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Protein

Siderophore iron transporter 1

Gene

SIT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in the transport of siderophore ferrioxamine B and so has a role in iron homeostasis.1 Publication

GO - Molecular functioni

  • siderophore uptake transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular iron ion homeostasis Source: SGD
  • siderophore transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciYEAST:G3O-30180-MONOMER.

Protein family/group databases

TCDBi2.A.1.16.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Siderophore iron transporter 1
Alternative name(s):
Ferrioxamine B permease
Siderophore iron transporter ARN3
Gene namesi
Name:SIT1
Synonyms:ARN3
Ordered Locus Names:YEL065W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YEL065W.
SGDiS000000791. SIT1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Transmembranei394 – 414HelicalSequence analysisAdd BLAST21
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21
Transmembranei488 – 508HelicalSequence analysisAdd BLAST21
Transmembranei559 – 579HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: SGD
  • endosome Source: SGD
  • endosome membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: GO_Central
  • vacuolar membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848781 – 628Siderophore iron transporter 1Add BLAST628

Proteomic databases

MaxQBiP39980.
PRIDEiP39980.

Interactioni

Protein-protein interaction databases

BioGridi36664. 30 interactors.
DIPiDIP-7273N.
MINTiMINT-4483600.

Structurei

3D structure databases

ProteinModelPortaliP39980.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002930.
HOGENOMiHOG000181235.
InParanoidiP39980.
KOiK08197.
OrthoDBiEOG092C2P9I.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequencei

Sequence statusi: Complete.

P39980-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGIANHTL PEEFEEVVVP EMLEKEVGAK VDVKPTLTTS SPAPSYIELI
60 70 80 90 100
DPGVHNIEIY AEMYNRPIYR VALFFSLFLI AYAYGLDGNI RYTFQAYATS
110 120 130 140 150
SYSQHSLLST VNCIKTVIAA VGQIFFARLS DIFGRFSIMI VSIIFYSMGT
160 170 180 190 200
IIESQAVNIT RFAVGGCFYQ LGLTGIILIL EVIASDFSNL NWRLLALFIP
210 220 230 240 250
ALPFIINTWI SGNVTSAIDA NWKWGIGMWA FILPLACIPL GICMLHMRYL
260 270 280 290 300
ARKHAKDRLK PEFEALNKLK WKSFCIDIAF WKLDIIGMLL ITVFFGCVLV
310 320 330 340 350
PFTLAGGLKE EWKTAHIIVP EVIGWVVVLP LYMLWEIKYS RHPLTPWDLI
360 370 380 390 400
QDRGIFFALL IAFFINFNWY MQGDYMYTVL VVAVHESIKS ATRITSLYSF
410 420 430 440 450
VSVIVGTILG FILIKVRRTK PFIIFGISCW IVSFGLLVHY RGDSGAHSGI
460 470 480 490 500
IGSLCLLGFG AGSFTYVTQA SIQASAKTHA RMAVVTSLYL ATYNIGSAFG
510 520 530 540 550
SSVSGAVWTN ILPKEISKRI SDPTLAAQAY GSPFTFITTY TWGTPERIAL
560 570 580 590 600
VMSYRYVQKI LCIIGLVFCF PLLGCAFMLR NHKLTDSIAL EGNDHLESKN
610 620
TFEIEEKEES FLKNKFFTHF TSSKDRKD
Length:628
Mass (Da):70,562
Last modified:February 1, 1995 - v1
Checksum:i39E711CF861CEF05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti386E → G in AAU09717 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18795 Genomic DNA. Translation: AAB65022.1.
AY723800 Genomic DNA. Translation: AAU09717.1.
BK006939 Genomic DNA. Translation: DAA07589.1.
PIRiS50524.
RefSeqiNP_010849.3. NM_001178880.3.

Genome annotation databases

EnsemblFungiiYEL065W; YEL065W; YEL065W.
GeneIDi856644.
KEGGisce:YEL065W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18795 Genomic DNA. Translation: AAB65022.1.
AY723800 Genomic DNA. Translation: AAU09717.1.
BK006939 Genomic DNA. Translation: DAA07589.1.
PIRiS50524.
RefSeqiNP_010849.3. NM_001178880.3.

3D structure databases

ProteinModelPortaliP39980.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36664. 30 interactors.
DIPiDIP-7273N.
MINTiMINT-4483600.

Protein family/group databases

TCDBi2.A.1.16.1. the major facilitator superfamily (mfs).

Proteomic databases

MaxQBiP39980.
PRIDEiP39980.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYEL065W; YEL065W; YEL065W.
GeneIDi856644.
KEGGisce:YEL065W.

Organism-specific databases

EuPathDBiFungiDB:YEL065W.
SGDiS000000791. SIT1.

Phylogenomic databases

GeneTreeiENSGT00390000002930.
HOGENOMiHOG000181235.
InParanoidiP39980.
KOiK08197.
OrthoDBiEOG092C2P9I.

Enzyme and pathway databases

BioCyciYEAST:G3O-30180-MONOMER.

Miscellaneous databases

PROiP39980.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSIT1_YEAST
AccessioniPrimary (citable) accession number: P39980
Secondary accession number(s): D3DLI5, E9P951
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.