Abstract]
Cited for: DISRUPTION PHENOTYPE, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18795 Genomic DNA. Translation: AAB65028.1.
PIRS50530.

3D structure databases

ProteinModelPortalP39982.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-5050N.
IntActP39982. 2 interactions.
MINTMINT-570183.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYEL059W; YEL059W; YEL059W.

Organism-specific databases

CYGDYEL059w.
SGDS000000785. HHY1.

Gene expression databases

ArrayExpressP39982.
GenevestigatorP39982.
GermOnlineYEL059W. Saccharomyces cerevisiae.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameHHY1_YEAST
AccessionPrimary (citable) accession number: P39982
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 21, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names