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Protein

Ubiquitin carboxyl-terminal hydrolase 9

Gene

UBP9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei143 – 1431NucleophilePROSITE-ProRule annotation
Active sitei618 – 6181Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: SGD

GO - Biological processi

  1. protein deubiquitination Source: SGD
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-30264-MONOMER.

Protein family/group databases

MEROPSiC19.A20.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 9 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 9
Ubiquitin thioesterase 9
Ubiquitin-specific-processing protease 9
Gene namesi
Name:UBP9
Ordered Locus Names:YER098W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER098w.
SGDiS000000900. UBP9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 754754Ubiquitin carboxyl-terminal hydrolase 9PRO_0000080594Add
BLAST

Proteomic databases

MaxQBiP39967.
PaxDbiP39967.
PRIDEiP39967.

Expressioni

Gene expression databases

GenevestigatoriP39967.

Interactioni

Protein-protein interaction databases

BioGridi36844. 41 interactions.
DIPiDIP-6551N.
MINTiMINT-688224.
STRINGi4932.YER098W.

Structurei

3D structure databases

ProteinModelPortaliP39967.
SMRiP39967. Positions 383-670.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 667534USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5077.
GeneTreeiENSGT00650000093027.
HOGENOMiHOG000141813.
InParanoidiP39967.
KOiK11872.
OMAiMECITEN.
OrthoDBiEOG7TF7JV.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39967-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKRWLSVNR KKSHPEKNTQ GNDEINRKAT SLKKTKGSGD PSIAKSPSAK
60 70 80 90 100
SSTSSIPSNL ASHERRSKFS SQTDNLAGNK HYHEHYHNMA STSDEREYDS
110 120 130 140 150
STTYEDRAFD TESSILFTTI TDLMPYGDGS NKVFGYENFG NTCYCNSVLQ
160 170 180 190 200
CLYNIPEFRC NVLRYPERVA AVNRIRKSDL KGSKIRVFTN ESFETSTNSG
210 220 230 240 250
NSNTGYQSND NEDAHNHHHL QQSDQDNSSS STQEKQNNFE RKRNSFMGFG
260 270 280 290 300
KDKSNYKDSA KKDDNNEMER PQPVHTVVMA SDTLTEKLHE GCKKIIVGRP
310 320 330 340 350
LLKQSDSLSK ASTTDCQANS HCQCDSQGSR ITSVDDDVLV NPESCNDAVN
360 370 380 390 400
NSNNNKENTF PTSEQRKKAA LIRGPVLNVD HLLYPTEEAT LYNGLKDIFE
410 420 430 440 450
SITENLSLTG IVSPTEFVKI LKKENVLFNT MMQQDAHEFL NFLLNDFSEY
460 470 480 490 500
IQRNNPRMRF GPQKTDNSND NFITDLFKGT LTNRIKCLTC DNITSRDEPF
510 520 530 540 550
LDFPIEVQGD EETDIQKMLK SYHQREMLNG VNKFYCNKCY GLQEAERMVG
560 570 580 590 600
LKQLPHILSL HLKRFKYSEE QKSNIKLFNK ILYPLTLDVS STFNTSVYKK
610 620 630 640 650
YELSGVVIHM GSGPQHGHYV CICRNEKFGW LLYDDETVES IKEETVLQFT
660 670 680 690 700
GHPGDQTTAY VLFYKETQAD KTENQNENID TSSQDQMQTD NNIEQLIKCD
710 720 730 740 750
DWLRDRKLRA AANIERKKTL GNIPEVKTAE TKTPLNDKKR NKQKRKSRIL

SFIK
Length:754
Mass (Da):86,244
Last modified:February 1, 1995 - v1
Checksum:iD2C03D233D14D693
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18839 Genomic DNA. Translation: AAB64653.1.
BK006939 Genomic DNA. Translation: DAA07759.1.
PIRiS50601.
RefSeqiNP_011024.1. NM_001178989.1.

Genome annotation databases

EnsemblFungiiYER098W; YER098W; YER098W.
GeneIDi856835.
KEGGisce:YER098W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18839 Genomic DNA. Translation: AAB64653.1.
BK006939 Genomic DNA. Translation: DAA07759.1.
PIRiS50601.
RefSeqiNP_011024.1. NM_001178989.1.

3D structure databases

ProteinModelPortaliP39967.
SMRiP39967. Positions 383-670.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36844. 41 interactions.
DIPiDIP-6551N.
MINTiMINT-688224.
STRINGi4932.YER098W.

Protein family/group databases

MEROPSiC19.A20.

Proteomic databases

MaxQBiP39967.
PaxDbiP39967.
PRIDEiP39967.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER098W; YER098W; YER098W.
GeneIDi856835.
KEGGisce:YER098W.

Organism-specific databases

CYGDiYER098w.
SGDiS000000900. UBP9.

Phylogenomic databases

eggNOGiCOG5077.
GeneTreeiENSGT00650000093027.
HOGENOMiHOG000141813.
InParanoidiP39967.
KOiK11872.
OMAiMECITEN.
OrthoDBiEOG7TF7JV.

Enzyme and pathway databases

BioCyciYEAST:G3O-30264-MONOMER.

Miscellaneous databases

NextBioi983138.
PROiP39967.

Gene expression databases

GenevestigatoriP39967.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUBP9_YEAST
AccessioniPrimary (citable) accession number: P39967
Secondary accession number(s): D3DM05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 7, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 98 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.