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P39967

- UBP9_YEAST

UniProt

P39967 - UBP9_YEAST

Protein

Ubiquitin carboxyl-terminal hydrolase 9

Gene

UBP9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei143 – 1431NucleophilePROSITE-ProRule annotation
    Active sitei618 – 6181Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: SGD

    GO - Biological processi

    1. protein deubiquitination Source: SGD
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30264-MONOMER.

    Protein family/group databases

    MEROPSiC19.A20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 9 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 9
    Ubiquitin thioesterase 9
    Ubiquitin-specific-processing protease 9
    Gene namesi
    Name:UBP9
    Ordered Locus Names:YER098W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER098w.
    SGDiS000000900. UBP9.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 754754Ubiquitin carboxyl-terminal hydrolase 9PRO_0000080594Add
    BLAST

    Proteomic databases

    MaxQBiP39967.
    PaxDbiP39967.
    PRIDEiP39967.

    Expressioni

    Gene expression databases

    GenevestigatoriP39967.

    Interactioni

    Protein-protein interaction databases

    BioGridi36844. 41 interactions.
    DIPiDIP-6551N.
    MINTiMINT-688224.
    STRINGi4932.YER098W.

    Structurei

    3D structure databases

    ProteinModelPortaliP39967.
    SMRiP39967. Positions 383-670.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini134 – 667534USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5077.
    GeneTreeiENSGT00650000093027.
    HOGENOMiHOG000141813.
    KOiK11872.
    OMAiMECITEN.
    OrthoDBiEOG7TF7JV.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39967-1 [UniParc]FASTAAdd to Basket

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    MIKRWLSVNR KKSHPEKNTQ GNDEINRKAT SLKKTKGSGD PSIAKSPSAK    50
    SSTSSIPSNL ASHERRSKFS SQTDNLAGNK HYHEHYHNMA STSDEREYDS 100
    STTYEDRAFD TESSILFTTI TDLMPYGDGS NKVFGYENFG NTCYCNSVLQ 150
    CLYNIPEFRC NVLRYPERVA AVNRIRKSDL KGSKIRVFTN ESFETSTNSG 200
    NSNTGYQSND NEDAHNHHHL QQSDQDNSSS STQEKQNNFE RKRNSFMGFG 250
    KDKSNYKDSA KKDDNNEMER PQPVHTVVMA SDTLTEKLHE GCKKIIVGRP 300
    LLKQSDSLSK ASTTDCQANS HCQCDSQGSR ITSVDDDVLV NPESCNDAVN 350
    NSNNNKENTF PTSEQRKKAA LIRGPVLNVD HLLYPTEEAT LYNGLKDIFE 400
    SITENLSLTG IVSPTEFVKI LKKENVLFNT MMQQDAHEFL NFLLNDFSEY 450
    IQRNNPRMRF GPQKTDNSND NFITDLFKGT LTNRIKCLTC DNITSRDEPF 500
    LDFPIEVQGD EETDIQKMLK SYHQREMLNG VNKFYCNKCY GLQEAERMVG 550
    LKQLPHILSL HLKRFKYSEE QKSNIKLFNK ILYPLTLDVS STFNTSVYKK 600
    YELSGVVIHM GSGPQHGHYV CICRNEKFGW LLYDDETVES IKEETVLQFT 650
    GHPGDQTTAY VLFYKETQAD KTENQNENID TSSQDQMQTD NNIEQLIKCD 700
    DWLRDRKLRA AANIERKKTL GNIPEVKTAE TKTPLNDKKR NKQKRKSRIL 750
    SFIK 754
    Length:754
    Mass (Da):86,244
    Last modified:February 1, 1995 - v1
    Checksum:iD2C03D233D14D693
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18839 Genomic DNA. Translation: AAB64653.1.
    BK006939 Genomic DNA. Translation: DAA07759.1.
    PIRiS50601.
    RefSeqiNP_011024.1. NM_001178989.1.

    Genome annotation databases

    EnsemblFungiiYER098W; YER098W; YER098W.
    GeneIDi856835.
    KEGGisce:YER098W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18839 Genomic DNA. Translation: AAB64653.1 .
    BK006939 Genomic DNA. Translation: DAA07759.1 .
    PIRi S50601.
    RefSeqi NP_011024.1. NM_001178989.1.

    3D structure databases

    ProteinModelPortali P39967.
    SMRi P39967. Positions 383-670.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36844. 41 interactions.
    DIPi DIP-6551N.
    MINTi MINT-688224.
    STRINGi 4932.YER098W.

    Protein family/group databases

    MEROPSi C19.A20.

    Proteomic databases

    MaxQBi P39967.
    PaxDbi P39967.
    PRIDEi P39967.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER098W ; YER098W ; YER098W .
    GeneIDi 856835.
    KEGGi sce:YER098W.

    Organism-specific databases

    CYGDi YER098w.
    SGDi S000000900. UBP9.

    Phylogenomic databases

    eggNOGi COG5077.
    GeneTreei ENSGT00650000093027.
    HOGENOMi HOG000141813.
    KOi K11872.
    OMAi MECITEN.
    OrthoDBi EOG7TF7JV.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30264-MONOMER.

    Miscellaneous databases

    NextBioi 983138.
    PROi P39967.

    Gene expression databases

    Genevestigatori P39967.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiUBP9_YEAST
    AccessioniPrimary (citable) accession number: P39967
    Secondary accession number(s): D3DM05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 98 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3