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Protein

Protein phosphatase 2C homolog 2

Gene

PTC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Responsible, together with PTC3, for the dephosphorylation of the cyclin-dependent protein kinase CDC28.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Manganese 1By similarity1
Metal bindingi62Manganese 2By similarity1
Metal bindingi63Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi234Manganese 2By similarity1
Metal bindingi283Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: SGD

GO - Biological processi

  • DNA damage checkpoint Source: SGD
  • endoplasmic reticulum unfolded protein response Source: SGD
  • inactivation of MAPK activity involved in osmosensory signaling pathway Source: SGD
  • protein dephosphorylation Source: SGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30258-MONOMER.
ReactomeiR-SCE-1169408. ISG15 antiviral mechanism.
R-SCE-380972. Energy dependent regulation of mTOR by LKB1-AMPK.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 2 (EC:3.1.3.16)
Short name:
PP2C-2
Gene namesi
Name:PTC2
Ordered Locus Names:YER089C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER089C.
SGDiS000000891. PTC2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577751 – 464Protein phosphatase 2C homolog 2Add BLAST464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei376PhosphothreonineCombined sources1
Modified residuei380PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39966.
PRIDEiP39966.

PTM databases

iPTMnetiP39966.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PAA1Q124477EBI-12795,EBI-33397

Protein-protein interaction databases

BioGridi36834. 125 interactors.
DIPiDIP-1539N.
IntActiP39966. 13 interactors.
MINTiMINT-411725.

Structurei

3D structure databases

ProteinModelPortaliP39966.
SMRiP39966.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 292PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST270

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00740000115384.
HOGENOMiHOG000233896.
InParanoidiP39966.
KOiK14803.
OMAiDEWAFEE.
OrthoDBiEOG092C1UK5.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQILSNPVI DKESHSGADS LTAFGLCAMQ GWRMSMEDSH ILEPNVLTKS
60 70 80 90 100
DKDHIAFYGI FDGHGGAKVA EYCGNKIVEI LQEQKSFHEG NLPRALIDTF
110 120 130 140 150
INTDVKLLQD PVMKEDHSGC TATSILVSKS QNLLVCGNAG DSRTVLATDG
160 170 180 190 200
NAKALSYDHK PTLASEKSRI VAADGFVEMD RVNGNLALSR AIGDFEFKSN
210 220 230 240 250
PKLGPEEQIV TCVPDILEHS LDYDRDEFVI LACDGIWDCL TSQDCVDLVH
260 270 280 290 300
LGLREGKTLN EISSRIIDVC CAPTTEGTGI GCDNMSIVVV ALLKEGEDVA
310 320 330 340 350
QWSDRMKSKA HRTSVRSFAD KRRRVFSYYD FSKCNDEQVF AITTKKPQDK
360 370 380 390 400
FTRDHEAAVA SVTAADNDDP MDIDDTDADT DAENLDPSSQ SKSKTSGPID
410 420 430 440 450
LASLEALLGA TGGVKTDSNG NKVTYTLPQS ALAQLLQTMG HDPASSHPEN
460
DSNTDHKAGR SHLQ
Length:464
Mass (Da):50,388
Last modified:February 1, 1995 - v1
Checksum:i61D82D2CA4ED3FED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18839 Genomic DNA. Translation: AAB64644.1.
U72498 Genomic DNA. Translation: AAB17392.1.
BK006939 Genomic DNA. Translation: DAA07750.1.
PIRiS50592.
RefSeqiNP_011013.1. NM_001178980.1.

Genome annotation databases

EnsemblFungiiYER089C; YER089C; YER089C.
GeneIDi856823.
KEGGisce:YER089C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18839 Genomic DNA. Translation: AAB64644.1.
U72498 Genomic DNA. Translation: AAB17392.1.
BK006939 Genomic DNA. Translation: DAA07750.1.
PIRiS50592.
RefSeqiNP_011013.1. NM_001178980.1.

3D structure databases

ProteinModelPortaliP39966.
SMRiP39966.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36834. 125 interactors.
DIPiDIP-1539N.
IntActiP39966. 13 interactors.
MINTiMINT-411725.

PTM databases

iPTMnetiP39966.

Proteomic databases

MaxQBiP39966.
PRIDEiP39966.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER089C; YER089C; YER089C.
GeneIDi856823.
KEGGisce:YER089C.

Organism-specific databases

EuPathDBiFungiDB:YER089C.
SGDiS000000891. PTC2.

Phylogenomic databases

GeneTreeiENSGT00740000115384.
HOGENOMiHOG000233896.
InParanoidiP39966.
KOiK14803.
OMAiDEWAFEE.
OrthoDBiEOG092C1UK5.

Enzyme and pathway databases

BioCyciYEAST:G3O-30258-MONOMER.
ReactomeiR-SCE-1169408. ISG15 antiviral mechanism.
R-SCE-380972. Energy dependent regulation of mTOR by LKB1-AMPK.

Miscellaneous databases

PROiP39966.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP2C2_YEAST
AccessioniPrimary (citable) accession number: P39966
Secondary accession number(s): D3DLZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 162 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 12600 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.