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P39966

- PP2C2_YEAST

UniProt

P39966 - PP2C2_YEAST

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Protein
Protein phosphatase 2C homolog 2
Gene
PTC2, YER089C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Responsible, together with PTC3, for the dephosphorylation of the cyclin-dependent protein kinase CDC28.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Manganese 1 By similarity
Metal bindingi62 – 621Manganese 2 By similarity
Metal bindingi63 – 631Manganese 1; via carbonyl oxygen By similarity
Metal bindingi234 – 2341Manganese 2 By similarity
Metal bindingi283 – 2831Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. protein serine/threonine phosphatase activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. DNA damage checkpoint Source: SGD
  2. endoplasmic reticulum unfolded protein response Source: SGD
  3. inactivation of MAPK activity involved in osmosensory signaling pathway Source: SGD
  4. protein dephosphorylation Source: SGD
  5. regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30258-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 2 (EC:3.1.3.16)
Short name:
PP2C-2
Gene namesi
Name:PTC2
Ordered Locus Names:YER089C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER089c.
SGDiS000000891. PTC2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Protein phosphatase 2C homolog 2
PRO_0000057775Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei376 – 3761Phosphothreonine1 Publication
Modified residuei380 – 3801Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39966.
PaxDbiP39966.
PeptideAtlasiP39966.
PRIDEiP39966.

Expressioni

Gene expression databases

GenevestigatoriP39966.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PAA1Q124477EBI-12795,EBI-33397

Protein-protein interaction databases

BioGridi36834. 121 interactions.
DIPiDIP-1539N.
IntActiP39966. 13 interactions.
MINTiMINT-411725.
STRINGi4932.YER089C.

Structurei

3D structure databases

ProteinModelPortaliP39966.
SMRiP39966. Positions 1-270.

Family & Domainsi

Sequence similaritiesi

Belongs to the PP2C family.

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00740000115384.
HOGENOMiHOG000233896.
KOiK14803.
OMAiDPDINTI.
OrthoDBiEOG79930T.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39966-1 [UniParc]FASTAAdd to Basket

« Hide

MGQILSNPVI DKESHSGADS LTAFGLCAMQ GWRMSMEDSH ILEPNVLTKS    50
DKDHIAFYGI FDGHGGAKVA EYCGNKIVEI LQEQKSFHEG NLPRALIDTF 100
INTDVKLLQD PVMKEDHSGC TATSILVSKS QNLLVCGNAG DSRTVLATDG 150
NAKALSYDHK PTLASEKSRI VAADGFVEMD RVNGNLALSR AIGDFEFKSN 200
PKLGPEEQIV TCVPDILEHS LDYDRDEFVI LACDGIWDCL TSQDCVDLVH 250
LGLREGKTLN EISSRIIDVC CAPTTEGTGI GCDNMSIVVV ALLKEGEDVA 300
QWSDRMKSKA HRTSVRSFAD KRRRVFSYYD FSKCNDEQVF AITTKKPQDK 350
FTRDHEAAVA SVTAADNDDP MDIDDTDADT DAENLDPSSQ SKSKTSGPID 400
LASLEALLGA TGGVKTDSNG NKVTYTLPQS ALAQLLQTMG HDPASSHPEN 450
DSNTDHKAGR SHLQ 464
Length:464
Mass (Da):50,388
Last modified:February 1, 1995 - v1
Checksum:i61D82D2CA4ED3FED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18839 Genomic DNA. Translation: AAB64644.1.
U72498 Genomic DNA. Translation: AAB17392.1.
BK006939 Genomic DNA. Translation: DAA07750.1.
PIRiS50592.
RefSeqiNP_011013.1. NM_001178980.1.

Genome annotation databases

EnsemblFungiiYER089C; YER089C; YER089C.
GeneIDi856823.
KEGGisce:YER089C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18839 Genomic DNA. Translation: AAB64644.1 .
U72498 Genomic DNA. Translation: AAB17392.1 .
BK006939 Genomic DNA. Translation: DAA07750.1 .
PIRi S50592.
RefSeqi NP_011013.1. NM_001178980.1.

3D structure databases

ProteinModelPortali P39966.
SMRi P39966. Positions 1-270.
ModBasei Search...

Protein-protein interaction databases

BioGridi 36834. 121 interactions.
DIPi DIP-1539N.
IntActi P39966. 13 interactions.
MINTi MINT-411725.
STRINGi 4932.YER089C.

Proteomic databases

MaxQBi P39966.
PaxDbi P39966.
PeptideAtlasi P39966.
PRIDEi P39966.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER089C ; YER089C ; YER089C .
GeneIDi 856823.
KEGGi sce:YER089C.

Organism-specific databases

CYGDi YER089c.
SGDi S000000891. PTC2.

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00740000115384.
HOGENOMi HOG000233896.
KOi K14803.
OMAi DPDINTI.
OrthoDBi EOG79930T.

Enzyme and pathway databases

BioCyci YEAST:G3O-30258-MONOMER.

Miscellaneous databases

NextBioi 983109.
PROi P39966.

Gene expression databases

Genevestigatori P39966.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Maeda T., Tsai A.Y.M., Saito H.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases."
    Cheng A., Ross K.E., Kaldis P., Solomon M.J.
    Genes Dev. 13:2946-2957(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-376 AND THR-380, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPP2C2_YEAST
AccessioniPrimary (citable) accession number: P39966
Secondary accession number(s): D3DLZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 12600 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

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