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Protein

Vacuolar amino acid transporter 2

Gene

AVT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable amino acid transporter of unknown specificity.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30179-MONOMER
ReactomeiR-SCE-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism
R-SCE-210500 Glutamate Neurotransmitter Release Cycle
R-SCE-352230 Amino acid transport across the plasma membrane

Protein family/group databases

TCDBi2.A.18.6.20 the amino acid/auxin permease (aaap) family

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar amino acid transporter 2
Gene namesi
Name:AVT2
Ordered Locus Names:YEL064C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YEL064C
SGDiS000000790 AVT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Transmembranei394 – 414HelicalSequence analysisAdd BLAST21
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938351 – 480Vacuolar amino acid transporter 2Add BLAST480

Proteomic databases

PaxDbiP39981

Interactioni

Protein-protein interaction databases

BioGridi36665, 10 interactors
DIPiDIP-5166N
IntActiP39981, 4 interactors
STRINGi4932.YEL064C

Structurei

3D structure databases

ProteinModelPortaliP39981
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119147
HOGENOMiHOG000188354
InParanoidiP39981
KOiK14997
OMAiYSMKQAG
OrthoDBiEOG092C1UR9

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 1 hit

Sequencei

Sequence statusi: Complete.

P39981-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELGEYSKL ENKELRTEFE LTNFPFPGTT DNDSDDGSQG QNSLNIITPD
60 70 80 90 100
MDDTLVNDVL RENDKKSSMR MAFMNLANSI LGAGIITQPF AIKNAGILGG
110 120 130 140 150
LLSYVALGFI VDWTLRLIVI NLTLAGKRTY QGTVEHVMGK KGKLLILFTN
160 170 180 190 200
GLFAFGGCIG YCIIIGDTIP HVLRAIFSQN DGNVHFWLRR NVIIVMVTTF
210 220 230 240 250
ISFPLSMKRN IEALSKASFL AVISMIIIVL TVVIRGPMLP YDWKGHSLKL
260 270 280 290 300
SDFFMKATIF RSLSVISFAL VCHHNTSFIF FSMRNRSVAK FTRLTHISII
310 320 330 340 350
ISVICCALMG YSGFAVFKEK TKGNVLNSFP GTDTAINIAR LCFGFNMLTT
360 370 380 390 400
FPMEIFVLRD VVGNLLHECN LIKNYDEHTQ LSGKQHVVIT SSLVFITMGI
410 420 430 440 450
SLTTCNLGAL FELIGATTAS TMAYILPPYT NLLLTSKKKS WKERLPFYLC
460 470 480
ICFGFMIMII SSTQTIIDAV NGSDGQHCQI
Length:480
Mass (Da):53,324
Last modified:February 1, 1995 - v1
Checksum:i45799CBD3695B78E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18795 Genomic DNA Translation: AAB65023.1
AY899246 mRNA Translation: AAX83931.1
BK006939 Genomic DNA Translation: DAA07590.1
PIRiS50525
RefSeqiNP_010850.1, NM_001178879.1

Genome annotation databases

EnsemblFungiiYEL064C; YEL064C; YEL064C
GeneIDi856645
KEGGisce:YEL064C

Similar proteinsi

Entry informationi

Entry nameiAVT2_YEAST
AccessioniPrimary (citable) accession number: P39981
Secondary accession number(s): D3DLI6, Q2VQX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health