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P39967 (UBP9_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 9

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 9
Ubiquitin thioesterase 9
Ubiquitin-specific-processing protease 9
Gene names
Name:UBP9
Ordered Locus Names:YER098W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length754 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Miscellaneous

Present with 98 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 754754Ubiquitin carboxyl-terminal hydrolase 9
PRO_0000080594

Regions

Domain134 – 667534USP

Sites

Active site1431Nucleophile By similarity
Active site6181Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
P39967 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: D2C03D233D14D693

FASTA75486,244
        10         20         30         40         50         60 
MIKRWLSVNR KKSHPEKNTQ GNDEINRKAT SLKKTKGSGD PSIAKSPSAK SSTSSIPSNL 

        70         80         90        100        110        120 
ASHERRSKFS SQTDNLAGNK HYHEHYHNMA STSDEREYDS STTYEDRAFD TESSILFTTI 

       130        140        150        160        170        180 
TDLMPYGDGS NKVFGYENFG NTCYCNSVLQ CLYNIPEFRC NVLRYPERVA AVNRIRKSDL 

       190        200        210        220        230        240 
KGSKIRVFTN ESFETSTNSG NSNTGYQSND NEDAHNHHHL QQSDQDNSSS STQEKQNNFE 

       250        260        270        280        290        300 
RKRNSFMGFG KDKSNYKDSA KKDDNNEMER PQPVHTVVMA SDTLTEKLHE GCKKIIVGRP 

       310        320        330        340        350        360 
LLKQSDSLSK ASTTDCQANS HCQCDSQGSR ITSVDDDVLV NPESCNDAVN NSNNNKENTF 

       370        380        390        400        410        420 
PTSEQRKKAA LIRGPVLNVD HLLYPTEEAT LYNGLKDIFE SITENLSLTG IVSPTEFVKI 

       430        440        450        460        470        480 
LKKENVLFNT MMQQDAHEFL NFLLNDFSEY IQRNNPRMRF GPQKTDNSND NFITDLFKGT 

       490        500        510        520        530        540 
LTNRIKCLTC DNITSRDEPF LDFPIEVQGD EETDIQKMLK SYHQREMLNG VNKFYCNKCY 

       550        560        570        580        590        600 
GLQEAERMVG LKQLPHILSL HLKRFKYSEE QKSNIKLFNK ILYPLTLDVS STFNTSVYKK 

       610        620        630        640        650        660 
YELSGVVIHM GSGPQHGHYV CICRNEKFGW LLYDDETVES IKEETVLQFT GHPGDQTTAY 

       670        680        690        700        710        720 
VLFYKETQAD KTENQNENID TSSQDQMQTD NNIEQLIKCD DWLRDRKLRA AANIERKKTL 

       730        740        750 
GNIPEVKTAE TKTPLNDKKR NKQKRKSRIL SFIK 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18839 Genomic DNA. Translation: AAB64653.1.
BK006939 Genomic DNA. Translation: DAA07759.1.
PIRS50601.
RefSeqNP_011024.1. NM_001178989.1.

3D structure databases

ProteinModelPortalP39967.
SMRP39967. Positions 132-167, 383-694.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36844. 41 interactions.
DIPDIP-6551N.
MINTMINT-688224.
STRING4932.YER098W.

Protein family/group databases

MEROPSC19.A20.

Proteomic databases

PaxDbP39967.
PRIDEP39967.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER098W; YER098W; YER098W.
GeneID856835.
KEGGsce:YER098W.

Organism-specific databases

CYGDYER098w.
SGDS000000900. UBP9.

Phylogenomic databases

eggNOGCOG5077.
GeneTreeENSGT00650000093027.
HOGENOMHOG000141813.
KOK11872.
OMAMECITEN.
OrthoDBEOG7TF7JV.

Enzyme and pathway databases

BioCycYEAST:G3O-30264-MONOMER.

Gene expression databases

GenevestigatorP39967.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio983138.
PROP39967.

Entry information

Entry nameUBP9_YEAST
AccessionPrimary (citable) accession number: P39967
Secondary accession number(s): D3DM05
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries