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Protein

Probable proline--tRNA ligase, mitochondrial

Gene

AIM10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • proline-tRNA ligase activity Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30256-MONOMER.
SABIO-RKP39965.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proline--tRNA ligase, mitochondrial (EC:6.1.1.15)
Alternative name(s):
Altered inheritance rate of mitochondria protein 10
Prolyl-tRNA synthetase
Short name:
ProRS
Gene namesi
Name:AIM10
Ordered Locus Names:YER087W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER087W.
SGDiS000000889. AIM10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Probable proline--tRNA ligase, mitochondrialPRO_0000139354Add
BLAST

Proteomic databases

MaxQBiP39965.
PeptideAtlasiP39965.

PTM databases

iPTMnetiP39965.

Interactioni

Protein-protein interaction databases

BioGridi36831. 32 interactions.
DIPiDIP-4922N.
IntActiP39965. 1 interaction.
MINTiMINT-520314.

Structurei

3D structure databases

ProteinModelPortaliP39965.
SMRiP39965. Positions 19-536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000010922.
HOGENOMiHOG000076895.
InParanoidiP39965.
KOiK01881.
OMAiDINIYAI.
OrthoDBiEOG7PGF12.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004500. Pro-tRNA-synth_IIa_bac-type.
[Graphical view]
PANTHERiPTHR11451:SF3. PTHR11451:SF3. 2 hits.
PfamiPF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSiPR01046. TRNASYNTHPRO.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00409. proS_fam_II. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39965-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKYRTLSRS CHIFHPKSLS NNTLKSETTQ ELLQTVGFVR RSQVGLFQWL
60 70 80 90 100
PLGLRSLNKV SNAIRNRMDS DGGAIEVSLS AISSKALWQA TDRWNNSELF
110 120 130 140 150
KLKDSKGKQY CLTATCEEDI TDLMKNYIAS YKDMPITIYQ MTRKYRDEIR
160 170 180 190 200
PRGGILRGRE FLMKDAYSFA SNEEDAFASF QKLDDTYNKI FKDLKIPFVS
210 220 230 240 250
AWADSGDIGG EFSKEFHLIH ESGEDTLMSC KHCGDISTLD MSQSYPEKDG
260 270 280 290 300
QYSGDVDCKY ALTKDHSTLI CFYYPKDRQL NWNLALNAMD KDIDLTLRNK
310 320 330 340 350
PNDHVLQVYE KDNEDIMFSK ILRVMDCRLN SKSNFPDFPL KKYLKNNFGQ
360 370 380 390 400
ISDVSIVDAQ ENEICGKCEE GRLEPLKSIE VGHIFLLGNK YSKPLNVKFV
410 420 430 440 450
DKENKNETFV HMGCYGIGVS RLVGAIAELG RDSNGFRWPA IMAPYKVSIC
460 470 480 490 500
TGPNNPENSQ RLQDVKSELL NDPTMQNLQN DILDQFNEKL GIGARIKLSH
510 520 530 540 550
AMGIPLCVIV GSKSWPNVEI EVRGIRWGEK DLWRKQFEKR CSELQWKCTK
560 570
NEHGIEKHTV PIQHLAEVIG VLLKDM
Length:576
Mass (Da):65,880
Last modified:February 1, 1995 - v1
Checksum:iD8C5BD76B47CCAF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18839 Genomic DNA. Translation: AAB64642.1.
BK006939 Genomic DNA. Translation: DAA07747.1.
PIRiS50590.
RefSeqiNP_011010.1. NM_001178978.1.

Genome annotation databases

EnsemblFungiiYER087W; YER087W; YER087W.
GeneIDi856820.
KEGGisce:YER087W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18839 Genomic DNA. Translation: AAB64642.1.
BK006939 Genomic DNA. Translation: DAA07747.1.
PIRiS50590.
RefSeqiNP_011010.1. NM_001178978.1.

3D structure databases

ProteinModelPortaliP39965.
SMRiP39965. Positions 19-536.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36831. 32 interactions.
DIPiDIP-4922N.
IntActiP39965. 1 interaction.
MINTiMINT-520314.

PTM databases

iPTMnetiP39965.

Proteomic databases

MaxQBiP39965.
PeptideAtlasiP39965.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER087W; YER087W; YER087W.
GeneIDi856820.
KEGGisce:YER087W.

Organism-specific databases

EuPathDBiFungiDB:YER087W.
SGDiS000000889. AIM10.

Phylogenomic databases

GeneTreeiENSGT00390000010922.
HOGENOMiHOG000076895.
InParanoidiP39965.
KOiK01881.
OMAiDINIYAI.
OrthoDBiEOG7PGF12.

Enzyme and pathway databases

BioCyciYEAST:G3O-30256-MONOMER.
SABIO-RKP39965.

Miscellaneous databases

NextBioi983100.
PROiP39965.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004500. Pro-tRNA-synth_IIa_bac-type.
[Graphical view]
PANTHERiPTHR11451:SF3. PTHR11451:SF3. 2 hits.
PfamiPF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSiPR01046. TRNASYNTHPRO.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00409. proS_fam_II. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  4. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
    Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
    J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSYPM_YEAST
AccessioniPrimary (citable) accession number: P39965
Secondary accession number(s): D3DLZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 11, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 477 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.