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P39981

- AVT2_YEAST

UniProt

P39981 - AVT2_YEAST

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Protein
Vacuolar amino acid transporter 2
Gene
AVT2, YEL064C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable amino acid transporter of unknown specificity.1 Publication

GO - Molecular functioni

  1. transporter activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. amino acid transport Source: UniProtKB-KW
  2. transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30179-MONOMER.

Protein family/group databases

TCDBi2.A.18.6.20. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar amino acid transporter 2
Gene namesi
Name:AVT2
Ordered Locus Names:YEL064C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYEL064c.
SGDiS000000790. AVT2.

Subcellular locationi

Vacuole membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei72 – 9221Helical; Reviewed prediction
Add
BLAST
Transmembranei95 – 11521Helical; Reviewed prediction
Add
BLAST
Transmembranei145 – 16521Helical; Reviewed prediction
Add
BLAST
Transmembranei214 – 23421Helical; Reviewed prediction
Add
BLAST
Transmembranei263 – 28321Helical; Reviewed prediction
Add
BLAST
Transmembranei297 – 31721Helical; Reviewed prediction
Add
BLAST
Transmembranei338 – 35821Helical; Reviewed prediction
Add
BLAST
Transmembranei394 – 41421Helical; Reviewed prediction
Add
BLAST
Transmembranei447 – 46721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
  3. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Vacuolar amino acid transporter 2
PRO_0000093835Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP39981.

Interactioni

Protein-protein interaction databases

BioGridi36665. 7 interactions.
DIPiDIP-5166N.
IntActiP39981. 1 interaction.
MINTiMINT-499697.
STRINGi4932.YEL064C.

Structurei

3D structure databases

ProteinModelPortaliP39981.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00710000106531.
HOGENOMiHOG000188354.
KOiK14997.
OMAiADSCEND.
OrthoDBiEOG7C2RBS.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39981-1 [UniParc]FASTAAdd to Basket

« Hide

MSELGEYSKL ENKELRTEFE LTNFPFPGTT DNDSDDGSQG QNSLNIITPD    50
MDDTLVNDVL RENDKKSSMR MAFMNLANSI LGAGIITQPF AIKNAGILGG 100
LLSYVALGFI VDWTLRLIVI NLTLAGKRTY QGTVEHVMGK KGKLLILFTN 150
GLFAFGGCIG YCIIIGDTIP HVLRAIFSQN DGNVHFWLRR NVIIVMVTTF 200
ISFPLSMKRN IEALSKASFL AVISMIIIVL TVVIRGPMLP YDWKGHSLKL 250
SDFFMKATIF RSLSVISFAL VCHHNTSFIF FSMRNRSVAK FTRLTHISII 300
ISVICCALMG YSGFAVFKEK TKGNVLNSFP GTDTAINIAR LCFGFNMLTT 350
FPMEIFVLRD VVGNLLHECN LIKNYDEHTQ LSGKQHVVIT SSLVFITMGI 400
SLTTCNLGAL FELIGATTAS TMAYILPPYT NLLLTSKKKS WKERLPFYLC 450
ICFGFMIMII SSTQTIIDAV NGSDGQHCQI 480
Length:480
Mass (Da):53,324
Last modified:February 1, 1995 - v1
Checksum:i45799CBD3695B78E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18795 Genomic DNA. Translation: AAB65023.1.
AY899246 mRNA. Translation: AAX83931.1.
BK006939 Genomic DNA. Translation: DAA07590.1.
PIRiS50525.
RefSeqiNP_010850.1. NM_001178879.1.

Genome annotation databases

EnsemblFungiiYEL064C; YEL064C; YEL064C.
GeneIDi856645.
KEGGisce:YEL064C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18795 Genomic DNA. Translation: AAB65023.1 .
AY899246 mRNA. Translation: AAX83931.1 .
BK006939 Genomic DNA. Translation: DAA07590.1 .
PIRi S50525.
RefSeqi NP_010850.1. NM_001178879.1.

3D structure databases

ProteinModelPortali P39981.
ModBasei Search...

Protein-protein interaction databases

BioGridi 36665. 7 interactions.
DIPi DIP-5166N.
IntActi P39981. 1 interaction.
MINTi MINT-499697.
STRINGi 4932.YEL064C.

Protein family/group databases

TCDBi 2.A.18.6.20. the amino acid/auxin permease (aaap) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YEL064C ; YEL064C ; YEL064C .
GeneIDi 856645.
KEGGi sce:YEL064C.

Organism-specific databases

CYGDi YEL064c.
SGDi S000000790. AVT2.

Phylogenomic databases

eggNOGi COG0814.
GeneTreei ENSGT00710000106531.
HOGENOMi HOG000188354.
KOi K14997.
OMAi ADSCEND.
OrthoDBi EOG7C2RBS.

Enzyme and pathway databases

BioCyci YEAST:G3O-30179-MONOMER.

Miscellaneous databases

NextBioi 982613.
PROi P39981.

Gene expression databases

Genevestigatori P39981.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE."
    Zhang Z., Dietrich F.S.
    Nucleic Acids Res. 33:2838-2851(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-94.
    Strain: ATCC 208353 / W303-1A.
  4. "A family of yeast proteins mediating bidirectional vacuolar amino acid transport."
    Russnak R., Konczal D., McIntire S.L.
    J. Biol. Chem. 276:23849-23857(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAVT2_YEAST
AccessioniPrimary (citable) accession number: P39981
Secondary accession number(s): D3DLI6, Q2VQX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

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