Reviewed, UniProtKB/Swiss-Prot P39970 (ACA1_YEAST)

Names and origin

Protein names

Recommended name:
    ATF/CREB activator 1

Gene names

Name:	ACA1
Ordered Locus Names:	YER045C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Transcriptional activator of promoters containing ATF/CREB sites. Can independently stimulate transcription through ATF/CREB sites. Important for a variety of biological functions including growth on non-optimal carbon sources. Regulates the expression of COS8. Has efficient silencing blocking activities. Ref.2 Ref.3 Ref.4 Ref.5
Subcellular location	Nucleus Potential.
Induction	By nitrogen limitation. Ref.6
Sequence similarities	Belongs to the bZIP family. Contains 1 bZIP domain.
Caution	This ORF was incorrectly assigned as MEI4.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription initiation from RNA polymerase II promoter Ref.2 Inferred from direct assay. Source: SGD
Cellular component	nucleus Ref.2 Inferred from physical interaction. Source: SGD
Molecular function	protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro specific RNA polymerase II transcription factor activity Ref.2 Inferred from direct assay. Source: SGD transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	ATF/CREB activator 1		PRO_0000076537
Regions
	DNA binding	386 – 406	21	Basic motif
	Compositional bias	258 – 267	10	Poly-Ser
Amino acid modifications
	Modified residue	105	1	Phosphoserine Ref.7

Sequences

	Sequence		Length	Mass (Da)
	P39970-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 2850D6C3DDF5C29D	FASTA	489	54,592
	10 20 30 40 50 60 MDYKHNFATS PDSFLDGRQN PLLYTDFLSS NKELIYKQPS GPGLVDSAYN FHHQNSLHDR 70 80 90 100 110 120 SVQENLGPMF QPFGVDISHL PITNPPIFQS SLPAFDQPVY KRRISISNGQ ISQLGEDLET 130 140 150 160 170 180 VENLYNCQPP ILSSKAQQNP NPQQVANPSA AIYPSFSSNE LQNVPQPHEQ ATVIPEAAPQ 190 200 210 220 230 240 TGSKNIYAAM TPYDSNIKLN IPAVAATCDI PSATPSIPSG DSTMNQAYIN MQLRLQAQMQ 250 260 270 280 290 300 TKAWKNAQLN VHPCTPASNS SVSSSSSCQN INDHNIENQS VHSSISHGVN HHTVNNSCQN 310 320 330 340 350 360 AELNISSSLP YESKCPDVNL THANSKPQYK DATSALKNNI NSEKDVHTAP FSSMHTTATF 370 380 390 400 410 420 QIKQEARPQK IENNTAGLKD GAKAWKRARL LERNRIAASK CRQRKKMSQL QLQREFDQIS 430 440 450 460 470 480 KENTMMKKKI ENYEKLVQKM KKISRLHMQE CTINGGNNSY QSLQNKDSDV NGFLKMIEEM IRSSSLYDE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed: 9169868] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress." Garcia-Gimeno M.A., Struhl K. Mol. Cell. Biol. 20:4340-4349(2000) [PubMed: 10825197] [Abstract] Cited for: FUNCTION.
[3]	"ATF/CREB sites present in sub-telomeric regions of Saccharomyces cerevisiae chromosomes are part of promoters and act as UAS/URS of highly conserved COS genes." Spode I., Maiwald D., Hollenberg C.P., Suckow M. J. Mol. Biol. 319:407-420(2002) [PubMed: 12051917] [Abstract] Cited for: FUNCTION.
[4]	"Barrier proteins remodel and modify chromatin to restrict silenced domains." Oki M., Valenzuela L., Chiba T., Ito T., Kamakaka R.T. Mol. Cell. Biol. 24:1956-1967(2004) [PubMed: 14966276] [Abstract] Cited for: FUNCTION.
[5]	"Transcriptional activators in yeast." Titz B., Thomas S., Rajagopala S.V., Chiba T., Ito T., Uetz P. Nucleic Acids Res. 34:955-967(2006) [PubMed: 16464826] [Abstract] Cited for: FUNCTION.
[6]	"The nature of the nitrogen source added to nitrogen depleted vinifications conducted by a Saccharomyces cerevisiae strain in synthetic must affects gene expression and the levels of several volatile compounds." Jimenez-Marti E., Aranda A., Mendes-Ferreira A., Mendes-Faia A., del Olmo M.L. Antonie Van Leeuwenhoek 92:61-75(2007) [PubMed: 17252314] [Abstract] Cited for: INDUCTION.
[7]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U18796 Genomic DNA. Translation: AAB64580.1.
PIR	S50548.
RefSeq	NP_010964.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1535N.
IntAct	P39970. 11 interactions.
STRING	P39970.
Genome annotation databases
Ensembl	YER045C; YER045C; YER045C; Saccharomyces cerevisiae. [Genome view]
GeneID	856769.
KEGG	sce:YER045C.
NMPDR	fig|4932.3.peg.2026.
Organism-specific databases
CYGD	YER045c.
SGD	S000000847. ACA1.
Phylogenomic databases
OrthoDB	EOG9TMSJC.
Gene expression databases
ArrayExpress	P39970.
Genevestigator	P39970.
GermOnline	YER045C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR011616. bZIP_1. IPR004827. TF_bZIP. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	982956.

Entry information

Entry name

ACA1_YEAST

Accession

Primary (citable) accession number: P39970

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	December 15, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)