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P39967

- UBP9_YEAST

UniProt

P39967 - UBP9_YEAST

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Protein
Ubiquitin carboxyl-terminal hydrolase 9
Gene
UBP9, YER098W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei143 – 1431Nucleophile By similarity
Active sitei618 – 6181Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: SGD

GO - Biological processi

  1. protein deubiquitination Source: SGD
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-30264-MONOMER.

Protein family/group databases

MEROPSiC19.A20.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 9 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 9
Ubiquitin thioesterase 9
Ubiquitin-specific-processing protease 9
Gene namesi
Name:UBP9
Ordered Locus Names:YER098W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER098w.
SGDiS000000900. UBP9.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 754754Ubiquitin carboxyl-terminal hydrolase 9
PRO_0000080594Add
BLAST

Proteomic databases

MaxQBiP39967.
PaxDbiP39967.
PRIDEiP39967.

Expressioni

Gene expression databases

GenevestigatoriP39967.

Interactioni

Protein-protein interaction databases

BioGridi36844. 41 interactions.
DIPiDIP-6551N.
MINTiMINT-688224.
STRINGi4932.YER098W.

Structurei

3D structure databases

ProteinModelPortaliP39967.
SMRiP39967. Positions 383-670.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 667534USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5077.
GeneTreeiENSGT00650000093027.
HOGENOMiHOG000141813.
KOiK11872.
OMAiMECITEN.
OrthoDBiEOG7TF7JV.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39967-1 [UniParc]FASTAAdd to Basket

« Hide

MIKRWLSVNR KKSHPEKNTQ GNDEINRKAT SLKKTKGSGD PSIAKSPSAK    50
SSTSSIPSNL ASHERRSKFS SQTDNLAGNK HYHEHYHNMA STSDEREYDS 100
STTYEDRAFD TESSILFTTI TDLMPYGDGS NKVFGYENFG NTCYCNSVLQ 150
CLYNIPEFRC NVLRYPERVA AVNRIRKSDL KGSKIRVFTN ESFETSTNSG 200
NSNTGYQSND NEDAHNHHHL QQSDQDNSSS STQEKQNNFE RKRNSFMGFG 250
KDKSNYKDSA KKDDNNEMER PQPVHTVVMA SDTLTEKLHE GCKKIIVGRP 300
LLKQSDSLSK ASTTDCQANS HCQCDSQGSR ITSVDDDVLV NPESCNDAVN 350
NSNNNKENTF PTSEQRKKAA LIRGPVLNVD HLLYPTEEAT LYNGLKDIFE 400
SITENLSLTG IVSPTEFVKI LKKENVLFNT MMQQDAHEFL NFLLNDFSEY 450
IQRNNPRMRF GPQKTDNSND NFITDLFKGT LTNRIKCLTC DNITSRDEPF 500
LDFPIEVQGD EETDIQKMLK SYHQREMLNG VNKFYCNKCY GLQEAERMVG 550
LKQLPHILSL HLKRFKYSEE QKSNIKLFNK ILYPLTLDVS STFNTSVYKK 600
YELSGVVIHM GSGPQHGHYV CICRNEKFGW LLYDDETVES IKEETVLQFT 650
GHPGDQTTAY VLFYKETQAD KTENQNENID TSSQDQMQTD NNIEQLIKCD 700
DWLRDRKLRA AANIERKKTL GNIPEVKTAE TKTPLNDKKR NKQKRKSRIL 750
SFIK 754
Length:754
Mass (Da):86,244
Last modified:February 1, 1995 - v1
Checksum:iD2C03D233D14D693
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18839 Genomic DNA. Translation: AAB64653.1.
BK006939 Genomic DNA. Translation: DAA07759.1.
PIRiS50601.
RefSeqiNP_011024.1. NM_001178989.1.

Genome annotation databases

EnsemblFungiiYER098W; YER098W; YER098W.
GeneIDi856835.
KEGGisce:YER098W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18839 Genomic DNA. Translation: AAB64653.1 .
BK006939 Genomic DNA. Translation: DAA07759.1 .
PIRi S50601.
RefSeqi NP_011024.1. NM_001178989.1.

3D structure databases

ProteinModelPortali P39967.
SMRi P39967. Positions 383-670.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36844. 41 interactions.
DIPi DIP-6551N.
MINTi MINT-688224.
STRINGi 4932.YER098W.

Protein family/group databases

MEROPSi C19.A20.

Proteomic databases

MaxQBi P39967.
PaxDbi P39967.
PRIDEi P39967.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER098W ; YER098W ; YER098W .
GeneIDi 856835.
KEGGi sce:YER098W.

Organism-specific databases

CYGDi YER098w.
SGDi S000000900. UBP9.

Phylogenomic databases

eggNOGi COG5077.
GeneTreei ENSGT00650000093027.
HOGENOMi HOG000141813.
KOi K11872.
OMAi MECITEN.
OrthoDBi EOG7TF7JV.

Enzyme and pathway databases

BioCyci YEAST:G3O-30264-MONOMER.

Miscellaneous databases

NextBioi 983138.
PROi P39967.

Gene expression databases

Genevestigatori P39967.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUBP9_YEAST
AccessioniPrimary (citable) accession number: P39967
Secondary accession number(s): D3DM05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 98 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

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