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P39980 (SIT1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Siderophore iron transporter 1
Alternative name(s):
Ferrioxamine B permease
Siderophore iron transporter ARN3
Gene names
Name:SIT1
Synonyms:ARN3
Ordered Locus Names:YEL065W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length628 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the transport of siderophore ferrioxamine B and so has a role in iron homeostasis. Ref.5

Subcellular location

Endosome membrane; Multi-pass membrane protein Ref.1 Ref.6.

Sequence similarities

Belongs to the major facilitator superfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 628628Siderophore iron transporter 1
PRO_0000084878

Regions

Transmembrane68 – 8821Helical; Potential
Transmembrane107 – 12721Helical; Potential
Transmembrane132 – 15221Helical; Potential
Transmembrane164 – 18421Helical; Potential
Transmembrane194 – 21421Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane285 – 30521Helical; Potential
Transmembrane317 – 33721Helical; Potential
Transmembrane354 – 37421Helical; Potential
Transmembrane394 – 41421Helical; Potential
Transmembrane420 – 44021Helical; Potential
Transmembrane448 – 46821Helical; Potential
Transmembrane488 – 50821Helical; Potential
Transmembrane559 – 57921Helical; Potential

Experimental info

Sequence conflict3861E → G in AAU09717. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P39980 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 39E711CF861CEF05

FASTA62870,562
        10         20         30         40         50         60 
MDPGIANHTL PEEFEEVVVP EMLEKEVGAK VDVKPTLTTS SPAPSYIELI DPGVHNIEIY 

        70         80         90        100        110        120 
AEMYNRPIYR VALFFSLFLI AYAYGLDGNI RYTFQAYATS SYSQHSLLST VNCIKTVIAA 

       130        140        150        160        170        180 
VGQIFFARLS DIFGRFSIMI VSIIFYSMGT IIESQAVNIT RFAVGGCFYQ LGLTGIILIL 

       190        200        210        220        230        240 
EVIASDFSNL NWRLLALFIP ALPFIINTWI SGNVTSAIDA NWKWGIGMWA FILPLACIPL 

       250        260        270        280        290        300 
GICMLHMRYL ARKHAKDRLK PEFEALNKLK WKSFCIDIAF WKLDIIGMLL ITVFFGCVLV 

       310        320        330        340        350        360 
PFTLAGGLKE EWKTAHIIVP EVIGWVVVLP LYMLWEIKYS RHPLTPWDLI QDRGIFFALL 

       370        380        390        400        410        420 
IAFFINFNWY MQGDYMYTVL VVAVHESIKS ATRITSLYSF VSVIVGTILG FILIKVRRTK 

       430        440        450        460        470        480 
PFIIFGISCW IVSFGLLVHY RGDSGAHSGI IGSLCLLGFG AGSFTYVTQA SIQASAKTHA 

       490        500        510        520        530        540 
RMAVVTSLYL ATYNIGSAFG SSVSGAVWTN ILPKEISKRI SDPTLAAQAY GSPFTFITTY 

       550        560        570        580        590        600 
TWGTPERIAL VMSYRYVQKI LCIIGLVFCF PLLGCAFMLR NHKLTDSIAL EGNDHLESKN 

       610        620 
TFEIEEKEES FLKNKFFTHF TSSKDRKD 

« Hide

References

« Hide 'large scale' references
[1]"Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake."
Yun C.-W., Ferea T., Rashford J., Ardon O., Brown P.O., Botstein D., Kaplan J., Philpott C.C.
J. Biol. Chem. 275:10709-10715(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Siderophore-mediated iron uptake in Saccharomyces cerevisiae: the SIT1 gene encodes a ferrioxamine B permease that belongs to the major facilitator superfamily."
Lesuisse E., Simon-Casteras M., Labbe P.
Microbiology 144:3455-3462(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Siderophore-iron uptake in Saccharomyces cerevisiae. Identification of ferrichrome and fusarinine transporters."
Yun C.-W., Tiedeman J.S., Moore R.E., Philpott C.C.
J. Biol. Chem. 275:16354-16359(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18795 Genomic DNA. Translation: AAB65022.1.
AY723800 Genomic DNA. Translation: AAU09717.1.
BK006939 Genomic DNA. Translation: DAA07589.1.
PIRS50524.
RefSeqNP_010849.3. NM_001178880.3.

3D structure databases

ProteinModelPortalP39980.
SMRP39980. Positions 385-415.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36664. 29 interactions.
DIPDIP-7273N.
MINTMINT-4483600.
STRING4932.YEL065W.

Protein family/group databases

TCDB2.A.1.16.1. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbP39980.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYEL065W; YEL065W; YEL065W.
GeneID856644.
KEGGsce:YEL065W.

Organism-specific databases

CYGDYEL065w.
SGDS000000791. SIT1.

Phylogenomic databases

eggNOGNOG281153.
GeneTreeENSGT00390000002930.
HOGENOMHOG000181235.
KOK08197.
OrthoDBEOG7PZS6Z.

Enzyme and pathway databases

BioCycYEAST:G3O-30180-MONOMER.

Gene expression databases

GenevestigatorP39980.

Family and domain databases

InterProIPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
SUPFAMSSF103473. SSF103473. 3 hits.
ProtoNetSearch...

Other

NextBio982610.

Entry information

Entry nameSIT1_YEAST
AccessionPrimary (citable) accession number: P39980
Secondary accession number(s): D3DLI5, E9P951
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families