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P39981

- AVT2_YEAST

UniProt

P39981 - AVT2_YEAST

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Protein

Vacuolar amino acid transporter 2

Gene

AVT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Probable amino acid transporter of unknown specificity.1 Publication

GO - Molecular functioni

  1. transporter activity Source: SGD

GO - Biological processi

  1. amino acid transport Source: UniProtKB-KW
  2. transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30179-MONOMER.

Protein family/group databases

TCDBi2.A.18.6.20. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar amino acid transporter 2
Gene namesi
Name:AVT2
Ordered Locus Names:YEL064C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYEL064c.
SGDiS000000790. AVT2.

Subcellular locationi

Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
  3. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Vacuolar amino acid transporter 2PRO_0000093835Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP39981.

Interactioni

Protein-protein interaction databases

BioGridi36665. 7 interactions.
DIPiDIP-5166N.
IntActiP39981. 1 interaction.
MINTiMINT-499697.
STRINGi4932.YEL064C.

Structurei

3D structure databases

ProteinModelPortaliP39981.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei72 – 9221HelicalSequence AnalysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence AnalysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence AnalysisAdd
BLAST
Transmembranei297 – 31721HelicalSequence AnalysisAdd
BLAST
Transmembranei338 – 35821HelicalSequence AnalysisAdd
BLAST
Transmembranei394 – 41421HelicalSequence AnalysisAdd
BLAST
Transmembranei447 – 46721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000188354.
InParanoidiP39981.
KOiK14997.
OMAiADSCEND.
OrthoDBiEOG7C2RBS.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39981-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSELGEYSKL ENKELRTEFE LTNFPFPGTT DNDSDDGSQG QNSLNIITPD
60 70 80 90 100
MDDTLVNDVL RENDKKSSMR MAFMNLANSI LGAGIITQPF AIKNAGILGG
110 120 130 140 150
LLSYVALGFI VDWTLRLIVI NLTLAGKRTY QGTVEHVMGK KGKLLILFTN
160 170 180 190 200
GLFAFGGCIG YCIIIGDTIP HVLRAIFSQN DGNVHFWLRR NVIIVMVTTF
210 220 230 240 250
ISFPLSMKRN IEALSKASFL AVISMIIIVL TVVIRGPMLP YDWKGHSLKL
260 270 280 290 300
SDFFMKATIF RSLSVISFAL VCHHNTSFIF FSMRNRSVAK FTRLTHISII
310 320 330 340 350
ISVICCALMG YSGFAVFKEK TKGNVLNSFP GTDTAINIAR LCFGFNMLTT
360 370 380 390 400
FPMEIFVLRD VVGNLLHECN LIKNYDEHTQ LSGKQHVVIT SSLVFITMGI
410 420 430 440 450
SLTTCNLGAL FELIGATTAS TMAYILPPYT NLLLTSKKKS WKERLPFYLC
460 470 480
ICFGFMIMII SSTQTIIDAV NGSDGQHCQI
Length:480
Mass (Da):53,324
Last modified:February 1, 1995 - v1
Checksum:i45799CBD3695B78E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18795 Genomic DNA. Translation: AAB65023.1.
AY899246 mRNA. Translation: AAX83931.1.
BK006939 Genomic DNA. Translation: DAA07590.1.
PIRiS50525.
RefSeqiNP_010850.1. NM_001178879.1.

Genome annotation databases

EnsemblFungiiYEL064C; YEL064C; YEL064C.
GeneIDi856645.
KEGGisce:YEL064C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18795 Genomic DNA. Translation: AAB65023.1 .
AY899246 mRNA. Translation: AAX83931.1 .
BK006939 Genomic DNA. Translation: DAA07590.1 .
PIRi S50525.
RefSeqi NP_010850.1. NM_001178879.1.

3D structure databases

ProteinModelPortali P39981.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36665. 7 interactions.
DIPi DIP-5166N.
IntActi P39981. 1 interaction.
MINTi MINT-499697.
STRINGi 4932.YEL064C.

Protein family/group databases

TCDBi 2.A.18.6.20. the amino acid/auxin permease (aaap) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YEL064C ; YEL064C ; YEL064C .
GeneIDi 856645.
KEGGi sce:YEL064C.

Organism-specific databases

CYGDi YEL064c.
SGDi S000000790. AVT2.

Phylogenomic databases

eggNOGi COG0814.
GeneTreei ENSGT00760000119147.
HOGENOMi HOG000188354.
InParanoidi P39981.
KOi K14997.
OMAi ADSCEND.
OrthoDBi EOG7C2RBS.

Enzyme and pathway databases

BioCyci YEAST:G3O-30179-MONOMER.

Miscellaneous databases

NextBioi 982613.
PROi P39981.

Gene expression databases

Genevestigatori P39981.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE."
    Zhang Z., Dietrich F.S.
    Nucleic Acids Res. 33:2838-2851(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-94.
    Strain: ATCC 208353 / W303-1A.
  4. "A family of yeast proteins mediating bidirectional vacuolar amino acid transport."
    Russnak R., Konczal D., McIntire S.L.
    J. Biol. Chem. 276:23849-23857(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAVT2_YEAST
AccessioniPrimary (citable) accession number: P39981
Secondary accession number(s): D3DLI6, Q2VQX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3