Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein phosphatase 2C homolog 2

Gene

PTC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible, together with PTC3, for the dephosphorylation of the cyclin-dependent protein kinase CDC28.1 Publication

Miscellaneous

Present with 12600 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Manganese 1By similarity1
Metal bindingi62Manganese 2By similarity1
Metal bindingi63Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi234Manganese 2By similarity1
Metal bindingi283Manganese 2By similarity1

GO - Molecular functioni

  • MAP kinase serine/threonine phosphatase activity Source: SGD
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: SGD

GO - Biological processi

  • DNA damage checkpoint Source: SGD
  • endoplasmic reticulum unfolded protein response Source: SGD
  • inactivation of MAPK activity Source: SGD
  • peptidyl-threonine dephosphorylation Source: SGD
  • protein dephosphorylation Source: SGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30258-MONOMER
ReactomeiR-SCE-1169408 ISG15 antiviral mechanism
R-SCE-380972 Energy dependent regulation of mTOR by LKB1-AMPK

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 2 (EC:3.1.3.16)
Short name:
PP2C-2
Gene namesi
Name:PTC2
Ordered Locus Names:YER089C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER089C
SGDiS000000891 PTC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577751 – 464Protein phosphatase 2C homolog 2Add BLAST464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei376PhosphothreonineCombined sources1
Modified residuei380PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39966
PaxDbiP39966
PRIDEiP39966

PTM databases

iPTMnetiP39966

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36834, 204 interactors
DIPiDIP-1539N
IntActiP39966, 18 interactors
MINTiP39966
STRINGi4932.YER089C

Structurei

3D structure databases

ProteinModelPortaliP39966
SMRiP39966
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 292PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST270

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

GeneTreeiENSGT00880000137909
HOGENOMiHOG000233896
InParanoidiP39966
KOiK14803
OMAiARVSAHC
OrthoDBiEOG092C1UK5

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

P39966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQILSNPVI DKESHSGADS LTAFGLCAMQ GWRMSMEDSH ILEPNVLTKS
60 70 80 90 100
DKDHIAFYGI FDGHGGAKVA EYCGNKIVEI LQEQKSFHEG NLPRALIDTF
110 120 130 140 150
INTDVKLLQD PVMKEDHSGC TATSILVSKS QNLLVCGNAG DSRTVLATDG
160 170 180 190 200
NAKALSYDHK PTLASEKSRI VAADGFVEMD RVNGNLALSR AIGDFEFKSN
210 220 230 240 250
PKLGPEEQIV TCVPDILEHS LDYDRDEFVI LACDGIWDCL TSQDCVDLVH
260 270 280 290 300
LGLREGKTLN EISSRIIDVC CAPTTEGTGI GCDNMSIVVV ALLKEGEDVA
310 320 330 340 350
QWSDRMKSKA HRTSVRSFAD KRRRVFSYYD FSKCNDEQVF AITTKKPQDK
360 370 380 390 400
FTRDHEAAVA SVTAADNDDP MDIDDTDADT DAENLDPSSQ SKSKTSGPID
410 420 430 440 450
LASLEALLGA TGGVKTDSNG NKVTYTLPQS ALAQLLQTMG HDPASSHPEN
460
DSNTDHKAGR SHLQ
Length:464
Mass (Da):50,388
Last modified:February 1, 1995 - v1
Checksum:i61D82D2CA4ED3FED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18839 Genomic DNA Translation: AAB64644.1
U72498 Genomic DNA Translation: AAB17392.1
BK006939 Genomic DNA Translation: DAA07750.1
PIRiS50592
RefSeqiNP_011013.1, NM_001178980.1

Genome annotation databases

EnsemblFungiiYER089C; YER089C; YER089C
GeneIDi856823
KEGGisce:YER089C

Similar proteinsi

Entry informationi

Entry nameiPP2C2_YEAST
AccessioniPrimary (citable) accession number: P39966
Secondary accession number(s): D3DLZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 25, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health