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P39981

- AVT2_YEAST

UniProt

P39981 - AVT2_YEAST

Protein

Vacuolar amino acid transporter 2

Gene

AVT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Probable amino acid transporter of unknown specificity.1 Publication

    GO - Molecular functioni

    1. transporter activity Source: SGD

    GO - Biological processi

    1. amino acid transport Source: UniProtKB-KW
    2. transport Source: SGD

    Keywords - Biological processi

    Amino-acid transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30179-MONOMER.

    Protein family/group databases

    TCDBi2.A.18.6.20. the amino acid/auxin permease (aaap) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar amino acid transporter 2
    Gene namesi
    Name:AVT2
    Ordered Locus Names:YEL064C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYEL064c.
    SGDiS000000790. AVT2.

    Subcellular locationi

    Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. integral component of membrane Source: UniProtKB-KW
    3. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 480480Vacuolar amino acid transporter 2PRO_0000093835Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP39981.

    Interactioni

    Protein-protein interaction databases

    BioGridi36665. 7 interactions.
    DIPiDIP-5166N.
    IntActiP39981. 1 interaction.
    MINTiMINT-499697.
    STRINGi4932.YEL064C.

    Structurei

    3D structure databases

    ProteinModelPortaliP39981.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei95 – 11521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei297 – 31721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei338 – 35821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei394 – 41421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei447 – 46721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0814.
    GeneTreeiENSGT00710000106531.
    HOGENOMiHOG000188354.
    KOiK14997.
    OMAiADSCEND.
    OrthoDBiEOG7C2RBS.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39981-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSELGEYSKL ENKELRTEFE LTNFPFPGTT DNDSDDGSQG QNSLNIITPD    50
    MDDTLVNDVL RENDKKSSMR MAFMNLANSI LGAGIITQPF AIKNAGILGG 100
    LLSYVALGFI VDWTLRLIVI NLTLAGKRTY QGTVEHVMGK KGKLLILFTN 150
    GLFAFGGCIG YCIIIGDTIP HVLRAIFSQN DGNVHFWLRR NVIIVMVTTF 200
    ISFPLSMKRN IEALSKASFL AVISMIIIVL TVVIRGPMLP YDWKGHSLKL 250
    SDFFMKATIF RSLSVISFAL VCHHNTSFIF FSMRNRSVAK FTRLTHISII 300
    ISVICCALMG YSGFAVFKEK TKGNVLNSFP GTDTAINIAR LCFGFNMLTT 350
    FPMEIFVLRD VVGNLLHECN LIKNYDEHTQ LSGKQHVVIT SSLVFITMGI 400
    SLTTCNLGAL FELIGATTAS TMAYILPPYT NLLLTSKKKS WKERLPFYLC 450
    ICFGFMIMII SSTQTIIDAV NGSDGQHCQI 480
    Length:480
    Mass (Da):53,324
    Last modified:February 1, 1995 - v1
    Checksum:i45799CBD3695B78E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18795 Genomic DNA. Translation: AAB65023.1.
    AY899246 mRNA. Translation: AAX83931.1.
    BK006939 Genomic DNA. Translation: DAA07590.1.
    PIRiS50525.
    RefSeqiNP_010850.1. NM_001178879.1.

    Genome annotation databases

    EnsemblFungiiYEL064C; YEL064C; YEL064C.
    GeneIDi856645.
    KEGGisce:YEL064C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18795 Genomic DNA. Translation: AAB65023.1 .
    AY899246 mRNA. Translation: AAX83931.1 .
    BK006939 Genomic DNA. Translation: DAA07590.1 .
    PIRi S50525.
    RefSeqi NP_010850.1. NM_001178879.1.

    3D structure databases

    ProteinModelPortali P39981.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36665. 7 interactions.
    DIPi DIP-5166N.
    IntActi P39981. 1 interaction.
    MINTi MINT-499697.
    STRINGi 4932.YEL064C.

    Protein family/group databases

    TCDBi 2.A.18.6.20. the amino acid/auxin permease (aaap) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YEL064C ; YEL064C ; YEL064C .
    GeneIDi 856645.
    KEGGi sce:YEL064C.

    Organism-specific databases

    CYGDi YEL064c.
    SGDi S000000790. AVT2.

    Phylogenomic databases

    eggNOGi COG0814.
    GeneTreei ENSGT00710000106531.
    HOGENOMi HOG000188354.
    KOi K14997.
    OMAi ADSCEND.
    OrthoDBi EOG7C2RBS.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30179-MONOMER.

    Miscellaneous databases

    NextBioi 982613.
    PROi P39981.

    Gene expression databases

    Genevestigatori P39981.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE."
      Zhang Z., Dietrich F.S.
      Nucleic Acids Res. 33:2838-2851(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-94.
      Strain: ATCC 208353 / W303-1A.
    4. "A family of yeast proteins mediating bidirectional vacuolar amino acid transport."
      Russnak R., Konczal D., McIntire S.L.
      J. Biol. Chem. 276:23849-23857(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiAVT2_YEAST
    AccessioniPrimary (citable) accession number: P39981
    Secondary accession number(s): D3DLI6, Q2VQX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3