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P39981 (AVT2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vacuolar amino acid transporter 2
Gene names
Name:AVT2
Ordered Locus Names:YEL064C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable amino acid transporter of unknown specificity. Ref.4

Subcellular location

Vacuole membrane; Multi-pass membrane protein Ref.4.

Sequence similarities

Belongs to the amino acid/polyamine transporter 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 480480Vacuolar amino acid transporter 2
PRO_0000093835

Regions

Transmembrane72 – 9221Helical; Potential
Transmembrane95 – 11521Helical; Potential
Transmembrane145 – 16521Helical; Potential
Transmembrane214 – 23421Helical; Potential
Transmembrane263 – 28321Helical; Potential
Transmembrane297 – 31721Helical; Potential
Transmembrane338 – 35821Helical; Potential
Transmembrane394 – 41421Helical; Potential
Transmembrane447 – 46721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P39981 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 45799CBD3695B78E

FASTA48053,324
        10         20         30         40         50         60 
MSELGEYSKL ENKELRTEFE LTNFPFPGTT DNDSDDGSQG QNSLNIITPD MDDTLVNDVL 

        70         80         90        100        110        120 
RENDKKSSMR MAFMNLANSI LGAGIITQPF AIKNAGILGG LLSYVALGFI VDWTLRLIVI 

       130        140        150        160        170        180 
NLTLAGKRTY QGTVEHVMGK KGKLLILFTN GLFAFGGCIG YCIIIGDTIP HVLRAIFSQN 

       190        200        210        220        230        240 
DGNVHFWLRR NVIIVMVTTF ISFPLSMKRN IEALSKASFL AVISMIIIVL TVVIRGPMLP 

       250        260        270        280        290        300 
YDWKGHSLKL SDFFMKATIF RSLSVISFAL VCHHNTSFIF FSMRNRSVAK FTRLTHISII 

       310        320        330        340        350        360 
ISVICCALMG YSGFAVFKEK TKGNVLNSFP GTDTAINIAR LCFGFNMLTT FPMEIFVLRD 

       370        380        390        400        410        420 
VVGNLLHECN LIKNYDEHTQ LSGKQHVVIT SSLVFITMGI SLTTCNLGAL FELIGATTAS 

       430        440        450        460        470        480 
TMAYILPPYT NLLLTSKKKS WKERLPFYLC ICFGFMIMII SSTQTIIDAV NGSDGQHCQI 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE."
Zhang Z., Dietrich F.S.
Nucleic Acids Res. 33:2838-2851(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-94.
Strain: ATCC 208353 / W303-1A.
[4]"A family of yeast proteins mediating bidirectional vacuolar amino acid transport."
Russnak R., Konczal D., McIntire S.L.
J. Biol. Chem. 276:23849-23857(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18795 Genomic DNA. Translation: AAB65023.1.
AY899246 mRNA. Translation: AAX83931.1.
BK006939 Genomic DNA. Translation: DAA07590.1.
PIRS50525.
RefSeqNP_010850.1. NM_001178879.1.

3D structure databases

ProteinModelPortalP39981.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36665. 7 interactions.
DIPDIP-5166N.
IntActP39981. 1 interaction.
MINTMINT-499697.
STRING4932.YEL064C.

Protein family/group databases

TCDB2.A.18.6.20. the amino acid/auxin permease (aaap) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYEL064C; YEL064C; YEL064C.
GeneID856645.
KEGGsce:YEL064C.

Organism-specific databases

CYGDYEL064c.
SGDS000000790. AVT2.

Phylogenomic databases

eggNOGCOG0814.
GeneTreeENSGT00710000106531.
HOGENOMHOG000188354.
KOK14997.
OMAADSCEND.
OrthoDBEOG7C2RBS.

Enzyme and pathway databases

BioCycYEAST:G3O-30179-MONOMER.

Gene expression databases

GenevestigatorP39981.

Family and domain databases

InterProIPR013057. AA_transpt_TM.
[Graphical view]
PfamPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982613.
PROP39981.

Entry information

Entry nameAVT2_YEAST
AccessionPrimary (citable) accession number: P39981
Secondary accession number(s): D3DLI6, Q2VQX2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families