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P39980

- SIT1_YEAST

UniProt

P39980 - SIT1_YEAST

Protein

Siderophore iron transporter 1

Gene

SIT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in the transport of siderophore ferrioxamine B and so has a role in iron homeostasis.1 Publication

    GO - Molecular functioni

    1. siderophore uptake transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. cellular iron ion homeostasis Source: SGD
    2. siderophore transmembrane transport Source: GOC
    3. siderophore transport Source: SGD
    4. transmembrane transport Source: SGD

    Keywords - Biological processi

    Ion transport, Iron transport, Transport

    Keywords - Ligandi

    Iron

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30180-MONOMER.

    Protein family/group databases

    TCDBi2.A.1.16.1. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Siderophore iron transporter 1
    Alternative name(s):
    Ferrioxamine B permease
    Siderophore iron transporter ARN3
    Gene namesi
    Name:SIT1
    Synonyms:ARN3
    Ordered Locus Names:YEL065W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYEL065w.
    SGDiS000000791. SIT1.

    Subcellular locationi

    Endosome membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: SGD
    2. endosome Source: SGD
    3. endosome membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 628628Siderophore iron transporter 1PRO_0000084878Add
    BLAST

    Proteomic databases

    MaxQBiP39980.
    PaxDbiP39980.

    Expressioni

    Gene expression databases

    GenevestigatoriP39980.

    Interactioni

    Protein-protein interaction databases

    BioGridi36664. 29 interactions.
    DIPiDIP-7273N.
    MINTiMINT-4483600.
    STRINGi4932.YEL065W.

    Structurei

    3D structure databases

    ProteinModelPortaliP39980.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei68 – 8821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei107 – 12721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei132 – 15221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei285 – 30521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei317 – 33721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei354 – 37421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei394 – 41421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei420 – 44021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei448 – 46821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei488 – 50821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei559 – 57921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the major facilitator superfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG281153.
    GeneTreeiENSGT00390000002930.
    HOGENOMiHOG000181235.
    KOiK08197.
    OMAiPRTELIL.
    OrthoDBiEOG7PZS6Z.

    Family and domain databases

    InterProiIPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    P39980-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPGIANHTL PEEFEEVVVP EMLEKEVGAK VDVKPTLTTS SPAPSYIELI    50
    DPGVHNIEIY AEMYNRPIYR VALFFSLFLI AYAYGLDGNI RYTFQAYATS 100
    SYSQHSLLST VNCIKTVIAA VGQIFFARLS DIFGRFSIMI VSIIFYSMGT 150
    IIESQAVNIT RFAVGGCFYQ LGLTGIILIL EVIASDFSNL NWRLLALFIP 200
    ALPFIINTWI SGNVTSAIDA NWKWGIGMWA FILPLACIPL GICMLHMRYL 250
    ARKHAKDRLK PEFEALNKLK WKSFCIDIAF WKLDIIGMLL ITVFFGCVLV 300
    PFTLAGGLKE EWKTAHIIVP EVIGWVVVLP LYMLWEIKYS RHPLTPWDLI 350
    QDRGIFFALL IAFFINFNWY MQGDYMYTVL VVAVHESIKS ATRITSLYSF 400
    VSVIVGTILG FILIKVRRTK PFIIFGISCW IVSFGLLVHY RGDSGAHSGI 450
    IGSLCLLGFG AGSFTYVTQA SIQASAKTHA RMAVVTSLYL ATYNIGSAFG 500
    SSVSGAVWTN ILPKEISKRI SDPTLAAQAY GSPFTFITTY TWGTPERIAL 550
    VMSYRYVQKI LCIIGLVFCF PLLGCAFMLR NHKLTDSIAL EGNDHLESKN 600
    TFEIEEKEES FLKNKFFTHF TSSKDRKD 628
    Length:628
    Mass (Da):70,562
    Last modified:February 1, 1995 - v1
    Checksum:i39E711CF861CEF05
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti386 – 3861E → G in AAU09717. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18795 Genomic DNA. Translation: AAB65022.1.
    AY723800 Genomic DNA. Translation: AAU09717.1.
    BK006939 Genomic DNA. Translation: DAA07589.1.
    PIRiS50524.
    RefSeqiNP_010849.3. NM_001178880.3.

    Genome annotation databases

    EnsemblFungiiYEL065W; YEL065W; YEL065W.
    GeneIDi856644.
    KEGGisce:YEL065W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18795 Genomic DNA. Translation: AAB65022.1 .
    AY723800 Genomic DNA. Translation: AAU09717.1 .
    BK006939 Genomic DNA. Translation: DAA07589.1 .
    PIRi S50524.
    RefSeqi NP_010849.3. NM_001178880.3.

    3D structure databases

    ProteinModelPortali P39980.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36664. 29 interactions.
    DIPi DIP-7273N.
    MINTi MINT-4483600.
    STRINGi 4932.YEL065W.

    Protein family/group databases

    TCDBi 2.A.1.16.1. the major facilitator superfamily (mfs).

    Proteomic databases

    MaxQBi P39980.
    PaxDbi P39980.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YEL065W ; YEL065W ; YEL065W .
    GeneIDi 856644.
    KEGGi sce:YEL065W.

    Organism-specific databases

    CYGDi YEL065w.
    SGDi S000000791. SIT1.

    Phylogenomic databases

    eggNOGi NOG281153.
    GeneTreei ENSGT00390000002930.
    HOGENOMi HOG000181235.
    KOi K08197.
    OMAi PRTELIL.
    OrthoDBi EOG7PZS6Z.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30180-MONOMER.

    Miscellaneous databases

    NextBioi 982610.

    Gene expression databases

    Genevestigatori P39980.

    Family and domain databases

    InterProi IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake."
      Yun C.-W., Ferea T., Rashford J., Ardon O., Brown P.O., Botstein D., Kaplan J., Philpott C.C.
      J. Biol. Chem. 275:10709-10715(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Siderophore-mediated iron uptake in Saccharomyces cerevisiae: the SIT1 gene encodes a ferrioxamine B permease that belongs to the major facilitator superfamily."
      Lesuisse E., Simon-Casteras M., Labbe P.
      Microbiology 144:3455-3462(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Siderophore-iron uptake in Saccharomyces cerevisiae. Identification of ferrichrome and fusarinine transporters."
      Yun C.-W., Tiedeman J.S., Moore R.E., Philpott C.C.
      J. Biol. Chem. 275:16354-16359(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSIT1_YEAST
    AccessioniPrimary (citable) accession number: P39980
    Secondary accession number(s): D3DLI5, E9P951
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3