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Protein

Ubiquitin carboxyl-terminal hydrolase 9

Gene

UBP9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 98 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei143NucleophilePROSITE-ProRule annotation1
Active sitei618Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • thiol-dependent ubiquitin-specific protease activity Source: SGD

GO - Biological processi

  • protein deubiquitination Source: SGD
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-30264-MONOMER
ReactomeiR-SCE-110314 Recognition of DNA damage by PCNA-containing replication complex

Protein family/group databases

MEROPSiC19.A20

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 9 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 9
Ubiquitin thioesterase 9
Ubiquitin-specific-processing protease 9
Gene namesi
Name:UBP9
Ordered Locus Names:YER098W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER098W
SGDiS000000900 UBP9

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805941 – 754Ubiquitin carboxyl-terminal hydrolase 9Add BLAST754

Proteomic databases

MaxQBiP39967
PaxDbiP39967
PRIDEiP39967

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36844, 106 interactors
DIPiDIP-6551N
IntActiP39967, 11 interactors
MINTiP39967
STRINGi4932.YER098W

Structurei

3D structure databases

ProteinModelPortaliP39967
SMRiP39967
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 667USPAdd BLAST534

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

GeneTreeiENSGT00890000139367
HOGENOMiHOG000141813
InParanoidiP39967
KOiK11872
OMAiECITENL
OrthoDBiEOG092C0UAA

Family and domain databases

InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

P39967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKRWLSVNR KKSHPEKNTQ GNDEINRKAT SLKKTKGSGD PSIAKSPSAK
60 70 80 90 100
SSTSSIPSNL ASHERRSKFS SQTDNLAGNK HYHEHYHNMA STSDEREYDS
110 120 130 140 150
STTYEDRAFD TESSILFTTI TDLMPYGDGS NKVFGYENFG NTCYCNSVLQ
160 170 180 190 200
CLYNIPEFRC NVLRYPERVA AVNRIRKSDL KGSKIRVFTN ESFETSTNSG
210 220 230 240 250
NSNTGYQSND NEDAHNHHHL QQSDQDNSSS STQEKQNNFE RKRNSFMGFG
260 270 280 290 300
KDKSNYKDSA KKDDNNEMER PQPVHTVVMA SDTLTEKLHE GCKKIIVGRP
310 320 330 340 350
LLKQSDSLSK ASTTDCQANS HCQCDSQGSR ITSVDDDVLV NPESCNDAVN
360 370 380 390 400
NSNNNKENTF PTSEQRKKAA LIRGPVLNVD HLLYPTEEAT LYNGLKDIFE
410 420 430 440 450
SITENLSLTG IVSPTEFVKI LKKENVLFNT MMQQDAHEFL NFLLNDFSEY
460 470 480 490 500
IQRNNPRMRF GPQKTDNSND NFITDLFKGT LTNRIKCLTC DNITSRDEPF
510 520 530 540 550
LDFPIEVQGD EETDIQKMLK SYHQREMLNG VNKFYCNKCY GLQEAERMVG
560 570 580 590 600
LKQLPHILSL HLKRFKYSEE QKSNIKLFNK ILYPLTLDVS STFNTSVYKK
610 620 630 640 650
YELSGVVIHM GSGPQHGHYV CICRNEKFGW LLYDDETVES IKEETVLQFT
660 670 680 690 700
GHPGDQTTAY VLFYKETQAD KTENQNENID TSSQDQMQTD NNIEQLIKCD
710 720 730 740 750
DWLRDRKLRA AANIERKKTL GNIPEVKTAE TKTPLNDKKR NKQKRKSRIL

SFIK
Length:754
Mass (Da):86,244
Last modified:February 1, 1995 - v1
Checksum:iD2C03D233D14D693
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18839 Genomic DNA Translation: AAB64653.1
BK006939 Genomic DNA Translation: DAA07759.1
PIRiS50601
RefSeqiNP_011024.1, NM_001178989.1

Genome annotation databases

EnsemblFungiiYER098W; YER098W; YER098W
GeneIDi856835
KEGGisce:YER098W

Similar proteinsi

Entry informationi

Entry nameiUBP9_YEAST
AccessioniPrimary (citable) accession number: P39967
Secondary accession number(s): D3DM05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health