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P39980

- SIT1_YEAST

UniProt

P39980 - SIT1_YEAST

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Protein

Siderophore iron transporter 1

Gene

SIT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Involved in the transport of siderophore ferrioxamine B and so has a role in iron homeostasis.1 Publication

GO - Molecular functioni

  1. siderophore uptake transmembrane transporter activity Source: SGD

GO - Biological processi

  1. cellular iron ion homeostasis Source: SGD
  2. siderophore transmembrane transport Source: GOC
  3. siderophore transport Source: SGD
  4. transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciYEAST:G3O-30180-MONOMER.

Protein family/group databases

TCDBi2.A.1.16.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Siderophore iron transporter 1
Alternative name(s):
Ferrioxamine B permease
Siderophore iron transporter ARN3
Gene namesi
Name:SIT1
Synonyms:ARN3
Ordered Locus Names:YEL065W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYEL065w.
SGDiS000000791. SIT1.

Subcellular locationi

Endosome membrane 2 Publications; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei68 – 8821HelicalSequence AnalysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence AnalysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence AnalysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST
Transmembranei285 – 30521HelicalSequence AnalysisAdd
BLAST
Transmembranei317 – 33721HelicalSequence AnalysisAdd
BLAST
Transmembranei354 – 37421HelicalSequence AnalysisAdd
BLAST
Transmembranei394 – 41421HelicalSequence AnalysisAdd
BLAST
Transmembranei420 – 44021HelicalSequence AnalysisAdd
BLAST
Transmembranei448 – 46821HelicalSequence AnalysisAdd
BLAST
Transmembranei488 – 50821HelicalSequence AnalysisAdd
BLAST
Transmembranei559 – 57921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: SGD
  2. endosome Source: SGD
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 628628Siderophore iron transporter 1PRO_0000084878Add
BLAST

Proteomic databases

MaxQBiP39980.
PaxDbiP39980.

Expressioni

Gene expression databases

GenevestigatoriP39980.

Interactioni

Protein-protein interaction databases

BioGridi36664. 29 interactions.
DIPiDIP-7273N.
MINTiMINT-4483600.
STRINGi4932.YEL065W.

Structurei

3D structure databases

ProteinModelPortaliP39980.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG281153.
GeneTreeiENSGT00390000002930.
HOGENOMiHOG000181235.
InParanoidiP39980.
KOiK08197.
OMAiPRTELIL.
OrthoDBiEOG7PZS6Z.

Family and domain databases

InterProiIPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequencei

Sequence statusi: Complete.

P39980-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPGIANHTL PEEFEEVVVP EMLEKEVGAK VDVKPTLTTS SPAPSYIELI
60 70 80 90 100
DPGVHNIEIY AEMYNRPIYR VALFFSLFLI AYAYGLDGNI RYTFQAYATS
110 120 130 140 150
SYSQHSLLST VNCIKTVIAA VGQIFFARLS DIFGRFSIMI VSIIFYSMGT
160 170 180 190 200
IIESQAVNIT RFAVGGCFYQ LGLTGIILIL EVIASDFSNL NWRLLALFIP
210 220 230 240 250
ALPFIINTWI SGNVTSAIDA NWKWGIGMWA FILPLACIPL GICMLHMRYL
260 270 280 290 300
ARKHAKDRLK PEFEALNKLK WKSFCIDIAF WKLDIIGMLL ITVFFGCVLV
310 320 330 340 350
PFTLAGGLKE EWKTAHIIVP EVIGWVVVLP LYMLWEIKYS RHPLTPWDLI
360 370 380 390 400
QDRGIFFALL IAFFINFNWY MQGDYMYTVL VVAVHESIKS ATRITSLYSF
410 420 430 440 450
VSVIVGTILG FILIKVRRTK PFIIFGISCW IVSFGLLVHY RGDSGAHSGI
460 470 480 490 500
IGSLCLLGFG AGSFTYVTQA SIQASAKTHA RMAVVTSLYL ATYNIGSAFG
510 520 530 540 550
SSVSGAVWTN ILPKEISKRI SDPTLAAQAY GSPFTFITTY TWGTPERIAL
560 570 580 590 600
VMSYRYVQKI LCIIGLVFCF PLLGCAFMLR NHKLTDSIAL EGNDHLESKN
610 620
TFEIEEKEES FLKNKFFTHF TSSKDRKD
Length:628
Mass (Da):70,562
Last modified:February 1, 1995 - v1
Checksum:i39E711CF861CEF05
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti386 – 3861E → G in AAU09717. (PubMed:17322287)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18795 Genomic DNA. Translation: AAB65022.1.
AY723800 Genomic DNA. Translation: AAU09717.1.
BK006939 Genomic DNA. Translation: DAA07589.1.
PIRiS50524.
RefSeqiNP_010849.3. NM_001178880.3.

Genome annotation databases

EnsemblFungiiYEL065W; YEL065W; YEL065W.
GeneIDi856644.
KEGGisce:YEL065W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18795 Genomic DNA. Translation: AAB65022.1 .
AY723800 Genomic DNA. Translation: AAU09717.1 .
BK006939 Genomic DNA. Translation: DAA07589.1 .
PIRi S50524.
RefSeqi NP_010849.3. NM_001178880.3.

3D structure databases

ProteinModelPortali P39980.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36664. 29 interactions.
DIPi DIP-7273N.
MINTi MINT-4483600.
STRINGi 4932.YEL065W.

Protein family/group databases

TCDBi 2.A.1.16.1. the major facilitator superfamily (mfs).

Proteomic databases

MaxQBi P39980.
PaxDbi P39980.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YEL065W ; YEL065W ; YEL065W .
GeneIDi 856644.
KEGGi sce:YEL065W.

Organism-specific databases

CYGDi YEL065w.
SGDi S000000791. SIT1.

Phylogenomic databases

eggNOGi NOG281153.
GeneTreei ENSGT00390000002930.
HOGENOMi HOG000181235.
InParanoidi P39980.
KOi K08197.
OMAi PRTELIL.
OrthoDBi EOG7PZS6Z.

Enzyme and pathway databases

BioCyci YEAST:G3O-30180-MONOMER.

Miscellaneous databases

NextBioi 982610.

Gene expression databases

Genevestigatori P39980.

Family and domain databases

InterProi IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake."
    Yun C.-W., Ferea T., Rashford J., Ardon O., Brown P.O., Botstein D., Kaplan J., Philpott C.C.
    J. Biol. Chem. 275:10709-10715(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Siderophore-mediated iron uptake in Saccharomyces cerevisiae: the SIT1 gene encodes a ferrioxamine B permease that belongs to the major facilitator superfamily."
    Lesuisse E., Simon-Casteras M., Labbe P.
    Microbiology 144:3455-3462(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Siderophore-iron uptake in Saccharomyces cerevisiae. Identification of ferrichrome and fusarinine transporters."
    Yun C.-W., Tiedeman J.S., Moore R.E., Philpott C.C.
    J. Biol. Chem. 275:16354-16359(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSIT1_YEAST
AccessioniPrimary (citable) accession number: P39980
Secondary accession number(s): D3DLI5, E9P951
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3